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Spectrum of Hypertriglyceridemia at the Onset of Type 2 Diabetes in Ouagadougou

Open Journal of Internal Medicine 2020年第1期10卷 83-89页

作者： Oumar Guira réné bognounou Lassané Zoungrana Aline Tonde André nagalo réné Traore Joseph Youssouf Drabo Unité de Formation et de recherche en Sciences de la Santé Université Joseph Ki Zerbo Ouagadougou Burkina Faso Service de Médecine Interne Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso Laboratoire de Biochimie Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso

Introduction: Hypertriglyceridemia is a frequent dyslipidemia in type 2 diabetes. We aimed to determine its prevalence, its typology, and its associated factors in newly type 2 diabetes patients in Ouagadougou. Material and Method: This cross-sectional, descriptive and analytic study has been performed from May 2015 to June 2016 in the Internal medicine department in Yalgado Ouédraogo teaching hospital, Ouagadougou. An accidental sample of newly type 2 diabetes outpatients, na?ve of antidiabetics therapy was studied. A 12-hour fasting triglyceridemia was performed;hypertriglyceridemia was defined for triglyceridemia > 1.5 g/L (1.7 mmol/L). Data were analyzed with Epi info 7.***.5.0. Proportions and means were compared respectively with Khi2 or Fisher’s test and Student’s test with a significance of p results: One hundred and three patients, i.e. 35 (34%) men and 68 (66%) women were included. The sex ratio was 0.51 and the mean age 49.3 ± 10.1 years [limits: 24 and 70]. The mean value of triglyceridemia was 1.8 ± 1.7 mmol/L [limits: 0.5 and 14.9]. Hypertriglyceridemia was reported in 32 patients (31.1%): minor (11.30 mmol/L) in one (3.1%) patients. Hypertriglyceridemia’s phenotype was commonly integrated into a mixed dyslipidemia;it was often combined with a total cholesterolemia increase and a HDL cholesterolemia decrease. In bivariate analysis, hyperglycemia was associated with severe hyperglycemia (p = 0.006) and renal failure (p = 0.03). Conclusion: Hypertriglyceridemia in type 2 diabetes is frequent and often combined with other lipids disorders. It may need an optimal care.

关键词： Hypertriglyceridemia Type 2 Diabetes Burkina Faso

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Quality of Diabetes Annual Management in the Internal Medicine Department in Yalgado Ouédraogo Teaching Hospital, Ouagadougou

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Open Journal of Internal Medicine 2020年第3期10卷 256-262页

作者： Oumar Guira Amsa Ouédraogo Lassané Zoungrana réné bognounou Solo Traoré Aline Tondé Joseph Y. Drabo Unité de Formation et de recherche en Sciences de la Santé Université Joseph Ki Zerbo Ouagadougou Burkina Faso Service de Médecine Interne Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso

Introduction: The periodic management of diabetes improves disease’s prognosis. We aimed to evaluate the quality of diabetes annual management and the effectiveness of its treatment in Ouagadougou. Material and Metho... 详细信息

rong>Introduction:rong> The periodic management of diabetes improves disease’s prognosis. We aimed to evaluate the quality of diabetes annual management and the effectiveness of its treatment in Ouagadougou. rong>Material and Method:rong> It was a cross-sectional and descriptive study, from retrospective records in the internal medicine department, Yalgado Ouédraogo Teaching Hospital (CHU-YO). Diabetic patient’s (15 years old and more) files that were registered between January, 2012 and December, 2016 have been analyzed. Files containing less than 80% data were excluded. Data relating to the baseline characteristics of the patients, the therapeutic education dispensation, the clinical and paraclinical assessment of the initial and annual visits at the first year of patient’s follow-up have been collected. The 2007 diabetes management standards of the French “Haute Autorité de Santé” as well as the biological standards of the same instance have been used. The quantitative variables were expressed as means and standard deviations and qualitative variables were expressed as absolute and relative frequencies. rong>results:rong> 317 patients, including 218 women (68.77%) were studied. The mean age of women was 51.67 ± 12.46 years, and that of men 55.71 ± 10.63. Diabetes was type 2 in 302 (95.26%) patients. The mean duration since the diagnosis of diabetes was 2.9 years. The completeness rate of therapeutic education at the annual visit was 10.46%. That of the clinical examinations was at best 38.17% and 44.23% for the measurement of weight and blood pressure;otherwise it was less than 5%. About the paraclinical data, apart from the measurement of the fasting blood glucose which completeness rate was 71.61%, that of the others exams were less than 10%. At the annual visit, the mean value of HbA1C was 7.5%, and the target for HbA1C was achieved in 47.90% patients. rong>Conclusion:rong> The quality of diabetes annual management is unsatisfying.

