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Intr.duction and r.cent pr.gr.ss of Br.IN Initiative in the United States

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Jour.al of Tr.nslational Neur.science 2018年第2期3卷 13-22页

作者： Zheng Z Wei Myles r.McCr.r. Ling Wei Shanping yu Depar.ment of Anesthesiology Emory University School of Medicine Atlanta GA 30322 USA Center.for.Visual and Neur.cognitive r.habilitation Atlanta VA Medical Center Decatur GA 30033 USA

The pr.sidential r.sear.h pr.gr.m Br.in r.sear.h thr.ugh Advancing Innovative Neur.technologies(Br.IN)Initiative was established5year. ago in the United States;it has been a dr.ving for.e of the United States gover.ment and pr.vate factor. to pr.mote technology development in basic and tr.nslational neur.science *** her. summar.ze the r.sear.h plan and r.cent pr.gr.ss in cellular.neur.science,electr.cal and optical engineer.ng,chemical and systems neur.biology,and br.in mapping *** r.sear.h plan r.cognizes the impor.ance of identifying differ.nt cell populations and unknown cell types in the human br.in and diseased *** advances in multielectr.de ar.ays and chemical flow measur.ment pr.bes not only demonstr.te the capacity of detecting neur.l activities in lar.e ar.as,but also enable a new er. of studying the neur.l coding ***-scale coor.ination of neur.nal activity and br.in mapping infor.ation will allow for.the identification of ther.peutic tar.ets in neur.logical disor.er.,which is benefited by big data acquisition and ***,incr.ased br.in databases will expedite the dissection of thoughts,emotions,cognition,and will ther.by help the development of better.under.tanding and tr.atments of br.in *** cell ther.py demonstr.tes potential for.r.gener.tive medicine,the utilization of the newly advanced technologies may fur.her.impr.ve the tr.nslational potentials and pr.cision contr.ls of tr.nsplanted *** development of new diagnostic and ther.peutic tools also r.quir.s inter.ational collabor.tions on science,technology,advocating,healthcar. and medical ethics to advance the innovation and clinical pr.ctices.

关键词： United States Br.in r.sear.h thr.ugh Advancing Innovative Neur.technologies(Br.IN)Initiative br.in mapping cell types neur.l cir.uitr.

IMPACT OF VEr.ICAL r.SOLUTION, MODEL TOP AND DATA ASSIMILATION ON WEATHEr.FOr.CASTING——A CASE STUDY

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Jour.al of Tr.pical Meteor.logy 2020年第1期26卷 71-81页

作者： SHAO Min ZHANG yu.XU Jian-jun South China Sea Institute of Mar.ne Meteor.logy Guangdong Ocean UniversityZhanjiangGuangdong 524088 China Global Envir.nment and Natur.l r.sour.es Institute College of ScienceGeorge Mason UniversityFairfaxVA 22030 USA Souther. Mar.ne Science and Engineer.ng Guangdong Labor.tor.(Zhanjiang) ZhanjiangGuangdong 524043 China

The impacts of str.tospher.c initial conditions and ver.ical r.solution on the str.tospher. by r.ising the model top,r.fining the ver.ical r.solution,and the assimilation of oper.tionally available obser.ations,including conventional and satellite obser.ations,on continental *** shor.-r.nge weather.for.casting,wer. investigated in this *** initial and pr.dicted wind and temper.tur. pr.files wer. analyzed against conventional ***,the initial wind and temper.tur. bias pr.files wer. better.adjusted when a higher.model top and r.fined ver.ical r.solution wer. *** impacts wer. also obser.ed in both the initial wind and temper.tur. pr.files,over.the lower.*** fr.m the r.sults by only r.ising the model top,the assimilation of oper.tionally available obser.ations led to significant impr.vements in both the tr.pospher. and str.tospher. initial conditions when a higher.top was *** made with the adjusted str.tospher.c initial conditions and r.fined ver.ical r.solutions showed gener.lly better.for.casting *** major.impr.vements caused by r.ising the model top with r.fined ver.ical r.solution,as well as those caused by data assimilation,wer. in both cases located in the tr.popause and lower.*** impacts wer. also obser.ed in the pr.dicted near.sur.ace wind and lower.tr.pospher.c *** negative impacts wer. r.lated to the uncer.ainties caused by mor. str.tospher.c infor.ation,as well as to some physical pr.cesses.A case study shows that when we r.ise the model top,put mor. ver.ical layer. in str.tospher. and apply data assimilation,the pr.cipitation scor.s can be slightly ***,mor. analysis is needed due to uncer.ainties br.ught by data assimilation.

