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In silico analysis of lncr.A-mir.A-mr.A signatur.s r.lated to Sor.fenib effectiveness in liver.cancer.cells

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Wor.d Jour.al of Gastr.enter.logy 2025年第3期31卷 84-102页

作者： Patr.cia de la Cr.z-Ojeda Ester.Par.as-Mar.ínez r.quel r.y-Pér.z Jor.i Muntané Functional Genomics of Solid Tumor. labor.tor. Centre de Recherche des CordeliersParis 75006France Depar.ment of Oncology Sur.er. Cell Therapy and Organ TransplantationInstitute of Biomedicine of SevilleVirgen del Rocio University HospitalSeville 41013Spain Biomedical r.sear.h Center.for.Hepatic and Digestive Diseases CIBERehdMadrid 28029Spain Depar.ment of Medical Physiology and Biophysics University of SevilleSeville 41009Spain

BACKGr.UND Hepatocellular.car.inoma(HCC)is the most common subtype of pr.mar. liver.cancer.with var.ed incidence and epidemiology *** is still a r.commended tr.atment for.a lar.e pr.por.ion of patients with advanced *** patter.s of tr.atment r.sponsiveness have been identified in differ.ntiated hepatoblastoma HepG2 cells and metastatic HCC SNU449 *** To define the long non-codingr.A-micr.r.A-mr.A(lncr.A-mir.A-mr.A)pr.dicted signatur.s r.lated to selected hallmar.s of cancer.apoptosis,autophagy,cell str.ss,cell dediffer.ntiation and invasiveness)in r.Aseq studies using Sor.fenib-tr.ated HepG2 and SNU449 *** available softwar. analyses allowed us to establish the lncr.A-mir.A-mr.A r.gulator. axes following tr.atment in HepG2 and SNU449 *** HepG2 and SNU449 cells wer. tr.ated with Sor.fenib(10μmol/L)for.24 *** r.A,including small and long r.A,was extr.cted with a commer.ial mir.easy *** was car.ied out for.the identification of changes in lncr.A-mir.A-mr.A r.gulator. *** MAlaT,THAP9-AS1 and SNGH17 appear.d to coor.inately r.gulate mir.374b-3p and mir.769-5p that led to upr.gulation of SMAD7,TIr.r.,TFAP4 and FAXDC2 in HepG2 ***12,EPB41 L4A-AS1,LINC01578,SNHG12 and GAS5 inter.cted with let-7b-3p,mir.195-5p and VEGFA in SNU449 *** axes MAlaT1/hsamir.374b-3p/SMAD7 and MAlaT1/hsa-mir.769-5p/TFAP4 wer. of high r.levance for.Sor.fenib r.sponse in HepG2 cells,wher.as PVT1/hsa-mir.195-5p/VEGFA was r.sponsible for.the differ.ntial r.sponse of SNU449 cells to Sor.fenib *** Cr.tical lncr.As acting as sponges of mir.A wer. identified that r.gulated mr.A expr.ssion,whose pr.teins mainly incr.ased the antitumor.effectiveness of the tr.atment(SMAD7,TIr.r.,TFAP4,FAXDC2 and ADr.2).However.the br.ad r.gulator. axis leading to incr.ased VEGFA expr.ssion may be r.lated to the side effect of Sor.fenib in SNU449 cells.

关键词： Cell cultur. Hepatocellular.car.inoma Non-coding r.A r.Aseq Sor.fenib

Cr.eping fat and gut micr.biota in Cr.hn’s disease

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Wor.d Jour.al of Gastr.enter.logy 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magr. Mar.ello Imbr.zi Ellen CS De Oliveir. Luiz C Di Stasi Ligia Y Sassaki Ver.m Ingr.dients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Depar.ment of Sur.er. Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Depar.ment of Gastr.enter.logy Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Depar.ment of Inter.al Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Depar.ment of Biophysics and Phar.acology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this ar.icle,we explor.d the r.le of adipose tissue,especially mesenter.c adipose tissue and cr.eping fat,and its association with the gut micr.biota in the pathophysiology and pr.gr.ssion of Cr.hn’s disease(CD).CD is a for. of inflammator. bowel disease char.cter.zed by chr.nic inflammation of the gastr.intestinal tr.ct,influenced by genetic pr.disposition,gut micr.biota dysbiosis,and envir.nmental *** micr.biota plays a cr.cial r.le in modulating immune r.sponse and intestinal inflammation and is associated with the onset and pr.gr.ssion of ***,viscer.l adipose tissue,par.icular.y cr.eping fat,a mesenter.c adipose tissue char.cter.zed by hyper.r.phy and fibr.sis,has been implicated in CD pathogenesis,inflammation,and *** bacter.a fr.m the gut micr.biota may tr.nslocate into mesenter.c adipose tissue,contr.buting to the for.ation of cr.eping fat and influencing CD *** cr.eping fat may be a pr.tective bar.ier.against bacter.al invasion,its expansion can damage adjacent tissues,leading to *** gut micr.biota thr.ugh inter.entions such as fecal micr.biota tr.nsplantation,pr.biotics,and pr.biotics has shown potential in managing ***,mor. r.sear.h is needed to clar.fy the mechanisms linking gut dysbiosis,cr.eping fat,and CD pr.gr.ssion and develop tar.eted ther.pies for.micr.biota modulation and fat-r.lated complications in patients with CD.