关键词： Chronic Disease’s Management Diabetes Sub-Saharan Africa

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Hypothyroidism in Hospitals (Burkina Faso)

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Open Journal of Internal Medicine 2021年第2期11卷 55-67页

作者： Lassane Zoungrana Hervé Tiéno Seydou Yaméogo Solo Traoré Oumar Guira Constance Tiendrebéogo réné bognounou Aline Tondé Jospeh Y. Drabo Health Sciences Training and research Unit Joseph Ki ZERBO University Ouagadougou Burkina Faso Internal Medicine Department Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso Internal Medicine Service Bogodogo Teaching Hospital Ouagadougou Burkina Faso

Background: The epidemiology of hypothyroidism has been characterized by an increase in its frequency, especially in females and the elderly. Our aim was to study hypothyroidism in hospitals in Ouagadougou. Material a... 详细信息

rong>Background:rong> The epidemiology of hypothyroidism has been characterized by an increase in its frequency, especially in females and the elderly. Our aim was to study hypothyroidism in hospitals in Ouagadougou. rong>Material and Method:rong> This was a cross-sectional descriptive study with retrospective data collection covering a period of four (04) years between January 1, 2015 and December 31, 2018. It included patients followed in the internal medicine departments of three (03) teaching hospitals in the city of Ouagadougou. Yalgado OUEDrAOGO, Bogodogo and Tengandogo Teaching Hospitals, were the study setting. rong>results:rong> 120 cases of hypothyroidism were enrolled. The mean age of the patients was 45.7 years with a sex ratio of 0.26. The signs frequently reported were weight gain (28.3%), asthenia (15.8%), and myalgia (15%). TSHus was elevated in 99.2% of patients in our series. The T3L assay level was lowered in 40.9%, with an average of 2.2 ± 1.5 pg/ml. T4L was lowered in 68.2% with an average of 6.6 ± 4 pg/ml. Primary hypothyroidism accounted for 99.2% of the cases, of which iatrogenic hypothyroidism was the most frequent with 77.5% followed by Hashimoto’s thyroiditis with 9.2% of the cases. Hormonal balance was achieved in the majority of patients (59.2%) who received hormonal supplementation with levothyroxine at an average dose of 84.5 μg/day. rong>Conclusion:rong> Hypothyroidism is common in women in their forties. Iatrogenic hypothyroidism was the predominant etiology reported in Ouagadougou.

关键词： Hypothyroidism Hospital Ouagadougou

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Performance of the Finnish Diabetes risk Score (FInDrISC) in the Identification of Dysglycemia in an Urban Population in Ouagadougou (Burkina Faso)

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Open Journal of Internal Medicine 2021年第2期11卷 39-54页

作者： Solo Traoré Boyo Constant Paré Désiré Lucien Dabourou Oumar Guira Yempabou Sagna Julie Patricia Kamouni Lassané Zoungrana réné bognounou Hervé Tiéno Youssoufou Joseph Drabo Training and research Unit in Health Sciences Joseph Ki ZERBO University Ouagadougou Burkina Faso Institute for research in Health Sciences/national Center for Scientific and Technical research Ouagadougou Burkina Faso Department of Internal Medicine Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso Higher Institute of Health Sciences/nazi BOnI University Bobo Dioulasso Burkina Faso Department of Internal Medicine Bogodogo Teaching Hospital Ouagadougou Burkina Faso

