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‘Invisible’ orthodontics by polymeric ‘clear’ aligners molded on 3D-printed personalized dental models

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Regenerative Biomaterials 2022年第1期9卷 1-12页

作者： Xiaoye Yu Guanghui Li Yikan Zheng Jingming Gao Ye Fu qunsong wang Lei Huang Xiaogang Pan Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China Department of Orthodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai 200011China R&D Center EA Medical Device Technologies Co.Ltd.Wuxi 214174China

The malalignment of teeth is treated classically by metal braces with alloy wires,which has an unfavorable influence on the patients appearance during the *** the development of digitization,computer simulation and three-dimensional(3D)printing technology,herein,a modern treatment was tried using clear polymeric aligners,which were fabricated by molding polyurethane films via thermoforming on the 3D-printed personalized dental *** key parameters of photocurable 3D printing of dental models and the mechanical properties of the clear aligner film material were *** precision of a 3D-printed dental model mainly relied on characteristics of photocurable resin,the resolution of light source and the exposure condition,which determined the eventual shape of the molded clear aligner and thus the orthodontic treatment *** biocompatibility of the polyurethane filmmaterial was confirmed through cytotoxicity and hemolysis tests in *** a series of 3D-printed personalized dental models and finite element analysis to predict and plan the fabrication and orthodontic processes,corresponding clear aligners were fabricated and applied in animal experiments,which proved the efficacy and biocompatibility in *** treatments of 120 orthodontic cases were finally carried out with success,which highlights the advantage of the clear aligners as an esthetic,compatible and efficient appliance.

关键词： 3D printing polymer biomaterial clear aligner orthodontics

Biaxial stretching of polytetrafluoroethylene in industrial scale to fabricate medical ePTFE membrane with node-fibril microstructure

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Regenerative Biomaterials 2023年第1期10卷 1161-1177页

作者： Gang wang Yusheng Feng Caiyun Gao Xu Zhang qunsong wang Jie Zhang Hongjie Zhang YongqiangWu Xin Li Lin wang Ye Fu Xiaoye Yu Deyuan Zhang Jianxiong Liu Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China R&D Center Lifetech Scientific(Shenzhen)Co.Ltd.Shenzhen 518057China R&D Center Lifevalve Medical Scientific Co.Ltd.Shenzhen 518057China

Expanded polytetrafluoroethylene(ePTFE)is promising in biomedical fields such as covered stents and plastic surgery owing to its excellent biocompatibility and mechanical ***,ePTFE material prepared by the traditional biaxial stretching process is with thicker middle and thinner sides due to the bowing effect,which poses a major problem in industrial-scale *** solve this problem,we design an olive-shaped winding roller to provide the middle part of the ePTFE tape with a greater longitudinal stretching amplitude than the two sides,so as to make up for the excessive longitudinal retraction tendency of the middle part when it is transversely *** as-fabricated ePTFE membrane has,as designed,uniform thickness and node-fibril *** addition,we examine the effects of mass ratio of lubricant to PTFE powder,biaxial stretching ratio and sintering temperature on the performance of the resultant ePTFE ***,the relation between the internal microstructure of the ePTFE membrane and its mechanical properties is *** stable mechanical properties,the sintered ePTFE membrane exhibits satisfactory biological *** make a series of biological assessments including in vitro hemolysis,coagulation,bacterial reverse mutation and in vivo thrombosis,intracutaneous reactivity test,pyrogen test and subchronic systemic toxicity test;all of the results meet the relevant international *** muscle implantation of the sintered ePTFE membrane into rabbits indicates acceptable inflammatory reactions of our sintered ePTFE membrane fabricated on industrial *** a medical-grade raw material with the unique physical form and condensed-state microstructure is expected to afford an inert biomaterial potentially for stent-graft membrane.

关键词： biomedical polymer medical-grade raw material expanded polytetrafluoroethylene olive roller polymer processing biaxial stretching

Research and clinical translation of trilayer stent-graft of expanded polytetrafluoroethylene for interventional treatment of aortic dissection

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Regenerative Biomaterials 2022年第1期9卷 650-664页

作者： Gang wang Caiyun Gao Benhao Xiao Jie Zhang Xunyuan Jiang qunsong wang Jingzhen Guo Deyuan Zhang Jianxiong Liu Yuehui Xie Chang Shu Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China R&D Center Lifetech Scientific(Shenzhen)Co.Ltd.Shenzhen 518057China Department of Vascular Surgery the Second Xiangya Hospital of Central South UniversityChangsha 410011China State Key Laboratory of Cardiovascular Diseases Center of Vascular SurgeryFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China

