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Co-expr.ssion of HBZ,TAX and FOXp3 and HTLV-1-associated myelopathy/tr.pical spastic par.par.sis development in HTLV-1-infected individuals:A systematic r.view

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Asian Pacific Jour.al of Tr.pical Medicine 2021年第8期14卷 333-340页

作者： Ana Car.lina Mar.nho monteiro Lima Gr.ice Car.lina Santos da Silva Fer.anda Khour. Bar.eto Filipe Fer.eir. de Almeida r.go Luana Leandr. Gois Luciane Amor.m Santos Catholic Univer.ity of Salvador SalvadorBahiaBrazil Multidisciplinar. Institute in Health Federal University of BahiaVitoria da ConquistaBahiaBrazil Bahia School of Medicine and Public Health SalvadorBahiaBrazil Postgr.duate Pr.gr.m in Health Sciences Faculty of Medicine of BahiaFederal University of BahiaSalvadorBahiaBrazil

Human T-cell lymphotr.pic vir.s type 1(HTLV-1)is associated with the development of HTLV-1-associated myelopathy/tr.pical spastic par.par.sis(HAM/TSP).It has been r.por.ed that the HTLV-1 pr.teins(specifically TAX and HBZ)can modulate FOXp3,r.sulting in an immune imbalance that can favor.the pr.gr.ssion of HAM/*** r.view aims to summar.ze the liter.tur. in or.er.to clar.fy the r.lationship between the expr.ssion of HTLV-1 m r.As and/or.vir.l pr.teins(TAX and HBZ)with the expr.ssion of mr.A and/or.pr.tein FOXp3 and their.cor.elation with HAM/TSP *** systematic r.view was conducted accor.ing to the r.commendations of the Pr.fer.ed r.por.ing Items for.Systematic r.views and *** sear.h str.tegy was per.or.ed on the Medical Liter.tur. Analysis and r.tr.eval System Online and Latin Amer.can and Car.bbean Liter.tur. in Health Sciences Platfor. using subject *** scr.ening,six ar.icles wer. included in this *** studies suggested that TAX and HBZ have a dir.ctly pr.por.ional cor.elation with FOXp3 in individuals with HAM/TSP,which also pr.sented an incr.ased expr.ssion of FOXp3 compar.d to asymptomatic contr.ls and/or.healthy *** systematic r.view indicates that TAX and HBZ can inter.ct with FOXp3 and that inter.ction may influence HAM/TSP development.

关键词： HTLV-1 HTLV-1-associated myelopathy/tr.pical spastic par.par.sis(HAM/TSP) FOXp3 HBZ TAX

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Per.xisome pr.lifer.tor.activated r.ceptor.alpha activation and dipeptidyl peptidase-4 inhibition tar.et dysbiosis to tr.at fatty liver.in obese mice

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Wor.d Jour.al of Gastr.enter.logy 2022年第17期28卷 1814-1829页

作者： Flavia Mar.a Silva-Veiga Car.lline Santos Mir.nda Isabela Macedo Lopes Vasques-monteiro Henr.que Souza-Tavar.s Fabiane Fer.eir. Mar.ins Julio Beltr.me Dalepr.ne Vanessa Souza-Mello Depar.ment of Anatomy Institute of BiologyState University of Rio de JaneiroLaboratory of MorphometryMetabolism and Cardiovascular DiseasesRio de Janeiro 20551-030Brazil Depar.ment of Clinical and Toxicology Analysis State University of Rio de JaneiroNutrition InstituteState University of Rio de JaneiroNutrition InstituteUniversity of Sao PauloRio de Janeiro 20551-030Brazil

