Engineering polymer nanoparticles using cell membrane coating technology and their application in cancer treatments:Opportunities and challenges

作     者：Kai Guo Nanyang Xiao Yixuan Liu Zhenming Wang Judit Tóth János Gyenis Vijay Kumar Thakur Ayako Oyane Quazi T.H.Shubhra Kai Guo;Nanyang Xiao;Yixuan Liu;Zhenming Wang;Judit Tóth;János Gyenis;Vijay Kumar Thakur;Ayako Oyane;Quazi T.H.Shubhra

作者机构：Stomatology Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou510140China Department of MicrobiologyThe University of ChicagoChicagoIL60637USA Department of PathologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing21116China State Key Laboratory of Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041China Research Centre for Natural SciencesInstitute of Materials and Environmental Chemistry1117BudapestMagyar Tudósok Körútja 2Hungary University of PannoniaEgyetem u.10H-8200VeszprémHungary Nanomaterials Research InstituteNational Institute of Advanced Industrial Science and Technology(AIST)Tsukuba305-8565Japan School of EngineeringUniversity of Petroleum&Energy Studies(UPES)Dehradun 248007India 

出 版 物：《Nano Materials Science》 (纳米材料科学（英文版）)

年 卷 期：2022年第4卷第4期

页      面：295-321页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：We thank Ayesha Akhter (School of Science and Technology  Georgia Gwinnett College  USA) for assisting in language editing 

主　　题：Cell membrane(CM) Nanoparticles(NPs) Cancer Camouflage Biomimetic coating Drug delivery 

摘      要：Nanotechnology has revolutionized cancer drug delivery,and recent research continues to focus on the development of“one-size-fits-all,i.e.,“all-in-onedelivery *** nanomedicines can address significant shortcomings of conventional therapy,biological barriers remain a challenge in their delivery and accumulation at diseased *** achieve long circulation time,immune evasion,and targeted accumulation,conventional nanocarriers need modifications,e.g.,PEGylation,peptide/aptamer attachment,*** such modification is a biomimetic coating using cell membrane(CM),which can offer long circulation or targeting,or *** top-down CM coating process is facile and can provide some advantageous features over surface modification by synthetic ***,an overview is provided on the engineering of CM camouflaged polymer nanoparticles.A short section on CM and the development of CM coating technology has been *** description of the preparation and characterization of CM camouflaged polymer NPs and their applications in cancer treatment has been reported.A brief comparison between CM coating and PEGylation has been *** targeting approaches to achieve tumor-specific delivery of CM coated NPs have been summarized ***,this review will give the readers a nice picture of CM coated polymer NPs,along with their opportunities and challenges.