Background: Diabetes mellitus is a real public health problem worldwide and is growing in developing countries. Our aim was to determine the prevalence of undiagnosed type 2 diabetes mellitus (T2DM) and to evaluate th... 详细信息

rong>Background:rong> Diabetes mellitus is a real public health problem worldwide and is growing in developing countries. Our aim was to determine the prevalence of undiagnosed type 2 diabetes mellitus (T2DM) and to evaluate the performance of the Finnish Diabetes risk Score (FInDrISC) questionnaire to identify type 2 diabetics in the urban population of Ouagadougou, Burkina Faso. rong>Methodology:rong> This was a cross-sectional study among volunteers aged 18 years and older recruited systematically from november 11 to 16, 2019, in the city of Ouagadougou, Burkina Faso, FInDrISC score was used. Analysis of the receiver Operating Characteristic (rOC) curve was used to study the diagnostic performance of FInDrISC for the identification of type 2 diabetics. The optimal threshold was determined by the sum of the highest sensitivity and specificity. Multivariate logistic regression was used to analyze the association of each variable used in the calculation of the FInDrISC score. rong>results:rong> A total of 1276 individuals were included in the analyses, of which 667 (52.27%) were women. The average age was 34.16 years (SD: ±12.42). The prevalence of T2DM was 10.74%. The mean FInDrISC score was 5.85 (SD: ±4.31). The majority (58.54%) of individuals had a low risk of diabetes according to the FInDrISC score 0 - 7, while 3.61% had a score ≥ 15. The FInDrISC score showed good performance (AUC = 0.70) in identifying undiagnosed type 2 diabetics. However, the variables in the score that best predicted the likelihood of being diabetic were age (p ntihypertensive medication (p = 0.007) and waist circumference (p re ≥ 7 was the best predictor of the likelihood of having T2DM. rong>Conclusion:rong> The Finnish risk Score (FInDrISC) is a good predictor of the risk of dysglycemia in Burkina Faso. It is a score to be promoted in daily clinical practice because it is

关键词： Identification Diabetes Type 2 FInDrISC Performance Burkina Faso

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Factors Associated with Prolonged Poor Glycemic Control in Type 2 Diabetes Mellitus (T2DM) Patients Followed in the Department of Internal Medicine at the Yalgado Ouedraogo Teaching Hospital, Ouagadougou (Burkina Faso)

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Open Journal of Internal Medicine 2021年第1期11卷 1-26页

作者： Solo Traoré Oumar Guira Lassané Zoungrana Yempabou Sagna réné bognounou Constant B. Paré Désiré L. Dabourou Lassina Séré Daniel Zemba Laurette S. Dembélé Patricia D. Somé Patrice P. C. Savadogo Aline Tondé Tiéno Hervé Joseph Y. Drabo Training and research Unit in Health Sciences Joseph Ki ZERBO University Ouagadougou Burkina Faso Department of Internal Medicine Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso Higher Institute of Health Sciences/nazi Boni University Bobo Dioulasso Burkina Faso Institute for research in Health Sciences/national Center for Scientific and Technical research Ouagadougou Burkina Faso Department of Internal Medicine Tengandogo Teaching Hospital Ouagadougou Burkina Faso Department of Internal Medicine Bogodogo Teaching Hospital Ouagadougou Burkina Faso

