Evaluation of Positive Inotropic Activity Induced bya Danazol Derivative in Isolated Rat Heart Model
Evaluation of Positive Inotropic Activity Induced bya Danazol Derivative in Isolated Rat Heart Model作者机构：Escuela Nacional de Ciencias Biológicasdel Instituto Politécnico Nacional Prol. Carpio y Plan de Ayala s/n Col Santo Tomas Mexico City Mexico Facultad de Nutrición Campus Xalapa Universidad Veracruzana Veracruz Mexico. Laboratory of Pharmaco-Chemistry Faculty of Chemical Biological Sciences The University Autonomous of Campeche Cam- peche Mexico
出 版 物：《Pharmacology & Pharmacy》 (药理与制药（英文）)
年 卷 期：2013年第4卷第4期
页 面：406-415页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Danazol Derivative Langendorff Inotropic Activity
摘 要：There is scarce information about the effects of danazol and its derivatives at cardiovascular level. In addition, to date the cellular site and mechanism of action of danazol at the cardiovascular level is very confusing. In order to clarify those phenomena in this study, a danazol derivative was synthesized with the objective of evaluating its activity on perfusion pressure and coronary resistance and comparing this phenomenon with the effect exerted by danazol. The Langendorff technique was used to measure changes on perfusion pressure and coronary resistance in an isolated rat heart model in the absence or presence of danazol and its derivative. Additionally, to characterize the molecular mechanism involved in the inotropic activity induced by danazol derivative was evaluated by measuring left ventricular pressure in the absence or presence of following compounds;flutamide, prazosin, metoprolol, indomethacin and nifedipine. The results showed that danazol derivative significantly increased the perfusion pressure and coronary resistance in comparison with the control conditions and danazol. Additionally, other data indicate that the danazol derivative increases left ventricular pressure in a dose-dependent manner;nevertheless, this phenomenon was significantly inhibited by flutamide. These data suggest that danazol derivative induces positive inotropic activity through of the activation androgen receptor.
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