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Weight r.gain after.intr.gastr.c balloon for.pr.-sur.ical weight loss

Wor.d Jour.al of Gastr.intestinal Sur.er. 2024年第7期16卷 2040-2046页

作者： Danielle Abbitt kevin Choy Alexandr. Kovar.Ter.sa S jones Kr.ysztof J Wikiel Edwar. L jones Depar.ment of Sur.er. University of ColoradoAuroraCO 80045United States Depar.ment of Sur.er. Rocky Mountain Regional Veteran Affairs Medical CenterAuroraCO 80045United States

BACKGr.UND Over.one-thir. of Amer.cans car.y the diagnosis of obesity,many also with obesity-r.lated *** can place patients at incr.ased r.sk of oper.tive and postoper.tive *** intr.gastr.c balloon has been shown to aid in minor.weight loss,however.its weight r.cidivism in patients r.quir.ng shor. inter.al weight loss has not been well *** To evaluate weight loss,ability to under.o successful elective sur.er. after.intr.gastr.c balloon placement,and weight management after.balloon *** This study is a r.tr.spective r.view of patients in a single academic institution under.oing intr.gastr.c balloon placement fr.m 2019-2023 to aid in weight loss pr.or.to under.oing elective *** outcomes including weight loss,dur.tion of balloon placement,successful elective sur.er.,weight r.gain postballoon and post-pr.cedur. complications wer. *** cr.ter.a included those with balloon in place at time of *** Thir.y-thr.e patients completed intr.gastr.c balloon ther.py fr.m 2019-2023 as a br.dge to elective *** patients wer. r.quir.d to par.icipate in a 12-month weight management pr.gr.m to be eligible for.balloon *** sur.er.es included incisional her.ia r.pair.umbilical her.ia r.pair.inguinal her.ia r.pair.and knee and hip *** aver.ge age at placement was 53 year.±11 year.,major.ty(91%)wer. *** aver.ge dur.tion of intr.gastr.c balloon ther.py was 186 days±41 *** aver.ge weight loss was 14.0 kg±7.4 kg and with an aver.ge per.ent excess body weight loss of 30.0%(7.9%-73.6%).Over.half of the patients(52.0%)achieved the goal of 30-50 lbs(14-22 kg)weight ***-one patients(64%)under.ent their.intended elective sur.er.,2 patients(6%)defer.ed sur.er. due to symptom r.lief with weight loss ***-one of the patients(64%)have documented weights in 3 months after.balloon r.moval,in these patients the major.ty(76%)gained weight after.balloon *** pat

关键词： Intr.gastr.c balloon Weight loss Obesity Bar.atr.c Body mass index

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透皮东莨菪碱贴剂联合昂丹司琼对比单独应用昂丹司琼用于预防门诊手术后恶心呕吐的一项随机双盲多中心研究

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麻醉与镇痛 2010年第5期6卷 34-40页

作者： Tong J. Gan, md Ashish C. Sinha, md, PhD Anthony L. Kovac, md r. kevin jones, md, cpi Stephen A.Cohen,md,MBA Jean P. Battildaa, MS Jonathan S. Deutsch, md Joseph V. Per.olizzi, Jr., md] TDS Study Gr.up 王琦(译) 李文志(校) Depar.ment of Anesthesiology Duke University Medical Center Durham North Carolina Univer.ity of Pennsylvania Philadelphia Pennsylvania ＊Univer.ity of Kansas Medical Center Kansas City Kansas Accur.te Clinical Tr.als Inc./Saddleback Memor.al Medical Center Laguna Hills California Beth Isr.el Deaconess Medical Center Boston Massachusetts Baxter.Healthcar. Cor.or.tion New Providence New Jersey Depar.r.ent of Medicine Johns Hopkins University School of Medicine Baltimore Maryland The TDS Study Gr.up consists of the following member.: Gr.gor. H. Adkisson (St. Agnes Healthcar. Inc. Baltimore MD St. Agnes Healthcare Inc. Clinical Research Center Baltimore MD) I(eith Candiotti(University of Miami School of Medidne Jackson Health Systems Miami FL) Stephen & Cohen(Beth Israel Deaconess Medical Center Boston MA) Nell R. Connelly(Baystate Medical Center Springfield MA) Patricia L. Dalby(Magee Women's Hospital of UPMC Pittsburgh PA) Robert D'Angelo(Forsyth Medical Center Winston-Salem NC) Albert R. Davis(Loyola University Medical Center Chicago IL) David 1L Drover (Stanford Hospital and Clinics Stanford CA) Tong J. Gan Fernando Altermatt Dianne Scott(Duke University Medical Center Durham NC Duke Health Raleigh Hospital Raleigh NC and Duke Center for Aesthetic Services Durham NC) Joseph S. Gimbel(AZ Research Center John C. Lincoln Hospital North Mountain and John C. Lincoln Hospital Deer Valley Phoenix AZ)R.Kevin Jones (Saddleback Memorial Medical Center Laguna Hills CA) Anthony L. Kovac(University of Kansas Medical Center Kansas City Kansas KS) John B. Leslie(Mayo Clinic Hospital Phoenix AZ) Roberta McI(inney Jr. (Trinity Clinic North Park Mother Frances Hospital and Tyler Square Tyler TX) Tricia A. Meyer ( Scott and White Hospital Temple TX ) Joseph Pergolizzi (Physicians Day Surgery Center Naples FL) Beverly tC Philip (Brigham and Women's Hospital Boston MA) Martin I. Redmond(State University of New York at Stony Brook Ambulatory Surgica