Background: Achieving and maintaining glycemic targets are a challenge for health practitioners around the world. We aimed to study the factors associated with prolonged poor diabetes control in the cohort of T2DM patients monitored and treated in the Department of Internal Medicine at the Yalgado OUEDRAOGO Teaching Hospital in Ouagadougou in order to optimize therapeutic education in these patients. Methodology: This was a descriptive and analytical cross-sectional study combining retrospective data collection from the last year of patient follow-up and prospective collection of some information. The study included all diabetic patients, aged at least 18 years old, followed and treated in the Department of Internal Medicine at the Yalgado OUEDRAOGO Teaching Hospital between January 1, 2010 and December 31, 2018 following a systematic random sampling with a sampling step of 10. The variables collected were sociodemographic, anthropometric, lifestyle, cardiovascular risk factors and diabetes-related characteristics. To determine the risk factors associated with prolonged poor glycemic control, we performed modeling using logistic regression. All variables associated with prolonged poor glycemic control, in bivariate logistic regression with a p-value less than 0.20 were included in the full model. Later, we used a stepwise descending method to obtain the final model, which was then tested by a receiver operating characteristic (ROC) curve. The significance threshold was set at 5%. Raw and fitted Odds-Ratio (OR) and 95% confidence interval were presented. Results: 270 patients were included. Prolonged poor control of diabetes mellitus was observed in 73.70%. The mean age was 55.97 years (SD: ±11.52) and the sex ratio was 0.6 in favor of female. The mean time since diabetes mellitus diagnoses was 5.85 years (SD: ±5.15). A monthly ga

关键词： Type 2 Diabetes Mellitus Prolonged Poor Control Prevalence Associated Factors Burkina Faso

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Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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neural regeneration research 2025年第8期20卷 2218-2230页

作者： rahul Mittal Keelin McKenna Grant Keith Evan McKenna Joana r.n.Lemos Jeenu Mittal Khemraj Hirani Diabetes research Institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

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Woody species composition,diversity and structure of riparian forests of four watercourses types in Burkina Faso

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Journal of Forestry research 2011年第2期22卷 145-158页

作者： Oumarou Sambaré Fidèle bognounou rüdiger Wittig Adjima Thiombiano Laboratoire de Biologie et Ecologie végétales UFR/SVTUniversité de OuagadougouBP 7021 Ouagadougou 03 Burkina Faso Botanical Institute J. W. Goethe-University Frankfurt/M. Germany

riparian forests are classified as endangered ecosystems in general,particularly in sahelian countries like Burkina Faso because of human-induced alterations and civil engineering *** modification of this important habitat is continuing,with little attention being paid to the ecological or human consequences of these *** objective of this study is to describe the variation of woody species diversity and dynamic in riparian forests on different type of watercourse banks along phytogeographical gradient in Burkina *** woody species were systematically measured in 90 sample plots with sides of 50 m × 20 ***,dominance,frequency and species and family importance values were computed to characterize the species *** diver-sity indices were calculated to examine the heterogeneity of riparian forests.A total of 196 species representing 139 genera and 51 families were recorded in the overall riparian *** species richness of individuals with dbh ≥ 5cm increased significantly from the north to the South along the phytogeographical gradient and varied significantly between the different types of riparian *** in tree species composition between riparian forests was low,which indicates high beta diversity and reflects differences in habitat conditions and *** structural characteristics varied significantly along the phyto-geographical gradient and between the different types of riparian *** diameter class distribution of trees in all riparian forests showed a reverse ＂J＂ shaped curve except riparian forest of stream indicating vegetation dominated by juvenile *** the ecological importance of riparian forest,there is a need to delineate and classify them along watercourses throughout the country.

关键词： biodiversity dynamic species richness rivers streams phytogeographical gradient.

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nucleoside modified mrnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural regeneration research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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Green ionic metal-organic frameworks as nanocatalysts for CO_(2)fixation

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nano research 2025年第1期18卷 260-269页

作者： nuria Martín Miguel Maireles-Porcar Julián Sánchez Velandia Belén Altava Francisco G.Cirujano Eduardo García-Verdugo Departamento de Química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(H_(2)dot)can be rapidly obtained under room temperature and aqueous conditions using either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TBAOH)as the base allows the green synthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XrD),Fourier transform infrared(FTIr),scanning electron microscopy(SEM),thermo gravimetric analysis(TGA),H-nuclear magnetic resonance(nMr),elemental analysis,and X-ray photoelectron spectroscopy(XPS),and employed in the pressure,solvent,and additive-free CO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TOns of the confined tetrabutylammonium bromide(TBABr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis CO_(2)conversion

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural regeneration research 2025年第4期20卷 1031-1041页

作者： ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOr),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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