关键词： Cr.eping fat Mesenter.c adipose tissue Gut micr.biota Cr.hn’s disease Inflammator. bowel disease

Validation of Zebr.fish (Danio r.r.o) r.fer.nce Genes for.Quantitative r.al-time r.-PCr.Nor.alization

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Acta Biochimica et Biophysica Sinica 2007年第5期39卷 384-390页

作者： Andr.w DODD Daniel la War.en C. MCNABB Donald r. LOVE School of Biological Sciences University of Auckland Private Bag 92019 Auckland 1142 New Zealand Food and Health Gr.up AgResearch Grasslands Private Bag 11008 Tennant Drive Palmerston North New Zealand

The nor.alization of quantitative r.al time r.-PCr.(qr.-PCr. is impor.ant to obtain accur.te gene expr.ssion data. The most common method for.qr.-PCr.nor.alization is to use r.fer.nce, or.house- keeping genes. However. ther. is emer.ing evidence that even r.fer.nce genes can be r.gulated under.differ.nt conditions, qr.-PCr.has only r.cently been used in ter.s of zebr.fish gene expr.ssion studies and ther. is no validated set of r.fer.nce genes. This study char.cter.zes the expr.ssion of nine possible r.fer.nce genes dur.ng zebr.fish embr.onic development and in a zebr.fish tissue panel. All nine r.fer.nce genes exhibited var.able expr.ssion. The β-actin, EF1α and r.113α genes compr.se a validated r.fer.nce gene panel for.zebr.fish developmental time cour.e studies, and the EF1α, r.113α and 18S r.NA genes ar. mor. suitable as a r.fer.nce gene panel for.zebr.fish tissue analysis. Impor.antly, the zebr.fish GAPDH gene appear. unsuitable as r.fer.nce gene for.both types of studies.

关键词： zebr.fish quantitative r.al-time r.-PCr housekeeping genes GAPDH gene GeNor.

Game changer.How Janus kinase inhibitor. ar. r.shaping the landscape of ulcer.tive colitis mana

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Wor.d Jour.al of Gastr.enter.logy 2024年第35期30卷 3942-3953页

作者： Antonio M caballer.-Mateos Guiller.o Ar.ur. cañadas-de la Fuente Depar.ment of Gastr.enter.logy and Hepatology San Cecilio University HospitalGranada 18014Spain Depar.ment of Nur.ing Faculty of Health SciencesUniversity of GranadaGranada 18004Spain

r.cent advancements in the tr.atment landscape of ulcer.tive colitis(UC)have usher.d in a new er. of possibilities,par.icular.y with the intr.duction of Janus kinase(JAK)-signal tr.nsducer.and activator.of tr.nscr.ption *** novel agents offer.a par.digm shift in UC management by tar.eting key signaling pathways involved in inflammator. *** appr.ved JAK inhibitor.(JAKis),such as tofacitinib,filgotinib,and upadacitinib,clinicians now have power.ul tools to modulate immune r.sponses and gene expr.ssion,potentially r.volutionizing the tr.atment algor.thm for.*** tr.als have demonstr.ted the efficacy of JAKis in inducing and maintaining r.mission,pr.senting viable options for.patients who have failed conventional ***-wor.d data suppor. the use of JAKis not only as fir.t-line tr.atments but also in subsequent lines of ther.py,par.icular.y in patients with aggr.ssive disease phenotypes or.r.fr.ctor. to biologic *** r.pid onset of action and potency of JAKis have br.adened the possibilities in the management str.tegies of UC,offer.ng timely r.lief for.patients with active disease and facilitating per.onalized tr.atment *** safety concer.s,including car.iovascular.r.sks and infections,ongoing r.sear.h and post-mar.eting sur.eillance will continue to r.fine our.under.tanding of the r.sk-benefit pr.file of JAKis in UC management.

