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Evaluation of Positive Inotr.pic Activity Induced bya Danazol Der.vative in Isolated r.t Hear. Model

Phar.acology & Phar.acy 2013年第4期4卷 406-415页

作者： l. Figuer.a-Valver.e F. Díaz-Cedillo E. Gar.ía-Cer.er. E. Pool Gómez M. lópez-r.mos M. r.sas-Nexticapa r. mendoza-lópez I. May-Gil A. Sar.o Escuela Nacional de Ciencias Biológicasdel Instituto Politécnico Nacional Prol. Carpio y Plan de Ayala s/n Col Santo Tomas Mexico City Mexico Facultad de Nutr.ción Campus Xalapa Universidad Veracruzana Veracruz Mexico. labor.tor. of Phar.aco-Chemistr. Faculty of Chemical Biological Sciences The University Autonomous of Campeche Cam- peche Mexico

Ther. is scar.e infor.ation about the effects of danazol and its der.vatives at car.iovascular.level. In addition, to date the cellular.site and mechanism of action of danazol at the car.iovascular.level is ver. confusing. In or.er.to clar.fy those phenomena in this study, a danazol der.vative was synthesized with the objective of evaluating its activity on per.usion pr.ssur. and cor.nar. r.sistance and compar.ng this phenomenon with the effect exer.ed by danazol. The langendor.f technique was used to measur. changes on per.usion pr.ssur. and cor.nar. r.sistance in an isolated r.t hear. model in the absence or.pr.sence of danazol and its der.vative. Additionally, to char.cter.ze the molecular.mechanism involved in the inotr.pic activity induced by danazol der.vative was evaluated by measur.ng left ventr.cular.pr.ssur. in the absence or.pr.sence of following compounds;flutamide, pr.zosin, metopr.lol, indomethacin and nifedipine. The r.sults showed that danazol der.vative significantly incr.ased the per.usion pr.ssur. and cor.nar. r.sistance in compar.son with the contr.l conditions and danazol. Additionally, other.data indicate that the danazol der.vative incr.ases left ventr.cular.pr.ssur. in a dose-dependent manner.never.heless, this phenomenon was significantly inhibited by flutamide. These data suggest that danazol der.vative induces positive inotr.pic activity thr.ugh of the activation andr.gen r.ceptor.

关键词： Danazol Der.vative langendor.f Inotr.pic Activity

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Exper.mental implementation of phase tr.plicator.gr.tings in a spatial light modulator

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Chinese Optics letter. 2024年第2期22卷 64-69页

作者：高尚 Mar.a del Mar.Sánchez-lópez Ignacio Mor.no Instituto de Bioingenier.a Universidad Miguel HernándezElche 03202Spain Depar.amento de Física Aplicada Universidad Miguel HernándezElche 03202Spain Depar.amento de Ciencia de Mater.ales Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this wor.,we compar. differ.nt methods for.implementing a tr.plicator.a phase gr.ting that gener.tes thr.e equiintense diffr.ction *** design with optimal efficiency featur.s a continuous phase pr.file,which cannot be easily r.pr.duced,and is typically affected by *** compar. its per.or.ance with binar. and sinusoidal phase *** also analyze the effect of quantizing the phase ***,a r.ndom appr.ach is adopted to eliminate the additional har.onic *** all cases,a liquid-cr.stal-on-silicon spatial light modulator.is employed to exper.mentally ver.fy and compar. the differ.nt appr.aches.

关键词： diffr.ction gr.tings phase modulation tr.plicator spatial light modulator.

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Metal-modulated epitaxy of Mg-doped Al_(0.80)In_(0.20)N-based layer.for.application as the electr.n blocking layer.in deep ultr.violet light-emitting diodes

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Jour.al of Semiconductor. 2024年第5期45卷 80-89页

