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Identification of miRNAs and their targets in tea (Camellia sinensis)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第10期14卷 916-923页

作者： quan-wu ZHU Yao-ping LUO Institute of Tea Science Zhejiang University

MicroRNAs(miRNAs) are endogenous small RNAs playing a crucial role in plant growth and development,as well as stress *** them,some are highly evolutionally conserved in the plant kingdom,this provide a powerful strategy for identifying miRNAs in a new ***(Camellia sinensis) is one of the most important commercial beverage crops in the world,but only a limited number of miRNAs have been *** the present study,a total of 14 new *** miRNAs were identified by expressed sequence tag(EST) analysis from 47 452 available *** *** miRNAs potentially target 51 mRNAs,which can act as transcription factors,and participate in stress response,transmembrane transport,and signal *** of gene ontology(GO),based on these targets,suggested that 37 biological processes were involved,such as oxidation-reduction process,stress response,and *** Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis inferred that the identified miRNAs took part in 13 metabolic *** study will help further understanding of the essential roles of miRNAs in *** growth and development,and stress response.

关键词： MicroRNA(miRNA) Camellia sinensis Tea Gene ontology Pathway

Two-Dimensional Animal-Like Fractals in Thin Films

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Chinese Physics Letters 1996年第2期13卷 121-124页

作者： GAO Hong-jun XUE Zeng-quan wu quan-de PANG Shi-jin Beijing Laboratory of Vacuum Physics Chinese Academy of SciencesBeijing 100080 Department of Radio-Electronics Peking UniversityBeijing 100871

we present a few unique animal-like fractal patterns in ionized-clnster-beam deposited fullerene-tetracyanoquinodimethane thin *** fractal patterns consisting of animal-like aggregates such as"fishes"and"quasi-seahorses"have been characterized by transnission electron *** results indicate that the sall aggregates ofthe aninmal-like body are composed of many single crystals whose crystalline directions are generally *** formation of tle fractal patterns can be attributed to the cluster-diffusion-lirnited aggregation.

关键词： aggregation fractal crystalline

Surface effects on static bending of nanowires based on non-local elasticity theory

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Progress in Natural Science:Materials International 2015年第5期25卷 520-524页

作者： quan wu Alex A.Volinsky Lijie Qiao Yanjing Su Corrosion and Protection Center Key Laboratory for Environmental Fracture (MOE) University of Science and Technology Beijing Department of Mechanical Engineering University of South Florida

The surface elasticity and non-local elasticity effects on the elastic behavior of statically bent nanowires are investigated in the present investigation. Explicit solutions are presented to evaluate the surface stress and non-local elasticity effects with various boundary *** with the classical Euler beam, a nanowire with surface stress and/or non-local elasticity can be either stiffer or less stiff, depending on the boundary conditions. The concept of surface non-local elasticity was proposed and its physical interpretation discussed to explain the combined effect of surface elasticity and non-local elasticity. The effect of the nanowire size on its elastic bending behavior was investigated. The results obtained herein are helpful to characterize mechanical properties of nanowires and aid nanowire-based devices design.

关键词： Surface effect Non-local elasticity Nanowires Size effect Euler–Bernoulli beam

Advances in self-assembly-based circularly polarized luminescent materials

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Science China Chemistry 2024年第10期67卷 3247-3257页

作者： Bing-Hao Liu Yang Zong Na Liu Zong-quan wu State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China The School of Pharmaceutical Sciences Jilin UniversityChangchun 130021China

Circularly polarized luminescent(CPL)materials have garnered attention for their diverse applications,including three-dimensional(3D)imaging,bio-imaging,chiral sensing,and other emerging ***,the fabrication of CPL-activated materials required the use of chiral luminescent small *** introduction of the idea of self-assembly has transformed the production of CPL-activated materials,providing new and promising opportunities for their *** utilizing self-assembly,it is now feasible to produce chiral nano-assemblies with CPL activity not only from chiral molecules but also from non-chiral substances and inorganic *** addition,self-assembly routes provide a way to increase the asymmetry factor,creating possibilities for additional refinement and adjustment of CPL material *** review offers a summary of the current progress and developments in the self-assembly of small molecules and polymers,with a specific emphasis on their capacity to create or enhance CPL in different *** aim of this review is to inspire interest in optical materials that are based on the principles of self-assembly.

关键词： circularly polarized luminescence photochemistry self-assembly chiral materials

Chiral Recognition and Resolution Based on Helical Polymers

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Chinese Journal of Polymer Science 2021年第12期39卷 1521-1527页

作者： Hui Zou Qi-Liang wu Li Zhou Xiao-Hua Hou Na Liu Zong-quan wu Department of Polymer Science and Engineering School of Chemistry and Chemical EngineeringHefei University of Technology and Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei 230009China

Helical polymers have attracted a great deal of attention and been extensively investigated due to their various *** of the most importa nt applicati ons of helical polymers is chiral recog nition and resolutio n ofe nan tiomersforthe reas on that a pair of e nan tiomers is comm only with differe nt physiological and toxicological behaviors in biological *** polymers usually prese nt un expected high chiral recogniti on ability to a variety of racemic compo *** more,the chiral recog nition and resolution abilities of the system are depe ndent on the highly ordered helical structures of the helical *** mini review mainly focuses on the recent progress in chiral recognition and resolution based on helical *** synthetic methodology for helical polymers is firstly discussed *** recent advances of chiral recog nition and resoluti on systems based on helical polymers,especially polyacetylenes and polyisocya nides,are *** hope this mini review will in spire more in terest in developing helical polymers and en courage further advances in chiral-related disciplines.