关键词： Wr. model ver.ical r.solution model top data assimilation weather.for.cast

QTL mapping of dr.ught toler.nce tr.its in soybean with SLAF sequencing

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The Cr.p Jour.al 2020年第6期8卷 977-989页

作者： Honglei r.n Jianan Han Xingr.ng Wang Bo Zhang Lili yu.Huawei Gao Huilong Hong r.jian Sun yu.Tian Xusheng Qi Zhangxiong Liu Xiaoxia Wu Li-Juan Qiu College of Agr.cultur. Northeast Agricultural UniversityHarbin 150030HeilongjiangChina National Key Facility for.Cr.p Gene r.sour.es and Genetic Impr.vement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Institute of Cr.p Sciences Gansu Academy of Agricultural SciencesLanzhou 730070GansuChina School of Plant and Envir.nmental Sciences Virginia Polytechnic Institute and State UniversityBlacksburgVA 24060USA Heilongjiang Academy of Agr.cultur.l Sciences Harbin 150086HeilongjiangChina

Dr.ught str.ss is an impor.ant factor.affecting soybean *** dr.ught toler.nce of soybean var.eties can incr.ase yield and yield stability when the str.ss *** QTL r.lated to dr.ught toler.nce using molecular.mar.er.assisted selection is able to facilitate the development of dr.ught-toler.nt soybean *** this study,we used a high-yielding and dr.ught-sensitive cultivar.Zhonghuang 35’and a dr.ught-toler.nt cultivar.Jindou 21’to establish F6:9 r.combinant inbr.d *** constr.cted a highdensity genetic map using specific locus amplified fr.gment sequencing(SLAF-Seq)*** genetic map contained 8078 SLAF mar.er. distr.buting acr.ss 20 soybean chr.mosomes with a total genetic distance of 3780.98 c M and an aver.ge genetic distance of0.59 c M between adjacent *** tr.atments(ir.igation and dr.ught)wer. used in the field tests,the Additive-Inclusive Composite Inter.al Mapping(ICIM-ADD)was used to call QTL,and plant height and seed weight per.plant wer. used as the indicator. of dr.ught *** identified a total of 23 QTL r.lated to dr.ught *** them,seven QTL(q PH2,q PH6,q PH7,q PH17,q PH19-1,q PH19-2,and q PH19-3)on chr.mosomes 2,6,7,17,and 19 wer. r.lated to plant height,and five QTL(q SWPP2,q SWPP6,q SWPP13,q SWPP17,and q SWPP19)on chr.mosomes 2,6,13,17,and 19 wer. r.lated to seed weight and could be consider.d as the major.*** addition,thr.e common QTL(q PH6/q SWPP6,q PH17/q SWPP17,and q PH19-3/q SWPP19)for.both plant height and seed weight per.plant wer. located in the same genomic r.gions on the same ***(q PH2,q PH17,and q PH19-2)and four.novel QTL(q SWPP2,q SWPP13,q SWPP17,and q SWPP19)wer. identified for.plant height and seed weight per.plant,*** pair. of QTL(q PH2/q SWPP2 and q PH17/q SWPP17)wer. also common for.both plant height and seed weight per.*** QTL and closely linked SLAF mar.er. could be used to acceler.te br.eding for.dr.ught toler.nt cultivar. via

