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Spectrum of Hypertriglyceridemia at the Onset of Type 2 Diabetes in Ouagadougou

Open Journal of Internal Medicine 2020年第1期10卷 83-89页

作者： Oumar Guira réné bognounou Lassané Zoungrana Aline Tonde André nagalo réné Traore Joseph Youssouf Drabo Unité de Formation et de recherche en Sciences de la Santé Université Joseph Ki Zerbo Ouagadougou Burkina Faso Service de Médecine Interne Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso Laboratoire de Biochimie Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso

Introduction: Hypertriglyceridemia is a frequent dyslipidemia in type 2 diabetes. We aimed to determine its prevalence, its typology, and its associated factors in newly type 2 diabetes patients in Ouagadougou. Material and Method: This cross-sectional, descriptive and analytic study has been performed from May 2015 to June 2016 in the Internal medicine department in Yalgado Ouédraogo teaching hospital, Ouagadougou. An accidental sample of newly type 2 diabetes outpatients, na?ve of antidiabetics therapy was studied. A 12-hour fasting triglyceridemia was performed;hypertriglyceridemia was defined for triglyceridemia > 1.5 g/L (1.7 mmol/L). Data were analyzed with Epi info 7.***.5.0. Proportions and means were compared respectively with Khi2 or Fisher’s test and Student’s test with a significance of p results: One hundred and three patients, i.e. 35 (34%) men and 68 (66%) women were included. The sex ratio was 0.51 and the mean age 49.3 ± 10.1 years [limits: 24 and 70]. The mean value of triglyceridemia was 1.8 ± 1.7 mmol/L [limits: 0.5 and 14.9]. Hypertriglyceridemia was reported in 32 patients (31.1%): minor (11.30 mmol/L) in one (3.1%) patients. Hypertriglyceridemia’s phenotype was commonly integrated into a mixed dyslipidemia;it was often combined with a total cholesterolemia increase and a HDL cholesterolemia decrease. In bivariate analysis, hyperglycemia was associated with severe hyperglycemia (p = 0.006) and renal failure (p = 0.03). Conclusion: Hypertriglyceridemia in type 2 diabetes is frequent and often combined with other lipids disorders. It may need an optimal care.

关键词： Hypertriglyceridemia Type 2 Diabetes Burkina Faso

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Quality of Diabetes Annual Management in the Internal Medicine Department in Yalgado Ouédraogo Teaching Hospital, Ouagadougou

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Open Journal of Internal Medicine 2020年第3期10卷 256-262页

作者： Oumar Guira Amsa Ouédraogo Lassané Zoungrana réné bognounou Solo Traoré Aline Tondé Joseph Y. Drabo Unité de Formation et de recherche en Sciences de la Santé Université Joseph Ki Zerbo Ouagadougou Burkina Faso Service de Médecine Interne Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso

Introduction: The periodic management of diabetes improves disease’s prognosis. We aimed to evaluate the quality of diabetes annual management and the effectiveness of its treatment in Ouagadougou. Material and Metho... 详细信息

rong>Introduction:rong> The periodic management of diabetes improves disease’s prognosis. We aimed to evaluate the quality of diabetes annual management and the effectiveness of its treatment in Ouagadougou. rong>Material and Method:rong> It was a cross-sectional and descriptive study, from retrospective records in the internal medicine department, Yalgado Ouédraogo Teaching Hospital (CHU-YO). Diabetic patient’s (15 years old and more) files that were registered between January, 2012 and December, 2016 have been analyzed. Files containing less than 80% data were excluded. Data relating to the baseline characteristics of the patients, the therapeutic education dispensation, the clinical and paraclinical assessment of the initial and annual visits at the first year of patient’s follow-up have been collected. The 2007 diabetes management standards of the French “Haute Autorité de Santé” as well as the biological standards of the same instance have been used. The quantitative variables were expressed as means and standard deviations and qualitative variables were expressed as absolute and relative frequencies. rong>results:rong> 317 patients, including 218 women (68.77%) were studied. The mean age of women was 51.67 ± 12.46 years, and that of men 55.71 ± 10.63. Diabetes was type 2 in 302 (95.26%) patients. The mean duration since the diagnosis of diabetes was 2.9 years. The completeness rate of therapeutic education at the annual visit was 10.46%. That of the clinical examinations was at best 38.17% and 44.23% for the measurement of weight and blood pressure;otherwise it was less than 5%. About the paraclinical data, apart from the measurement of the fasting blood glucose which completeness rate was 71.61%, that of the others exams were less than 10%. At the annual visit, the mean value of HbA1C was 7.5%, and the target for HbA1C was achieved in 47.90% patients. rong>Conclusion:rong> The quality of diabetes annual management is unsatisfying.

