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Biomedical and Environmental Sciences 2024年第7期37卷 785-789页

作者： Hui Zhang Jinfeng Yuan Yuanyuan Xu Mengjie Yang Jialin Lyu Xinjie Yang Shuyan Sheng Zhe Qian qunhui wang Yu Pang Ying Hu Department of Medical Oncology Beijing Chest HospitalCapital Medical University&Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China Department of Bacteriology and Immunology Beijing Key Laboratory on Drug-Resistant Tuberculosis ResearchBeijing Chest HospitalCapital Medical University/Beijing Tuberculosis&Thoracic Tumor Research InstituteBeijing 101149China Chinese Center for Disease Control and Prevention Beijing 102206China

Lung cancer is the top cause of cancer deaths *** in immune checkpoint inhibitors(ICIs)have transformed cancer treatment,but their use in lung cancer has led to more side *** study examined if past pulmonary tuberculosis(TB)affects ICIs’effectiveness and safety in lung cancer *** reviewed lung cancer patients treated with ICIs at Beijing Chest Hospital from January 2019 to August 2022.

关键词： Lung lung Cancer

Advanced treatment of wet-spun acrylic fiber manufacturing wastewater using three-dimensional electrochemical oxidation

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Journal of Environmental Sciences 2016年第12期28卷 21-31页

作者： Tianlong Zheng, qunhui wang Zhining Shi Yue Fang Shanshan Shi Juan wang Chuanfu Wu Department of Environmental Engineering University of Science and Technology Beijing Beijing 100083 China. Beijing Key Laboratory on Resource-oriented Treatment of lndustrial Pollutants University of Science and Technology Beijing Beijing 100083 China School of Earth and Environmental Sciences The University of Adelaide South Australia 5005 Australia

A three-dimensional electrochemical oxidation （3D-EC） reactor with introduction of activated carbon （AC） as particle micro-electrodes was apphed for the advanced treatment of secondary wastewater effluent of a wet-spun acrylic fiber manufacturing plant. Under the optimized conditions （current density of 500 A/m2, circulation rate of 5 mL/min, AC dosage of 50 g, and chloride concentration of 1.0 g/L）, the average removal efficiencies of chemical oxygen demand （CODer）, NH3-N, total organic carbon （TOC）, and ultraviolet absorption at 254 nm （UV2s4） of the 3D-EC reactor were 64.5%, 60.8%, 46.4%, and 64.8%, respectively; while the corresponding effluent concentrations of CODcr, NH3-N, TOC, and UV2s4 were 76.6, 20.1, and 42.5 mg/L, and 0.08 Abs/cm, respectively. The effluent concentration of CODer was less than 100 mg/L, which showed that the treated wastewater satisfied the demand of the integrated wastewater discharge standard （GB 8978-1996）. The 3D-EC process remarkably improved the treatment efficiencies with synergistic effects for CODer, NH3-N, TOC, and UV2s4 during the stable stage of 44.5%, 38.8%, 27.2%, and 10.9%, respectively, as compared with the sum of the efficiencies of a two-dimensional electrochemical oxidation （2D-EC） reactor and an AC adsorption process, which was ascribed to the numerous micro-electrodes of AC in the 3D-EC reactor. Gas chromatography mass spectrometry （GC-MS） analysis revealed that electro- chemical treatment did not generate more toxic organics, and it was proved that the increase in acute biotoxicity was caused primarily by the production of free chlorine.

关键词： Advanced treatment Synergistic effect Three-dimensional electrochemicaloxidation Wet-spun acrylic fiber wastewater

Cathode catalyst prepared from bacterial cellulose for ethanol fermentation stillage treatment in microbial fuel cell

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Chinese Journal of Chemical Engineering 2021年第12期34卷 256-261页

作者： Huiyu Li Ming Gao Pan wang Hongzhi Ma Ting Liu Jin Ni qunhui wang Tien-Chin Chang Department of Environmental Engineering University of Science and Technology BeijingBeijing Key Laboratory of Resource-oriented Treatment of Industrial PollutantsBeijing 100083China Key Laboratory of Cleaner Production and Integrated Resource Utilization of China National Light Industry Beijing Technology and Business UniversityBeijing 100048China Institute of Environmental Engineering and Management National Taipei University of TechnologyTaipei 106China

Bacterial cellulose doped with P and Cu was used as a catalyst for a microbial fuel cell(MFC) cathode,which was then used to treat ethanol fermentation stillage from food *** output power,coulombic efficiency(CE),and biological toxicity were *** a series of characterization experiments,the addition of the cathode catalyst was found to improve catalytic activity and accelerate the consumption of the *** resulting maximum output power was 572.16 mW·m^(-2).CE and the removal rate of chemical oxygen demand(COD) in the fermentation stillage by P-Cu-BC reached 26% and 64.5%,*** rate of biotoxicity removal by MFC treatment reached 84.7%.The aim of this study was apply a novel catalyst for MFC and optimize the treatment efficiency of fermentation stillage.

