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利用生物信息学方法和多抗原表位DNA免疫方法研制有效的抗蛇毒血清

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利用生物信息学方法和多抗原表位DNA免疫方法研制有效的抗蛇毒血清

Low prevalence of epilepsy and onchocerciasis after more than 20 years of ivermectin treatment in the Imo river Basin in Nigeria

第八届中国生物毒素学术研讨会

作者： Sinmon C.Wagstaff Gavin D.Laing r.David G.Theakston 余方芳范泉水云南农业大学动物科技学院成都军区疾病预防控制中心军事医学研究所

传统的抗蛇毒血清是从用全毒免疫的马或绵羊的血清中提取的,但目前的免疫方法包括对马或绵羊进行的超免也不能达到对大多数临床上重要的毒素都产生免疫应答的目标。目前利物浦大学的simon ***等研究人员开发了一种最新的研制抗蛇毒血清... 详细信息

传统的抗蛇毒血清是从用全毒免疫的马或绵羊的血清中提取的,但目前的免疫方法包括对马或绵羊进行的超免也不能达到对大多数临床上重要的毒素都产生免疫应答的目标。目前利物浦大学的simon ***等研究人员开发了一种最新的研制抗蛇毒血清的方法——通过鉴定蛇毒金属蛋白酶（SVMPs,SVMPs主要是产生持续性致死性出血,SVMPs很复杂,它具有多种功能型,能作用于多种底物）中有重要临床意义的7个部分,并将它们改造成单链cNA作为免疫原免疫小鼠产生特异抗体。为研发更合理的抗蛇毒血清制备方法提供了依据。

关键词：抗蛇毒血清蛇毒金属蛋白酶(SVMPs) 多抗原表位

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Infectious Diseases of Poverty 2019年第1期8卷 36-44页

作者： Joseph N.F.Siewe Chinyere N.Ukaga Ernest O.Nwazor Murphy O.Nwoke Modebelu C.Nwokeji Blessing C.Onuoha simon O.Nwanjor Joel Okeke kate Osahor Lilian Chimechefulam Ann I.Ogomaka Augustine A.Amaechi Chika I.Ezenwa Monika N.Ezike Chidimma I.kpeama Ogechi Nwachukwu Austine I.Eriama-Joseph Berthram E.B.Nwoke robert Colebunders Global Health Institute University of AntwerpCam pus Drie EikenDoornstraat 3312610 WilrijkAntwerpBelgium Imo State University OwerriNigeria Federal Medical Centre OwerriNigeria Madonna University Teaching Hospital EleleNigeria Imo State Ministry of Health OwerriNigeria

Background:High epilepsy prevalence and incidence have been reported in areas with high onchocerciasis *** findings suggest that proper community-directed treatment with ivermectin(CDTI)is potentially able to prevent onchocerciasis-associated epilepsy(OAE).We assessed the epilepsy prevalence and onchocerciasis transmission in two Nigerian villages following more than 20 years of ***:A cross-sectional door-to-door survey was performed in two villages in the Imo river Basin reported to be mesoendomic for onchocerciasis(Umuoparaodu and Umuezeala).Individuals were screened for epilepsy using a validated 5-item *** suspected to have epilepsy were examined by a neurologist or a physician with training in epilepsy for *** was investigated via skin snip microscopy and rapid diagnostic tests for Ov16 *** were compared with previous findings from the Imo river ***:A total of 843 individuals from 257 households in the two villages were *** detected four persons with epilepsy(PWE)giving a crude epilepsy prevalence of 0.5%.This finding differs from observations reported 14 years ago which showed an epilepsy prevalence of 2.8%in the neighbouring village of Umulolo(P=0.0001),and 1.2%from 13 villages in the Imo river basin(P=0.07).The seroprevalence of Ov16 antibodies was found to be 0%.Only 4.6%of skin snips were positive compared to 26.8%in previous surveys(Prmectin mass distribution coverage in the study sites in 2017 was 79.7%.Conclusions:A low epilepsy and onchocerciasis prevalence was observed following more than 20 years of CDTI in the Imo river *** of Ov16 antibodies indicates minimal transmission of *** results contrast with observations from areas of high onchocerciasis transmission,where epilepsy prevalence and incidence remain *** from this study suggest that sustained efforts could eventually achieve elimination of onch