关键词： Chronic Disease’s Management Diabetes Sub-Saharan Africa

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Hypothyroidism in Hospitals (Burkina Faso)

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Open Journal of Internal Medicine 2021年第2期11卷 55-67页

作者： Lassane Zoungrana Hervé Tiéno Seydou Yaméogo Solo Traoré Oumar Guira Constance Tiendrebéogo réné bognounou Aline Tondé Jospeh Y. Drabo Health Sciences Training and research Unit Joseph Ki ZERBO University Ouagadougou Burkina Faso Internal Medicine Department Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso Internal Medicine Service Bogodogo Teaching Hospital Ouagadougou Burkina Faso

Background: The epidemiology of hypothyroidism has been characterized by an increase in its frequency, especially in females and the elderly. Our aim was to study hypothyroidism in hospitals in Ouagadougou. Material a... 详细信息

rong>Background:rong> The epidemiology of hypothyroidism has been characterized by an increase in its frequency, especially in females and the elderly. Our aim was to study hypothyroidism in hospitals in Ouagadougou. rong>Material and Method:rong> This was a cross-sectional descriptive study with retrospective data collection covering a period of four (04) years between January 1, 2015 and December 31, 2018. It included patients followed in the internal medicine departments of three (03) teaching hospitals in the city of Ouagadougou. Yalgado OUEDrAOGO, Bogodogo and Tengandogo Teaching Hospitals, were the study setting. rong>results:rong> 120 cases of hypothyroidism were enrolled. The mean age of the patients was 45.7 years with a sex ratio of 0.26. The signs frequently reported were weight gain (28.3%), asthenia (15.8%), and myalgia (15%). TSHus was elevated in 99.2% of patients in our series. The T3L assay level was lowered in 40.9%, with an average of 2.2 ± 1.5 pg/ml. T4L was lowered in 68.2% with an average of 6.6 ± 4 pg/ml. Primary hypothyroidism accounted for 99.2% of the cases, of which iatrogenic hypothyroidism was the most frequent with 77.5% followed by Hashimoto’s thyroiditis with 9.2% of the cases. Hormonal balance was achieved in the majority of patients (59.2%) who received hormonal supplementation with levothyroxine at an average dose of 84.5 μg/day. rong>Conclusion:rong> Hypothyroidism is common in women in their forties. Iatrogenic hypothyroidism was the predominant etiology reported in Ouagadougou.

关键词： Hypothyroidism Hospital Ouagadougou

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Performance of the Finnish Diabetes risk Score (FInDrISC) in the Identification of Dysglycemia in an Urban Population in Ouagadougou (Burkina Faso)

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Open Journal of Internal Medicine 2021年第2期11卷 39-54页

作者： Solo Traoré Boyo Constant Paré Désiré Lucien Dabourou Oumar Guira Yempabou Sagna Julie Patricia Kamouni Lassané Zoungrana réné bognounou Hervé Tiéno Youssoufou Joseph Drabo Training and research Unit in Health Sciences Joseph Ki ZERBO University Ouagadougou Burkina Faso Institute for research in Health Sciences/national Center for Scientific and Technical research Ouagadougou Burkina Faso Department of Internal Medicine Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso Higher Institute of Health Sciences/nazi BOnI University Bobo Dioulasso Burkina Faso Department of Internal Medicine Bogodogo Teaching Hospital Ouagadougou Burkina Faso

