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Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood-brain barrier

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Acta Pharmaceutica Sinica B 2023年第9期13卷 3834-3848页

作者： Thuy Giang Nguyen Cao Ji Hee Kang Su Jin Kang quan truong hoang Han Chang Kang Won Jong Rhee Yu Shrike Zhang Young Tag Ko Min Suk Shim Division of Bioengineering Incheon National UniversityIncheon 22012Republic of Korea College of Pharmacy Gachon UniversityIncheon 21936Republic of Korea Department of Pharmacy Integrated Research Institute of Pharmaceutical Sciencesand BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future PharmacyCollege of Pharmacythe Catholic University of KoreaGyeonggi-do 14662Republic of Korea Research Center for Bio Materials&Process Development Incheon National UniversityIncheon 22012Republic of Korea Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA

Glioblastoma(GBM)is the most aggressive malignant brain tumor and has a high mortality *** therapy(PDT)has emerged as a promising approach for the treatment of malignant brain ***,the use of PDT for the treatment of GBM has been limited by its low blood-brain barrier(BBB)permeability and lack of cancer-targeting ***,brain endothelial cell-derived extracellular vesicles(bEVs)were used as a biocompatible nanoplatform to transport photosensitizers into brain tumors across the *** enhance PDT efficacy,the photosensitizer chlorin e6(Ce6)was linked to mitochondria-targeting triphenylphosphonium(TPP)and entrapped into *** Ce6(TPP-Ce6)selectively accumulated in the mitochondria,which rendered brain tumor cells more susceptible to reactive oxygen species-induced apoptosis under light ***,the encapsulation of TPP-Ce6 into b EVs markedly improved the aqueous stability and cellular internalization of TPP-Ce6,leading to significantly enhanced PDT efficacy in U87MG GBM *** in vivo biodistribution study using orthotopic GBM-xenografted mice showed that b EVs containing TPP-Ce6[b EV(TPP-Ce6)]substantially accumulated in brain tumors after BBB penetration via transferrin receptor-mediated *** such,b EV(TPP-Ce6)-mediated PDT considerably inhibited the growth of GBM without causing adverse systemic toxicity,suggesting that mitochondria are an effective target for photodynamic GBM therapy.

关键词： Extracellular vesicle Chlorin e6 Triphenylphosphonium Mitochondria-targeting photosensitizer Photodynamic therapy Blood-brain barrier Glioblastoma Transferrin receptor

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Anti-inflammatory effects of Solanum procumbens on a low dose complete Freund's adjuvant-induced arthritis rat model

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Asian Pacific Journal of Tropical Biomedicine 2023年第5期13卷 214-221页

作者： Xuan-Hai Do Trong Nghia Nguyen Thanh Chung Dang Thi Thanh Mai Nguyen Trung Nhan Nguyen Van Nhat truong Do Huu Tho Le Xuan Hai Nguyen hoang Phu Dang Giang-Linh Nguyen Dinh-Khanh hoang Van-quan Le Van-Mao Can Department of Practical and Experimental Surgery Vietnam Military Medical UniversityHanoi 10000Vietnam Department of Reconstructive and Microsurgery Craniofacial and Reconstructive Surgery CentreMilitary Central Hospital 108Hanoi 10000Vietnam Department of Anatomic Pathology Military Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Faculty of Chemistry University of ScienceVietnam National University Ho Chi Minh CityHo Chi Minh City 70000Vietnam Faculty of Medicine University of Medicine and PharmacyVietnam National UniversityHanoi 10000Vietnam Department of Ultrasound Imaging Diagnostics CentreMilitary Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Department of Functional Diagnostics Military Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Department of Pathophysiology Vietnam Military Medical UniversityHanoi 10000Vietnam