背景手术后恶心、呕吐（PONV）是门诊手术常见的并发症。本试验目的是观察透皮东莨菪碱贴剂（TDS）联合静脉注射昂丹司琼（OND）对门诊患者PONV的疗效是否优于单独应用昂丹司琼。方法此项随机双盲多中心的临床试验纳入了620例接受门诊... 详细信息

背景手术后恶心、呕吐（PONV）是门诊手术常见的并发症。本试验目的是观察透皮东莨菪碱贴剂（TDS）联合静脉注射昂丹司琼（OND）对门诊患者PONV的疗效是否优于单独应用昂丹司琼。方法此项随机双盲多中心的临床试验纳入了620例接受门诊腹腔镜或隆胸手术的PONV高危女性患者，进入手术室前2小时分别给患者贴上TDS贴剂或外观相同的空白贴剂。在全麻诱导前2—5分钟给所有患者静脉注射OND4mg。手术后24~48小时评估止吐是否完善（彻底止吐标准为无呕吐或干呕，且没有追加止吐药）。同时记录发生呕吐、干呕、恶心以及追加止吐药的患者比例，记录手术后首次发生PONV的时间及离院时间，记录呕吐、干呕、恶心的发作次数与严重程度及患者对于止吐治疗的满意度。结果TDS＋OND组与OND组相比，手术后24小时恶心、呕吐的发生率显著降低，但手术后48小时两者差异无显著性。TDS＋OND组没有呕吐、干呕且未追加过止吐药的患者占48％，而OND组占39％（P〈0．02）。TDS＋OND组的彻底止吐（无恶心、呕吐或干呕，且未追加止吐药）率显著高于OND组（分别为35％和25％，P〈0．01）。TDS＋OND组手术后首次发生恶心、呕吐、干呕及追加止吐药的时间明显晚于OND组（P〈0．05）。前者不良反应的总发生率也低于后者（分别为36．7％和49％，P〈0．01）。结论与单独应用OND相比。TDS＋OND能更大程度地减少PONV，主要是通过减少不良反应而获得。

关键词：手术后恶心呕吐东莨菪碱贴剂多中心研究昂丹司琼门诊手术随机双盲应用单独

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Multinuclear.Mr.and Mr. study of lithium-ion cells using a var.able field magnet and a fixed fr.quency r. pr.be

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Magnetic r.sonance Letter. 2024年第1期4卷 10-20页

作者： Andr.s r.mír.z Aguiler. Flor.n Mar.ca kevin J.Sander. md Al r.ihan C.Adam Dyker.Gillian r.Gowar. Br.ce *** UNB Mr. Centr. Department of PhysicsUniversity of New BrunswickFrederictonNew BrunswickE3B 5A3Canada Depar.ment of Chemistr. McMaster UniversityHamiltonOntarioL8S 4L8Canada Depar.ment of Chemistr. University of New BrunswickFrederictonNew BrunswickE3B 5A3Canada

An explor.tor. multinuclear.magnetic r.sonance(Mr.and magnetic r.sonance imaging(Mr.)study was per.or.ed on lithium-ion batter. cells with ^(7)Li,^(19)F,and ^(1)H measur.ments.A var.able field super.onducting magnet with a fixed fr.quency par.llel-plate r.diofr.quency(r.)pr.be was employed in the *** magnetic field was changed to set the r.sonance fr.quency of each nucleus to the fixed r. pr.be fr.quency of 33.7 *** car.r.dge-like lithium-ion cells,with gr.phite anodes and LiNi_(0.5)Mn_(0.3)Co_(0.2)O_(2)(NMC)cathodes,wer. *** cell was pr.stine,and one was char.ed to a cell voltage of 4.2 *** r.sults pr.sented demonstr.te the gr.at potential of the var.able field magnet appr.ach in multinuclear.measur.ment of lithium-ion *** methods open the door.for.developing faster.and simpler.methods for.detecting,quantifying,and inter.r.ting Mr.and Mr. data fr.m lithium-ion and other.batter.es.