Background: Diabetes mellitus is a real public health problem worldwide and is growing in developing countries. Our aim was to determine the prevalence of undiagnosed type 2 diabetes mellitus (T2DM) and to evaluate th... 详细信息

rong>Background:rong> Diabetes mellitus is a real public health problem worldwide and is growing in developing countries. Our aim was to determine the prevalence of undiagnosed type 2 diabetes mellitus (T2DM) and to evaluate the performance of the Finnish Diabetes risk Score (FInDrISC) questionnaire to identify type 2 diabetics in the urban population of Ouagadougou, Burkina Faso. rong>Methodology:rong> This was a cross-sectional study among volunteers aged 18 years and older recruited systematically from november 11 to 16, 2019, in the city of Ouagadougou, Burkina Faso, FInDrISC score was used. Analysis of the receiver Operating Characteristic (rOC) curve was used to study the diagnostic performance of FInDrISC for the identification of type 2 diabetics. The optimal threshold was determined by the sum of the highest sensitivity and specificity. Multivariate logistic regression was used to analyze the association of each variable used in the calculation of the FInDrISC score. rong>results:rong> A total of 1276 individuals were included in the analyses, of which 667 (52.27%) were women. The average age was 34.16 years (SD: ±12.42). The prevalence of T2DM was 10.74%. The mean FInDrISC score was 5.85 (SD: ±4.31). The majority (58.54%) of individuals had a low risk of diabetes according to the FInDrISC score 0 - 7, while 3.61% had a score ≥ 15. The FInDrISC score showed good performance (AUC = 0.70) in identifying undiagnosed type 2 diabetics. However, the variables in the score that best predicted the likelihood of being diabetic were age (p ntihypertensive medication (p = 0.007) and waist circumference (p re ≥ 7 was the best predictor of the likelihood of having T2DM. rong>Conclusion:rong> The Finnish risk Score (FInDrISC) is a good predictor of the risk of dysglycemia in Burkina Faso. It is a score to be promoted in daily clinical practice because it is

关键词： Identification Diabetes Type 2 FInDrISC Performance Burkina Faso

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Structural changes in the obese brain

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neural regeneration research 2024年第12期19卷 2561-2562页

作者： Anna r.r.Da Conceicao Marcelo n.n.Vieira Fernanda G.De Felice D’Or Institute for research and Education Rio de JaneiroBrazil Institute of Medical Biochemistry Leopoldo De Meis Federal University of Rio de JaneiroRio de JaneiroBrazil Centre for neuroscience Studies Department of Biomedical and Molecular Sciences&Department of PsychiatryQueen’s UniversityKingstonONCanada

Obesity represents a major global health concern,with widespread growing prevalence and severe consequences for the quality of life and life expectancy of affected individuals and for the economic burden of healthcare systems(Prospective Studies Collaboration,2009).Obesity is a well-established risk factor for a variety of conditions including metabolic,vascula r,and heart diseases,and seve ral types of cancer(Prospective Studies Collaboration,2009).

关键词： diseases consequences prevalence

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Aberrant adult neurogenesis in intractable epilepsy:can GABAergic progenitor transplantation normalize this process?

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neural regeneration research 2024年第7期19卷 1419-1420页

作者： Muhammad n.Arshad Janice r.naegele Department of Biology Wesleyan UniversityMiddletownCTUSA Department of neuroscience Tufts University School of MedicineBostonMAUSA

Temporal lobe epilepsy(TLE) is a common type of focal epilepsy characterized by seizure foci within the temporal *** surgical resection of the foci is an established and effective approach for controlling seizures,both temporal lobes cannot be removed,due to their prominent roles in learning and ***,seizures induce changes to the temporal lobes that contribute to hyperexcitability,including mossy fiber sprouting,astrogliosis.

