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Protein-mediated interactions in the dynamic regulation of acute inflammation

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BIOCELL 2023年第6期47卷 1191-1198页

作者： rYAN stark Department of Pediatric Critical Care Medicine Vanderbilt University Medical CenterNashvilleTN37232-9075USA

Protein-mediated interactions are the fundamental mechanism through which cells regulate health and *** interactions require physical contact between proteins and their respective targets of *** targets include not only other proteins but also nucleic acids and other important molecules as *** proteins are often involved in multibody complexes that work dynamically to regulate cellular health and *** techniques have been adapted to study these important interactions,such as affinity-based assays,mass spectrometry,and fluorescent *** application of these techniques has led to a greater understanding of how protein interactions are responsible for both the instigation and resolution of acute inflammatory *** pursuits aim to provide opportunities to target specific protein interactions to alleviate acute inflammation.

关键词： Protein interactions Inflammation Sepsis rNA DNA Therapeutics

Apologos:A Lightweight Design Method for Sociotechnical Inquiry

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Journal of Social Computing 2021年第4期2卷 297-308页

作者： Luke stark the Faculty of Information and Media Studies Western UniversityLondonN6A 0A2Canada

While scholars involved in studying the ethics and politics flowing from digital information and communication systems have sought to impact the design and deployment of digital technologies,the fast pace and iterative tempo of technical development in these contexts,and the lack of structured engagement with sociotechnical questions,have been major barriers to ensuring values are considered explicitly in the r&D *** I introduce Apologos,a lightweight design methodology informed by the author’s experience of the challenges and opportunities of interdisciplinary collaboration between computational and social sciences over a five-year ***,which is inspired by“design apologetics”,is intended as an initial mechanism to introduce technologists to the process of considering how human values impact the digital design process.

关键词： values in design values sensitive design(VSD) artificial intelligence Values@Play design methods sociotechnical ethics values

The Mechanism of Ground Granulated Blastfurnace Slag Preventing Alkali Aggregate reaction

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Journal of Wuhan University of Technology(Materials Science) 2010年第2期25卷 332-341页

作者： stark Jochen FrEYBUrG Ernst F A Finger-Institute for Building Material Science of Bauhaus-University Weimar

Three different methods were applied to study the alkali content of gelpores in cement. In the closed system, the concentration of K＋, Na＋ and OH - have not reduced with the increase of age. In the open system, the diffusion and transferring of K＋ and Na＋ towards free space leads to the de-crease of total alkali content. In the micro-analysis system, the contents of K＋ and Na＋ in the first hy- drated layer of ground granulated blastfurnace slag （GBFS） are very low, while the contents of calcium and magnesium are relatively high. This phenomenon shows that the mechanism of GBFS preventing alkali aggregate reaction （AAr） is： when GBFS is dissolved by alkali medium, SiO2 and Al2O3 are dissolved into the cement matrix, then around GBFS particles form reaction rings rich in Ca2＋ and Mg^2＋, and the C-S-H gel of positive charges formed in the area repulses K＋ and Na＋, which are forced to transfer to the mortar＇s matrix, pore or mortar sample surface. The transferred K ^＋ and Na^＋ form alkali gel products with other dissolved ions, then become evenly distributed in the mortar sample and react with Ca（OH）2 in pore solutions to form （Na,K）x-2z·zCa·（SiO2）y·（OH）x gel products; and thus changes the AAr gel products＇ structure. The gel products will not expand, and so they can delay expansion destruction.

关键词： granulated blastfurnace slag (GBFS) alkali aggregate reaction (AAr) alkali content preventing mechanism

role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis

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World Journal of Gastroenterology 2019年第23期25卷 2846-2862页

作者： Alaattin Sen Holger stark Department of Molecular Biology and Genetics Faculty of Life and Natural SciencesAbdullah Gul UniversityKayseri 38080Turkey Biology Department Faculty of Arts and SciencesPamukkale UniversityDenizli 20070Turkey Institute of Pharmaceutical and Medicinal Chemistry Heinrich Heine University DüsseldorfDuesseldorf 40225Germany

Cytochromes P450 s(CYPs) are terminal enzymes in CYP dependent monooxygenases, which constitute a superfamily of enzymes catalysing the metabolism of both endogenous and exogenous substances. One of their main tasks is to facilitate the excretion of these substances and eliminate their toxicities in most phase 1 reactions. Endogenous substrates of CYPs include steroids, bile acids, eicosanoids, cholesterol, vitamin D and neurotransmitters. About 80% of currently used drugs and environmental chemicals comprise exogenous substrates for CYPs. Genetic polymorphisms of CYPs may affect the enzyme functions and have been reported to be associated with various diseases and adverse drug reactions among different populations. In this review, we discuss the role of some critical CYP isoforms(CYP1 A1, CYP2 D6, CYP2 J2, CYP2 r1,CYP3 A5, CYP3 A7, CYP4 F3, CYP24 A1, CYP26 B1 and CYP27 B1) in the pathogenesis or aetiology of ulcerative colitis concerning gene polymorphisms. In addition, their significance in metabolism concerning ulcerative colitis in patients is also discussed showing a clear underestimation in genetic studies performed so far.