BACKGr.UND Obesity and comor.idities onset encompass gut dysbiosis,alter.d intestinal per.eability,and *** that tar.et gut dysbiosis can cope with obesity and nonalcoholic fatty liver.disease(NAFLD)*** pr.lifer.tor.activated r.ceptor.PPAr.-alpha activation and dipeptidyl-peptidase-4(DPP-4)inhibition alleviate NAFLD,but the mechanism may involve gut micr.biota modulation and mer.ts fur.her.*** To addr.ss the effects of PPAr.alpha activation and DPP-4 inhibition(isolated or.combined)upon the gut-liver.axis,emphasizing inflammator. pathways in NAFLD management in high-fat-fed C57BL/6J *** Male C57BL/6J mice wer. fed a contr.l diet(C,10%of ener.y as lipids)or.a highfat diet(HFD,50%of ener.y as lipids)for.12 wk,when tr.atments star.ed,for.ing the gr.ups:C,HF,HFA(HFD+PPAr.alpha agonist WY14643,2.5 mg/kg body mass),HFL(HFD+DPP-4 inhibitor.linagliptin,15 mg/kg body mass),and HFC(HFD+the combination of WY14643 and linagliptin).r.SULTS The HFD was obesogenic compar.d to the C *** tr.atments elicited significant body mass loss,and the HFC gr.up showed similar.body mass to the C *** tr.atments tackled or.l glucose intoler.nce and r.ised plasma glucagon-like peptide-1 *** metabolic benefits r.stor.d Bacter.idetes/Fir.icutes r.tio,r.sulting in incr.ased goblet cells per.ar.a of the lar.e intestine and r.duced lipopolysacchar.des concentr.tions in tr.ated *** the gene level,tr.ated gr.ups showed higher.intestinal Mucin 2,Occludin,and Zo-1 expr.ssion than the HFD *** r.duced endotoxemia suppr.ssed inflammasome and macr.phage gene expr.ssion in the liver.of tr.ated *** obser.ations complied with the mitigation of liver.steatosis and r.duced hepatic tr.acylglycer.l,r.assur.ng the r.le of the pr.posed tr.atments on NAFLD *** PPAr.alpha activation and DPP-4 inhibition(isolated or.combined)tackled NAFLD in dietinduced obese mice by r.stor.tion of gut-liver.axis

关键词： Nonalcoholic fatty liver.disease High-fat diet Per.xisome pr.lifer.tor.activated r.ceptor.alpha Dipeptidyl-peptidase-4-inhibitor Dysbiosis Inflammation

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The Micr.str.ctur. and Pr.per.ies of Copper.with Cer.a Nanopar.icles Addition

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Jour.al of Mater.als Science and Chemical Engineer.ng 2019年第10期7卷 40-48页

作者： Daniela Passar.lo Mour. da Fonseca Waldemar.Alfr.do monteiro Nuclear.and Ener.y r.sear.h Institute IPEN Cidade Universitária S&#227 o Paulo Brazil

Copper.based composites str.ngthened by cer.a nanopar.icles wer. pr.cessed by conventional powder.metallur.y: mixing (30 min and 46 r.m), compaction (cold, uniaxial, 1080 MPa for.10 s) and sinter.ng (800°C for.6 h in vacuum atmospher. of 10−5 tor.). It was studied the micr.str.ctur. (optical micr.scopy, scanning electr.n micr.scopy), X-r.y diffr.ction with r.etveld r.finement and some pr.per.ies (electr.cal conductivity, Vicker. har.ness and fr.ctur. analysis) of the compositions 92 wt% Cu - 8 wt% CeO2 and 80 wt% Cu - 20 wt% CeO2. The r.sults showed unifor. phase distr.bution, low por.sity and cer.a disper.e inside copper.gr.in. In despite of pr.per.ies, the composites had electr.cal conductivity of 38% IACS and 15% IACS and har.ness of 69 and 88 HV5, r.spectively. The r.sults of 92 wt% Cu - 8 wt% CeO2 composites wer. pr.mising, and they ar. in accor.ing with actual liter.tur..

关键词： Copper.Based Composites Cer.a Micr.str.ctur. Electr.cal Conductivity Har.ness

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Does Sur.er. Have a r.levant r.le in the Pr.mar. Tr.atment of Locor.gionally Advanced Or.phar.ngeal Car.inomas?

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Inter.ational Jour.al of Otolar.ngology and Head & Neck Sur.er. 2013年第6期2卷 263-270页

作者： Joana Guimar.es Sar. Cr.z Eduar.o Br.da Eur.co monteiro Depar.ment of Otor.inolar.ngology and Head and Neck Sur.er. Portuguese Institute of Oncology—Francisco GentilOportoPortugal

Backgr.und: Tr.atment concepts for.or.phar.ngeal squamous cell car.inomas ar. contr.ver.ial. This r.view compar.s the r.sults obtained by distinct tr.atment options in locor.gionally or.phar.ngeal advanced car.inomas: pr.mar. sur.ical r.section followed by concur.ent chemor.diother.py and concur.ent chemor.diother.py alone. Methods: 57 patients with stage III and IV or.phar.ngeal squamous cell car.inoma wer. selected. 17 patients wer. tr.ated with pr.mar. sur.ical r.section followed by concur.ent chemor.diother.py and 40 patients wer. tr.ated only with concur.ent chemor.diother.py. Statistical analysis was per.or.ed r.gar.ing sur.ival r.tes accor.ing to tumor.location, stage, tr.atment r.gimen and r.cur.ence. r.sults: Two-year.loco-r.gional contr.l r.tes wer. 94% after.sur.er. plus chemor.diother.py and 55% after.chemor.diother.py (p = 0.016). Pr.gr.ssion fr.e sur.ival r.tes wer. 88% and 27%, r.spectively (p 0.001). Over.ll sur.ival r.tes wer. 88% and 45%, r.spectively (p = 0.002). Conclusions: In this study, pr.mar. sur.ical r.section followed by concur.ent chemor.diother.py showed better.clinical outcomes with a lower.r.sk of death associated with tumor.and tumor.pr.gr.ssion.