关键词： Epilepsy Onchocerciasis Nigeria Ivermectin Ov16

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斑马鱼模型在中医药研究中的应用现状

中西医结合学报 2012年第11期10卷 1189-1197页

作者：王佑华黎晌杨彬睿张伦青周昕许贝文李铭源上海中医药大学龙华医院高血压病研究室上海200032 中药质量研究国家重点实验室(澳门大学)澳门大学中华医药研究院

中药及中药复方是一个复杂系统,中药药效物质是中医药发挥临床治疗作用的基础,中药药效筛选和评价方面的新技术新方法引进已成为学术界关注的问题。斑马鱼作为新型模式动物的优势正在逐渐被人们所认识,应用的领域也越来越宽广,其在中药... 详细信息

中药及中药复方是一个复杂系统,中药药效物质是中医药发挥临床治疗作用的基础,中药药效筛选和评价方面的新技术新方法引进已成为学术界关注的问题。斑马鱼作为新型模式动物的优势正在逐渐被人们所认识,应用的领域也越来越宽广,其在中药药效筛选和评价中的应用日见广泛,并逐步扩展至毒性评价、药物代谢等多个方面。本文介绍了近年国内外斑马鱼模型在中医药研究中的应用概况,以期有利于中医药基础研究。

关键词：斑马鱼疾病模型,动物中医药综述

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最小侵入性眼眶减压术局部麻醉和人造骨

美国医学会眼科杂志（中文版） 2006年第4期18卷 252-252页

作者： Guy J. Ben simon robert M. Schwarcz Ahmad M. Mansury Lillian Wang John D. McCann robert A. Goldberg 刘亮（译）

目的：探讨用刮匙进行骨性减压和经结膜切口圆锥内脂肪切除的保守的眼眶减压术对甲状腺相关性眼病和轻中度突眼患者的安全性和有效性。

关键词：眼眶减压术最小侵入性局部麻醉人造骨甲状腺相关性眼病经结膜切口脂肪切除有效性

Principles for managing marine ecosystems prone to tipping points

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Ecosystem Health and Sustainability 2015年第5期1卷 15-32页

作者： Kimberly A.Selkoe Thorsten Blenckner Margaret r.Caldwell Larry B.Crowder Ashley L.Erickson Timothy E.Essington James A.Estes rod M.Fujita Benjamin S.Halpern Mary E.Hunsicker Carrie V.kappel ryan P.Kelly John N.Kittinger Phillip S.Levin John M.Lynham Megan E.Mach rebecca G.Martone Lindley A.Mease Anne KSalomon Jameal F.Samhouri Courtney Scarborough Adrian C.Stier Crow White Joy Zedler National Center for Ecological Analysis and Synthesis 735 State StreetSuite 300Santa BarbaraCalifornia 93101 USA Hawaii Institute of Marine Biology University of HawaiiKaneoheHawaii 96744 USA Stockholm resilience Centre Stockholm UniversityKra¨ftriket 2B10691 StockholmSweden Center for Ocean Solutions Stanford Woods Institute for the EnvironmentStanford University473 Via Ortega Room 193StanfordCalifornia 94305 USA School of Aquatic and Fishery Sciences University of WashingtonSeattleWashington 98195 USA Department of Ecology and Evolutionary Biology 100 Shaffer RoadUniversity of CaliforniaSanta CruzCalifornia 95060 USA Environmental Defense Fund 123 Mission Street28th FloorSan FranciscoCalifornia 94105 USA Bren School of Environmental Science and Management University of CaliforniaSanta BarbaraCalifornia 93106 USA Imperial College London Silwood Park CampusBuckhurst RoadAscot SL57PY United Kingdom School of Marine and Environmental Affairs University of Washington3707 Brooklyn Avenue NESeattleWashington 98105-6715 USA Conservation International Betty and Gordon Moore Center for Science and Oceans7192 Kalaniana‘ole HighwaySuite G230HonoluluHawaii 96825 USA Conservation Biology Division Northwest Fisheries Science CenterNational Marine Fisheries ServiceNational Oceanic and Atmospheric Administration2725 Montlake Boulevard EastSeattleWashington 98112 USA Department of Economics University of Hawaii at ManoaHonoluluHawaii 96822 USA School of resource and Environmental Management Simon Fraser UniversityBurnabyBritish Columbia V5A1S6 Canada Department of Biological Sciences California Polytechnic State UniversitySan Luis ObispoCalifornia 93407 USA Botany Department University of WisconsinMadisonWisconsin 53706 USA