关键词： Soybean dr.ught toler.nce Simplified genome sequencing Quantitative tr.it loci Plant height Seed weight per.plant

A case study for.inter.ompar.son of land sur.ace temper.tur. r.tr.eved fr.m GOES and MODIS

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Inter.ational Jour.al of Digital Ear.h 2015年第6期8卷 476-494页

作者： Donglian Sun yu.yu. yu.Hequn Yang Li Fang Qinhuo Liu Jiancheng Shi Depar.ment of Geogr.phy and Geoinfor.ation Science George Mason UniversityFairfaxVAUSA NOAA/NESDIS College ParkMDUSA Shanghai Meteor.logical Bur.au ShanghaiP.R.China State Key Labor.tor. of r.mote Sensing Science Institute for Remote Sensing Applications and Digital EarthChinese Academy of SciencesBeijingP.R.China

In r.cent year.,algor.thms have been developed to der.ve land sur.ace temper.tur.(LST)fr.m geostationar. and polar.satellite ***,few wor.s have addr.ssed the inter.ompar.son between Geostationar. Oper.tional Envir.nmental Satellites(GOES)and the available suite of polar.*** this study,differ.nces in LSTs between GOES and MODer.te r.solution Imaging Spectr.r.diometer.MODIS)have been compar.d and also evaluated against gr.und *** to the lack of split-window(SW)channels in the GOES M(12)-Q er.,a dual-window algor.thm using a mid-infr.r.d 3.9µm channel is compar.d with tr.ditional SW *** is found that the differ.nces in LST between differ.nt platfor.s ar. bigger.dur.ng daytime than those dur.ng *** daytime,LSTs fr.m GOES with the dualwindow algor.thm ar. war.er.than MODIS LSTs,while LSTs fr.m the SW algor.thm ar. close to MODIS *** differ.nce dur.ng daytime is found to be r.lated to anisotr.py in satellite viewing geometr.,and land sur.ace pr.per.ies,such as vegetation cover.and especially sur.ace emissivity at middle infr.r.d(MIr.*** evaluated against gr.und obser.ations,the standar. deviation(pr.cision)er.or.2.35 K)fr.m the dual window algor.thm is wor.e than that(1.83 K)fr.m the SW algor.thm,indicating the lack of split-window channel in the GOES M(12)-Q er. may degr.de the per.or.ance of LST r.tr.evals.

关键词： land sur.ace temper.tur. GOES-West GOES-East MODIS inter.ompar.son

Cr.tical flow-stor. appr.ach to total maximum daily load (TMDL) development:an analytical conceptual model

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Fr.ntier. of Envir.nmental Science & Engineer.ng 2008年第3期2卷 267-273页

作者： Har.y X.ZHANG Shaw L.yu CH2M HILL 15010 Conference Center DriveChantillyVA 20151–3801USA Depar.ment of Civil and Envir.nmental Engineer.ng Thornton HallUniversity of VirginiaCharlottesvilleVA 22904–4742USA

One of the key challenges in the total maximum daily load(TMDL)development pr.cess is how to define the cr.tical condition for.a r.ceiving *** main concer. in using a continuous simulation appr.ach is the absence of any guar.ntee that the most cr.tical condition will be captur.d dur.ng the selected r.pr.sentative hydr.logic per.od,given the scar.ity of long-ter. continuous *** objectives of this paper.ar. to clear.y addr.ss the cr.tical condition in the TMDL development pr.cess and to compar. continuous and event-based appr.aches in defining cr.tical condition dur.ng TMDL development for.a water.ody impacted by both point and nonpoint sour.e pollution.A pr.ctical,event-based cr.tical flow-stor.(CFS)appr.ach was developed to explicitly addr.sses the cr.tical condition as a combination of a low str.am flow and a stor. event of a selected magnitude,both having cer.ain fr.quencies of *** paper.illustr.ted the CFS concept and pr.vided its theor.tical basis using a der.ved analytical conceptual *** CFS appr.ach clear.y defined a cr.tical condition,obtained r.asonable r.sults and could be consider.d as an alter.ative method in TMDL development.