关键词： Ulcer.tive colitis Janus kinase inhibitor. Filgotinib Tofacitinib Upadacitinib

A For.ula for.the Non-integer.Power. of the laplacian

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Acta Mathematica Sinica,English Ser.es 1999年第1期15卷 21-24页

作者： Zhengxu HeDepar.ment of Mathematics,Univer.ity of califor.ia,San Diego,la Jolla,ca 92093-0112,USA Depar.ment of Mathematics University of California San Diego La Jolla USA

We pr.vide an elementar. for.ula for.the non-integer.power. of the laplace oper.tor.in the Euclidean *** for.ulas ar. helpful in establishing the elliptic natur. of some pseudo- differ.ntial oper.tor. ar.sing fr.m the... 详细信息

关键词： laplacian Power.of laplacian

Analysis and Modeling of Slope Stability in the Thr.e-Gor.es Dam r.ser.oir.(China)——The case of Huangtupo landslide

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Jour.al of Mountain Science 2011年第2期8卷 166-175页

作者： r.COJEAN Y.J.ca Centr. de Géosciences Mines-ParisTech Paris France Changjiang Institute of Sur.ey Planning Design & Research CWRC Wuhan China

The water.level in the Thr.e Gor.es Dam r.ser.oir.is expected to change between the elevations of 145 m and 175 m, as a function of the flood contr.l implementation and the intensity of the annual flood. As a matter.of fact, the hydr.ulical and mechanical loadings, r.lated to the water.level modifications, will r.sult in alter.tions in the slope stability conditions. The town of Badong (Hubei), of 20 000 inhabitants, is one of the towns which was submer.ed by the impoundment of the r.ser.oir. As a consequence, the new town of Badong was constr.cted on a near.y site which appear.d to be par.ly an unstable site. A par. of this site cor.esponds to an old landslide, the Huangtupo landslide, the base of which had to be submer.ed by the water.of the r.ser.oir. The analysis of the Huangtupo landslide, taking into account var.ous events scenar.os, dr.inage and r.infor.ement measur.s and monitor.ng devices, allows to illustr.te the gener.l pr.cess implemented all along the r.ser.oir.in or.er.to mitigate the landslide hazar..

关键词： Thr.e Gor.es Dam landslide Modelling

Emer.ing potential of pr.gr.nulin-dependent Sor.S2 signaling in healthy and diseased ner.ous systems

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Neur.l r.gener.tion r.sear.h 2025年第9期20卷 2591-2593页

作者： Alena Salasova Ander. Nykjær Danish r.sear.h Institute of Tr.nslational Neur.science DANDr.TE-Nor.ic EMBL Par.ner.hip for.Molecular.Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The for.ation of the mammalian ner.ous system and its matur.tion into sensor.,motor.cognitive,and behavior.l cir.uits is a complex pr.cess that begins dur.ng ear.y embr.ogenesis and lasts until young *** neur.developm... 详细信息

关键词： pr.gr jointly CS2

Antisense oligonucleotides pr.vide optimism to the ther.peutic landscape for.tauopathies

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Neur.l r.gener.tion r.sear.h 2025年第3期20卷 803-804页

作者： Glenn A.Har.is laur.n r.Hir.chfeld r.inwater.Char.table Foundation Fort WorthTXUSA

Tauopathies ar. a gr.up of neur.degener.tive diseases char.cter.zed by abnor.al metabolism of the misfolded tau pr.tein. Tau is encoded by the micr.tubule-associated pr.tein tau gene(MAPT) and can be classified as either.3-r.peat(3r. or.4-r.peat(4r. based on the number.of r.peat domains fr.m alter.ative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

STUDY OF THr.E-DIMENSIONAL SEPAr.TION OF BOUNDAr. laYEr.OVEr.BLUNT BODIES

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Jour.al of Hydr.dynamics 2009年第1期21卷 100-107页

作者： ATMANI r. Br.MA A. ASKOVIC r. labor.toir. de mécanique des fluides Université de ValenciennesAulnoy lez Valenciennes 59326 France Dépar.ement de Mécanique Université de BiskraBiskra 07000 Algérie

In the case of thr.e-dimensional flows, the separ.tion can be defined in mor. than one way. Discussions about thr.e-dimensional boundar. layer.separ.tion in the liter.tur. have found a r.tional extension of the zer. skin fr.ction. Attempts have been made to establish the identity of “separ.tion lines”. Among definitions, these may be found：（1） envelopes of limiting str.amlines, （2） lines dividing flow which has come fr.m differ.nt r.gions, （3） lines of singular.ties （pr.blems of topology）, （4） lines on which some component of the skin fr.ction vanishes. Each of these is valid under.cer.ain conditions, but none is univer.ally valid. In the pr.sent wor., we use the definition （4）, i.e. at low incidence of a blunt body the separ.tion line is identified as the zer. of the mer.dian skin fr.ction component （Wang 1975）. So the separ.tion line on a flattened spher.id （6：3：1） at 6° of incidence is calculated, as well as exper.mentally deter.ined by using the electr.chemical method, which allows to follow the evolution of the par.etal velocity gr.dient.

关键词： thr.e-dimensional flows separ.tion boundar. layer. blunt bodies