The aortic dissection(AD)is a life-threatening *** transcatheter endovascular aortic repair(EVAR)affords a minimally invasive technique to save the lives of these critical patients,and an appropriate stent-graft gets to be the key medical device during an EVAR ***,we report a trilayer stent-graft and corresponding delivery system used for the treatment of the AD *** stent-graft is made of nitinol stents with an asymmetric Z-wave design and two expanded polytetrafluoroethylene(ePTFE)*** of the inner and outer surfaces of the stent-graft was covered by an ePTFE membrane,and the two membranes were then sintered *** biological studies of the sintered ePTFE membranes indicated that the stent-graft had excellent cytocompatibility and hemocompatibility in *** the stent-graft and the delivery system exhibited satisfactory mechanical properties and *** safety and efficacy of this stent-graft and the corresponding delivery system were demonstrated in *** nine canine experiments,the blood vessels of the animals implanted with the stent-grafts were of good patency,and there were no thrombus and obvious stenosis by angiography after implantation for ***,all of the nine clinical cases experienced successful implantation using the stent-graft and its postrelease delivery system,and the 1-year follow-ups indicated the preliminary safety and efficacy of the trilayer stent-graft with an asymmetric Z-wave design for interventional treatment.

关键词： aortic dissection stent-graft expanded polytetrafluoroethylene delivery system for interventional treatment clinical translation of biomaterials

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抑郁症相关疲劳感的研究进展

中国全科医学 2019年第31期22卷 3901-3904页

作者：李苗王群松贾竑晓南京医科大学附属无锡精神卫生中心中西医结合精神科江苏省无锡市214151 首都医科大学附属北京安定医院中西医结合研究所北京市100088

疲劳感与抑郁症的关系十分复杂,其是抑郁症的一种常见症状;是一种普遍的抑郁症前驱症状,尤其是抑郁症首次发作时;也是抑郁症的一种残留症状,并且比其他抑郁症状更易趋于慢性化,与患者工作和社会功能缺损高度相关。因此,关注抑郁症患者... 详细信息

疲劳感与抑郁症的关系十分复杂,其是抑郁症的一种常见症状;是一种普遍的抑郁症前驱症状,尤其是抑郁症首次发作时;也是抑郁症的一种残留症状,并且比其他抑郁症状更易趋于慢性化,与患者工作和社会功能缺损高度相关。因此,关注抑郁症患者的疲劳感症状对临床治疗抑郁症、改善患者的生活质量及降低复发率具有重要的临床意义。本文就抑郁症相关疲劳感的定义、临床表现、不良后果、产生机制、诊治进展进行综述,以期为广大医生提供参考。

关键词：疲劳感抑郁症体征和症状生活质量综述

针刺对肝郁化火型不寐患者不同神经递质表达的影响

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中国针灸 2015年第6期35卷 549-552页

作者：季向东王群松朱文娴无锡市精神卫生中心中西医结合精神科江苏无锡214151

目的:比较针刺与药物曲唑酮治疗肝郁化火型不寐患者的疗效差异及其对不同神经递质表达的影响。方法:将70例确诊为肝郁化火型不寐患者随机分为观察组和对照组,每组35例。观察组采用针刺疗法,穴取神门、百会、印堂、合谷、太冲等,每次留针... 详细信息

目的:比较针刺与药物曲唑酮治疗肝郁化火型不寐患者的疗效差异及其对不同神经递质表达的影响。方法:将70例确诊为肝郁化火型不寐患者随机分为观察组和对照组,每组35例。观察组采用针刺疗法,穴取神门、百会、印堂、合谷、太冲等,每次留针20min,每日1次,2周为一疗程,治疗2个疗程;对照组口服曲唑酮治疗,100mg,每日1次,2周为一疗程,治疗2个疗程。比较两组患者治疗前后匹兹堡睡眠质量指数(PSQI)、Asberg副作用量表评分(SERS)、5-羟色胺(5-HT)、去甲肾上腺素(NE)等神经递质含量以及外周血蛋白激酶C(PKC)、脑源性神经营养因子(BDNF)基因表达水平。结果:两组治疗后PSQI、SERS评分均较治疗前明显降低(均P<0.05),治疗后,观察组患者PSQI评分、SERS评分明显低于对照组(均P<0.05);两组治疗后血清NE含量、PKC水平明显降低,血清5-HT含量、BDNF mRNA表达明显增高(均P<0.05);观察组NE含量、PKC水平明显低于对照组(P<0.05);观察组血清5-HT含量及BDNF mRNA表达明显高于对照组(均P<0.05)。结论:针刺疗法能够改善肝郁化火型不寐患者的睡眠质量,同时降低患者血清NE,提高5-HT,增加BDNF表达,其作用均优于西药曲唑酮,是肝郁化火型不寐的有效治疗手段之一。

