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Br.in-der.ved neur.tr.phic factor.s.gnaling in the neur.mus.ular.junction dur.ng developmental axonal competition and s.naps. elimination

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neur.l r.gener.tion r.s.ar.h 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor.Ciller.s.mañé Laia Jus.-Bor.às.mar.a Balanyà-s.gur. Aleks.ndr. Polis.chuk Laur. nadal mar.a Tomàs.Car.lina s.lver.-s.món manel M.s.ntafé mar.a A.Lanuza Unitat d’His.ologia i neur.biologia(UHneur.b) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

Dur.ng the development of the ner.ous.s.s.em,ther. is.an over.r.duction of neur.ns.and *** competition between neighbor.ng ner.e endings.and s.naps.s.per.or.ing differ.nt activity levels.leads.to their.elimination or.*** have extens.vely s.udied the involvement of the br.in-der.ved neur.tr.phic factor.Tr.pomyos.n-r.lated kinas. B r.ceptor.neur.tr.phic r.tr.gr.de pathway,at the neur.mus.ular.junction,in the axonal development and s.naps. elimination pr.ces. ver.us.the s.naps. *** pur.os. of this.r.view is.to des.r.be the neur.tr.phic influence on developmental s.naps. elimination,in r.lation to other.molecular.pathways.that we and other. have found to r.gulate this.*** par.icular.we s.mmar.ze our.publis.ed r.s.lts.bas.d on tr.ns.itter.r.leas. analys.s.and axonal counts.to s.ow the differ.nt involvement of the pr.s.naptic acetylcholine mus.ar.nic autor.ceptor.,coupled to downs.r.am s.r.ne-thr.onine pr.tein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at differ.nt ner.e endings.in developmental *** dynamic changes.that occur.s.multaneous.y in s.ver.l ner.e ter.inals.and s.naps.s.conver.e acr.s. a pos.s.naptic s.te,influence each other.and r.quir. car.ful s.udies.to individualize the mechanis.s.of s.ecific *** des.r.be an activity-dependent balance(r.lated to the extent of tr.ns.itter.r.leas.)between the pr.s.naptic mus.ar.nic s.btypes.and the neur.tr.phin-mediated Tr.B/p75nTr.pathways.that can influence the timing and fate of the competitive inter.ctions.between the differ.nt axon *** downs.r.am dis.lacement of the PKA/PKC activity r.tio to lower.values.both in competing ner.e ter.inals.and at pos.s.naptic s.tes.plays.a r.levant r.le in contr.lling the elimination of s.per.umer.r. ***,calcium entr. thr.ugh L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.ar. pr.s.nt,together.with the n-type channel in developing ner.e ter.inals.contr.butes.to r.d

关键词： acetylcholine r.leas. adenos.ne r.ceptor. axonal competition br.in-der.ved neur.tr.phic factor calcium channels motor.end-plate mus.ar.nic acetylcholine r.ceptor. pos.natal s.naps. elimination s.r.ne kinas.s tr.pomyos.n-r.lated kinas. r.ceptor.

Emer.ing s.r.ctur.s.and dynamic mechanis.s.ofγ-s.cr.tas. for.Alzheimer.s.dis.as.

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neur.l r.gener.tion r.s.ar.h 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Pr.gr.m and Depar.ment of Phar.acology University of North Carolina–Chapel HillChapel HillNCUSA Depar.ment of Medicinal Chemis.r. University of KansasLawrenceKSUSA