关键词： epilepsy progenitor seizures

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Factors Associated with Prolonged Poor Glycemic Control in Type 2 Diabetes Mellitus (T2DM) Patients Followed in the Department of Internal Medicine at the Yalgado Ouedraogo Teaching Hospital, Ouagadougou (Burkina Faso)

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Open Journal of Internal Medicine 2021年第1期11卷 1-26页

作者： Solo Traoré Oumar Guira Lassané Zoungrana Yempabou Sagna réné bognounou Constant B. Paré Désiré L. Dabourou Lassina Séré Daniel Zemba Laurette S. Dembélé Patricia D. Somé Patrice P. C. Savadogo Aline Tondé Tiéno Hervé Joseph Y. Drabo Training and research Unit in Health Sciences Joseph Ki ZERBO University Ouagadougou Burkina Faso Department of Internal Medicine Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso Higher Institute of Health Sciences/nazi Boni University Bobo Dioulasso Burkina Faso Institute for research in Health Sciences/national Center for Scientific and Technical research Ouagadougou Burkina Faso Department of Internal Medicine Tengandogo Teaching Hospital Ouagadougou Burkina Faso Department of Internal Medicine Bogodogo Teaching Hospital Ouagadougou Burkina Faso

Background: Achieving and maintaining glycemic targets are a challenge for health practitioners around the world. We aimed to study the factors associated with prolonged poor diabetes control in the cohort of T2DM patients monitored and treated in the Department of Internal Medicine at the Yalgado OUEDRAOGO Teaching Hospital in Ouagadougou in order to optimize therapeutic education in these patients. Methodology: This was a descriptive and analytical cross-sectional study combining retrospective data collection from the last year of patient follow-up and prospective collection of some information. The study included all diabetic patients, aged at least 18 years old, followed and treated in the Department of Internal Medicine at the Yalgado OUEDRAOGO Teaching Hospital between January 1, 2010 and December 31, 2018 following a systematic random sampling with a sampling step of 10. The variables collected were sociodemographic, anthropometric, lifestyle, cardiovascular risk factors and diabetes-related characteristics. To determine the risk factors associated with prolonged poor glycemic control, we performed modeling using logistic regression. All variables associated with prolonged poor glycemic control, in bivariate logistic regression with a p-value less than 0.20 were included in the full model. Later, we used a stepwise descending method to obtain the final model, which was then tested by a receiver operating characteristic (ROC) curve. The significance threshold was set at 5%. Raw and fitted Odds-Ratio (OR) and 95% confidence interval were presented. Results: 270 patients were included. Prolonged poor control of diabetes mellitus was observed in 73.70%. The mean age was 55.97 years (SD: ±11.52) and the sex ratio was 0.6 in favor of female. The mean time since diabetes mellitus diagnoses was 5.85 years (SD: ±5.15). A monthly ga

关键词： Type 2 Diabetes Mellitus Prolonged Poor Control Prevalence Associated Factors Burkina Faso

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Polyelectrolyte Complexes between Hyperbranched and Linear Polysaccharides: Fucoidan/Chitosan

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Chinese Journal of Polymer Science 2024年第4期42卷 468-479页

作者： Ekaterina r.Gasilova Daria n.Poshina Aleksandra O.Sitnikova natalia n.Saprykina Yury A.Skorik Institute of Macromolecular Compounds of the russian Academy of Sciences Bolshoi VO 31St.Petersburg199004Russian Federation

Polyelectrolyte complexes(PECs)of hyperbranched(HB)and linear polysaccharides are promising as more effective encapsulation agents compared to PECs formed by linear *** investigated the PECs between the HB anionic polysaccharide fucoidan(FUC)and the cationic linear polysaccharide chitosan(CS).The FUC had a molecular weight(MW)of 30×*** PECs were prepared in three solvents(water,0.01 and 0.1 mol/L acetic acid)with CS of MW of 15,110 and 170 kDa,and deacetylation degrees(DDA)of 70%and 97%.The structures of the PECs and the initial FUC were investigated by multi-angle static and dynamic light *** the FUC contained 18 wt%of—OSO3 groups and 5 wt%of uronic acid units,it was a“strong-weak”copolyanion,so the HB macromolecules of the FUC formed nanogel particles in 0.1 mol/L AcOH and open branched structures in water,as confirmed by the Kratky *** mixing the solutions of original components,the PEC structures underwent an equilibration period,the duration of which increased with the MW of *** the charge stoichiometry was approached,the PECs shrank;the fractal dimension approached unity,indicating the side-by-side packing of adjacent FUC branches with the help of *** aggregation in the vicinity of the charge compensation was hardly observed,as it occurred in a very narrow *** PEC content at theζ-potential inversion depended on solvents’pH and the DDA of *** the extreme case of core-shell PECs in 0.1 mol/L AcOH,obtained by mixing FUC nanogels with the solutions of high MW CS of 97%DDA,the protruding tails of CS formed a positively charged shell in the whole range of FUC content(10 wt%nning electron microscopy and atomic force microscopy images of dried samples were discussed in relation to the light scattering results.