As climatic changes and human uses intensify,resource managers and other decision makers are taking actions to either avoid or respond to ecosystem tipping points,or dramatic shifts in structure and function that are often costly and hard to *** indicates that explicitly addressing tipping points leads to improved management *** on theory and examples from marine systems,we distill a set of seven principles to guide effective management in ecosystems with tipping points,derived from the best available *** principles are based on observations that tipping points(1)are possible everywhere,(2)are associated with intense and/or multifaceted human use,(3)may be preceded by changes in earlywarning indicators,(4)may redistribute benefits among stakeholders,(5)affect the relative costs of action and inaction,(6)suggest biologically informed management targets,and(7)often require an adaptive response to *** suggest that early action to preserve system resilience is likely more practical,affordable,and effective than late action to halt or reverse a tipping *** articulate a conceptual approach to management focused on linking management targets to thresholds,tracking early-warning signals of ecosystem instability,and stepping up investment in monitoring and mitigation as the likelihood of dramatic ecosystem change *** approach can simplify and economize management by allowing decision makers to capitalize on the increasing value of precise information about threshold relationships when a system is closer to tipping or by ensuring that restoration effort is sufficient to tip a system into the desired regime.

关键词： critical transition ecosystem-based management marine spatial planning nonlinear relationships restoration ecology stakeholder engagement

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阿梅格尔巴克/哥本山

城市环境设计 2019年第2期 172-183页

作者： Nanna Gyldholm M?ller Alberto Cumerlato Aleksander Wadas Alexander Codda Alexander Ejsing Alexandra Gustafsson Alina Tamosiunaite Armor Gutierrez Anders Hjortn?s Andreas Klok Pedersen Annette Jensen Ariel Wallner Ask Andersen Balaj IIulian Blake Smith Borko Nikolic Brygida Zawadzka Buster Christensen Chris Falla Chris Zhongtian Yuan Daniel Selensky Dennis rasmussen Espen Vik Finn N?rkj?r Franck Fdida Gonzalo Castro Gül Ertekin George Abraham Helen Chen Henrick Poulsen Henrik r?mer kania Horia Spirescu Jakob Ohm Laursen Jelena Vucic Jeppe Ecklon Ji-young Yoon Jing Xu Joanna Jakubowska Johanna Nenander kamilla Heskje katarzyna Siedlecka Krzysztof Marciszewski Laura W?tte Liang Wang Lise Jessen Long Zuo Maciej Zawadzki Mads Enggaard Stidsen Marcelina Kolasinska Marcos Bano Maren Allen Mathias Bank Matti N?rgaard Michael Andersen Narisara Ladawal Schr?der Niklas A. rasch Nynne Madsen ?ssur Nols? Pero Vukovic richard Howis ryohei Koike Se Hyeon Kim simon Masson Sunming Lee Toni Mateu Xing Xiong Zoltan David kalaszi rasmus Hjortshoj 陈子钰

垃圾焚烧发电厂阿梅格尔巴克/哥本山位于工业区,多年来,该工业区已成为冒险者们的极限运动目的地。原始的工业设施为各种极限运动活动提供了场所,如缆绳滑水、卡丁车和攀岩等。阿梅格尔巴克/哥本山是该地区最重要的地标,其建筑亟须更新... 详细信息

垃圾焚烧发电厂阿梅格尔巴克/哥本山位于工业区,多年来,该工业区已成为冒险者们的极限运动目的地。原始的工业设施为各种极限运动活动提供了场所,如缆绳滑水、卡丁车和攀岩等。阿梅格尔巴克/哥本山是该地区最重要的地标,其建筑亟须更新。我们提出了一种新型的垃圾焚烧发电厂,这种工厂能产生经济、环保和社会效益。我们不将阿梅格尔巴克/哥本山视为一个孤立的对象,而是调动起建筑的

关键词：巴克本山

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大连国际会议中心

城市环境设计 2020年第4期 220-233页

作者：沃尔夫·狄·普瑞克斯 Nico Boyer Jan Brosch Jessie Chen Yue Chen Debora Creel simon Diesendruck Pola Dietrich Wendy Fok Keigo Fukugaki Francois Gandon Alice Gong reinhard Hacker Thomas Hindelang Veronika Janovska Moritz Keitel Matt Kirkham Ariane Marx Gaspar Gonzalez Melero Matthias Niemeyer reinhard Platzl Ian robertson Peter rose Liisi Salumaa Anja Sorger Giacomo Tinari Vanessa Castro Vélez Markus Wings Hui-Cheng Manfred Yuen Cristiano Bianchi Duccio Malagamba ShuHe COOP HIMMELB(L)AU Markus Pillhofer

