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利用特征灵敏度分析对弹性支撑矩形板的振动分析

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钢结构(中英文) 2010年第5期 80-80页

作者： r. joseph watkins O. Bar.on

对弹性支撑的各向同性矩形板的标准频率进行计算。基于特征灵敏度分析,通过Mauclar.n级数和一个闭合屈服方程,对特征参数进行近似计算。近似闭合方程的好处是其计算比较简单有效,且便于重复计算。通过与利用正交多项式和梁形状系数的r.y... 详细信息

对弹性支撑的各向同性矩形板的标准频率进行计算。基于特征灵敏度分析,通过Mauclar.n级数和一个闭合屈服方程,对特征参数进行近似计算。近似闭合方程的好处是其计算比较简单有效,且便于重复计算。通过与利用正交多项式和梁形状系数的r.yleigh-r.tz法计算的结果进行对比,验证了近似方程的有效性。通过简支、固定和无支撑等几种组合支撑方式,考虑了各种不同的边界条件。结果表明:敏感分析中对高频率计算的准确性更多地依赖于基函数的选择。

关键词：模态分析弹性点支撑矩形板边界条件特征灵敏度分析

Hybr.d Shor.-ter. Load For.casting Method Based on Empir.cal Wavelet Tr.nsfor. and Bidir.ctional Long Shor.-ter. Memor. Neur.l Networ.s

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Jour.al of Moder. Power.Systems and Clean Ener.y 2022年第5期10卷 1216-1228页

作者： Xiaoyu Zhang Stefanie Kuenzel Nicolo Colombo Chr.s watkins School of Ar.ificial Intelligence Anhui UniversityHefei 230601China Depar.ment of Electr.nic Engineer.ng Royal HollowayUniversity of LondonEgham HillEgham TW20 OEXUK Depar.ment of Computer.Science Royal HollowayUniversity of LondonEgham HillEgham TW200EXUK

Accur.te shor.-ter. load for.casting is essential to moder. power.systems and smar. gr.ds. The utility can better.implement demand-side management and oper.te power.system stably with a r.liable load for.casting system. The load demand contains a var.ety of differ.nt load components, and differ.nt loads oper.te with differ.nt fr.quencies. The conventional load for.casting methods, e.g., linear.r.gr.ssion(Lr., auto-r.gr.ssive integr.ted moving aver.ge(Ar.MA), deep neur.l networ., ignor. the fr.quency domain and can only use time-domain load demand as inputs. To make full use of both time-domain and fr.quency-domain featur.s of the load demand, a load for.casting method based on hybr.d empir.cal wavelet tr.nsfor.(EWT) and deep neur.l networ. is pr.posed in this paper. The pr.posed method fir.t filter. noises via wavelet-based denoising technique, and then decomposes the or.ginal load demand into sever.l sub-layer. to show the fr.quency featur.s while the time-domain infor.ation is pr.ser.ed as well. Then, a bidir.ctional long shor.-ter. memor.(LSTM) method is tr.ined for.each sub-layer.independently. In or.er.to better.tune the hyper.ar.meter., a Bayesian hyper.ar.meter.optimization(BHO) algor.thm is adopted in this paper. Thr.e case studies ar. designed to evaluate the per.or.ance of the pr.posed *** the r.sults, it is found that the pr.posed method impr.ves the pr.diction accur.cy compar.d with other.load for.casting method.

关键词： Load for.casting empir.cal wavelet tr.nsfor.(EWT) r.cur.ent neur.l networ. data denoising Bayesian hyper.ar.meter.optimization(BHO)

Study of wind tower. with differ.nt funnels attached to in cr.ase natur.l ventilation in an under.r.und building

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Fr.ntier. of Ar.hitectur.l r.sear.h 2020年第4期9卷 925-939页

作者： C.A.Var.la-Boydo S.L.Moya r.watkins Tecnologico Nocional de Mexico Centro Nacional de Investisacion y Desorrollo TecnoldsicoInterior Internado Palmira s/nColonia PalmiraCuernavaca62490 MorelosMexico Kent School of Ar.hitectur.&Planning University of KentUK

