Homer signaling pathways as effective therapeutic targets for ischemic and traumatic brain injuries and retinal lesions

作     者：Xiu-Quan Wu Ning Su Zhou Fei Fei Fei 

作者机构：Department of NeurosurgeryXijing Hospitalthe Fourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Radiation OncologyXijing Hospitalthe Fourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of OphthalmologyXijing Hospitalthe Fourth Military Medical UniversityXi’anShaanxi ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第7期

页      面：1454-1461页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100212[医学-眼科学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China Nos.81600738(to FF) 81771239(to ZF) 81801300(to NS) 

主　　题：brain injury calcium signaling cerebral ischemia dendritic spine glutamate receptor Homer scaffolding protein neuron neuroprotection retinal ganglion cell review traumatic brain injury 

摘      要：Ischemic and traumatic insults to the central nervous system account for most serious acute and fatal brain injuries and are usually characterized by primary and secondary *** damage presents the greatest challenge for medical staff;however,there are currently few effective therapeutic targets for secondary *** proteins are postsynaptic scaffolding proteins that have been implicated in ischemic and traumatic insults to the central nervous *** signaling can exert either positive or negative effects during such insults,depending on the specific subtype of Homer *** 1b/c couples with other proteins to form postsynaptic densities,which form the basis of synaptic transmission,while Homer 1a expression can be induced by harmful external *** 1c is used as a unique biomarker to reveal alterations in synaptic connectivity before and during the early stages of apoptosis in retinal ganglion cells,mediated or affected by extracellular or intracellular signaling or cytoskeletal *** review summarizes the structural features,related signaling pathways,and diverse roles of Homer proteins in physiological and pathological *** Homer 1a or downregulating Homer 1b/c may play a neuroprotective role in secondary brain *** also plays an important role in the formation of photoreceptor *** findings confirm the neuroprotective effects of Homer,and support the future design of therapeutic drug targets or gene therapies for ischemic and traumatic brain injuries and retinal disorders based on Homer proteins.