γ-s.cr.tas.,called“the pr.teas.me of the membr.ne,”is.a membr.ne-embedded pr.teas. complex that cleaves.150+peptide s.bs.r.tes.with centr.l r.les.in biology and medicine,including amyloid pr.cur.or.pr.tein and the notch family of cell-s.r.ace *** inγ-s.cr.tas. and amyloid pr.cur.or.pr.tein lead to ear.y-ons.t familial Alzheimer.s.dis.as..γ-s.cr.tas. has.thus.s.r.ed as.a cr.tical dr.g tar.et for.tr.ating familial Alzheimer.s.dis.as. and the mor. common late-ons.t Alzheimer.s.dis.as. as.***,cr.tical gaps.r.main in under.tanding the mechanis.s.of pr.ces.ive pr.teolys.s.of s.bs.r.tes.the effects.of familial Alzheimer.s.dis.as. mutations.and allos.er.c modulation of s.bs.r.te cleavage byγ-*** this.r.view,we focus.on r.cent s.udies.of s.r.ctur.l dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Tr.m,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been pr.pos.d for.s.bs.r.te pr.teolys.s.of amyloid pr.cur.or.pr.tein byγ-s.cr.tas. bas.d on all-atom molecular.dynamics.*** an incor.ect r.gis.r. of the notch1 s.bs.r.te was.identified in the cr.o-electr.n micr.s.opy s.r.ctur. of notch1-boundγ-s.cr.tas.,molecular.dynamics.s.mulations.on a r.s.lved model of notch1-boundγ-s.cr.tas. that was.r.cons.r.cted us.ng the amyloid pr.cur.or.pr.tein-boundγ-s.cr.tas. as.a template s.cces.fully captur.dγ-s.cr.tas. activation for.pr.per.cleavages.of both wildtype and mutant notch,being cons.s.ent with biochemical exper.mental *** appr.ach could be potentially applied to decipher.the pr.ces.ing mechanis.s.of var.ous.s.bs.r.tes.byγ-*** addition,contr.ver.y over.the effects.of familial Alzheimer.s.dis.as. mutations.par.icular.y the is.ue of whether.they s.abilize or.des.abilizeγ-s.cr.tas.-s.bs.r.te complexes.is.***,an outlook is.pr.vided for.futur. s.udies.ofγ-s.cr.tas.,including pathways.of s.bs.r.te binding and pr.duct r.leas.,effects.of modulator. on familial Alzheimer.s.dis.as. mutations

关键词： Alzheimer.s.dis.as. amyloid pr.cur.or.pr.tein cr.o-EM s.r.ctur.s dr.g des.gn intr.membr.ne pr.teolys.s molecular.dynamics notch

Complementar. r.les.of glial cells.in gener.ting r.gion-s.ecific neur.inflammator. r.s.ons.s.and phagocytos.s.in Par.ins.n’s.dis.as.

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neur.l r.gener.tion r.s.ar.h 2025年第10期20卷 2917-2918页

作者： Leyr. Ayer.a mar.a s.Aymer.ch Univer.idad de navar.a Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIma-Univer.idad de navar.a PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

neur.inflammation is.as.ociated with Par.ins.n’s.dis.as.:r.active glios.s.and neur.inflammation ar. hallmar.s.of Par.ins.n’s.dis.as.(PD),a multis.s.em neur.degener.tive dis.r.er.char.cter.zed by a pr.gr.s.ive los. of dopaminer.ic *** has.long been cons.der.d a mer. cons.quence of neur.nal los.,but whether.it pr.motes.PD or.is.a key player.in dis.as. pr.gr.s.ion r.mains.to be *** leukocyte antigen.

关键词： inflammation leukocyte gener.ting

nucleos.de modified mr.A-lipid nanopar.icles.as.a new deliver. platfor. for.the r.pair.of the injur.d s.inal cor.

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neur.l r.gener.tion r.s.ar.h 2025年第8期20卷 2311-2312页

作者： Kr.s.tián Pajer.Tamás.Bellák Antal nógr.di Depar.ment of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

s.inal cor. injur. and tr.atment oppor.unities.The adult mammalian s.inal cor. has.a ver. limited capacity for.s.ontaneous.r.gener.tion due to var.ous.intr.ns.c molecular.and cellular.*** the s.inal cor. neur.ns.have the capacity to r.gener.te their.axons.the expr.s.ion of gr.wth inhibitor. factor.,lack or.s.ppr.s.ion of pr.per.guidance cues.and pr.found inflammator. r.s.ons.s.do not per.it s.cces.ful r.gener.tion(Khyeam et al.,2021).

关键词： injur.d capacity modified

r.gulator.of G pr.tein s.gnaling 6 mediates.exer.is.-induced r.cover. of hippocampal neur.genes.s.lear.ing,and memor. in a mous. model of Alzheimer.s.dis.as.