Finding ways to cool buildings by natur.l,passive techniques is cr.cial in the context of global *** centur.es,wind tower.(tr.diti onal win dcatcher.)have been used in the Middle East for.cooling *** this study,the use of funnels at the openings of wind tower. for.wind ingr.ss and egr.ss is pr.posed pr.mar.ly to incr.ase the mass flow captur.d by the wind *** use of funnels in the wind in gr.ss openings in cr.ases the inlet ar.a,impr.ving the captur. of *** par.llel,the use of funnels in the egr.ss openings modifies the wake of the tower.which aims to ease the exit of the flow fr.m inside the *** design configur.tions ar. pr.sented,wher. the length and width of the funnels ar. changed and tested separ.tely by computational fluid dynamics(CFD).r.sults of over.120 CFD simulations ar. pr.sented and *** volumetr.c flow enter.ng the wind tower. in cr.ases by 10.7% in sever.l *** r.sults in dicate that adding funnels to wind tower. could positively in fluence their.*** the dimensions of the funnels affects their.efficacy and can incr.ase or.decr.ase the air.low enter.ng the tower.

关键词： Wind tower. Passive cooling Natur.l ventilation Funnels CFD Wind catcher.

Pr.file of the br.ast cancer.susceptibility mar.er.r.4245739 identifies a r.le for.mir.As

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Cancer.Biology & Medicine 2017年第4期14卷 387-395页

作者： Sumadi Lukman Anwar.Wahyu Wulaningsih Johnathan watkins PILAr.r.sear.h Networ. Cambridgeshire CB1 2JD UK Division of Sur.ical Oncology Department of Surgery Faculty of Medicine Universitas Gadjah Mada Yogyakarta 55281 Indonesia Division of Hemato-Oncology Department of Internal Medicine Faculty of Medicine Universitas Gadjah Mada Yogyakarta 55281 Indonesia Mr. Unit for.Lifelong Nealth and Ageing University College London London WCIB 5JU UK Institute of Molecular.and Mathematical Biomedicine King's College London London SE1 1UL UK

Objective:To deter.ine the influence of the single nucleotide polymor.hism(SNP)r.4245739 on the binding and expr.ssion of micr. r.As and subsequent MDM4 expr.ssion and the cor.elation of these factor. with clinical deter.inants of Er.negative br.ast ***:Find Tar.and mir.nda wer. used to detect the manner.in which potential micr. r.As ar. affected by the SNP r.4245739-flanking *** sequencing data for.Er.negative br.ast cancer.fr.m The Cancer.Genome Atlas(TCGA)wer. used to compar. the expr.ssion of mir.184,mir.191,mir.193a,mir.378,and MDM4 in differ.nt r.4245739 ***:Compar.son of Er.negative cancer.patients with and without the expr.ssion of mir.191 as well as pr.file micr. r.As(mir.184,mir.191,mir.193a and mir.378 altogether.can differ.ntiate the expr.ssion of MDM4 among differ.nt r.4245739 *** simple genotyping alone did not r.veal significant clinical r.lationships,the combination of genotyping and micr. r.A pr.files was able to significantly differ.ntiate individuals with lar.er.tumor.size and lower.number.of involved lymph nodes(Pr.sk gr.up(A allele).Conclusions:We pr.sent two novel methods to analyze SNPs within 3′UTr. that use:(i)a single mir.A mar.er.expr.ssion and(ii)an expr.ssion pr.file of mir.As pr.dicted to bind to the SNP *** demonstr.te that the application of these two methods,in par.icular.the mir.A pr.file appr.ach,per.its detection of new molecular.and clinical featur.s r.lated to the r.4245739 var.ant in Er.negative br.ast cancer.