关键词： Multinuclear.Mr.Mr. Var.able field magnet Lithium-ion batter. Par.llel-plate r. pr.be

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A ther.odynamic per.pective on electr.de poisoning in solid oxide fuel cells

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Inter.ational Jour.al of Miner.ls,Metallur.y and Mater.als 2024年第6期31卷 1449-1455页

作者： kevin Huang Depar.ment of Mechanical Engineer.ng University of South CarolinaColumbiaUSA

A cr.tical challenge to the commer.ialization of clean and high-efficiency solid oxide fuel cell(SOFC)technology is the insuf-ficient stack lifespan caused by a var.ety of degr.dation mechanisms,which ar. associated with cell components and chemical *** components r.lated degr.dation r.fer. to ther.al/chemical/electr.chemical deter.or.tion of cell mater.als under.oper.ting conditions,wher.as the latter.r.gar.s impur.ties in feedstocks of oxidant(air.and r.ductant(fuel).This ar.icle pr.vides a ther.odynamic per.pective on the under.tanding of the impur.ties-induced degr.dation mechanisms in *** discussion focuses on using ther.odynamic ana-lysis to elucidate poisoning mechanisms in cathodes by impur.ty species such as Cr.CO_(2),H_(2)O,and SO_(2) and in the anode by species such as S(or.H_(2)S),SiO_(2),and P_(2)(or.PH_(3)).The author.hopes the pr.sented fundamental insights can pr.vide a theor.tical foundation for.sear.h-ing for.better.technical solutions to addr.ss the cr.tical degr.dation challenges.

关键词： impur.ties air fuel r.action activity

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Integr.ted photonic fr.ctional convolution acceler.tor

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Photonics r.sear.h 2024年第8期12卷 1828-1839页

作者： kevin ZELAYA MOHAMMED-ALI MIr. Depar.ment of Physics Queens College of the City University of New YorkQueensNew York 11367USA Physics Pr.gr.m The Graduate Center of the City University of New YorkNew YorkNew York 10016USA

An integr.ted photonic cir.uit ar.hitectur. to per.or. a modified-convolution oper.tion based on the discr.te fr.ctional Four.er.tr.nsfor.(DFr.T) is intr.duced. This is accomplished by utilizing two nonunifor.ly coupled waveguide lattices with equally spaced eigenmode spectr., the lengths of which ar. chosen so that the DFr.T and its inver.e oper.tions ar. achieved. A pr.gr.mmable modulator.ar.ay is inter.aced so that the r.quir.d fr.ctional convolution oper.tion is per.or.ed. Numer.cal simulations demonstr.te that the pr.posed ar.hitectur. can effectively per.or. smoothing and edge detection tasks even for.noisy input signals, which is fur.her.ver.fied by electr.magnetic wave simulations. Notably, mild lattice defects do not jeopar.ize the ar.hitectur. per.or.ance, showing its r.silience to manufactur.ng er.or..

关键词： fr.ctional convolution utilizing

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Speed and sur.ace steepness affect inter.al tibial loading dur.ng r.nning

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Jour.al of Spor. and Health Science 2024年第1期13卷 118-124页

作者： Hannah r.ce Mar.us Kur. Patr.ck Mai Leon r.ber.z kevin Bill Timothy r.Der.ick Steffen Willwacher Depar.ment of Physical Per.or.ance Norwegian School of Sport SciencesOslo 0806Norway Spor.s Tech r.sear.h Centr. Mid Sweden UniversityÖstersund SE-83125Sweden Depar.ment of Mechanical and Pr.cess Engineer.ng Offenburg University of Applied SciencesOffenburg 77652Germany Institute of Biomechanics and Or.hopaedics German Sport University CologneCologne 50933Germany Depar.ment of Kinesiology Iowa State UniversityAmesIA 50011USA

