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Inhibiting Protein Aggregation by Small Molecule-Based Colloidal Nanoparticles

Accounts of Materials research 2022年第1期3卷 54-66页

作者： Koushik Debnath Ankan Kumar Sarkar Nihar r.jana Nikhil r.jana Department of Pharmacology and regenerative Medicine College of MedicineUniversity of Illinois at ChicagoChicagoIllinois 60612United States Department of Biomedical Engineering College of MedicineUniversity of Illinois at ChicagoChicagoIllinois 60607United States School of Materials Sciences Indian Association for the Cultivation of ScienceKolkata 700032India

CONSPECTUS:Protein aggregation is associated with different human diseases such as Alzheimer’s,Huntington’s,Parkinson’s,diabetes type II,and *** no effective treatment exists for many of these diseases,particularly for neurological *** research focuses on understanding the origin of protein aggregation,nucleation−growth mechanism of protein aggregation,origin of cytotoxicity of protein aggregates,cellular response of toxic protein aggregates,progress of diseases at intra/extracellular space,and drug developments for respective *** issues are the identification of molecular drugs that can inhibit protein aggregation at early stage,lowering of toxicity due to protein aggregates,delivery of drugs to remote organ and intracellular space,clearing matured protein aggregates from cell/extracellular space/brain,and design of effective therapeutic *** and materials scientists have identified a wide variety of antiamyloidogenic small molecules,macromolecules,and *** is shown that antiamyloidogenic molecules prevent protein oligomerization via binding to protein,masking metal ions(via chelating with metal ions)that are responsible for protein aggregation via generating reactive oxygen species(rOS),and lowering protein−protein interaction via macromolecular crowding ***,nanoscale materials with curved surface and multiple chemical functional groups act as adsorption/binding sites of proteins,modulate nucleation−growth kinetics of protein aggregation,and delay/inhibit protein aggregation in many ***,performance of all these antiamyloidogenic materials needs significant improvement,and proper therapeutic strategies are required for effective drug *** this Account,we describe that the performance of antiamyloidogenic molecules can be greatly improved via appropriate design into colloidal and nanoparticle *** first discuss different human diseases that are linked with protein agg

关键词： integrating Huntington curved

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Entropy analysis of unsteady magneto-nanofluid flow past accelerating stretching sheet with convective boundary condition

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Applied Mathematics and Mechanics(English Edition) 2015年第12期36卷 1593-1610页

作者： S.DAS S.CHAKrABOrTY r.N.jana O.D.MAKINDE Department of Mathematics University of Gour Banga Department of Applied Mathematics Vidyasagar University Faculty of Military Science Stellenbosch University

The unsteady laminar magnetohydrodynamics （MHD） boundary layer flow and heat transfer of nanofluids over an accelerating convectively heated stretching sheet are numerically studied in the presence of a transverse magnetic field with heat source/sink The unsteady governing equations are solved by a shooting method with the runge-Kutta- Fehlberg scheme. Three different types of water based nanofluids, containing copper, aluminium oxide, and titanium dioxide, are taken into consideration. The effects of the pertinent parameters on the fluid velocity, the temperature, the entropy generation num- ber, the Bejan number, the shear stress, and the heat transfer rate at the sheet surface are graphically and quantitatively discussed in detail. A comparison of the entropy generation due to the heat transfer and the fluid friction is made with the help of the Bejan number. It is observed that the presence of the metallic nanoparticles creates more entropy in the nanofluid flow than in the regular fluid flow.

关键词： unsteady MHD flow nanofluid heat source/sink entropy generation Bejan number

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Hydromagnetic flow between two porous disks rotating about non-coincident axes

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Acta Mechanica Sinica 2008年第5期24卷 489-496页

作者： M.Guria B.K.Das r.N.jana C.Erdem Imrak Department of Applied Mathematics Vidyasagar UniversityMidnapore 721 102West BengalIndia Department of Mechanical Engineering Istanbul Technical UniversityGumussuyuIstanbul 34439Turkey

Hydromagnetic flow between two porous disks rotating with same angular velocity Ω about two noncoincident axes has been studied in the presence of a uniform transverse magnetic field. An exact solution of the governing equations has been obtained in a closed form. It is found that the primary velocity f/Ωl increases and the secondary velocity g/Ωl decreases with increase in either reynolds number re or the Hartman number M. It is also found that the torque at the disk η= 0 increases with increase in either M^2 or K^2. On the other hand there is no torque at the disk η= 1 for large M^2 and K^2. The heat transfer characteristic has also been studied on taking viscous and Joule dissipation into account. It is seen that the temperature increases with increase in either M^2 or K^2. It is found that the rate of heat transfer at the disk η= 0 increases with increase in either M or K. On the other hand the rate of heat transfer at the disk η= 1 increases with increase in K but decreases with increase in M.