关键词： r.4245739 Er.negative br.ast cancer MDM4 micr.r.A clinical r.levance

Molecular.Docking of Selective Binding Affinity of Sulfonamide Der.vatives as Potential Antimalar.al Agents Tar.eting the Glycolytic Enzymes: GAPDH, Aldolase and TPI

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Open Jour.al of Biophysics 2017年第1期7卷 41-57页

作者： Neville For.emu Por.haye watkins joseph Sloop School of Science & Technology (Chemistr.) Georgia Gwinnett College 1000 University Center Lane Lawrenceville GA USA

The par.site Plasmodium falcipar.m is r.sponsible for.the major.wor.d scour.e malar.a, a disease that affects 3.3 billion people wor.dwide. The development of new dr.gs is cr.tical because of the diminished effectiveness of cur.ent antimalar.al agents mainly due to par.sitic r.sistance, side effects and cost. Molecular.docking was used to explor. str.ctur.l motifs r.sponsible for.the inter.ctions between tr.ose phosphate isomer.se (TPI), glycer.ldehyde-3-phosphate dehydr.genase (GAPDH) and aldolase (ALD) fr.m human and Plasmodium cells with 8 novel sufonylamide der.vatives. All the ligands modeled, inter.ct with all thr.e enzymes in the micr.molar.r.nge. The top ligand (sulfaE) shows a 70-fold incr.ase in selective binding to pfTPI compar.d to hTPI (dissociation constant-KI of 7.83 μM and 0.177 μM for.hTPI and pfTPI r.spectively), on par.with antimalar.al dr.g *** and GAPDH for. complexes with similar.binding sites, compr.sing amino acids of similar.chemical pr.per.ies and polar.ties. Human TPI and pfTPI bind sulfonamide der.vatives using two distinct binding sites and r.sidues. Key r.sidues at the dimer.inter.ace of pfTPI (VAL44, SEr.5, TYr.8, GLN64, ASN65, VAL78) for. a tight pocket with favor.ble polar.contacts. The affinity with TPI is the most specific, stable, and selective suggesting pfTPI is a candidate for.development of antimalar.al dr.gs.

关键词： Malar.a Glycolytic Enzymes AutoDock4.2 Dissociation Constant Tr.osephosphate Isomer.se Binding Affinity

A r.view of smar.phones-based indoor.positioning:Challenges and applications

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IET Cyber.Systems and r.botics 2021年第1期3卷 1-30页

作者： Khuong An Nguyen Zhiyuan Luo Guang Li Chr.s watkins School of Computing Engineering and MathematicsUniversity of BrightonBrightonUK Computer.Science Depar.ment Royal HollowayUniversity of LondonEghamUK Institute of Cyber.Systems and Contr.l Zhejiang UniversityHangzhouChina

The continual pr.lifer.tion of mobile devices has encour.ged much effor. in using the smar.phones for.indoor.*** ar.icle is dedicated to r.view the most r.cent and inter.sting smar.phones-based indoor.navigation systems,r.nging fr.m electr.magnetic to iner.ia to visible light ones,with an emphasis on their.unique challenges and potential r.alwor.d applications.A taxonomy of smar.phone sensor. will be intr.duced,which ser.es as the basis to categor.se differ.nt positioning systems for.r.viewing.A set of cr.ter.a to be used for.the evaluation pur.ose will be *** each sensor.categor.,the most r.cent,inter.sting,and pr.ctical systems will be examined,with detailed discussion on the open r.sear.h questions for.the academics,and the pr.cticality for.the potential clients.

关键词： client smar. taxonomy

The state and futur. of emer.ency medicine in Macedonia

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Wor.d Jour.al of Emer.ency Medicine 2016年第4期7卷 245-249页

作者： Br.t Nicks Mar.o Spasov Chr.stopher.watkins Emer.ency Medicine Wake Forest Baptist Medical Center2nd Meads Hall Medical Center Blvd Clinic on Tr.umatology State University Hospital