作者： Hor.cio Ir.n Solís-Cisner.s Car.os Alber.o Her.ández-Gutiér.ez Enr.que Campos-González Máximo lópez-lópez Optomechatr.nics Gr.up Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Depar.amento de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Depar.amento de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This wor. r.por.s the gr.wth and char.cter.zation of p-AlInN layer. doped with Mg by plasma-assisted molecular.beam epitaxy(PAMBE).AlInN was gr.wn with an Al molar.fr.ction of 0.80 by metal-modulated epitaxy(MME)with a thickness of 180 nm on Si(111)substr.tes using AlN as buffer.*** substr.te temper.tur.s wer. used to enhance the incor.or.tion of indium atoms into the alloy without cluster.ng,as confir.ed by X-r.y diffr.ction(Xr.).Cathodoluminescence measur.ments r.vealed ultr.violet(UV)r.nge ***,Hall effect measur.ments indicated a maximum hole mobility of 146 cm^(2)/(V∙s),cor.esponding to a fr.e hole concentr.tion of 1.23×10^(19)cm^(−3).The samples wer. analyzed by X-r.y photoelectr.n spectr.scopy(XPS)estimating the alloy composition and extr.cting the Fer.i level by valence band ***-doped AlInN layer. wer. studied for.use as the electr.n-blocking layer.EBl)in lED *** var.ed the Al composition in the EBl fr.m 0.84 to 0.96 molar.fr.ction to assess its theor.tical effects on electr.luminescence,car.ier.concentr.tion,and electr.c field,using SIlVACO *** r.sults fr.m this study highlight the impor.ance and capability of pr.ducing high-quality Mg-doped p-AlInN layer. thr.ugh *** simulations suggest that an Al content of 0.86 is optimal for.achieving desir.d outcomes in electr.luminescence,car.ier.concentr.tion,and electr.c field.

关键词： metal-modulated epitaxy AlInN DUV-lED EBl simulation

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Enhancement of the CO_(2)adsor.tion and hydr.genation to CH_(4)capacity of r.–Na–Ca/γ–Al_(2)O_(3)dual function mater.al by contr.lling the r. calcination atmospher.

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Jour.al of Envir.nmental Sciences 2024年第6期140卷 292-305页

作者： Alejandr. Ber.ejo-lópez Beñat Per.da-Ayo Jon A.Onr.bia-Calvo JoséA.González-Mar.os Juan r.González-Velasco Depar.ment of Chemical Engineer.ng Faculty of Science and TechnologyUniversidad del País Vasco UPV/EHUBarrio Sarrienas/n48940 LeioaBizkaiaSpain

Integr.ted CO_(2)captur. and utilization(ICCU)technology r.quir.s dual functional mater.als(DFMs)to car.y out the pr.cess in a single r.action *** influence of the calcination atmospher. on efficiency of 4%r.-8%Na_(2)CO_(3)-8%CaO/γ-Al_(2)O_(3)DFM is *** adsor.ent pr.cur.or. ar. fir.t co-impr.gnated onto alumina and calcined in ***,r. pr.cur.or.is impr.gnated and four.aliquotes ar. subjected to differ.nt calcination pr.tocols:static air.in muffle or.under.differ.nt mixtur.s(10%H_(2)/N_(2),50%H_(2)/N_(2)and N_(2))*** ar. char.cter.zed by Xr.,N_(2)adsor.tion-desor.tion,H_(2)chemisor.tion,TEM,XPS,H_(2)-TPD,H_(2)-TPr.CO_(2)-TPD and *** catalytic behavior.is evaluated,in cycles of CO_(2)adsor.tion and hydr.genation to CH_(4),and tempor.l evolution of r.actants and pr.ducts concentr.tions is *** calcination atmospher. influences the physicochemical pr.per.ies and,ultimately,activity of *** data and catalytic per.or.ance discover.the acccomodation of r. nanopar.icles disposition and basic sites is mostly influencing the catalytic *** calcined under.N_(2)flow(r.NaCa-N_(2))shows the highest CH_(4)pr.duction(449μmol/g at 370℃),because a well-contr.lled decomposition of pr.cur.or. which favor. the better.accomodation of adsor.ent and r. phases,maximizing the specific sur.ace ar.a,the r.-basic sites inter.ace and the par.icipation of differ.nt basic sites in the CO_(2)methanation ***,the calcination in a N_(2)flow is r.vealed as the optimal calcination pr.tocol to achieve highly efficient DFM for.integr.ted CO_(2)adsor.tion and hydr.genation applications.

关键词： CO_(2)methanation Integr.ted CO_(2)captur. and utilization(ICCU) Dual functional mater.al(DFM) r. calcination atmospher.

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Oligodendr.ctyes:the for.otten player. of diabetes pathophysiology

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Neur.l r.gener.tion r.sear.h 2024年第11期19卷 2349-2350页

作者： Juan Antonio lópez-Villodr.s Beatr.z Gar.ía-Díaz Depar.amento Fisiología Humana Histología HumanaAnatomía Patológica y Educación Física y DeportivaFacultad de MedicinaUniversidad de MálagaMálagaSpain UGC Neur.ciencia.Instituto de Investigación Biomédica de Málaga y Platafor.a en Nanomedicina(IBIMA Platafor.a Bionand) MálagaSpain

Oligodendr.cytes(Ols),glial cells that pr.vide myelin sheaths to axons in the centr.l ner.ous system(CNS),have a dual ***,this myelin fatty cover.ar.und the axons pr.tects the ner.es and is cr.cial for.the saltator. pr.pagation of action *** and not less impor.ant,Ols pr.vide tr.phic suppor. to neur.ns and ***,Ol metabolism is impor.ant for.Ol well-being and the pr.per.accomplishment of their.functions,and Ol metabolism ener.etics dir.ctly affect the ener.y metabolism of neighbor.ng neur.ns.