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neur.l r.gener.tion r.s.ar.h 2025年第10期20卷 2969-2981页

作者： mackenzie M.s.icer.Jianqi Yang Daniel Fu Alis.n n.DeVor. mar.s.l Lauffer.nilufer.s.Atas.y Deniz Atas.y r.r. A.Fis.er Depar.ment of neur.s.ience and Phar.acology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neur.s.ience Ins.itute University of Iowa Carver College of MedicineIowa CityIAUSA Inter.is.iplinar. Gr.duate Pr.gr.m in Molecular.Medicine University of Iowa Carver College of MedicineIowa CityIAUSA neur.l Cir.uits.and Behavior.Cor. University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neur.nal los. caus.s.cognitive dys.unction in Alzheimer.s.*** hippocampal neur.genes.s.is.r.duced in patients.with Alzheimer.s.*** s.imulates.adult hippocampal neur.genes.s.in r.dents.and impr.ves.memor. and s.ows.cognitive decline in patients.with Alzheimer.s.***,the molecular.pathways.for.exer.is.-induced adult hippocampal neur.genes.s.and impr.ved cognition in Alzheimer.s.dis.as. ar. poor.y ***,r.gulator.of G pr.tein s.gnaling 6(r.s.)was.identified as.the mediator.of voluntar. r.nning-induced adult hippocampal neur.genes.s.in ***,we gener.ted novel r.s.fl/fl;APP_(s.E) mice and us.d r.tr.vir.l appr.aches.to examine the impact of r.s. deletion fr.m dentate gyr.s.neur.nal pr.genitor.cells.on voluntar. r.nning-induced adult hippocampal neur.genes.s.and cognition in an amyloid-bas.d Alzheimer.s.dis.as. mous. *** found that voluntar. r.nning in APP_(s.E) mice r.s.or.d their.hippocampal cognitive impair.ents.to that of contr.l *** cognitive r.s.ue was.abolis.ed by r.s. deletion in dentate gyr.s.neur.nal pr.genitor.cells.which als. abolis.ed r.nning-mediated incr.as.s.in adult hippocampal *** hippocampal neur.genes.s.was.r.duced in s.dentar. APP_(s.E) mice ver.us.contr.l mice,with bas.l adult hippocampal neur.genes.s.r.duced by r.s. deletion in dentate gyr.s.neur.l pr.cur.or.***6 was.expr.s.ed in neur.ns.within the dentate gyr.s.of patients.with Alzheimer.s.dis.as. with s.gnificant los. of thes. r.s.-expr.s.ing ***,r.s. mediated voluntar. r.nning-induced r.s.ue of impair.d cognition and adult hippocampal neur.genes.s.in APP_(s.E) mice,identifying r.s. in dentate gyr.s.neur.l pr.cur.or.cells.as.a pos.ible ther.peutic tar.et in Alzheimer.s.dis.as..

关键词： adult hippocampal neur.genes.s Alzheimer.s.dis.as. dentate gyr.s exer.is. lear.ing/memor. neur.l pr.cur.or.cells r.gulator.of G pr.tein s.gnaling 6(r.s.)

Tr.ns.ent r.ceptor.potential channels.and calcium dys.0}gulation: a pathogenic duo in Par.ins.n's.dis.as.

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neur.l r.gener.tion r.s.ar.h 2025年第3期20卷 808-810页

作者： Iqir. s.eed Linlin ma Gr.ffith Ins.itute for.Dr.g Dis.over. Griffith UniversityNathanBrisbaneQLDAustralia s.hool of Envir.nment and s.ience Griffith University NathanBrisbaneQLDAustralia

Par.ins.n's.dis.as.(PD) has.a complex and multifactor.al pathophys.ology. Var.ous.s.udies. conducted both in pr.-clinical models.and PD patients. have r.por.ed a link between the dis.0}ption of calcium(Ca^(2+)) homeos.as.s.and the s.bs.quent development of PD. Ca^(2+) r.gulation is.cr.cial for.neur.nal s.r.ival, differ.ntiation,exocytos.s.at s.naps.s.gene tr.ns.r.ption,and pr.lifer.tion.

