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Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation

Protein & Cell 2024年第7期15卷 512-529页

作者： Kai-Hui Zhang Fei-Fei Zhang Zhi-Ling Zhang Ke-Fei Fang Wen-Xing Sun Na Kong Min Wu Hai-Ou Liu Yan Liu Zhi Li Qing-Qing Cai Yang Wang quan-wei wei Peng-Cheng Lin Yan Lin wei Xu Cong-Jian Xu Yi-Yuan Yuan Shi-Min Zhao The Obstetrics&Gynecology Hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200090China Shanghai Key Laboratory of Metabolic Remodeling and Children’s Hospital of Fudan UniversityShanghai 200032China School of Life Sciences and Institutes of Biomedical Sciences Fudan UniversityShanghai 200438China Department of Nutrition and Food Hygiene School of Public HealthNantong UniversityNantong 226019China Reproductive Medicine Center The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Shanghai Fifth People’s Hospital of Fudan University Fudan UniversityShanghai 200240China Department of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210014China Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province College of PharmacyQinghai University for NationalitiesXining 810007China Pediatric Research Institute Children’s Hospital Affiliated to Shandong University(Jinan Children’s Hospital)Jinan 250022China

Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory *** understanding of the ovulation drivers hinders PCOS ***,we report that follicle stimulating hormone(FSH)controls follicular fluid(FF)glutamine levels to determine *** ovulation starts from FF-exposing granulosa cell(GC)*** glutamine,which decreases in pre-ovulation porcine FF,elevates in PCOS patients ***-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal,metabolic,and morphologic PCOS ***,follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine,which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic *** and glutamine inhibit the rapture of cultured murine *** removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or *** suggest that glutamine,FSH,and ASK1-JNK pathway are targetable to alleviate PCOS.

关键词： ovulation glutamine granulosa cells PCOS FSH

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A novel method to prepare SPR sensor chips based on photografting molecularly imprinted polymer

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Chinese Chemical Letters 2011年第6期22卷 721-724页

作者： Qing quan wei Tian Xin wei Key Laboratory of Cluster Science of Ministry of Education Beijing Institute of Technology Beijing 100081 China

A novel method to prepare surface plasmon resonance（SPR） sensor chips based on grafted imprinted polymer is explored. Benzophenone photografting system is used to grow molecularly imprinted polymer（MIP） films from the modified surface of gold *** surface morphology and thickness of MIP films were investigated by scanning electronic microscope（SEM）.The adsorption properties of sensor chip were studied by SPR *** results demonstrate that nano-MIP films can be constructed on the surface of gold substrate with the good adsorption of template molecules.

关键词： Surface plasmon resonance Molecularly imprinted polymer Photografting

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Cell-specific expression and immunolocalization of nitric oxide synthase isoforms and the related nitric oxide/cyclic GMP signaling pathway in the ovaries of neonatal and immature rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第1期12卷 55-64页

作者： wei ZHANG quan-wei wei Zheng-chao WANG wei DING wei WANG Fang-xiong SHI Laboratory of Animal Reproduction College of Animal Science and Technology Nanjing Agricultural University Nanjing 210095 China

Objective: The present study is designed to investigate the cellular expressions and immunolocalizations of three different nitric oxide synthase (NOS) isoforms and the related nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway in the ovaries of neonatal and immature ***: The ovaries were obtained from ICR (Institute for Cancer Research) female Sprague-Dawley rats at postnatal days 1,5,7,10,and *** we carried out the histologic examination,immunohistochemistry,measurement of NOS activity,and modifications within the NO/cGMP ***: During postnatal days 1,5,7,10,and 19,all three isoforms of NOS were mainly localized to the oocytes and expressed as a gradual increase in granulosa cells and theca cells within the growing *** ovarian total NOS activities and NO levels were increased at postnatal days 7 and 10 compared with other ***: Our findings suggest that the locally produced NO and the NO/NOS signaling systems are involved in the follicular development to puberty.

关键词： Nitric oxide synthase Nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway Ovary Neonatal rats Prepuberty

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Hydrogen Peroxide in Plants:a Versatile Molecule of the Reactive Oxygen Species Network

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Journal of Integrative Plant Biology 2008年第1期50卷 2-18页

作者： Li-Juan quan Bo Zhang wei-wei Shi Hong-Yu Li MOE Key Laboratory of Arid and Grassland Ecology School of Life Sciences Lanzhou University Lanzhou 730000 China

Plants often face the challenge of severe environmental conditions, which include various biotic and abiotic stresses that exert adverse effects on plant growth and development. During evolution, plants have evolved complex regulatory mechanisms to adapt to various environmental stressors. One of the consequences of stress is an increase in the cellular concentration of reactive oxygen species （ROS）, which are subsequently converted to hydrogen peroxide （H2O2）. Even under normal conditions, higher plants produce ROS during metabolic processes. Excess concentrations of ROS result in oxidative damage to or the apoptotic death of cells. Development of an antioxidant defense system in plants protects them against oxidative stress damage. These ROS and, more particularly, H2O2, play versatile roles in normal plant physiological processes and in resistance to stresses. Recently, H2O2 has been regarded as a signaling molecule and regulator of the expression of some genes in cells. This review describes various aspects of H2O2 function, generation and scavenging, gene regulation and cross-links with other physiological molecules during plant growth, development and resistance responses.