关键词： Or.phar.ngeal Car.inoma Tr.atment Concur.ent Chemor.diother.py Pr.mar. Sur.ical r.section Sur.ival r.tes

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Computational Fluid Dynamics Analysis of Gr.enhouses with Ar.ificial Heat Tube

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Wor.d Jour.al of Mechanics 2012年第4期2卷 181-187页

作者： Nuno Couto Abel r.uboa Eliseu monteiro José Vier. Depar.ment of Engineer.ng Universidade de Trás-os-Montes e Alto Douro Vila Real Portugal Depar.ment of Mechanical Engineer.ng and Applied Science University of Pennsylvania Philadelphia USA r.sear.h Depar.ment of Agr.cultur. Secr.tar. Lisbon Portugal

With the wor.manship decr.ase in far.s, the necessity to r.tionalize the use of other.inputs and the development of technology has r.pidly expanded the use of computer.simulation in agr.cultur.l systems. One of the agr.cultur.l systems in which the modeling pr.cess of plant gr.wth has been mor. engaged is the gr.enhouse pr.duction for.hor.icultur.l cr.ps. In Mediter.anean climate, it is dur.ng the night that the ener.y losses ar. impor.ant and can be compensated with an ar.ificial heat input. In this wor. an exper.ment was per.or.ed in a gr.enhouse in the nor.h of Por.ugal. Temper.tur. values in sever.l points and air.velocity in the aper.ur. wer. measur.d dur.ng the night for.thr.e differ.nt cases: natur.l convective heating (case A);ar.ificial heating tubes (AHT) (case B);AHT and natur.l ventilation (case C). A CFD simulation, car.ied out using FLOTr.N module of ANSYS, was also per.or.ed in two-dimensional configur.tion to obtain the indoor.air.temper.tur. and velocity fields for.the thr.e cases. A ver. good agr.ement between exper.mental and numer.cal temper.tur. values wer. ver.fied, which allows to validate the adopted numer.cal pr.cedur.. In case A, the aver.ge temper.tur. was 2.2℃. An aver.ge incr.ase of 6.7℃ and 3.5℃ on the air.temper.tur. was obtained for.the case B and case C, r.spectively. These r.sults clear.y emphasis the influence of each ther.al load on gr.enhouse indoor.air.pr.per.ies.

关键词： Gr.enhouses Ar.ificial Heating Tubes CFD Finite Element Method

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Sur.ace r.noff and soil er.sion in a natur.l r.gener.tion ar.a of the Br.zilian Cer.ado

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Inter.ational Soil and Water.Conser.ation r.sear.h 2020年第2期8卷 124-130页

作者： Kar.na dos Santos Falcao Elói Panachuki Felipe das Neves monteiro r.niedison da Silva Menezes Dulce B.B.r.dr.gues Jullian Souza Sone Paulo Tar.o S.Oliveir. Depar.ment of Agr.nomy State University of Mato Grosso do SulAgronomy DepartmentAquidauanaMS79200-000Brazil Feder.l Univer.ity of Mato Gr.sso do Sul CxP 549Campo GrandeMS79070-900Brazil Depar.ment of Hydr.ulics and Sanitation Sao Carlos School of EngineeringUniversity of Sao PauloCxP.359Sao CarlosSP13566-590Brazil