关键词： homeos.as.s clinical s.bs.quent

s.lution‑Pr.ces.ed Thin Film Tr.ns.ar.nt Photovoltaics.Pr.s.nt Challenges.and Futur. Development

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nano-Micr. Letter. 2025年第2期17卷 566-600页

作者： Tianle Liu Muner.h M.s.Almutair. Jie ma Ais.ing s.ewar. Zhaohui Xing Mengxia Liu Bo Hou Yuljae Cho UM-s.TU Joint Ins.itute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China s.hool of Phys.cs.and As.r.nomy Cardiff UniversityCardiff CF243AAWalesUK Depar.ment of Electr.cal and Computer.Engineer.ng Yale UniversityNew HavenCT 06511USA Ener.y s.iences.Ins.itute Yale UniversityWest HavenCT 06516USA Futur. Photovoltaics.r.s.ar.h Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electr.cal ener.y is.es.ential for.moder. s.ciety to s.s.ain economic *** s.ar.ng demand for.the electr.cal ener.y,together.with an awar.nes. of the envir.nmental impact of fos.il fuels.has.been dr.ving a s.ift towar.s.the utilization of s.lar.***,tr.ditional s.lar.ener.y s.lutions.often r.quir. extens.ve s.aces.for.a panel ins.allation,limiting their.pr.cticality in a dens. ur.an *** over.ome the s.atial cons.r.int,r.s.ar.her. have developed tr.ns.ar.nt photovoltaics.TPV),enabling windows.and facades.in vehicles.and buildings.to gener.te electr.c *** TPV advancements.ar. focus.d on impr.ving both tr.ns.ar.ncy and power.output to r.val commer.ially available s.licon s.lar.*** this.r.view,we fir.t br.efly intr.duce wavelength-and non-wavelengths.lective s.r.tegies.to achieve *** of mer.t and theor.tical limits.of TPVs.ar. dis.us.ed to compr.hens.vely under.tand the s.atus.of cur.ent TPV *** we highlight r.cent pr.gr.s. in differ.nt types.of TPVs.with a par.icular.focus.on s.lution-pr.ces.ed thin-film photovoltaics.PVs.,including colloidal quantum dot PVs.metal halide per.vs.ite PVs.and or.anic *** applications.of TPVs.ar. als. r.viewed,with emphas.s.on agr.voltaics.s.ar. windows.and ***,cur.ent challenges.and futur. oppor.unities.in TPV r.s.ar.h ar. pointed out.

关键词： Tr.ns.ar.nt s.miconductor. s.lution-pr.ces.able tr.ns.ar.nt s.lar.cell Emer.ing s.lar.cell mater.als Buildingintegr.ted photovoltaics

A compr.hens.ve inves.igation on nonlinear.vibr.tion and bending char.cter.s.ics.of bio-ins.ir.d helicoidal laminated compos.te s.r.ctur.s

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Applied mathematics.and Mechanics.Englis. Edition) 2025年第1期46卷 81-100页

作者： s.s.Ur.BH r.KIr.n D.s.nGH r.VAIs. V.s.CHAUHAn s.hool of Mechanical and mater.als.Engineer.ng Indian Institute of Technology Mandi

Bio-ins.ir.d helicoidal compos.te laminates. ins.ir.d by the intr.cate helical s.r.ctur.s.found in natur., pr.s.nt a pr.mis.ng fr.ntier.for.enhancing the mechanical pr.per.ies.of s.r.ctur.l des.gns. Hence, this.s.udy pr.vides.a compr.hens.ve inves.igation into the nonlinear.fr.e vibr.tion and nonlinear.bending behavior.of bio-ins.ir.d compos.te plates. The inver.e hyper.olic s.ear.defor.ation theor.(IHs.T) of plates.is.employed to char.cter.ze the dis.lacement field, with the incor.or.tion of Gr.en-Lagr.nge nonlinear.ty. The pr.blem is.modeled us.ng the C0finite element method(FEM), and an in-hous. code is.developed in the maTLAB envir.nment to s.lve it numer.cally. Var.ous.helicoidal layup configur.tions.including helicoidal r.cur.ive(Hr., helicoidal exponential(HE), helicoidal s.mi-cir.ular.Hs., linear.helicoidal(LH), and Fibonacci helicoidal(FH)with differ.nt layup s.quences.and quas.-is.tr.pic configur.tions.ar. s.udied. The model is.validated, and par.metr.c s.udies.ar. conducted. Thes. s.udies.inves.igate the effects.of layup configur.tions. s.de-to-thicknes. r.tio, modulus.r.tios. boundar. conditions. and loading conditions.at differ.nt load amplitudes.on the nonlinear.vibr.tion and nonlinear.bending behavior. of bio-ins.ir.d compos.te plates. The r.s.lts.s.ow that the laminate s.quence exer.s.a s.bs.antial impact on both nonlinear.natur.l fr.quencies.and nonlinear.bending behavior.. Mor.over. this.influence var.es.acr.s. differ.nt s.de-to-thicknes. r.tios.and boundar. conditions.of the bio-ins.ir.d compos.te plate.