Objective:To investigate the anti-inflammatory and analgesic effects of Solanum procumbens on complete Freund’s adjuvantinduced arthritis rat ***:We isolated and identified five compounds in the ethanolsoluble Solanum procumbens extract(SP)with anti-inflammatory effects,including ursolic acid,β-sitosterol,hexadecanoic acid,cisvaccenic acid,and vanillic ***,we investigated the anti-inflammatory effects of SP on rheumatoid arthritis symptoms,including paw volumes,local temperatures,withdrawal latency,and mechanical withdrawal threshold at the hind paw and white blood cell(WBC)number from complete Freund’s adjuvant-induced arthritis rat ***:We have successfully established a complete Freund’s adjuvant-induced arthritis rat model at a low dose(1 mg/mL).SP extract significantly reduced paw volumes(P<0.05),prolonged withdrawal latencies(P<0.05),decreased local temperature,and increased the mechanical withdrawal threshold(P<0.05),but only SP extract at the dose of 300 mg/kg significantly decreased WBC ***:SP extract could be a potential medication candidate with anti-inflammatory effects for arthritis,but it requires further investigation into the mechanism of the SP and its effectiveness on other models as well as clinical trials.

关键词： Solanum procumbens Arthritis Anti-inflammation Complete Freund's adjuvant Rats

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Analysis of Trends in Drought with the Non-Parametric Approach in Vietnam: A Case Study in Ninh Thuan Province

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American Journal of Climate Change 2021年第1期10卷 51-84页

作者： Nguyen hoang Tuan truong Thanh Canh University of Science VNU.HCM Ho Chi Minh City Vietnam

A quantitative study was used in the study of the tendency to change drought indicators in Vietnam through the Ninh Thuan province case study. The research data are temperature and precipitation data of 11 stations from 1986 to 2016 inside and outside Ninh Thuan province. To do the research, the author uses a non-parametric analysis method and the drought index calculation method. Specifically, with the non-parametric method, the author uses the analysis, Mann-Kendall (MK) and Theil-Sen (Sen’s slope), and to analyze drought, the author uses the Standardized Precipitation Index (SPI) and the Moisture Index (MI). Two Softwares calculated in this study are ProUCL 5.1 and MAKENSEN 1.0 by the US Environmental Protection Agency and Finnish Meteorological Institute. The calculation results show that meteorological drought will decrease in the future with areas such as Phan Rang, Song Pha, quan The, Ba Thap tend to increase very clearly, while Tam My and Nhi Ha tend to increase very clearly short. With the agricultural drought, the average MI results increased 0.013 per year, of which Song Pha station tended to increase the highest with 0.03 per year and lower with Nhi Ha with 0.001 per year. The forecast results also show that by the end of the 21st century, the SPI tends to decrease with SPI 1 being −0.68, SPI 3 being −0.40, SPI 6 being −0.25, SPI 12 is 0.42. Along with that is the forecast that the MI index will increase 0.013 per year to 2035, the MI index is 0.93, in 2050 it is 1.13, in 2075 it will be 1.46, and by 2100 it is 1.79. Research results will be used in policymaking, environmental resources management agencies, and researchers to develop and study solutions to adapt and mitigate drought in the context of variable climate change.

关键词： Drought Mann-Kendall Sen’s Slope Non-Parametric

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A Study on Optimizing the Double-Spine Type Flow Path Design for the Overhead Transportation System Using Tabu Search Algorithm

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Intelligent Automation & Soft Computing 2024年第2期39卷 255-279页

作者： Nguyen Huu Loc Khuu Thuy Duy truong Quoc Dien Le Tran Thanh Cong Vu Hoa Binh Tran Tuong quan Vo Department of Mechatronics Faculty of Mechanical EngineeringHo Chi Minh City University of Technology(HCMUT)Ho Chi Minh CityVietnam Bach Khoa Research Center for Manufacturing Engineering Ho Chi Minh City University of Technology(HCMUT)Ho Chi Minh CityVietnam VietnamNational University Ho ChiMinh City Ho ChiMinh CityVietnam

Optimizing Flow Path Design(FPD)is a popular research area in transportation system design,but its application to Overhead Transportation Systems(OTSs)has been *** study focuses on optimizing a double-spine flow path design for OTSs with 10 stations by minimizing the total travel distance for both loaded and empty *** employ transportation methods,specifically the North-West Corner and Stepping-Stone methods,to determine empty vehicle travel ***,the Tabu Search(TS)algorithm is applied to branch the 10 stations into two main layout *** results obtained from our proposed method demonstrate a reduction in the objective function value compared to the initial feasible ***,we explore howchanges in the parameters of the TS algorithm affect the optimal *** validate the feasibility of our approach by comparing it with relevant literature and conducting additional tests on layouts with 20 and 30 stations.