关键词： Microbial fuel cell Oxygen reduction reaction Fermentation Catalyst Biomass Biotoxicity

Pilot-scale experiments on multilevel contact oxidation treatment of poultry farm wastewater using saran lock carriers under different operation model

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Journal of Environmental Sciences 2019年第3期31卷 336-345页

作者： Tianlong Zheng Peng Li Xiaoyu Ma Xiaohong Sun Chuanfu Wu qunhui wang Ming Gao State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Department of Environmental Engineering University of Science and Technology Beijing Xinkai Water Environmental Investment Co.Ltd Beijing Agro-Biotechnology Research Center Beijing Academy of Agriculture and Forestry Sciences

A pilot-scale multilevel contact oxidation reactors system, coupled with saran lock carriers,was applied for the treatment of poultry farm wastewater. The removal efficiencies of CODcr, ammonia, and the total nitrogen as well as the elimination performance of CODcr and total nitrogen along the three-level contact oxidation tanks under six designed operational models were investigated. Based on the performance of the nitrogen removal of the saran lock carriers and the distribution of anoxic–aerobic interspace under the suitable operation model, the mechanism of nitrogen removal of the system was also explored. The results revealed that the intermittent aeration under parallel model is the most suitable operation model, while the removal efficiencies of CODcr, ammonia, and the total nitrogen were 86.86%, 84.04%, and 80.96%, respectively. The effluent concentration of CODcr,ammonia, and the total nitrogen were 55.6 mg/L, 8.3 mg/L, and 12.0 mg/L, which satisfy both the discharge standard of pollutants for livestock and poultry breeding industry(GB18596–2001) and the first grade of the integrated wastewater discharge standard(GB 8978–1996). Moreover, the mechanism for the nitrogen removal should be attributed to the plenty of anoxic–aerobic interspaces of the biofilm and the three-dimensional spiral structure of the saran lock carriers, where the oxygen-deficient distribution was suitable for the happening of the simultaneous nitrification and denitrification process. Therefore, the multilevel contact oxidation tanks system is an effective pathway for the treatment of the poultry farm wastewater on the strength of a suitable operation model and novel carriers.

关键词： Multilevel contact oxidation tanks Nitrogen removal Mechanism Operation model Poultry farm wastewater Saran lock carriers

Pollution characteristics of polycyclic aromatic hydrocarbons in common used mineral oils and their transformation during oil regeneration

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Journal of Environmental Sciences 2017年第6期29卷 247-253页

作者： Xiaohui Wu Bo Yue Yi Su Qi Wan Qifei Huang qunhui wang Hongying Cai State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Beijing 100012China Civil and Environmental Engineering Institute University of Science and Technology BeijingBeijing 100083China The Solid Waste Management Center of Chongqing Chongqing 401147China

The pollution characteristic of polycyclic aromatic hydrocarbons （PAHs） in common used mineral oils, semi-refined oils, refined oils and solid wastes produced during the used mineral oil regeneration process was analyzed. The results showed that total PAHs content in six common used mineral oils was as follows： used engine oil 〉 used quenching oil 〉 used casting oil 〉 used hydraulic oil 〉 used antimst oil 〉 used industrial lubricating oil. Furthermore, this order was dependent on the source of PAHs and oil working temperatures. Additionally, total PAt-Is content in regenerated oils was as follows： semi-refined oil 〉 refined oil 〉 crude oil, which was related to the catalytic cracking process of crude oil and adsorption refining process of semi-refined oil. The ranking of total PAHs content in regenerated wastes varied depending on the regeneration technology used as follows： waste adsorption sand 〉 acid sludge 〉 waste clay 〉 precipitation sludge 〉 cracked residue. In all types of used mineral oils and regenerated wastes, the maximum and minimum proportions of the total PAHs content were composed of 2-3 ring-PAHs and 5-6 ring-PAHs, respectively. The majority of PAHs in the used mineral oils entered into regenerated wastes during regeneration process, while a small number remained in the regenerated oil.