关键词： finite element method (FEM) nonlinear Gr.en-Lagr.nge inver.e hyper.olic s.ear.defor.ation theor. (IHs.T) bio-ins.ir.d compos.te plate helicoidal O322

Olfactor. r.ceptor. in neur.l r.gener.tion in the centr.l ner.ous.s.s.em

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neur.l r.gener.tion r.s.ar.h 2025年第9期20卷 2480-2494页

作者： r.fael Fr.nco Claudia Gar.igós.Toni Capó Joan s.r.ano-mar.n r.fael r.vas.s.ntis.eban Jaume Lillo Molecular.neur.biology Labor.tor. Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Ciber.ed networ. Center.for.Biomedical r.s.ar.h in neur.degener.tive Dis.as.s Spanish National Health Institute Carlos ⅢMadridSpain s.hool of Chemis.r. Universitat de BarcelonaBarcelonaSpain Depar.ment of Biochemis.r. and Phys.ology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Labor.tor. of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactor. r.ceptor. ar. cr.cial for.detecting odor. and play a vital r.le in our.s.ns. of s.ell,influencing behavior. fr.m food choices.to emotional *** r.ceptor. als. contr.bute to our.per.eption of flavor.and have potential applications.in medical diagnos.ics.and envir.nmental *** ability of the olfactor. s.s.em to r.gener.te its.s.ns.r. neur.ns.pr.vides.a unique model to s.udy neur.l r.gener.tion,a phenomenon lar.ely abs.nt in the centr.l ner.ous.*** gained fr.m how olfactor. neur.ns.continuous.y r.place thems.lves.and r.es.ablis. functional connections.can pr.vide s.r.tegies.to pr.mote s.milar.r.gener.tive pr.ces.es.in the centr.l ner.ous.s.s.em,wher. damage often r.s.lts.in per.anent *** the molecular.and cellular.mechanis.s.under.inning olfactor. neur.n r.gener.tion could pave the way for.developing ther.peutic appr.aches.to tr.at s.inal co r. injur.es.and neur.degener.tive dis.as.s.like Alzheimer.s.*** ctor. r.ceptor. ar. found in almos. any cell of eve r. or.a n/tis.ue of the mammalian *** ectopic expr.s.ion pr.vides.ins.ghts.into the chemical s.r.ctur.s.that can activate olfactor. *** addition to odor.,olfactor. r.ceptor. in ectopic expr.s.ion may r.s.ond to endogenous.compounds.and molecules.pr.duced by mucos.l colonizing *** analys.s.of the function of olfactor. r.ceptor. in ectopic expr.s.ion pr.vides.valuable infor.ation on the s.gnaling pathway engaged upon r.ceptor.activation and the r.ceptor.s.r.le in pr.lifer.tion and cell differ.ntiation *** r.view explo r.s.the ectopic expr.s.ion of olfa ctor. r.ceptor. and the r.le they may play in neur.l r.gener.tion within the centr.l ner.ous.s.s.em,with par.icular.attention to compounds.that can activate thes. r.ceptor. to initiate r.gener.tive *** s.gges.s.that olfactor. r.ceptor. could s.r.e as.potential ther.peutic tar.ets.for.enhancing neur.l r.pair.and r.cover. following centr.l ner.ous.s.s.e

关键词： adenos.ne r.ceptor. adr.ner.ic r.ceptor. ectopic expr.s.ion G pr.teincoupled r.ceptor. glia neur.ns