关键词： Overhead transportation systems tabu search double-spine layout transportationmethod empty travel flow path design

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越南冷水花属(荨麻科)一新记录种

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热带亚热带植物学报 2014年第5期22卷 450-452页

作者：黄石连刘影 DO Van truong 符龙飞温放韦毅刚广西师范大学生命科学学院广西桂林541004 广西壮族自治区中国科学院广西植物研究所广西桂林541006 维管束植物分类与多样性保育中心越南国家自然博物馆

报道了越南荨麻科(Urticaceae)冷水花属(Pilea Lindl.)一新记录种——基心叶冷水花(*** *** ex ***)。该种在越南Pu Hu自然保护区发现,与产自越南北部的*** Gagnep.相似,主要区别在于其雄花序聚伞圆锥状,托叶大,叶先端渐尖或短尾状渐尖。

关键词：新记录冷水花属基心叶冷水花荨麻科越南

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旱季补水对桉树幼龄林叶片非结构性碳水化合物的影响

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中南林业科技大学学报 2021年第5期41卷 42-48页

作者：余斐张水云华雷刘文泉邱权何茜苏艳刘效东李吉跃华南农业大学林学与风景园林学院广东广州510642 广东省林业科学研究院广东省森林培育与保护利用重点实验室广东广州510520 顺化农林大学越南顺化49116

【目的】叶片非结构性碳水化合物含量能体现植物在当前生长阶段对环境的适应性。华南地区的季节性干旱严重限制人工林的生长,开展旱季补水和常规施肥处理,研究尾巨桉人工林叶片非结构性碳水化合物含量变化,对于桉树人工林质量精准化提... 详细信息

【目的】叶片非结构性碳水化合物含量能体现植物在当前生长阶段对环境的适应性。华南地区的季节性干旱严重限制人工林的生长,开展旱季补水和常规施肥处理,研究尾巨桉人工林叶片非结构性碳水化合物含量变化,对于桉树人工林质量精准化提升的研究具有重要意义,并且提供了数据支持,具有很强的实用性。【方法】通过对尾巨桉Eucalyptus uorphylla×***无性系DH32-29幼龄林进行旱季补水和常规施肥的添加试验,探究旱季补水和常规施肥措施对叶片非结构性碳水化合物含量的影响。同时,利用当地的气候条件,研究叶片非结构性碳水化合物含量在雨季和旱季的差异。【结果】1)叶片可溶性糖含量的季度变化存在波动性,而叶片淀粉含量随时间变化逐渐下降。总体而言,叶片非结构性碳水化合物含量随着尾巨桉的生长时间呈现波动下降趋势。2)在旱季,常规施肥处理F(无水有肥处理)和WF(有水有肥处理)的叶片可溶性糖含量显著高于无施肥处理CK(无水无肥处理)和W(有水无肥处理)。3)叶片可溶性糖含量、淀粉含量和非结构性碳水化合物含量在雨季和旱季之间不存在显著性差异。4)最影响叶片可溶性糖含量的为施肥措施,而最影响叶片淀粉含量和非结构性碳水化合物含量的为生长时间段。【结论】施肥能显著提高叶片可溶性糖含量,从而能更好地维持叶片生理活动,更有利于树木的碳源输出;而旱季补水能有效地缓解尾巨桉受到的季节性干旱胁迫,从而使得叶片中的可溶性糖含量以及淀粉含量均较低,能有效将光合产物转移到其他器官组织。

关键词：尾巨桉人工林旱季补水可溶性糖浓度非结构性碳水化合物浓度淀粉浓度

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