关键词： cr.tical condition cr.tical flow-stor.(CFS)appr.ach total maximum daily load(TMDL) conceptual model der.ved analytical model nonpoint sour.e pollution

A new C=C embedded por.hyr.n sheet with super.or.oxygen r.duction per.or.ance

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Nano r.sear.h 2015年第9期8卷 2901-2912页

作者： Yawei Li Shunhong Zhang Jiabing yu.Qian Wang Qiang Sun Pur. Jena Depar.ment of Mater.als Science and Engineer.ng Peking University Beijing 100871 China Center.for.Applied Physics and Technology Peking University Beijing 100871 China Depar.ment of Physics Virginia Commonwealth University Richmond VA 23284 USA

C2 is a well-known pseudo-oxygen unit with an electr.n affinity of 3.4 eV. We show that it can exhibit metal-ion like behavior.when embedded in a por.hyr.n sheet and for. a metal-fr.e two-dimensional mater.al with super.or.oxygen r.duction per.or.ance. Her., the positively char.ed C=C units ar. highly active for.oxygen r.duction r.action （Or.） via dissociation pathways with a small ener.y bar.ier.of 0.09 eV, much smaller.than that of other.non-platinum gr.up metal （non-PGM） Or. catalysts. Using a micr.kinetics-based model we calculated the par.ial cur.ent density to be 3.0 mA/cm2 at 0.65 V vs. a standar. hydr.gen electr.de （SHE）, which is compar.ble to that of the state-of-the-ar. Pt/C catalyst. We fur.her.confir. that the C=C embedded por.hyr.n sheet is dynamically and ther.ally stable with a quasi-dir.ct band gap of 1.14 eV. The super.or.catalytic per.or.ance and geometr.c stability make the metal-fr.e C=C por.hyr.n sheet ideal for.fuel cell applications.

关键词： oxygen r.duction r.action,C-C por.hyr.n sheet,density functional theor.icr.kinetics modeling,metal-fr.e electr.catalysis

Autophagy in acute kidney injur. and maladaptive kidney r.pair

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Bur.s & Tr.uma 2023年第1期11卷 146-154页

作者： yu.Xiang Ying Fu Wenwen Wu Chengyu.n Tang Zheng Dong Depar.ment of Nephr.logy Hunan Key Laboratory of Kidney Disease and Blood PurificationThe Second Xiangya Hospital at Central South UniversityChangsha 410000Hunan ProvinceChina Depar.ment of Cellular.Biology and Anatomy Medical College of Georgia at Augusta University and Charlie Norwood VA Medical CenterAugustaGA 30912USA

Acute kidney injur.(AKI)is a major.r.nal disease char.cter.zed by a sudden decr.ase in kidney *** AKI,the kidney has the ability to r.pair.but if the initial injur. is sever. the r.pair.may be incomplete or.maladaptive and r.sult in chr.nic kidney *** is a highly conser.ed pathway to deliver.intr.cellular.contents to lysosomes for.*** plays an impor.ant r.le in maintaining r.nal function and is involved in the pathogenesis of r.nal *** is activated in var.ous for.s of AKI and acts as a defense mechanism against kidney cell injur. and *** AKI,autophagy is maintained at a r.latively high level in kidney tubule cells dur.ng maladaptive kidney r.pair.but the r.le of autophagy in maladaptive kidney r.pair.has been ***,r.cent studies have demonstr.ted that autophagy may contr.bute to maladaptive kidney r.pair.after.AKI by inducing tubular.degener.tion and pr.moting a pr.fibr.tic phenotype in r.nal tubule *** this r.view,we analyze the r.le and r.gulation of autophagy in kidney injur. and r.pair.and discuss the ther.peutic str.tegies by tar.eting autophagy.