关键词： Cytochrome P450 Polymorphism Function Ulcerative colitis Aetiology

Synthetic demand data generation for individual electricity consumers:Inpainting

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Energy and AI 2024年第1期15卷 36-43页

作者： Dascha Dobrovolskij Hans-Georg stark Universität Bremen Bibliothekstraβe 528359 BremenGermany Technische Hochschule Aschaffenburg Würzburger Straβe4563743 AschaffenburgGermany

In this contribution we deal with the problem of producing“reasonable”data,when considering recorded energy consumption data,which are at certain sections incomplete and/or *** task is important,when energy providers employ prediction models for expected energy consumption,which are based on past recorded consumption data,which then of course should be reliable and *** a related contribution Yilmaz(2022),GAN-based methods for producing such“artificial data”have been *** this contribution,we describe an alternative and complementary method based on signal inpainting,which has been successfully applied to audio processing Lieb and stark(2018).After giving a short overview of the theory of proximity-based convex optimization,we describe and adapt an iterative inpainting scheme to our *** usefulness of this approach is demonstrated by analyzing real-world-data provided by a German energy supplier.

关键词： Time series Missing data points Time-frequency analysis Convex optimization Douglas-rachford-algorithm Gabor transform

Methods for rejecting daytime waste heat to outer space

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National Science review 2017年第6期4卷 789-790页

作者： Addison K.stark US Department of Energy Advanced Research Projects Agency-Energy (ARPA-E)

Outer space constitutes an extremely low temperature（T;K）thermodynamic reservoir of boundless thermal capacity,with the potential to serve as a cold reservoir for cooling objects to sub-ambient temperatures in the *... 详细信息

关键词： Methods for rejecting daytime waste heat to outer space

Evidence-Based Cesarean Section for Universal Use in China:The"stark(Misgav Ladach)Method"

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Maternal-Fetal Medicine 2019年第1期1卷 48-52页

作者： Michael stark New European Surgical Academy Unter den Linden 21Berlin 10117Germany Department ofObstetrics and Gynecology CharitéUniversity HospitalCharitépl.1Berlin 10117Germany ELSANHospital Group 58 Rue la BoétieParis 75008France

There are many ways to perform cesarean section,with many methods developing from local *** a 3-year study process,a modified,evidence-based method has bean developed,which is now in use in many *** abdomen incision is based on the Joel-Cohen incision,the peritoneum is opened by repeated stretching,and the uterus is opened transversely after pushing the bladder *** delivery the uterus is sutured with one layer using a large needle,and the abdomen is closed with only two layers,fascia and *** method was subject to scores of studies,with all upholding its superiority over traditional *** a result,the"stark(Misgav Ladach)method"is recommended to become a standard procedure across China.

关键词： Cesarean section stark cesarean Misgav Ladach

The effect of hydrogen bond acceptor properties of ionic liquids on their cellulose solubility

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Science China Chemistry 2012年第8期55卷 1663-1670页

作者： stark Annegret SELLIN Martin ONDrUSCHKA Bernd MASSONNE Klemens Institute of Chemical Technology University of Leipzig Linnéstr. 3-4 04107 Leipzig Germany Thuringian Institute of Textile and Plastics research Breitscheidstr. 97 07407 Rudolstadt-Schwarza Germany Institute for Technical Chemistry and Environmental Chemistry Friedrich-Schiller-University Lessingstr. 12 07743 Jena Germany BASF SE Chemical Research & Engineering 67056 Ludwigshafen Germany

It is nowadays well-known that ionic liquids can dissolve cellulose. However, little systematic data has been published that shed light onto the influence of the ionic liquid structure on the dissolution of cellulose. We have conducted 1H NMr spec- troscopy of ethanol in a large number of ionic liquids, and found an excellent correlation of the data obtained with the hydro- gen acceptor properties （B-values）. With this tool in hand, it is possible to distinguish between cellulose-dissolving and non-dissolving ionic liquids. A modulating effect of both, the anion of the non-dissolving ionic liquid and its cation was found in solubility studies with binary ionic liquid mixtures. The study was extended to other non-dissolving liquids, namely water and dimethylsulfoxide, and the effect of the cation was also investigated.

关键词： ionic liquids cellulose dissolution hydrogen bonding

Hemoglobin expression in rat experimental granulation tissue

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Journal of Molecular Cell Biology 2011年第3期3卷 190-196页

作者： Miretta Tommila Christoffer stark Anne Jokilammi Ville Peltonen risto Penttinen Erika Ekholm Department of Medical Biochemistry and Genetics University of TurkuTurkuFinland Department of Anesthesiology Intensive CareEmergency and Pain MedicineTurku University HospitalTurkuFinland

The general opinion that hemoglobin is only a carrier protein for oxygen and carbon dioxide has been challenged by several recent studies showing hemoglobin expression in other cells than those of the erythroid series,for example,in *** discovered b-globin expression in rat experimental granulation tissue induced by subcutaneously implanted cellulose *** investigation revealed also a-globin *** first peak of the biphasic globin expression noticed during granulation tissue formation correlated with the invasion of monocytes/macrophages,whereas the second one seemed to be connected to the appearance of hematopoietic *** presented in this study indicate globin expression both in macrophages and in immature erythroid cells as validated by erythroid-specific markers.

关键词： granulation tissue wound healing hemoglobin expression extramedullary hematopoiesis rat