关键词： Helical polymer Chiral recog nition Chiral resolution Polyacetylenes Polyisocyanides

Homer signaling pathways as effective therapeutic targets for ischemic and traumatic brain injuries and retinal lesions

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Neural Regeneration Research 2022年第7期17卷 1454-1461页

作者： Xiu-quan wu Ning Su Zhou Fei Fei Fei Department of Neurosurgery Xijing Hospitalthe Fourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Radiation Oncology Xijing Hospitalthe Fourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology Xijing Hospitalthe Fourth Military Medical UniversityXi’anShaanxi ProvinceChina

Ischemic and traumatic insults to the central nervous system account for most serious acute and fatal brain injuries and are usually characterized by primary and secondary *** damage presents the greatest challenge for medical staff;however,there are currently few effective therapeutic targets for secondary *** proteins are postsynaptic scaffolding proteins that have been implicated in ischemic and traumatic insults to the central nervous *** signaling can exert either positive or negative effects during such insults,depending on the specific subtype of Homer *** 1b/c couples with other proteins to form postsynaptic densities,which form the basis of synaptic transmission,while Homer 1a expression can be induced by harmful external *** 1c is used as a unique biomarker to reveal alterations in synaptic connectivity before and during the early stages of apoptosis in retinal ganglion cells,mediated or affected by extracellular or intracellular signaling or cytoskeletal *** review summarizes the structural features,related signaling pathways,and diverse roles of Homer proteins in physiological and pathological *** Homer 1a or downregulating Homer 1b/c may play a neuroprotective role in secondary brain *** also plays an important role in the formation of photoreceptor *** findings confirm the neuroprotective effects of Homer,and support the future design of therapeutic drug targets or gene therapies for ischemic and traumatic brain injuries and retinal disorders based on Homer proteins.

关键词： brain injury calcium signaling cerebral ischemia dendritic spine glutamate receptor Homer scaffolding protein neuron neuroprotection retinal ganglion cell review traumatic brain injury

Does gemcitabine-based combination therapy improve the prognosis of unresectable pancreatic cancer?

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World Journal of Gastroenterology 2012年第35期18卷 4944-4958页

作者： Chen Sun Daniel Ansari Roland Andersson De-quan wu Department of Surgery Second Af-filiated Hospital of Harbin Medical University Harbin 150086Heilongjiang Province China Department ofSurgery Clinical Sciences Lund Lund University Sk~ne Univer-sity Hospital SE-22185 Lurid Sweden

AIM:To assess whether gemcitabine-based combination therapy improves the prognosis of unresectable pancreatic cancer compared with gemcitabine treatment ***:A quantitative up-to-date meta-analysis was undertaken to investigate the efficacy of gemcitabine-based combination treatment compared with gemcitabine monotherapy in locally advanced or metastatic pancreatic *** was limited to highquality randomized clinical ***:Twenty-six studies were included in the present analysis,with a total of 8808 patients *** studies were divided into four subgroups based on the different kinds of cytotoxic agents,including platinum,fluoropyrimidine,camptothecin and targeted *** treated with gemcitabine monotherapy had significantly lower objective response rate [risk ratio(RR),0.72;95% confidence interval(CI):0.63-0.83;P < 0.001],and lower 1-year overall survival(RR,0.90;95%CI:0.82-0.99;P = 0.04).Gemcitabine monotherapy caused fewer complications,including fewer grade 3-4 toxicities:including vomiting(RR,0.75;95%CI:0.62-0.89;P = 0.001),diarrhea(RR,0.66;95%CI:0.49-0.89;P = 0.006),neutropenia(RR,0.88;95%CI:0.72-1.06;P = 0.18),anemia(RR,0.96;95%CI:0.82-1.12;P = 0.60),and thrombocytopenia(RR,0.76;95%CI:0.60-0.97;P = 0.03) compared with gemcitabine combination ***:Gemcitabine combination therapy provides a modest improvement of survival,but is associated with more toxicity compared with gemcitabine monotherapy.

关键词： Pancreatic cancer Gemcitabine Combina-tion therapy Outcome Meta-analysis

Preparation and characterization of polystyrene-based monolith with ordered macroporous structure

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Chinese Chemical Letters 2012年第4期23卷 474-477页

作者： quan Zhou wu Jian Feng He Ji Ming Ou College of Chinese Materia Medica Guangzhou University of Chinese MedicineGuangzhou 510006China

In this paper,polystyrene-based monoliths with highly ordered macroporous structure were synthesized by using SiO_2 colloidal crystal as *** observation shows that the macropores are highly ordered and are interconnected by small *** BET surface area of PS monolith is about 36.17 m^2/*** polymer monoliths can resist 5 MPa pressure,showing high mechanical and compressive strength.

关键词： Monolith Polystyrene Polymer Ordered macropore

Categorization of two-loop Feynman diagrams in the O(α^(2))correction to e^(+)e^(-)→ZH

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Chinese Physics C 2021年第5期45卷 49-57页

作者： Zhao Li Yefan Wang quan-feng wu Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physics Sciences University of Chinese Academy of SciencesBeijing 100049China Center of High Energy Physics Pek ing UniversityBeijing 100871China

The e^(+)e^(-)→ZHprocess is the dominant process for the Higgs boson production at the future Higgs *** order to match the analysis on the Higgs properties with highly precise experiment data,it will be crucial to include the theoretical prediction to the full next-to-next-to-leading order electroweak effect in the production rate or(e^(+)e^(-)→ZH).In this inspiring work,we categorize the two-loop Feynman diagrams of theO(α^(2)))correction to e^(+)e^(-)→ZH into 6 categories according to relevant topological *** 25377 diagrams contribute to the O(α^(2))correction in total,the number of the most challenging diagrams with seven denominators is 2250,which contain only 312 non-planar diagrams with 155 independent *** categorization could be a valuable reference for the complete calculation in future.

关键词： categorization Higgsstrahlung O(α^(2))correction