The Br.zilian Cer.ado has been conver.ed to far.land,and ther. is little evidence that this expansion will decr.ase,mainly because agr.cultur. is the countr.'s main economic ***,the impacts of intense modification of land use and land cover.on sur.ace r.noff and soil er.sion ar. still poor.y un-der.tood in this ***,we assessed sur.ace r.noff and soil loss in a woodland Cer.ado ar.a under.a for.er.pastur. ar.a,which was abandoned and has under.one a natur.l r.gener.tion pr.cess for.7 year.(r.).Its r.sults wer. compar.d with that found in an undistur.ed ar.a of woodland Cer.ado(CE),40-month-old eucalyptus(3.0×1.8 m)(EU),and pastur. under.r.tational gr.zing(PA).The study was conducted on r.d Acr.sol located in the Br.zilian *** per.or.ed r.infall simulations on a plot of 0.7 m2 and using thr.e constant r.infall intensities of 60,90,and 120 mm h-1 for.1 *** each r.infall intensity,we car.ied out four.r.petitions using differ.nt plots in each tr.atment,i.e.12 plots per.tr.at-ment studied and 48 plots in *** noted that the soil physical pr.per.ies wer. impr.ved in r. and,consequently,water.infiltr.tion and soil er.sion contr.l;r. pr.sented sur.ace r.noff and soil loss differ.nt fr.m EU and PA(a=0.05).The macr.por.sity and soil bulk density affected sur.ace r.noff in r. and PA because the r. was used as pastur. and is cur.ently r.gener.ting back to the cer.ado *** the r.infall intensity incr.ased,EU became mor. similar.to PA,which showed the highest sur.ace r.noff and soil *** findings indicate that natur.l r.gener.tion pr.cesses(pastur. to the cer.ado vegetation)tend to impr.ve the soil ecosystem ser.ices,impr.ving infiltr.tion and r.ducing sur.ace r.noff and soil er.sion.

关键词： Cer.ado defor.station For.st r.gener.tion Soil er.sion

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Exper.mental Investigations of Var.ous Methods of Sludge Measur.ments in Stor.ge Oil Tanks

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Advances in r.mote Sensing 2015年第2期4卷 119-137页

作者： Manuel monteiro Victor.Svet Donald Sandilands Ser.ey Tsysar Inter.ational Tank Ser.ices (Asia Pacific) PTE Ltd. Singapore Singapore

This ar.icle descr.bes the r.sults of exper.mental studies into var.ous methods of measur.ng sludge volume and its 3D spatial distr.bution using a base of data r.ceived fr.m the inspection of mor. than 30 stor.ge tanks of differ.nt types: exter.al floating r.of, inter.al floating r.of and fixed r.of. The advantages and disadvantages of making measur.ments with existing methods ar. discussed, including the pr.blem of accur.cy. Numer.us examples of tank sur.ey r.sults ar. pr.sented.

关键词： Stor.ge Tanks Sludge Volume of Sludge Acoustic Bathymetr. Ther.ogr.phy

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Effectiveness in Gr.up Facilitation Tr.ining in the Hospitality Industr.: A Case Study

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Jour.al of Tour.sm and Hospitality Management 2021年第1期9卷 26-45页

作者： Fer.ando Car.oso Sousa Ileana Par.al monteiro Car.a Machado APGICO(Por.uguese Association for.Cr.ativity and Innovation) LouléPortugal Univer.ity of the Algar.e Faro APGICO LouléPortugal

This paper.aims at demonstr.ting that an acceptable level of per.or.ance as a gr.up facilitator.can be achieved byhospitality industr. manager. in a 35-hour.cour.e, to a maximum of four.een tr.inees, exper.enced in gr.upleader.hip but not in small-gr.up facilitation or.lar.e-gr.up coor.ination. Based on a six-step model for.r.anizational inter.ention, the cour.e was r.n in co-facilitation, using the effect of demonstr.tion, modelling, andobser.ation to impr.ve per.or.ance at individual level. The cour.e r.pr.sents a mix of or.anizational behaviour.nd human r.sour.es management that has pr.ved to be effective in pr.par.ng manager. to impr.ve or.anizationalinnovation and acceler.te change in companies. Each step pr.duced outputs, namely thr.e innovation *** r.ted the cour.e in ever. item of an extensive questionnair. as Good and Ver. Good, except theintr.duction (pr.-consult), which was consider.d “too theor.tical”. Ther.for., the cour.e model pr.ved to beadequate for.the pr.par.tion of manager. as coaches for.or.anizational innovation in the hospitality industr.. As tofutur. developments, they will have to do mostly with the functioning of a matr.x str.ctur. in the hospitality industr.,so that the whole appr.ach may have a full impact on the company.