关键词： Non-coincident Viscous fluid Torque ,Hydromagnetic

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Hall effects on hydromagnetic flow on an oscillating porous plate

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Applied Mathematics and Mechanics(English Edition) 2009年第4期30卷 503-512页

作者： S.L.Maji A.K.Kanch M.Guria r.N.jana Department of Applied Mathematics Vidyasagar University

In this paper, an analysis is made on the unsteady flow of an incompressible electrically conducting viscous fluid bounded by an infinite porous flat plate. The plate executes harmonic oscillations at a frequency n in its own plane. A uniform magnetic field Ho is imposed perpendicular to the direction of the flow. It is found that the solution also exists for blowing at the plate. The temperature distribution is also obtained by taking viscous and Joule dissipation into account. The mean wall temperature θo（O） decreases with the increase in the Hall parameter m. It is found that no temperature distribution exists for the blowing at the plate.

关键词： Hall effects oscillation resonance heat transfer and mean temperature

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radiation Effect on Natural Convection Near a Vertical Plate Embedded in Porous Medium with ramped Wall Temperature

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Open Journal of Fluid Dynamics 2011年第1期1卷 1-11页

作者： S. Das M. jana r. N. jana 不详

radiation effect on the natural convection flow of an optically thin viscous incompressible fluid near a vertical plate with ramped wall temperature in a porous medium has been studied. The exact solution of momentum and energy equations is obtained by the use of Laplace transform technique. The variations in fluid velocity and temperature are shown graphically whereas the numerical values of shear stress and the rate of heat transfer at the wall are presented in tabular form for various values of flow parameters. The results show that the fluid velocity increases with increase in Grashof number, Darcy number and time parameters whereas the fluid velocity decreases with increase in the radiation parameter and Prandtl number for ramped temperature as well as isothermal wall temperature. It is found that an increase in radiation parameter leads to rise the temperature for both ramped wall temperature as well as isothermal wall temperature. Further, it is found that an increase in Prandtl number leads to fall the temperature for both ramped wall temperature as well as isothermal wall temperature. The shear stress at the wall decreases with increases in either Prandtl number or porosity parameter while the result shows reverse in the case of radiation parameter. Finally, the rate of heat transfer is increased with increases in the radiation parameter for both ramped wall temperature as well as isothermal wall temperature.

关键词： Natural Convection Darcy Number radiation Parameter Prandtl Number Porous Medium ramped Wall Temperature and Isothermal Wall Temperature

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A knowledge base model for evaluation of bio-physical tendency of dryland

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Journal of Geographical Sciences 2004年第1期14卷 25-31页

作者： r jana M V KHIrE Centre of Studies in resources Engineering Indian Institute of Technology PowaiMumbai-400 076 IndiaCentre of Studies in Resources Engineering Indian Institute of Technology PowaiMumbai-400 076 India

The present study aims the evaluation of bio-physical characteristics towards soil-water-vegetation stress and a rule is envisaged to assess the degree of temporal changes. The digital rule for assessment is initialized through the index of land Instability (ILI) where the variance indicates the temporal instability of the pixel i.e., smallest land unit. It is assumed that the biophysical characteristic of land is in command of land-dynamics where there is no change in Land Use/Land Cover (LU&LC). The intensity map on tendency of albedo (IALB) assesses the intensity of soil erosion and water stress whereas intensity map on tendency of NDVI (INDVI) appraises the stress on vegetation. The carry-out study covers a part of semiarid Western India. Primarily remote sensing technique, which carries the digital information of land temporally and spatially, is adopted in this paper. A part of the study area is represented using two sets of IrS 1A/1B LISS-I data of March with a decadal time domain (1989-1998) as a test area. It is assumed that the soil-water-vegetation stress is maximum during summer(March-April-May) in any tropical belt and decadal data will stretch the possibility of climate as well as man-made activity over the land.