关键词： metabolism ner.es myelin

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Exper.mental and numer.cal investigation to elucidate the fluid flow thr.ugh packed beds with str.ctur.d par.icle packings

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Par.icuology 2024年第6期89卷 218-237页

作者： Shir.n Patil Chr.stian Gor.es Joel lòpez Bonilla Mor.tz Stelter.Fr.nk Beyr.u Ber.nd van Wachem labor.tor. of Technical Ther.odynamics Otto-von-Guericke-Universität MagdeburgUniversitätsplatz 239106 MagdeburgGermany Chair.of Mechanical Pr.cess Engineer.ng Otto-von-Guericke-Universität MagdeburgUniversitätsplatz 239106 MagdeburgGermany

The pr.sent paper.pr.sents an exper.mental and numer.cal investigation of the disper.ion of the gaseous jet flow and co-flow for.the simple unit cell(SUC)and body-centr.d cubic(BCC)configur.tion of par.icles in packed *** exper.mental setup is built in such a way that suitable and simplified boundar. conditions ar. imposed for.the cor.esponding numer.cal fr.mewor.,so the simulations can be done under.ver. similar.conditions as the ***,a por.us plate is used for.the co-flow to achieve the unifor. velocity and the fully developed flow is ensur.d for.the jet *** SUC and BCC par.icle beds consist of 3D-pr.nted spher.s,and the non-isotr.py near.the walls is mostly eliminated by placing half-spher.s at the channel *** flow velocities ar. analysed dir.ctly at the exit of the par.icle bed for.both beds over.36 por.s for.the SUC configur.tion and 60 por.s for.the BCC configur.tion,for.par.icle r.ynolds number. of 200,300,and *** par.icle image velocimetr. is exper.mentally ar.anged in such a way that the velocities over.the entir. r.gion at the exit of the packed bed ar. obtained *** numer.cal method consists of a state-of-the-ar. immer.ed boundar. method with adaptive mesh *** paper.pr.sents the por. jet str.ctur. and velocity field exiting fr.m each por. for.the SUC and BCC packed par.icle *** numer.cal and exper.mental studies show a good agr.ement for.the SUC configur.tion for.all flow *** the BCC configur.tion,some differ.nces can be obser.ed in the por. jet flow str.ctur. between the simulations and the exper.ments,but the gener.l flow velocity distr.bution shows a good over.ll *** axial velocity is gener.lly higher.for.the por.s located near.the centr. of the packed bed than for.the por.s near.the *** addition,the axial velocities ar. obser.ed to incr.ase near.the per.pher.l por.s of the packed *** behaviour.is pr.dominant for.the BCC configur.tion as compar.d to t

关键词： Unifor. par.icle packing Packed bed r.actor Ster.o par.icle image velocimetr. Immer.ed boundar. method

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Digital Social Connectedness as a lifeline for.Older.People: Use and Non-use of VinclesBCN Dur.ng the Pandemic

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Inter.ational Jour.al of Disaster.r.sk Science 2024年第2期15卷 251-264页

作者： Isr.el r.dr.guez‑Gir.lt Daniel lópez‑Gómez r.ser.Beneito‑Montagut Car.Net IN3Universitat Oberta de Catalunya08018 BarcelonaSpain School of Social Sciences Cardif UniversityCardif CF103NSWalesUK