关键词：失眠,肝郁化火针刺 5-羟色胺去甲肾上腺素血蛋白激酶C 随机对照试验

金匮肾气丸治疗肾虚肝郁型抑郁症的治疗效果及其对人血清神经生长因子的影响

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首都医科大学学报 2019年第2期40卷 220-225页

作者：李苗王群松袁国桢南京医科大学附属无锡精神卫生中心中西医结合精神科江苏无锡214151

目的探讨金匮肾气丸对肾虚肝郁型抑郁症患者人血清神经生长因子(nerve growth factor,NGF)的影响。方法 60例肾虚肝郁型抑郁症患者,采用数字表法将患者随机分为研究组30例和对照组30例,研究组口服草酸艾司西酞普兰联合金匮肾气丸方,1剂... 详细信息

目的探讨金匮肾气丸对肾虚肝郁型抑郁症患者人血清神经生长因子(nerve growth factor,NGF)的影响。方法 60例肾虚肝郁型抑郁症患者,采用数字表法将患者随机分为研究组30例和对照组30例,研究组口服草酸艾司西酞普兰联合金匮肾气丸方,1剂/d,分2次服用。对照组口服草酸艾司西酞普兰,20 mg/d。两组均治疗8周。在治疗前及治疗的2、4、8周末分别评定蒙哥马利抑郁量表(Montgomery-Asberg-Rating Scale,MADRS)及抑郁症中医证候要素量表,同时分别测定治疗前、后患者NGF浓度。结果研究组和对照组治疗前MADRS评分、中医证候要素量表评分差异无统计学意义(P> 0. 05),以量表评定时间(2、4、8周末)为组内因素、组别(研究组和对照组)为组间因素,通过重复测量方差分析可知,组内因素(MADRS)自变量效应显著[F(2,58)=301. 367,P=0. 000],组内与组间因素交互作用显著[F(2,58)=4. 022,P=0. 008],同时组间因素自变量效应显著[F(2,58)=9. 658,P=0. 003];组内因素(中医证候要素量表评分)自变量效应显著[F(2,58)=355. 130,P=0. 000],组内因素与组间因素交互作用不显著[F(2,58)=0. 970,P=0. 374],组间效应显著[F(2,58)=5. 336,P=0. 024],提示随着治疗周期的延长,研究组治疗效果优于对照组。治疗前两组NGF浓度比较,差异无统计学意义(P>0. 05),治疗后研究组NGF浓度较对照组显著升高(P <0. 05)。Pearson相关分析结果显示,研究组患者治疗前后NGF浓度差值与中医证候要素量表评分中肾虚评分差值呈正相关(r=0. 481,P=0. 007),与肝郁评分差值呈正相关(r=0. 370,P=0. 044)。结论金匮肾气丸可有效改善肾虚肝郁型抑郁症患者症状,同时对比单独使用草酸艾司西酞普兰的患者,其大幅度提升了血清NGF浓度。

关键词：金匮肾气丸抑郁症肾虚肝郁型神经生长因子

Alzhermer′s病患者胰岛素水平测定与对照分析

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临床心身疾病杂志 2006年第6期12卷 406-407页

作者：于海燕王群松无锡市精神卫生中心江苏无锡214151

目的探讨阿尔次海默病患者空腹血糖和空腹血浆胰岛素水平，以期发现胰岛素抵抗与阿尔次海默病的关系。方法将2002年1月～2006年3月期间临床诊断为阿尔次海默病，且排除糖尿病的30例在院患者设为研究组，选取同期匹配的30名健康人为对照... 详细信息

目的探讨阿尔次海默病患者空腹血糖和空腹血浆胰岛素水平，以期发现胰岛素抵抗与阿尔次海默病的关系。方法将2002年1月～2006年3月期间临床诊断为阿尔次海默病，且排除糖尿病的30例在院患者设为研究组，选取同期匹配的30名健康人为对照组，检测空腹血糖、空腹胰岛素、餐后2h血糖、餐后2h胰岛素，并进行比较。结果研究组空腹胰岛素、HOMA胰岛素抵抗指数明显低于健康对照组，差异有极显著性（P〈0．01）。空腹血糖、餐后2h血糖两组无显著性差异。结论阿尔次海默病患者的空腹胰岛素水平和HOMA胰岛素抵抗指数较低，未发现有胰岛素抵抗。

关键词：阿尔次海默病胰岛素胰岛素抵抗血糖

电针对新型抗精神病药物所致代谢综合征的干预效果

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首都医科大学学报 2023年第4期44卷 614-619页