关键词： or.anizational innovation or.anizational change matr.x or.anizations management tr.ining or.anizational inter.ention gr.up facilitation

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Pr.valence of non-alcoholic fatty liver.disease in patients with nephr.tic syndr.me:A population-based study

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Wor.d Jour.al of Hepatology 2023年第2期15卷 265-273页

作者： Somtochukwu Stephen Onwuzo Asif Ali Hitawala Antoine Boustany Pr.bhat Kumar.Ashr.f Almomani Chider. Onwuzo Jessy Mascar.nhas monteiro Imad Asaad Inter.al Medicine Cleveland Clinic FoundationClevelandOH 44111United States Digestive Disease and Hepatology Cleveland Clinic Foundation FloridaWestonFI 33331United States Depar.ment of Medicine&Sur.er. General Hospital Lagos IslandLagos Island 101223LagosNigeria Depar.ment of Medicine Ross University School of MedicineBridgetown B11093St MichaelBarbados Digestive Disease and Hepatology Cleveland Clinic FoundationClevelandOH 44111United States

BACKGr.UND Non-alcoholic fatty liver.disease(NAFLD) is a global health concer. with a pr.valence of about 25% amongst United States adults. Its incr.ased pr.valence is attr.buted to incr.ase in patients with obesity and metabolic syndr.me, par.ly due to similar.mechanisms of injur.. Nephr.tic syndr.me(NS) is a clinical entity r.sulting fr.m extensive pr.teinur.a leading to hypoalbuminemia, hyper.ipidemia, edema, and other.complications. Given its association with hyper.ipidemia, ther. is concer. that patients with NS may be at incr.ased r.sk of *** To per.or. a cr.ss-sectional population-based study to investigate the pr.valence and r.sk factor. of NAFLD in patients with *** A lar.e multicenter.database(Explor.s Inc., Cleveland, OH, United States) was utilized for.this r.tr.spective cohor. study. A cohor. of 49700 patients with a diagnosis of “Non-Alcoholic fatty liver.disease” using the Systematized Nomenclatur. of Medicine-Clinical Ter.s(SNOMED-CT) between 1999-2022 was identified. Inclusion cr.ter.a wer. age ≥ 18 year., pr.sence of NAFLD, pr.sence of NS. Ther. wer. no specific exclusion cr.ter.a. Univar.ate and multivar.ate analysis wer. per.or.ed to adjust for.multiple r.sk factor. including age, gender. Caucasian r.ce, NS, type Ⅱ diabetes mellitus, hypothyr.idism, dyslipidemia, obesity, metabolic syndr.me and chr.nic kidney disease. Statistical analysis was conducted using r. and for.all analyses, a 2-sided P value of r.d statistically *** Among the 78734750 individuals scr.ened in this database, ther. wer. a total of 49700 subjects with NAFLD. In univar.ate analysis, the odds of having NAFLD in patients with NS, type 2 diabetes mellitus, hypothyr.idism, dyslipidemia, obesity, metabolic syndr.me and chr.nic kidney disease wer. 14.84 [95% confidence inter.al(95%CI) 13.67-16.10], 17.05(95%CI 16.78-17.32), 6.99(95%CI 6.87-7.11), 13.61(95%CI 13.38-13.84), 19.19(95%CI 18.89-19.50), 29.09(95%CI 28.26--29.95), and 9.05(95

关键词： Non-alcoholic fatty liver.disease Nephr.tic syndr.me Chr.nic kidney disease Hyper.ipidemia Population-based study Database

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大学校园网架构

大学校园网架构

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作者： (?)gueda Sofia monteiro Tavar.s 重庆大学

学位级别：硕士

今天,信息化技术已成为公司企业、政府部门以及高等学府等机构非常重要的目标与愿望。随着全球新兴信息技术的发展,现代通信能够提供快速通信服务并提高个人通信效率,因此现代大学校园通信面对新的挑战,比如:需要提供一个信息网络能够... 详细信息

今天,信息化技术已成为公司企业、政府部门以及高等学府等机构非常重要的目标与愿望。随着全球新兴信息技术的发展,现代通信能够提供快速通信服务并提高个人通信效率,因此现代大学校园通信面对新的挑战,比如:需要提供一个信息网络能够支持个人需求并适应多元化的校园环境。一个新的网络架构成为校园网的骨干基础之一,它能够使教师,研究者,学生,管理者和员工组成一个社会群体更方便的进行教学、科研、学习并相互沟通。本文重点在于对校园网架构的定义以及校园网的基本组成部分的介绍。三个最重要的高质量的架构特征为:开放的网络架构、服务导向的特征以及基于包交换的IP网络。架构中四个重要的组成部分为:服务和网络管理、网络控制、中心交换单元和边缘接入。本文的理论贡献是提出大学校园网的参考模型架构,这个参考模型架构可以适用于建立一个健壮的灵活的网络能够满足下一代需求。结果的建立可以为建立现代校园网提供一个重要的参考指导。研究的校园网模型是可靠的、健壮的并且具有扩展性。

关键词：校园网架构接入技术网络管理移动代理

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