项目大事记/CHrONOLOGY竞赛/Competition:03/2008规划设计/Start of Planning:07/2008动工/Start of Construction:11/2008竣工/Completion:09/2012项目参数/PrOJECT DATA用地面积/Site Area:40 000m2会议中心总建筑面积/Gross Floor Area Conference Center:91 250m2,总建筑面积/Total:146 180m2占地面积/Footprint:33 000m2表皮面积/Fa?ade Area:30 600m2屋顶面积/roof area:28 000m2建筑高度-长度-宽度/Building Height-Length-Width:60m-220m-200m层数/Number of Floors:8

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伊森伯格管理学院商业创新中心

当代建筑 2020年第2期 122-127页

作者：无 Yu Inamoto Pauline Lavie-Luong Hung kai Liao Alice Cladet Amina Blacksher Barbara Stallone Cheyenne Vandevoorde Daniel Kidd Davide Maggio Deborah Campbell Denys Kozak Derek Wong Domenic Schmid Douglass Alligood Elena Bresciani Emily Mohr Fabian Lorenz Francesca Portesine Ibrahim Salman Jan Leenknegt Justyna Mydlak kai-Uwe Bergmann Ku Hun Chung Linda Halim Lucas Hong Manon Otto Maria Eugenia Dominguez Mustafa Khan Nicolas Gustin Pei Pei Yang Peter Lee Seoyoung Shin simon Lee Terrence Chew Tianqi Zhang Yixin Li BIG建筑事务所不详

位于马萨诸塞州艾摩斯特市的商业创新中心外墙为覆铜设计,极具现代艺术之感。该建筑为伊森伯格管理学院(全美排名前30的公立商学院)增加了7万***(约为0.6万m2)的超协作研究与社交空间。此次扩建和部分翻新使得伊森伯格管理学院的既有空... 详细信息

位于马萨诸塞州艾摩斯特市的商业创新中心外墙为覆铜设计,极具现代艺术之感。该建筑为伊森伯格管理学院(全美排名前30的公立商学院)增加了7万***(约为0.6万m2)的超协作研究与社交空间。此次扩建和部分翻新使得伊森伯格管理学院的既有空间几乎扩大了一倍,不仅能够满足该学院在过去十年间的快速发展需求,同时也为学院150多名教职人员和5000名本科、硕士及博士生引进了新的设施。

关键词：商业创新教职人员马萨诸塞州协作研究外墙社交空间伊森商学院

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Correction:Clinical outcome measures in dementia with Lewy bodies trials:critique and recommendations

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Translational Neurodegeneration 2022年第1期11卷 588-588页

作者： Federico rodriguez-Porcel kathryn A.Wyman-Chick Carla Abdelnour ruiz Jon B.Toledo Daniel Ferreira Prabitha Urwyler rimona S.Weil Joseph kane Andrea Pilotto Arvid rongve Bradley Boeve John-Paul Taylor Ian McKeith Dag Aarsland simon J.G.Lewis the Lewy Body Dementias Clinical Trials Workgroup from the Lewy Body Dementias Professional Interest Area-Alzheimer’s Association International Society to Advance Alzheimer’s research and Treatment(ISTAArT) Department of Neurology Medical University of South Carolina208b Rutledge Av.CharlestonSC 29403USA Department of Neurology Center for Memory and AgingHealthPartnersSaint PaulMNUSA Autonomous University of Barcelona BarcelonaSpain Fixel Institute for Neurological Diseases University of FloridaGainesvilleFLUSA Division of Clinical Geriatrics Department of NeurobiologyCare Sciencesand SocietyCenter for Alzheimer’s ResearchKarolinska InstitutetStockholmSweden Department of radiology Mayo ClinicRochesterMNUSA ArTOrG Center for Biomedical Engineering research University of BernBernSwitzerland Dementia research Centre University College LondonLondonUK Centre for Public Health Queen’s UniversityBelfastUK Neurology Unit Department of Clinical and Experimental SciencesUniversity of BresciaBresciaItaly Department of research and Innovation Helse FonnaHaugesund HospitalHaugesundNorway Institute of Clinical Medicine(K1) The University of Ber-genBergenNorway Department of Neurology Center for Sleep MedicineMayo ClinicRochesterMNUSA Translational and Clinical research Institute Newcastle University Newcastle upon TyneUK Department of Old Age Psychiatry Institute of Psychiatry Psychology and Neuroscience King’s College LondonLondonUK ForeFront Parkinson’s Disease research Clinic Brain and Mind CentreSchool of Medical SciencesUniversity of Sydney100 Mallett StreetCamperdownNSW 2050Australia. 不详

Correction to:Translational Neurodegeneration(2022)11:24 https://***/10.1186/s40035-022-00299-w Following publication of the original article[1],the authors identified some errors in the Additional files *** original ... 详细信息

关键词： degeneration Clinical measures