Inhibiting Protein Aggregation by Small Molecule-Based Colloidal Nanoparticles

作     者：Koushik Debnath Ankan Kumar Sarkar Nihar R.Jana Nikhil R.Jana 

作者机构：Department of Pharmacology and Regenerative MedicineCollege of MedicineUniversity of Illinois at ChicagoChicagoIllinois 60612United States Department of Biomedical EngineeringCollege of MedicineUniversity of Illinois at ChicagoChicagoIllinois 60607United States School of Materials SciencesIndian Association for the Cultivation of ScienceKolkata 700032India 

出 版 物：《Accounts of Materials Research》 (材料研究述评（英文）)

年 卷 期：2022年第3卷第1期

页      面：54-66页

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：Nikhil R.J.acknowledges DST-SERB(CRG/2019/000030) Government of India for financial assistance.A.K.S.acknowledges CSIR India for providing research fellowship 

主　　题：integrating Huntington curved 

摘      要：CONSPECTUS:Protein aggregation is associated with different human diseases such as Alzheimer’s,Huntington’s,Parkinson’s,diabetes type II,and *** no effective treatment exists for many of these diseases,particularly for neurological *** research focuses on understanding the origin of protein aggregation,nucleation−growth mechanism of protein aggregation,origin of cytotoxicity of protein aggregates,cellular response of toxic protein aggregates,progress of diseases at intra/extracellular space,and drug developments for respective *** issues are the identification of molecular drugs that can inhibit protein aggregation at early stage,lowering of toxicity due to protein aggregates,delivery of drugs to remote organ and intracellular space,clearing matured protein aggregates from cell/extracellular space/brain,and design of effective therapeutic *** and materials scientists have identified a wide variety of antiamyloidogenic small molecules,macromolecules,and *** is shown that antiamyloidogenic molecules prevent protein oligomerization via binding to protein,masking metal ions(via chelating with metal ions)that are responsible for protein aggregation via generating reactive oxygen species(ROS),and lowering protein−protein interaction via macromolecular crowding ***,nanoscale materials with curved surface and multiple chemical functional groups act as adsorption/binding sites of proteins,modulate nucleation−growth kinetics of protein aggregation,and delay/inhibit protein aggregation in many ***,performance of all these antiamyloidogenic materials needs significant improvement,and proper therapeutic strategies are required for effective drug *** this Account,we describe that the performance of antiamyloidogenic molecules can be greatly improved via appropriate design into colloidal and nanoparticle *** first discuss different human diseases that are linked with protein agg