关键词： assessment biophysical tendency degeneration land instability semiarid land India

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海洋结核矿电解氯化回收铜、镍、钴(下)

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中国锰业 1993年第6期11卷 41-43页

作者： r.K.jana 黄元琼

5 讨论5.1 阳极极化研究当加入 Na2S 时,开路电势飘移活性指示表明在一个较低的能量势状态,说明阳极反应较易开始。这可以通过有 Na2S 试样的极限电流密度达104A/m2,而没有 Na2S时,只有5A/m2的事实得以进一步确证。加有硫化钠时。

关键词：锰结核电解氯化铜镍钴回收

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海洋结核矿电解氯化回收铜、镍、钴(上)

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中国锰业 1993年第5期11卷 55-59页

作者： r.K.jana 黄元琼

利用海水中极易获得的氯化钠,处理海洋结核矿使人们联想到开发电解氯化法的可能性。海洋结核矿这类复合氧化矿物的电解氯化是比较困难的。阳极极化研究表明通过向矿物中加入硫化钠可使电解过程变得容易。氯化铵体系在隔膜槽电解氯化的... 详细信息

利用海水中极易获得的氯化钠,处理海洋结核矿使人们联想到开发电解氯化法的可能性。海洋结核矿这类复合氧化矿物的电解氯化是比较困难的。阳极极化研究表明通过向矿物中加入硫化钠可使电解过程变得容易。氯化铵体系在隔膜槽电解氯化的实验证实了硫化钠添加剂是有益处的,并取得满意的金属回收率。实验研究发现:加入40％的硫化钠,槽电压7.5V,电解海洋结核4h,金属回收率Cu95％、Ni81％、Co82％。不加硫化钠时,金属的回收率仅为Cu40％、Ni31％、Co14％.Nacl体系在最佳条件下,也可获得Cu88％、Ni85％和Co88％的金属回收率。同时还研究了添加硫化钠时,电解氯化锰结核矿和各种可能的反应机理和金属溶解行为。

关键词：海洋结核电解氯化铜镍钴回收

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Combined Effects of Hall Current and rotation on Unsteady Couette Flow in a Porous Channel

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World Journal of Mechanics 2011年第3期1卷 87-99页

作者： Sankar Guchhait Sanatan Das r. N. jana Swapan Kumar Ghosh 不详

The combined influences of Hall currents and rotation on the MHD Couette flow of a viscous incompressible electrically conducting fluid between two infinite horizontal parallel porous plates channel in a rotating system in the presence of a uniform transverse magnetic field have been carried out. The solutions for the velocity field as well as shear stresses have been obtained for small time as well as for large times by Laplace transform technique. It is found that for large times the Hall currents accelerates primary flow whereas it retards secondary flow while the rotation retards the primary flow whereas it accelerates the secondary flow. It is also found that the velocity components converge more rapidly for small time solution than the general solution. The asymptotic behavior of the solution is analyzed for small as well as large values of magnetic parameter M2, rotation parameter K2 and reynolds number re. It is observed that a thin boundary layer is formed near the moving plate of the channel and the thicknesses of the layer increases with increase in either Hall parameter m or reynolds number re while it decreases with increase in Hartmann number M. It is interesting to note that for large values of M2 , the boundary layer thickness is independent of the rotation parameter.

关键词： MHD Couette Flow Hall Current Hartmann Number rotation Parameter reynolds Number And Boundary Layer

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Trilayer anisotropic structure versus randomly oriented structure in heart valve leaflet tissue engineering

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Bio-Design and Manufacturing 2023年第4期6卷 423-438页

作者： Yuriy Snyder Soumen jana Department of Bioengineering University of MissouriColumbiaMO 65211USA

It has been hypothesized that leaflet substrates with a trilayer structure and anisotropicmechanical properties could be useful for the production of functional and long-lasting tissue-engineered *** investigate the influence of the anisotropic structural and mechanical characteristics of a substrate on cells,in this study,we electrospun trilayer anisotropic fibrous substrates and randomly oriented isotropic fibrous substrates(used as controls)from polycaprolactone ***,the random substrates had higher radial and lower circumferential tensile properties than the trilayer substrates;however,they had similar flexural *** valvular interstitial cells cultured on both substrates produced random and trilayer cell-cultured constructs,*** trilayer cell-cultured constructs had more anisotropic mechanical properties,17%higher cellular proliferation,14%more extracellular matrix(i.e.,collagen and glycosaminoglycan)production,and superior gene and protein expression,suggesting that more cells were in a growth state in the trilayer constructs than in the random ***,the random and radial layers of the trilayer constructs had more vimentin,collagen,transforming growth factor-beta 1(TGF-ß1),transforming growth factor-beta 3(TGF-ß3)gene expression than in the circumferential layer of the *** study verifies that the differences in structural,tensile,and anisotropic properties of the trilayer and random substrates influence the characteristics of the cells and ECM in the constructs.

关键词： Heart valve leaflet Trilayer Tissue engineering Fiber Electrospinning

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