This ar.icle pr.sents the r.sults of a study that evaluated VinclesBCN dur.ng COVID-19. This digital-based public social ser.ice aims to pr.vent loneliness and isolation in +65-year.old adults living in Bar.elona. Thr.ugh ser.ice user.N = 12) and pr.fessional(N = 6) inter.iews and a questionnair. with ser.ice user.(N = 255), we demonstr.te the pivotal r.le of digital connectedness in tr.nsfor.ing VinclesBCN into a lifeline dur.ng the pandemic. The analysis r.vealed the impor.ance of sociability, social suppor., and, especially, enter.ainment in coping with pandemic fatigue and facilitating social connectivity and suppor. among user.. User. engaged in activities such as shar.ng images, songs, memes, and daily gr.etings to pr.vide pr.ximity, sociability, and car. among user., whether.they belonged to pr.existing gr.ups or.wer. newly intr.duced to the platfor.. It also facilitated the identification of individuals who needed companionship, comfor., or.mor. specialized suppor.. The findings emphasize the significance of enter.ainment as a r.silience-building str.tegy dur.ng times of uncer.ainty. Despite the positive impact, not all user. equally used the platfor.. Non-use was str.ngly associated with being a woman, having a low educational level, having pr.existing social r.lationships, less time of enr.lment in the platfor., as well as a high per.eption of loneliness, poor.self-r.por.ed health, and low mood. The ar.icle under.cor.s the need for.fur.her.r.sear.h into older.adults' digital engagement dur.ng cr.ses, its r.le in building r.silience, and advocating for.inclusive digital inter.entions that take into account diver.e older.adults' needs and exper.ences in cr.sis contexts.

关键词： Bar.elona COVID-19 pandemic Digital social connectedness Enter.ainment Older.adult r.silience Public digital ser.ice

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Pr.valence of Helicobacter.pylor. infection among patients with esophageal car.inoma

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Wor.d Jour.al of Gastr.enter.logy 2024年第29期30卷 3479-3487页

作者： Mir.am lópez-Gómez Mar.a Mor.les r.beca Fuer.e Mar.a Muñoz Pedr.-David Delgado-lópez Jor.e Fr.ncisco Gómez-Cer.zo Enr.que Casado Depar.ment of Medical Oncology Precision Oncology LaboratoryInfanta Sofía University HospitalSan Sebastián de los Reyes 28231MadridSpain Depar.ment of Medical Oncology Infanta Sofía University HospitalSan Sebastián de los Reyes 28702Spain Depar.ment of Inter.al Medicine Infanta Sofía University HospitalSan Sebastián de los Reyes 28703MadridSpain Depar.ment of Pathology Infanta Sofía University HospitalSan Sebastián de los Reyes 28702Spain Depar.ment of Neur.sur.er. Burgos University HospitalBurgos 09006Spain Depar.ment of Inter.al Medicine Infanta Sofía University Hospital and Henares University Hospital Foundation for Biomedical Research and InnovationSan Sebastian de los Reyes 28702MadridSpain Depar.ment of Medical Oncology Infanta Sofia University Hospital and Henares University Hospital Foundation for Biomedical Research and InnovationSan Sebastian de los Reyes 28702MadridSpain

BACKGr.UND Helicobacter.pylor.(***)is a widespr.ad micr.or.anism r.lated to gastr.c adenocar.inoma(AC).In contr.st,it has been r.por.ed that an inver.e association exists between *** infection and esophageal *** mechanisms under.ying this supposedly pr.tective effect r.main *** To deter.ine the pr.valence of *** infection in esophageal car.inoma patients,we per.or.ed a r.tr.spective obser.ational study of esophageal tumor. diagnosed in our.*** We r.tr.spectively r.viewed the pr.valence of *** infection in a cohor. of patients diagnosed with esophageal *** or.pr.vious pr.ton pump inhibitor.PPI)usage was also *** A total of 89 patients with esophageal car.inoma(69 males,77.5%),with a mean age of 66 year.(r.nge,26-93 year.)wer. *** was the most fr.quent pathological var.ant(n=47,52.8%),followed by squamous cell car.inoma(n=37,41.6%).Four.een ACs(29.8%)or.ginated in the gastr.esophageal junction and 33(70.2%)in the esophageal ***,54 patients(60.7%)pr.sented at stages III and *** *** infection occur.ed only in 4 patients(4.5%),3 with AC(6.3%of all ACs)and 1 with squamous cell car.inoma(2.7%of all squamous cell tumor.).All patients with pr.vious *** infection had stage *** one patient had r.ceived pr.or.*** er.dication ther.py,wher.as 86(96.6%)had r.ceived pr.vious or.concomitant PPI *** In our.cohor. of patients,and after.histologic evaluation of par.ffin-embedded pr.mar. tumor.,we found a ver. low pr.valence of pr.vious *** *** also r.viewed the medical histor. of the patients,concluding that the major.ty had r.ceived or.wer. on PPI *** minimal pr.valence of *** infection found in this cohor. of patients with esophageal car.inoma suggests a pr.tective r.le.