关键词： antioxidant system gene regulation hydrogen peroxide (H2O2) reactive oxygen species (ROS) signaling molecule.

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Age-dependent expression of forkhead box O proteins in the duodenum of rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第9期12卷 730-735页

作者： Pan HUANG Zhen-qi ZHOU Rui-hua HUANG Bo ZHOU quan-wei wei Fang-xiong SHI College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China

The O subfamily of forkhead box(FoxO) proteins is the downstream effector of the insulin-like growth factor-1/phosphoinositide 3-kinase/protein kinase B(IGF-1/PI3K/PKB) signal *** objective of the present study was to examine the expressions of three members of FoxO proteins,FoxO1,FoxO3a,and FoxO4 in the duodenum of Sprague-Dawley rats at different *** result demonstrated that the expression of FoxO4 in rat duodenum showed an age-dependent *** Day 21,there were no detectable localization and expression of FoxO4 in the duodenum,while,at Months 2 and 6,localization and expression of FoxO4 were *** addition,FoxO4 staining was primarily concentrated in the cell nuclei of the lamina propria around the intestinal gland of the duodenum in 2-month-old rats,but was not detectable in the same area in 6-month-old *** results showed also that although FoxO3a existed in the cytoplasm of the lamina propria at a low level at the 2-and 6-month marks,it was still not detectable at Day ***,FoxO1 was not detectable in all parts and *** together,our findings suggested that the cell-specific and age-dependent expressional patterns of FoxO4 and FoxO3a proteins in the duodenum play some roles in the development and growth performance of the rat duodenum.

关键词： O subfamily of forkhead box(FoxO) Age-dependence Duodenum Rat

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Aerial target threat assessment based on gated recurrent unit and self-attention mechanism

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Journal of Systems Engineering and Electronics 2024年第2期35卷 361-373页

作者： CHEN Chen quan wei SHAO Zhuang School of Automation Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Intelligent Control and Decision of Complex Systems Beijing 100081China

Aerial threat assessment is a crucial link in modern air combat, whose result counts a great deal for commanders to make decisions. With the consideration that the existing threat assessment methods have difficulties in dealing with high dimensional time series target data, a threat assessment method based on self-attention mechanism and gated recurrent unit(SAGRU) is proposed. Firstly, a threat feature system including air combat situations and capability features is established. Moreover, a data augmentation process based on fractional Fourier transform(FRFT) is applied to extract more valuable information from time series situation features. Furthermore, aiming to capture key characteristics of battlefield evolution, a bidirectional GRU and SA mechanisms are designed for enhanced ***, after the concatenation of the processed air combat situation and capability features, the target threat level will be predicted by fully connected neural layers and the softmax classifier. Finally, in order to validate this model, an air combat dataset generated by a combat simulation system is introduced for model training and testing. The comparison experiments show the proposed model has structural rationality and can perform threat assessment faster and more accurately than the other existing models based on deep learning.

关键词： target threat assessment gated recurrent unit(GRU) self-attention(SA) fractional Fourier transform(FRFT)

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Model-driven full system dynamics estimation of PMSM-driven chain shell magazine

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Defence Technology（防务技术） 2024年第9期39卷 147-156页

作者： Kai wei Longmiao Chen quan Zou School of Mechanical Engineering NanJing University of Science and TechnologyNanjing210094China

Based on the system dynamic model, a full system dynamics estimation method is proposed for a chain shell magazine driven by a permanent magnet synchronous motor(PMSM). An adaptive extended state observer(AESO) is proposed to estimate the unmeasured states and disturbance, in which the model parameters are adjusted in real time. Theoretical analysis shows that the estimation errors of the disturbances and unmeasured states converge exponentially to zero, and the parameter estimation error can be obtained from the extended state. Then, based on the extended state of the AESO, a novel parameter estimation law is designed. Due to the convergence of AESO, the novel parameter estimation law is insensitive to controllers and excitation signal. Under persistent excitation(PE) condition, the estimated parameters will converge to a compact set around the actual parameter value. Without PE signal, the estimated parameters will converge to zero for the extended state. Simulation and experimental results show that the proposed method can accurately estimate the unmeasured states and disturbance of the chain shell magazine, and the estimated parameters will converge to the actual value without strictly continuous PE signals.