关键词： Used mineral oilPAHsPollution characteristicsRegenerationTransformation

Sludge reduction during brewery wastewater treatment by hydrolyzation-food chain reactor system

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Frontiers of Environmental Science & Engineering 2008年第1期2卷 32-35页

作者： Lijie LI qunhui wang Xuesong LI Shuo YANG Department of Environmental Engineering University of Science and Technology BeijingBeijing 100083China Department of Environmental Science&Engineering Harbin Institute of TechnologyHarbin 150090China

During brewery wastewater treatment by a hydrolyzation-food chain reactor(FCR)system,sludge was recycled to the anaerobic *** the function of hydrolyzation acidification in the anaerobic segment and the processes of aerobic oxidation and antagonism,preda-tion,interaction and symbiosis among microbes in multi-level oxidation segment,residual sludge could be reduced *** 6-month dynamic experiments show that the average chemical oxygen demand(COD)removal ratio was 92.6% and average sludge production of the aerobic segment was 8.14%,with the COD of the influent at 960–1720 mg/L and hydraulic retention time(HRT)of 12 *** the producedsludge could be recycled and hydrolyzed in the anaerobic segment,no excess sludge was produced during the steady running for this system.

关键词： hydrolyzation multilevel oxidation excess sludge reduction

Wastewater-nitrogen removal using polylactic acid/starch as carbon source： Optimization of operating parameters using response surface methodology

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Frontiers of Environmental Science & Engineering 2016年第4期10卷 137-146页

作者： Yan GUO Chuanfu WU qunhui wang Min YANG Qiqi HUANG Markus MAGEP Tianlong ZHENG School of Civil and Environmental Engineering University of Science and Technology Beijing Beijing 100083 China

Nitrogen removal from ammonium-containing wastewater was conducted using polylactic acid （PLA）/ starch blends as carbon source and carrier for fimctional bacteria. The exclusive and interactive influences of operating parameters （i.e., temperature, pH, stirring rate, and PLA-to-starch ratio （PLA proportion）） on nitrification （Y1）, denitrification （Y2）, and COD release rates （Y3） were investigated through response surface methodology. Experimental results indicated that nitrogen removal could be successfully achieved in the PLA/starch blends through simultaneous mtnncatlon anti clenltnncatlon. The carbon release rate of the blends was controllable. The sensitivity of Y1, Y2, and Y3 to different operating parameters also differed. The sequence for each response was as follows： for Y1, pH 〉 stirring rate 〉 PLA proportion 〉 temperature; for Y2, PH 〉 PLA proportion 〉.temperature.〉 stirring rate; and for Y3, stirring rate 〉pH 〉 PLA proportion 〉 temperature. In this study, the following optimum conditions were observed： temperature, 32.0℃; pH 7.7; stirring rate, 200.0 r · min^-1 and PLA proportion 0.4. Under these conditions Y1 Y2 and Y3 were 134.0 μg-N·g-blend^-1·h^-1, 160.9μg-N-g-blend^-1·h^-1, and 7.6 × 10^3 μg-O·g-blend^-1·h^-1, respectively. These results suggested that the PLA/starch blends may be an ideal packing material for nitrogen removal.

关键词： Nitrogen removal Polylactic acid Starch Carbon source Response surface methodology

园林废弃物对滨海盐渍土固碳减排效应与微生物群落结构的影响

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环境工程 2024年第1期42卷 95-101页

作者：李婧男汪群慧梁宝瑞王万清刘俊杰北京科技大学天津学院环境工程系天津301830 北京科技大学能源与环境工程学院北京100083

为了探讨发酵园林废弃物对盐渍土性质的影响及其固碳减排效应,利用大田试验,设置发酵园林废弃物施用(T1)、混施膨润土(T2)与对照(CK)3组处理。通过土壤pH、EC、总孔隙度、饱和导水率、速效氮磷钾、有机碳储量变化(ΔSOC)、微生物量碳(M... 详细信息

为了探讨发酵园林废弃物对盐渍土性质的影响及其固碳减排效应,利用大田试验,设置发酵园林废弃物施用(T1)、混施膨润土(T2)与对照(CK)3组处理。通过土壤pH、EC、总孔隙度、饱和导水率、速效氮磷钾、有机碳储量变化(ΔSOC)、微生物量碳(MBC)、细菌与真菌群落结构揭示其变化规律。结果表明:园林废弃物堆肥相比于传统焚烧处理可减少53%碳排放,发酵园林废弃物的施用可使ΔSOC增加5~24倍。T1、T2组处理的土壤容重与EC显著低于CK组,总孔隙度和饱和导水率显著高于CK组。T2的养分含量最高,土壤有机质和速效氮的含量均为CK组的2倍,堆肥与膨润土混施可显著提高土壤养分含量,改良效果显著高于其他处理。发酵园林废弃物的施用还可以改变微生物群落结构,变形菌门、放线菌门、拟杆菌门、绿弯菌门、芽单孢菌门和酸杆菌门为主要的优势菌。真菌中子囊菌门、担子菌门、壶菌门、被孢霉门为主要的优势菌。Pearson相关分析也表明:酸杆菌门和放线菌门与有机碳储量、微生物量碳、土壤养分等呈显著正相关,与土壤盐分、容重呈显著负相关。