Backgr.und:Inter.al tibial loading is influenced by modifiable factor. with implications for.the r.sk of str.ss *** encounter.var.ed sur.ace steepness(gr.dients)when r.nning outdoor. and may adapt their.speed accor.ing to the *** study aimed to quantify tibial bending moments and str.ss at the anter.or.and poster.or.per.pher.es when r.nning at differ.nt speeds on sur.aces of differ.nt ***:Twenty r.cr.ational r.nner. r.n on a tr.admill at 3 differ.nt speeds(2.5 m/s,3.0 m/s,and 3.5 m/s)and gr.dients(level:0%;uphill:+5%,+10%,and+15%;downhill:-5%,-10%,and-15%).For.e and mar.er.data wer. collected synchr.nously *** moments wer. estimated at the distal thir. centr.id of the tibia about the medial-later.l axis by ensur.ng static equilibr.um at each 1%of *** was der.ved fr.m bending moments at the anter.or.and poster.or.per.pher.es by modeling the tibia as a hollow ***-way r.peated-measur.s analysis of var.ance wer. conducted using both functional and discr.te statistical ***:Ther. wer. significant main effects for.r.nning speed and gr.dient on peak bending moments and peak anter.or.and poster.or.*** r.nning speeds r.sulted in gr.ater.tibial *** uphill at+10%and+15%r.sulted in gr.ater.tibial loading than level *** downhill at-10%and-15%r.sulted in r.duced tibial loading compar.d to level *** was no differ.nce between+5%or.5%and level ***:r.nning at faster.speeds and uphill on gr.dients≥+10%incr.ased inter.al tibial loading,wher.as slower.r.nning and downhill r.nning on gr.dients≥-10%r.duced inter.al *** r.nning speed accor.ing to the gr.dient could be a pr.tective mechanism,pr.viding r.nner. with a str.tegy to minimize the r.sk of tibial str.ss injur.es.

关键词： Bending moments Gr.dient Musculoskeletal modeling Over.se injur. Tibial str.ss Tr.ining factor.

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Neur.n-to-astr.cyte pr.teostatic str.ss signaling in r.sponse to tau pathology

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Neur.l r.gener.tion r.sear.h 2024年第3期19卷 505-506页

作者： kevin Llewelyn Batenbur. Wiep Scheper Amster.am UMC location Vr.je Univer.iteit Amster.am Department of Human GeneticsAmsterdam Neuroscience-NeurodegenerationAmsterdamThe Netherlands Depar.ment of Functional Genomics Center for Neurogenomics and Cognitive ResearchVrije Universiteit AmsterdamAmsterdam Neuroscience-NeurodegenerationAmsterdamThe Netherlands

Maintenance of pr.tein homeostasis or.pr.teostasis”is essential for.the functioning and viability of *** is in par.icular.the case for.cells like neur.ns that cannot self-r.new and acquir. unique functional pr.per.ies dur.ng their.*** pr.teostatic str.ss r.sponses ar. in place to pr.tect cells fr.m damage in case of pr.teostatic *** integr.ted str.ss r.sponse(ISr.is one of the key pr.teostatic str.ss r.sponses in the cell(Costa-Mattioli and Walter.2020).The ISr.is the downstr.am conver.ence point for.the four.str.ss-induced eIF2αkinases(EIF2AK1-4)that contr.l str.ss-r.gulated pr.tein tr.nslation via phosphor.lation of the tr.nslation factor.eIF2α.ISr.activation r.sults in a tr.nsient r.duction of global tr.nslation while it concomitantly enhances the tr.nslation of specific mr.As,including that encoding the activating tr.nscr.ption factor.4(ATF4).Together.the tr.nslational contr.l mediated by the ISr.r.sults in a tempor.r. r.duction of the over.ll pr.tein load and the selectively incr.ased expr.ssion of pr.teins that contr.bute to r.stor.tion of the pr.teostatic balance.