关键词： Helicobacter.pylor. Er.dication Esophageal tumor Dysbiosis Pr.ton pump inhibitor. Car.inogenesis Micr.biota Incidence

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Anomalous negative magnetor.sistance in quantum dot Josephson junctions with Kondo cor.elations

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Science China(Physics,Mechanics & Astr.nomy) 2024年第8期67卷 3-13页

作者： Mingtang Deng Chunlin Yu Guangyao Huang r.sa lópez Philippe Car.ff Sepideh Ghalamestani Glor.a Plater. Hongqi Xu Institute for.Quantum Infor.ation&State Key labor.tor. of High Per.or.ance Computing College of Computer Science and TechnologyNational University of Defense TechnologyChangsha 410073China Nanolund and Division of Solid State Physics Lund UniversityLund S-22100Sweden China Gr.atwall Quantum labor.tor. Changsha 410006China Institut de Física Inter.isciplinàr.a i de Sistemes Complexos IFISC Palma de Mallorca E-07122Spain Instituto de Ciencia de Mater.ales de Madr.d Madrid 28049Spain Beijing Key labor.tor. of Quantum Devices Key Laboratory for the Physics and Chemistry of Nanodevicesand Department of ElectronicsPeking UniversityBeijing 100871China Beijing Academy of Quantum Infor.ation Sciences Beijing 100193China Hefei National labor.tor. Hefei 230088China

The inter.lay between super.onductivity and the Kondo effect has stimulated significant inter.st in condensed matter.*** compete when their.cr.tical temper.tur.s ar. close and can give r.se to a quantum phase tr.nsition that can mimic Major.na zer. ***,we have fabr.cated and measur.d Al-InSb nanowir. quantum dot-Al *** the Kondo r.gime,a super.ur.ent-induced zer.-bias conductance peak *** zer.-bias peak shows an anomalous negative magnetor.sistance(NMr.at weak magnetic *** attr.bute this anomalous NMr.to quasipar.icle tr.pping at vor.ices in the super.onductor.leads as a weak magnetic field is *** tr.pping effect lower. the quasipar.icle-caused dissipation and thus enhances the Josephson *** wor. connects the vor.ex physics and the super.ur.ent tunneling in Kondo r.gimes and can help fur.her.under.tand the physics of Josephson quantum dot system.

关键词： quantum dot Kondo cor.elation InSb nanowir. quasipar.icle tr.pping

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Explor.ng hemp seed hull biomass for.an integr.ted C-5 bior.finer.:Xylose and activated car.on

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Jour.al of Bior.sour.es and Biopr.ducts 2024年第3期9卷 310-321页

作者： Sr.esha Malayil luke loughr.n Fr.der.k mendoza Ulken Jagannadh Satyavolu Conn Center.for.r.newable Ener.y r.sear.h University of LouisvilleKentucky 40292United States Biopr.ducts llC LouisvilleKentucky 40206United States r.I Inter.ational Research Triangle ParkNC 27709United States

lar.e quantities of hemp hulls can be completely utilized for.cr.ation of value-added pr.ducts (cost effective biofuels and biochemicals) thr.ugh a bior.finer. appr.ach. A sustainable appr.ach in making xylose, a low calor.e sweetener.and high sur.ace ar.a activated car.ons (AC) for.super.capacitor., attr.cts inter.st. The AC when lever.ged as a co-pr.duct fr.m bior.finer. pr.cess makes it mor. cost effective and, in this paper. we discuss the pr.duction of xylose and AC fr.m hemp seed hull with methane sulphonic acid (MSA) hydr.lysis. Xylose r.cover. with MSA hydr.lysis was 25.15 g/l when compar.d to the tr.ditional sulphur.c acid (SA) hydr.lysis of 19.96 g/l at the same acid loading of 1.8 %. The scanning electr.n micr.scope (SEM) images and Four.er.tr.nsfor. infr.r.d (FT-Ir. spectr. indicate par.ial delignification along with hemicellulose hydr.lysis r.sponsible for.high xylose r.cover.. Post hydr.lysis fiber. wer. KOH activated and car.onized to make AC. The MSA hydr.lyzed and KOH activated fiber.pr.duced pur., fluffier.and finer.par.icle AC with a dr.stic incr.ase in sur.ace ar.a 1 452 m2/g when compar.d to SA hydr.lyzed of 977 m2/g. These r.sults indicate the potential of MSA in dilute acid hydr.lysis of biomass for.xylose r.cover. and pr.duction of high sur.ace ar.a activated car.on. Fr.m a pr.duction standpoint this can lead to incr.ased use of sustainable low-cost agr.cultur.l biomass for.making high sur.ace ar.a AC as components in super.apacitor..

关键词： Xylose C-5 bior.finer. Methane sulphonic acid Delignification Activated car.on Dilute acid hydr.lysis

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