作者：王群松于海燕季向东李苗蒋怡烨江南大学附属无锡市精神卫生中心中西医结合精神科江苏无锡214151

目的观察电针治疗对于新型抗精神病药物引起的代谢综合征(metabolic syndrome,MS)的疗效。方法将70例服用新型抗精神病药物所致MS患者,按照数字表法随机分为治疗组和对照组,每组各35例,对照组接受饮食及运动干预,治疗组在接受饮食及运... 详细信息

目的观察电针治疗对于新型抗精神病药物引起的代谢综合征(metabolic syndrome,MS)的疗效。方法将70例服用新型抗精神病药物所致MS患者,按照数字表法随机分为治疗组和对照组,每组各35例,对照组接受饮食及运动干预,治疗组在接受饮食及运动干预的同时采用电针治疗。观察两组患者在治疗前、治疗第28天和治疗第56天的腰围、体质量指数(body mass index,BMI)、血压、血脂、血糖的变化,并在治疗前后评定生活质量评价量表(Short Form 36-item Health Survey,SF-36)。结果治疗前两组患者各项指标差异均无统计学意义(P>0.05)。对照组治疗56 d后仅三酰甘油(triglyceride,TG)、餐后2 h血糖(2 h postprandial blood glucose,2hPG)较治疗前明显降低(P<0.05),其余指标无明显变化,而治疗组在治疗后各时间点收缩压、舒张压、TG、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)、空腹血糖(fasting plasma glucose,FPG)及2hPG与治疗前相比,差异均有统计学意义(P<0.05)。治疗56 d后,治疗组患者的腰围、BMI与治疗前相比,差异均有统计学意义(P<0.05)。两两比较分析结果显示,在治疗56 d后,治疗组患者的腰围、BMI、收缩压、舒张压、TG、HDL-C、FPG及2hPG与对照组相比,差异均有统计学意义(P<0.05)。治疗后,与对照组相比,治疗组SF-36量表评分明显升高(P<0.05)。结论电针治疗新型抗精神病药物所致MS患者的临床疗效较好,能降低患者的腰围、BMI、血压、血糖及血脂,明显改善生活质量,安全性好。

关键词：电针新型抗精神病药物代谢综合征

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针刺治疗对阴虚火旺型抑郁症的血清BDNF影响

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首都医科大学学报 2016年第2期37卷 176-180页

作者：王群松季向东朱文娴于海燕无锡市精神卫生中心中西医结合精神科江苏无锡214151

目的评价针刺对阴虚火旺型抑郁症患者的疗效及血清脑源性神经营养因子(brain derived neurotrophic factor,BDNF)浓度影响。方法将64例阴虚火旺型抑郁症患者采用数字表法随机分为两组,试验组(n=32)接受针刺治疗,对照组(n=32)接受米氮平... 详细信息

目的评价针刺对阴虚火旺型抑郁症患者的疗效及血清脑源性神经营养因子(brain derived neurotrophic factor,BDNF)浓度影响。方法将64例阴虚火旺型抑郁症患者采用数字表法随机分为两组,试验组(n=32)接受针刺治疗,对照组(n=32)接受米氮平治疗,疗程为8周,分别于治疗前后抽取外周静脉血检测血清BDNF浓度,并在入组时、治疗4周末及8周末评定汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)-24来评估疗效,比较两组治疗前后血清BDNF浓度的变化及HAMD评分差异,并在8周末采用Asberg抗抑郁药不良反应量表(Side Effects Rating Scale,SERS)评估两组不良反应情况。结果 1治疗前两组HAMD评分差异无统计学意义(P>0.05),重复测量方差分析发现,评定时间主效应显著(F=381.87,P=0.000),事后检验(LSD法)发现,两组治疗4周末、8周末的HAMD-24评分均较治疗前显著降低,且治疗8周末的评分显著低于治疗4周末(P均0.05);评定时间组别的交互作用不显著(F=0.063,P=0.939),组间效应不显著(F=0.008,P=0.931);根据治疗8周末的HAMD减分率计算试验组有效率为71.88%,对照组有效率为75%,组间差异无统计学意义(P>0.05);2治疗前两组血清BDNF浓度差异无统计学意义(P>0.05),经治疗后两组血清BDNF浓度均显著升高(P0.05);3治疗8周末试验组SERS评分显著低于对照组(P<0.05)。结论针刺可显著提高阴虚火旺型抑郁症患者的血清BDNF浓度,其抗抑郁作用与米氮平相当,且无明显不良反应。

关键词：抑郁症阴虚火旺型针刺脑源性神经营养因子