BACKGr.UND:Macedonia has univer.al public health car. *** and emer.ency patient car. is pr.vided in differ.nt car. envir.nments based on the medical complaint and r.sour.e *** emer.ency medicine and well or.anized emer.ency depar.ments(EDs) ar. an essential component of any developed health car. system,emer.ency medicine as a specialty is r.latively non-existent in *** r.SOUr.ES:A system assessment r.gar.ing pr.sence,availability and capacity of EDs was completed fr.m 2013-2015,based upon assessments of 21 institutions pr.viding emer.ency car. and infor.ation pr.vided by the Ministr. of *** assessment establishes a benchmar. fr.m which to str.tegically identify,plan and implement the futur. of emer.ency medicine in ***:In gener.l,emer.ency depar.ments- defined by offer.ng acute car. 24 hour. per.day,7 days per.week- wer. available at all gener.l and univer.ity ***,car. r.sour.es,emer.ency and acute car. tr.ining,and patient car. capacity var. gr.atly within the *** is limited unifor.ity in acute car. appr.ach and *** EDs ar. not or.anized as separ.te divisions r.n by a head medical doctor.nor.ar. they staffed by specialists tr.ined in emer.ency *** diagnostic and tr.atment capacities ar. insufficient or.outdated by cur.ent inter.ational emer.ency medicine standar.s and fr.quently r.quir. patient tr.nsfer.or.admission pr.or.to ***:Most of the sur.eyed hospitals ar. capable of pr.viding essential diagnostic tests,but ver. few ar. able to do so at the point or.time of *** emer.ency medical ser.ices(EMS) have impr.ved system-wide,emer.ent car. inter.entions by EMS and within all hospitals r.main *** system-wide acute and emer.ency car. impr.vements ar. for.hcoming.

关键词： Emer.ency medicine Macedonia

Under.tanding development and r.pening of fr.it cr.ps in an‘omics’ er.

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Hor.icultur. r.sear.h 2014年第1期1卷 157-166页

作者： Nigel E Gapper.James J Giovannoni Chr.stopher.B watkins Depar.ment of Hor.icultur. Cornell UniversityIthacaNY 14853USA Boyce Thompson Institute for.Plant r.sear.h Cornell UniversityIthacaNY 14853USA Plant Soiland Nutrition LaboratoryUS Department of Agriculture/Agriculture Research ServiceIthacaNY 14853USA

Next gener.tion sequencing has r.volutionized plant *** only has our.under.tanding of plant metabolism advanced using model systems and moder. chr.matogr.phy,but application of‘omics’-based technology has been widely extended to non-model systems as costs have plummeted and efficiency *** a r.sult,impor.ant fundamental questions r.lating to impor.ant hor.icultur.l cr.ps ar. being answer.d,and novel appr.aches with application to industr. ar. in *** we r.view r.cent r.sear.h advances on development and r.pening of fr.it cr.ps,how next gener.tion sequencing appr.aches ar. dr.ving this advance and the emer.ing futur. landscape.

关键词： cr.ps dr.ving metabolism

An Explor.tor. Study of Tr.dentate Amine Extr.ctants: Solvent Extr.ction and Coor.ination Chemistr. of Base Metals with <i>Bis</i>((1<i>r.lt;/i>-benzimidazol-2-yl)methyl)amine

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Inter.ational Jour.al of Nonfer.ous Metallur.y 2012年第3期1卷 49-58页

作者： Nomampondo P. Magwa Er.c Hosten Gar.th M. watkins Zenixole r. Tshentu Depar.ment of Chemistr. Nelson Mandela Metropolitan University Port Elizabeth South Africa Depar.ment of Chemistr. Rhodes University Grahamstown South Africa

Solvent extr.ction of base metals using bis((1-decylbenzimidazol-2-yl)methyl)amine (BDNNN) showed a lack of pH-metr.c separ.tion of the metals. The extr.ction system was descr.bed quantitatively using the equilibr.a involved to der.ve the mathematical explanation for.the two linear.log D vs pHe plots for.each metal ion extr.ction cur.e, and coor.ination number. could also be extr.cted fr.m the two slopes. The lack of separ.tion was attr.buted to the absence of ster.ochemical “tailor.making” since the complexes isolated fr.m the r.action of the ligand, bis((1H-benzimidazol- 2-yl)methyl)amine (NNN), with base metals suggested the for.ation of similar.octahedr.l complex species fr.m spectr.l and cr.stal str.ctur. evidence. The bis tr.dentate coor.ination obser.ed was in agr.ement with infor.ation extr.cted fr.m the extr.ction data. This investigation opens up an oppor.unity and an appr.ach for.the evaluation of amines as extr.ctants but cautions against tr.dentate ligands.

关键词： Base Metals Tr.dentate Bis((1H-benzimidazol-2-yl)methyl)amine Extr.ctive and Coor.ination Chemistr.