关键词： tr.nslation str.ss Together

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High temper.tur. defor.ation and r.cr.stallization behavior.of magnesium bicr.stals with 90°<1010>and 90°<1120>tilt gr.in boundar.es

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Jour.al of Magnesium and Alloys 2024年第2期12卷 625-638页

作者： kevin Bissa Talal Al-Samman Dmitr. A.Molodov Institute of Physical Metallur.y and Mater.als Physics RWTH Aachen University52056 AachenGermany Inter.ational r.sear.h Or.anization for.Advanced Science and Technology(Ir.AST) Kumamoto UniversityKumamoto 860-8555Japan

The defor.ation mechanisms and dynamic r.cr.stallization(Dr.)behavior.of specifically gr.wn bicr.stals with a symmetr.c 90°and 90°tilt gr.in boundar.,r.spectively,wer. investigated under.defor.ation in plane str.in compr.ssion at 200℃and 400℃.The micr.str.ctur.s wer. analyzed by panor.mic optical micr.scopy and lar.e-ar.a electr.n backscatter.diffr.ction(EBSD)or.entation *** analysis employed a meticulous appr.ach utilizing hundr.ds of individual,small EBSD maps with a small step size that wer. stitched together.to pr.vide compr.hensive access to or.entation and misor.entation data on a macr.scopic *** slip pr.mar.ly gover.ed the ear.y stages of defor.ation at the two temper.tur.s,and the r.sulting shear.induced lattice r.tation ar.und the tr.nsver.e dir.ction(TD)of the *** existence of the gr.in boundar. gave r.se to dislocation pile-up in its vicinity,leading to much lar.er.TD-lattice r.tations within the boundar. r.gion compar.d to the *** incr.asing temper.tur.,the defor.ation was gener.lly mor. unifor. towar.s the bulk due to enhanced dislocation mobility and mor. unifor. str.ss *** r.cr.stallization at 200℃was initiated in{1011}-compr.ssion twins at str.ins of 40%and *** 400℃,Dr. consumed the entir. gr.in boundar. r.gion and gr.dually r.placed the defor.ed micr.str.ctur. with pr.gr.ssing *** r.cr.stallized gr.ins displayed char.cter.stic or.entations,such that their.c-axes wer. per.endicular.to the TD and additionally scatter.d between 0°and 60°fr.m the loading *** r.cr.stallized gr.ins displayed mutual r.tations of up to 30°ar.und the c-axes of the initial gr.ins,for.ing a discer.ible basal fiber.textur. component,pr.minently visible in the{1120}pole *** is notewor.hy that the defor.ation and Dr. behavior. of the two analyzed bicr.stals exhibited mar.inal var.ations in r.sponse to str.in and defor.ation temper.tur..

关键词： Elevated defor.ation temper.tur.s Plain str.in compr.ssion Magnesium bicr.stals Panor.ma EBSD Dynamic r.cr.stallization

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Or.hogonal polynomial expansions for.the valuation ofoptions under.the stochastic volatility models with stochastic cor.elation

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Jour.al of Management Science and Engineer.ng 2024年第2期9卷 239-253页

作者： kevin Z.Tong Depar.ment of Mathematics and Statistics University of Ottawa585 King EdwardOttawaOntarioK1N 6N5Canada

This wor. pr.vides a new method for.pr.cing options under.the gener.lized stochastic volatility models with Jacobi stochastic *** method is based on the obser.ation that the gener.lized models belong to the class of polynomial diffusions and ther.for. the option pr.ces can be efficiently computed via or.hogonal polynomial *** take the Heston and Schöbel-Zhu models with stochastic cor.elation as two specific examples and ar. able to der.ve the analytical for.ulas for.the option *** also illustr.te the accur.cy of the pr.posed method thr.ugh a number.of numer.cal exper.ments.

关键词： Or.hogonal polynomial expansions Polynomial diffusions Stochastic cor.elation Jacobi pr.cess Stochastic volatility

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Neur.lithogr.phy:Lithogr.phy as an enabling technology in neur.logy and neur.science

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Medicine in Novel Technology and Devices 2024年第2期22卷 15-18页

作者： kevin Zhai Depar.ment of Medical Education Weill Cornell Medicine-QatarP.O.Box 24144DohaQatar

Moder. lithogr.phy,which enables the fabr.cation of complex str.ctur.s in biomedical devices with exceptional pr.cision,is a potentially tr.nsfor.ative for.e in the neur.l *** such as photolithogr.phy,electr.n beam lithogr.phy,and soft lithogr.phy have been utilized to pr.duce devices that guide neur.nal gr.wth and differ.ntiation and measur. electr.physiological signals at the single-cell *** the clinical spher.,lithogr.phy plays a r.le in the manufactur.ng of devices for.deep br.in stimulation,br.in-computer.inter.ace,and ***,we br.efly r.view the applications of lithogr.phy in basic and tr.nslational neur.science and clinical neur.logy,with an eye towar. futur. advancement.

关键词： Lithogr.phy Neur.lithogr.phy Semiconductor. Micr.fluidics Neur.l devices

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