关键词：园林废弃物盐渍土微生物群落结构固碳减排

Icotinib, an EGFR-TKI, for the treatment of brain metastases in non-small cell lung cancer:a retrospective study

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Oncology and Translational Medicine 2016年第6期2卷 268-274页

作者： qunhui wang Hua Zheng Ying Hu Baohua Lu Fanbin Hu Hongmei Zhang Baolan Li Department of Oncology Beijing Chest Hospital Capital Medical University

Objective Treatment of brain metastases from non-small cell lung cancer(NSCLC) is a challenge because of the poor prognosis. Icotinib is a new type of oral epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor(TKI) used in the treatment of advanced NSCLC. The aim of this study was to evaluate the efficacy of icotinib in NSCLC patients with brain *** This study reviewed records of 51 NSCLC patients with brain metastases who took icotinib 125 mg, 3 times a day. Response rate, progression free survival, and overall survival were analyzed. SPSS software version 17.0 was used for univariate analysis, and Cox regression analysis to analyze factors affecting survival. Results Thirty-six cases had partial response, 6 cases had stable disease, and 10 cases had progressive disease. In 31 cases, EGFR gene mutation test were performed. EGFR was mutated in 26 cases and was with wild-type in 5 cases. In patients with EGFR mutations, 23 patients responded to icotinib [the disease control rate(DCR) was 88.5%], significantly higher than in patients with wild-type EGFR(1 patient, DCR 20%)(P = 0.005). The overall median progression-free survival(PFS) was 7.6 months. PFS was longer in the patients with EGFR mutations than in those with wild type EGFR(7.8 months vs 1.2 months, P = 0.03). The overall median overall survival(OS) time was 10.7 months. OS was longer in patients with EGFR mutations than in those with wild type EGFR(15.1 months vs 6.7 months, P = 0.003). The main side effects of the treatment were skin rash and diarrhea; no stage 3 or 4 toxic effects occurred. Univariate analysis demonstrated that OS was related to sex, Eastern Cooperative Oncology Group performance status(ECOG PS), smoking history, and EGFR mutation. Multivariate analysis showed that OS was independently related to sex, ECOG PS, and EGFR *** Icotinib has a favorable effect on NSCLC patients with brain metastases harboring EGFR mutations. Icotinib can be a new choice

关键词： non-small cell lung cancer(NSCLC) brain metastases icotinib epidermal growth factor receptor(EGFR)

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剩余污泥吸附痕量典型药物影响因素

化工学报 2017年第8期68卷 3266-3274页

作者：曹达啟王振郝晓地汪群慧北京建筑大学城市雨水系统与水环境省部共建教育部重点实验室/中-荷未来污水处理技术研发中心北京100044 北京科技大学土木与环境工程学院北京100083

传统的污水处理工艺不能完全去除药物和个人护理用品(PPCPs),可能通过吸附作用存在于剩余污泥中。当污泥经土地或农业利用,其中含有的PPCPs可能释放出来,污染水环境,因此,揭示PPCPs经污泥吸附去除的影响因素,对于预测或评估污泥中PPCPs... 详细信息

传统的污水处理工艺不能完全去除药物和个人护理用品(PPCPs),可能通过吸附作用存在于剩余污泥中。当污泥经土地或农业利用,其中含有的PPCPs可能释放出来,污染水环境,因此,揭示PPCPs经污泥吸附去除的影响因素,对于预测或评估污泥中PPCPs含量尤其重要。以北京某污水处理厂剩余污泥为对象,利用高效液相色谱-质谱联用仪,研究了痕量浓度下3种典型药物在污泥中的赋存特性。随pH增大,环丙沙星与磺胺甲唑的吸附容量减小,而扑热息痛的吸附容量增加;主要是因为pH不仅改变药物在水中的存在形态,而且影响微生物细胞体的表面电位。胞外聚合物(EPS)对污泥吸附3种典型药物均有促进作用,且不依赖于pH;主要是因为EPS中含有的金属离子与有机物成分决定污泥吸附药物性能。

关键词：药品和个人护理用品剩余污泥吸附胞外聚合物金属离子有机物