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RARRES2's impact on lipid metabolism in triplenegative breast cancer:a pathway to brain metastasis

Military Medical Research 2024年第2期11卷 311-312页

作者： quazi t.h.shubhra Institute of Chemistry University of Silesia in Katowice41‑500 ChorzowPoland Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060China

Breast cancer brain metastasis(BCBrM)is a crucial and hard area of research which guarantees an urgent need to understand the underlying molecular mechanisms.A recent study by Li et al.[1]published in Military Medical Research investigated the role of retinoic acid receptor responder 2(RARRES2)in regulating lipid metabolism in BCBrM,highlighting the clinical relevance of alterations in lipid metabolites,such as phosphatidylcholine(PC)and triacylglycerols(tAGs),by RARRES2 through the modulation of phosphatase and tensin homologue(PtEN)-mammalian target of rapamycin(mtOR)-sterol regulatory element-binding protein 1(SREBP1)signaling *** commentary aims to elaborate on the key findings and their relevance to the field.

关键词： Retinoic acid receptor responder 2(RARRES2) Lipid metabolism Cancer PtEN-mtOR-SREBP1 signaling Metabolic reprogramming Brain metastasis

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Pre-activated macrophage membrane-encased aggregationinduced emission featuring nanoparticles:a novel possibility for tuberculosis treatment

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Signal transduction and targeted therapy 2024年第7期9卷 2848-2850页

作者： Qiang Cai Yihao tian quazi t.h.shubhra Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanChina Department of human Anatomy and histology and Embryology School of Basic Medical SciencesWuhan UniversityWuhanChina Institute of Chemistry University of Silesia in KatowiceSzkolna 9KatowicePoland

In a recent study published in Nature Nanotechnology,Li et *** the synthesis of a novel photosensitizer with unique aggregation-induced emission(AIE)characteristics.1 they microencapsulated this photosensitizer inside engineered nanoparticles(NPs)coated with pre-activated macrophage cell membranes(CMs),an innovative approach marking a significant leap in nanomedicine by offering a pathway to potent tuberculosis(tB)treatments that bypass antibiotic resistance with unparalleled precision.

关键词： tuberculosis macrophage aggregation

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Iron oxide nanoparticles in magnetic drug targeting and ferroptosis-based cancer therapy

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Medical Review 2023年第5期3卷 444-447页

作者： quazi t.h.shubhra Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Institute of Chemistry University of Silesia in Katowice41-500 ChorzówPoland

Iron oxide(IO)nanoparticles(NPs)have gained significant attention in the field of biomedicine,particularly in drug targeting and cancer *** potential in magnetic drug targeting(MDt)and ferroptosis-based cancer therapy is highly *** NPs serve as an effective drug delivery system(DDS),utilizing external magnetic fields(EMFs)to target cancer cells while minimizing damage to healthy ***,IO NPs can generate reactive oxygen species(ROS)and induce ferroptosis,resulting in cytotoxic effects on cancer *** article explores how IO NPs can potentially revolutionize cancer research,focusing on their applications in MDt and ferroptosis-based therapy.

关键词： magnetic nanoparticles ferroptosis drug targeting cancer

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Engineering polymer nanoparticles using cell membrane coating technology and their application in cancer treatments:Opportunities and challenges

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Nano Materials Science 2022年第4期4卷 295-321页

作者： Kai Guo Nanyang Xiao Yixuan Liu Zhenming Wang Judit tóth János Gyenis Vijay Kumar thakur Ayako Oyane quazi t.h.shubhra Stomatology hospital of Guangzhou Medical University Guangzhou Medical UniversityGuangzhou510140China Department of Microbiology The University of ChicagoChicagoIL60637USA Department of Pathology School of Basic Medical SciencesNanjing Medical UniversityNanjing21116China State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu610041China Research Centre for Natural Sciences Institute of Materials and Environmental Chemistry1117BudapestMagyar Tudósok Körútja 2Hungary University of Pannonia Egyetem u.10H-8200VeszprémHungary Nanomaterials Research Institute National Institute of Advanced Industrial Science and Technology(AIST)Tsukuba305-8565Japan School of Engineering University of Petroleum&Energy Studies(UPES)Dehradun 248007India

Nanotechnology has revolutionized cancer drug delivery,and recent research continues to focus on the development of“one-size-fits-all,”i.e.,“all-in-one”delivery *** nanomedicines can address significant shortcomings of conventional therapy,biological barriers remain a challenge in their delivery and accumulation at diseased *** achieve long circulation time,immune evasion,and targeted accumulation,conventional nanocarriers need modifications,e.g.,PEGylation,peptide/aptamer attachment,*** such modification is a biomimetic coating using cell membrane(CM),which can offer long circulation or targeting,or *** top-down CM coating process is facile and can provide some advantageous features over surface modification by synthetic ***,an overview is provided on the engineering of CM camouflaged polymer nanoparticles.A short section on CM and the development of CM coating technology has been *** description of the preparation and characterization of CM camouflaged polymer NPs and their applications in cancer treatment has been reported.A brief comparison between CM coating and PEGylation has been *** targeting approaches to achieve tumor-specific delivery of CM coated NPs have been summarized ***,this review will give the readers a nice picture of CM coated polymer NPs,along with their opportunities and challenges.

关键词： Cell membrane(CM) Nanoparticles(NPs) Cancer Camouflage Biomimetic coating Drug delivery

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Antagonistic effect of early stage zinc on arsenic toxicity induced preterm birth during pregnancy:evidence from a rural Bangladesh birth cohort

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Chinese Medical Journal 2021年第5期134卷 619-621页

作者： Yong-Yue Wei hui huang Yan-Kai Xia Liang-Min Wei Xin Chen Ru-Yang Zhang Wei-Wei Duan Li Su Mohammad L.Rahman Mahmudur Rahman Md.Golam Mostofa quazi Qamruzzaman Wen-hui Guo Xian Sun hao Yu hong-Bing Shen Zhi-Bin hu David CChristiani Feng Chen State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjingJiangsu 211166China China International Cooperation Center for Environment and human health Center of Global HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Biostatistics School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Key Laboratory of Modern toxicology of Ministry of Education School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Environmental health Harvard T.H.Chan School of Public HealthBostonMA 02115USA harvard Medical School Department of Population Medicine and Harvard Pilgrim Health Care InstituteBostonMA 02115USA Dhaka Community hospital trust DhakaBangladesh Department of Epidemiology School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China

to the Editor:Preterm birth(PtB),defined as livebirth before 37 completed weeks of gestation,is associated with a high degree of immaturity of various organs,and thus are at greater *** a range of short-term and long-term comorbidities.[1]the estimated PtB prevalence in Bangladesh,already among the highest at 19.1%,[2] is even higher in rural areas in Bangladesh,[3]posing a significant economic and emotional burden to these families and the country.

关键词： organs birth maturity

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