关键词： Polyelectrolyte complexes Chitosan Hyperbranched fucoidan Light scattering

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A concise review on surface and structural modification of porous zeolite scaffold for enhanced hydrogen storage

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Chinese Journal of Chemical Engineering 2024年第6期70卷 33-53页

作者： B.A.Abdulkadir r.S.r.Mohd Zaki A.T.Abd Wahab S.n.Miskan Anh-Tam nguyen Dai-Viet n.Vo H.D.Setiabudi Centre for research in Advanced Fluid&Processes Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Faculty of Chemical&Process Engineering Technology Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Center of Excellence for Green Energy and Environmental nanomaterials(CE@GrEEn) Nguyen Tat Thanh University300A Nguyen Tat ThanhDistrict 4Ho Chi Minh City 755414Viet Nam

Investigating zeolites as hydrogen storage scaffolds is imperative due to their porous nature and favorable physicochemical ***,the storage capacity of the unmodified zeolites has been rather unsatisfactory(0.224%-1.082%(mass))compared to its modified ***,the contemporary focus on enhancing hydrogen storage capacities has led to significant attention towards the utilization of modified zeolites,with studies exploring surface modifications through physical and chemical treatments,as well as the integration of various active *** enhanced hydrogen storage properties of zeolites are attributed to the presence of aluminosilicates from alkaline and alkaline-earth metals,resulting in increased storage capacity through interactions with the charge density of these ***,there is a great demand to critically review their role such as well-defined topology,pore structure,good thermal stability,and tunable hydrophilicity in enhanced hydrogen *** article aimed to critically review the recent research findings based on modified zeolite performance for enhanced hydrogen *** of the factors affecting the hydrogen storage capacities of zeolites that can affect the rate of reaction and the stability of the adsorbent,like pressure,structure,and morphology were studied,and ***,future perspectives,recommendations,and directions for modified zeolites were discussed.

关键词： Zeolites Hydrogen storage Surface modification Adsorption Active metal

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Ion heat transport in electron cyclotron resonance heated L-mode plasma on the T-10 tokamak

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Plasma Science and Technology 2024年第4期26卷 52-60页

作者： V.A.KrUPIn M.r.nUrGALIEV A.r.nEMETS I.A.ZEMTSOV S.D.SUnTSOV T.B.MYALTOn D.S.SErGEEV n.A.SOLOVEV D.V.SArYCHEV D.V.rYJAKOV S.n.TUGArInOV n.n.nAUMEnKO national research Centre“Kurchatov Institute” Moscow 123182Russia Bauman Moscow State Technical University Moscow 105005Russia Institution“Project Center ITEr” Moscow 123098Russia JSC“SOLAr” Minsk 220034Belarus

Anomalous ion heat transport is analyzed in the T-10 tokamak plasma heated with electron cyclotron resonance heating(ECrH) in second-harmonic extra-ordinary mode. Predictive modeling with empirical scaling for Ohmical heat conductivity shows that in ECrH plasmas the calculated ion temperature could be overestimated, so an increase of anomalous ion heat transport is required. To study this effect two scans are presented: over the EC resonance position and over the ECrH power. The EC resonance position varies from the high-field side to the low-field side by variation of the toroidal magnetic field. The scan over the heating power is presented with on-axis and mixed ECrH regimes. Discharges with high anomalous ion heat transport are obtained in all considered regimes. In these discharges the power balance ion heat conductivity exceeds the neoclassical level by up to 10 times. The high ion heat transport regimes are distinguished by three parameters: the ratio Te/Ti, the normalized electron density gradient r/■, and the ion–ion collisionality νii~*. The combination of high Te/Ti, high νii~*, and r/■=6-10 results in values of normalized anomalous ion heat fluxes up to 10 times higher than in the low transport scenario.

关键词： tokamak L-mode electron cyclotron resonance heating ion heat transport

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