关键词： Chain shell magazine Full system dynamics estimation Disturbance estimation Parameter estimation Adaptive extended state observer

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Distributed Harmonic Power Sharing with Voltage Distortion Suppression in Islanded Microgrids Considering Non-linear Loads

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 117-128页

作者： Guannan Lou Shanlin Li wei Gu quan Yang School of Electrical Engineering Southeast UniversityNanjingJiangsu 210096China the Jiangsu Provincial Key Laboratory of Smart Grid Technology and Equipment Southeast University Dongguan Power Supply Bureau of Guangdong Power Grid Company Guangdong 523000China

In contemporary power grids or microgrids,harmonic distortion has emerged as one of the critical power quality issues for utility power grids,which has escalated especially due to the high penetration of power-electronic-converter-interfaced distributed generation(DG).This paper first illustrates the prevalent dispute revolving around the harmonic power sharing and distortion restraint,and subsequently proposes a consensusbased framework that facilitates an accurate sharing of harmonics among multi-DGs connected in parallel,with an effective suppression of the output voltage *** with the majority of existing studies addressing the issue of voltage harmonics at the point of common coupling(PCC),our method primarily emphasizes on the output voltage distortion since the power quality requirement for certain local critical loads is often known to be *** the help of adaptive regulation,the overall distortion produced at the output terminals of DGs can be retained within an acceptable *** working principle of the proposed control method,which is not only easy to implement but also independent of model parameters,is further described in *** the small-signal dynamic model,the system stability and robustness are *** hardware-in-the-loop(HIL)simulations aid in determining the outcome of the proposed strategy in microgrid control.

关键词： Distributed generation droop control harmonic power sharing microgrid voltage distortion mitigation

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Selective adsorption of tetracycline by β-CD-immobilized sodium alginate aerogel coupled with ultrafiltration for reclaimed water

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Chinese Journal of Chemical Engineering 2024年第4期68卷 27-34页

作者： Xi quan Jun Zhang Linlin Yin wei Zuo Yu Tian State Key Laboratory of Urban Water Resource and Environment(SKLUWRE) School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

In this work,a novel composite material based on β-cyclodextrin-immobilized sodium alginate aerogel(β-CD/NaAlg) was developed utilizing cross-linker of epichlorohydrin and applied as an adsorbent to remove tetracycline antibiotics from reclaimed wastewater.A series of characterizations were utilized to confirm the successful synthesis of the adsorbent and this β-CD/NaAlg presented a three-dimensional network at the nanoscale or *** optimal conditions(pH=4,t=8 h,β-CD:NaAlg=9,adsorbent dosage = 1.5 g·L-1),the maximum removal rate of β-CD/NaAlg to tetracycline was 70%.The adsorption behavior of tetracycline on β-CD/NaAlg conformed to the Freundlich isotherm model(R2=0.9977) and the pseudo-second-order kinetic model(R^(2)=0.9993).Moreover,the adsorbent still removed 55.3% of tetracycline after five ***,the adsorbent was integrated with ultrafiltration to adsorb tetracycline antibiotics from simulated reclaimed wastewater,and the removal rate of tetracycline reached 78.9% within 2 *** existence of Cr(Ⅵ) had a negligible impact on tetracycline removal,while the presence of humic acid exhibited a promoting *** possible adsorption mechanisms were also elucidated through X-ray photoelectron spectroscopy and density functional theory *** summary,β-CD/NaAlg represents an environmentally friendly,efficient,and sustainable adsorbent for removing tetracycline antibiotics from reclaimed water.

关键词： b-CD/NaAlg aerogel Covalent grafting Tetracycline antibiotics Ultrafiltration Selective adsorption Reclaimed water

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Numerical simulation of transient characteristics in a bulb turbine during the load rejection process

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Journal of Hydrodynamics 2024年第1期36卷 170-183页

作者： Yue Lu Yu-quan Zhang Zhong-wei He Yuan Zheng College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210098China College of Energy and Electrical Engineering Hohai UniversityNanjing210098China Huadong Engineering Corporation Ltd. Hangzhou311122China

To evaluate the safety of the bulb tubular turbine,the dynamic hydraulic characteristics of a hydropower station system during the load rejection process are studied through numerical simulations and a prototype *** the developed model,a dynamic grid technology(DGT)controls the closure of the guide vane and the blade,whilst the moment balance equation and the user-defined function(UDF)provide the runner’s rotation *** 3-D transient simulation method can well predict the rotation speed and mass flow curves in the state of load *** simulation outcomes of the system performance are basically consistent with the measurement data of the *** observed,the runner is subjected to the reversely increased torque and axial force,the system is in a braking phase,and the maximum speed peaks at 144.6%of the rated ***,the internal flow of the runner is greatly affected by the closure of the guide vane,and the draft tube forms an eccentric spiral vortex *** breaks downstream,aggravating the instability of the draft ***,the transient characteristics span for the first five seconds,demonstrating the importance of establishing an efficient governing *** obtained results are useful for designing the turbine’s flow channel with a double regulating function and comprehending the turbine’s transient characteristics.

关键词： Bulb tubular turbine load rejection numerical simulation dynamic grid prototype test

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