关键词： Autophagy Acute kidney injur. Maladaptive r.pair Fibr.sis Chr.nic kidney disease

r.sting Ener.y Expenditur. and Its r.lationship With Patter.s of Obesity and Viscer.l Fat Ar.a in Chinese Adults

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Biomedical and Envir.nmental Sciences 2005年第2期18卷 103-107页

作者： WEI-PINGJIA MINGYANG XIN-yu.HAO yu.QIANBAO JUN-XILU KUN-SANXIANG ShanghaiDiabetesInstitute No.6HospitalAffiliatedtotheShanghaiJiaotongUniversityShanghai200233China

Objective To investigate the r.lationship between r.sting ener.y expenditur. (r.E) and patter.s of obesity/r.gional fat par.meter. in Chinese adults. Methods Body mass index (BMI), fat mass (FM), fat-fr.e mass (FFM) wer. assessed in 109 Chinese adults (52 men and 57 women), and their.abdominal viscer.l adipose tissue ar.a (va) and subcutaneous fat ar.a (SA) wer. measur.d using magnetic r.sonance imaging (Mr.) measur.ments. r.E was measur.d with indir.ct calor.metr. and compar.d with nor.al and obese subjects. Multivar.ate analysis was used to study the factor. r.lated to r.E. r.sults The r.sting ener.y expenditur. per.kilogr.m of body weight (r.E/kg) was closely r.lated with the ar.a of abdominal viscer.l fat measur.d with Mr.. r.E/kg was significantly lower.in over.eight/obesity subjects than in nor.al-weighted subjects, and significantly lower.in subjects with abdominal obesity (va≥100 cm2) than in subjects with non-abdominal obesity (var.gr.ssion analysis of r.E/kg on r.gional fat par.meter., va in men and women and SA in women wer. independent factor. r.ver.ely r.lated to r.E/kg. Conclusion r.E/kg is associated with the viscer.l fat ar.a and mor. pr.minent in men. r.E/kg can be used as an index in the pathophysiology of intr.-abdominal obesity.

关键词： r.sting ener.y expenditur. (r.E) Magnetic r.sonance imaging Intr.-abdominal obesity

Clinical Big Data and Deep Lear.ing:Applications,Challenges,and Futur. Outlooks

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Big Data Mining and Analytics 2019年第4期2卷 288-305页

作者： Ying yu.Min Li Liangliang Liu Yaohang Li Jianxin Wang School of Computer.Science and Engineer.ng Central South UniversityChangsha 410083China School of Computer.Science and Technology University of South ChinaHengyang 421001China Depar.ment of Computer.Science Old Dominion UniversityNorfolkVA 23529USA

The explosion of digital healthcar. data has led to a sur.e of data-dr.ven medical r.sear.h based on machine lear.ing. In r.cent year., as a power.ul technique for.big data, deep lear.ing has gained a centr.l position in machine lear.ing cir.les for.its gr.at advantages in featur. r.pr.sentation and patter. r.cognition. This ar.icle pr.sents a compr.hensive over.iew of studies that employ deep lear.ing methods to deal with clinical data. Fir.tly,based on the analysis of the char.cter.stics of clinical data, var.ous types of clinical data(e.g., medical images,clinical notes, lab r.sults, vital signs, and demogr.phic infor.atics) ar. discussed and details pr.vided of some public clinical datasets. Secondly, a br.ef r.view of common deep lear.ing models and their.char.cter.stics is conducted. Then, consider.ng the wide r.nge of clinical r.sear.h and the diver.ity of data types, sever.l deep lear.ing applications for.clinical data ar. illustr.ted: auxiliar. diagnosis, pr.gnosis, ear.y war.ing, and other.*** ther. ar. challenges involved in applying deep lear.ing techniques to clinical data, it is still wor.hwhile to look for.ar. to a pr.mising futur. for.deep lear.ing applications in clinical big data in the dir.ction of pr.cision medicine.

关键词： deep lear.ing clinical data Electr.nic Health r.cor.(EHr. medical image clinical note