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Cognitive dysfunction of patients infected with SARS-CoV-2 omicron variant in Shanghai,China

Translational Neurodegeneration 2023年第1期12卷 511-513页

作者： Ping Yuan Yong Bi Yu Luo quan tao Sugang Gong Yi Wang Lize Xiong Xiaohuan Xia Jialin C.Zheng Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200081China Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200081China Center for Translational Neurodegeneration and Regenerative Therapy Tongji Hospital Affiliated to Tongji UniversityShanghai 200081China Department of Anesthesiology and Perioperative Medicine School of MedicineShanghai Fourth People’s Hospital Affiliated to Tongji UniversityShanghai 200081China Department of Radiology Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200081China Shanghai Frontiers Science Center of Nanocatalytic Medicine Tongji University School of MedicineShanghai 200081China Center for Translational Neurodegeneration and Regenerative Therapy Yangzhi Rehabilitation Hospital Affiliated to Tongji UniversityShanghai 200081China Collaborative Innovation Center for Brain Science Tongji UniversityShanghai 200081China Clinical Research Center for Anesthesiology and Perioperative Medicine Tongji UniversityShanghai 200081China

Previous studies have reported that nearly one-fourth of coronavirus disease 2019(COVID-19)survivors suf-fer from persistent cognitive impairment,including impaired memory,attention,concentration,executive function,and speed of information processing[1-3].Omicron is the latest severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variant of concern(VOC)reported in November 2021[4],characterized by a large number of spike mutations,great transmissibility in the presence of other VOCs,and an ability to spread in populations with high level of immunity[4].However,whether patients infected with Omicron COVID-19 variant develop cognitive impairment,similar to those infected with other VOCs,remains unclear.

关键词： infected patients impaired

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2011年法网赛我国女单选手技术优劣势及其发展对策

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体育与科学 2011年第4期32卷 102-106+34页

作者：陶权淮海工学院体育教研部

通过法国网球公开赛的官方网站数据统计,采用个案调查法、描述性分析法对2011年法国网球公开赛我国女单选手与对手的技术统计进行分析。研究结果表明,我国女单都属于底线型打法选手,发球成功率较高,但速度不够快;上网成功率较高,击球稳... 详细信息

通过法国网球公开赛的官方网站数据统计,采用个案调查法、描述性分析法对2011年法国网球公开赛我国女单选手与对手的技术统计进行分析。研究结果表明,我国女单都属于底线型打法选手,发球成功率较高,但速度不够快;上网成功率较高,击球稳定性较强;在主动得分能力上李娜表现非常的出色,而郑洁、彭帅、张帅主动得分能力相对较弱;在技术、战术运用方面,李娜表现非常全面,而彭帅、郑洁、张帅表现不太理想。分析其胜、负的原因,观察现今网坛的发展趋势,为我国的网球运动训练提供一些理论参考依据。

关键词：法国网球公开赛我国运动员女子网球研究分析

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Expression and significant roles of the long non-coding RNA CASC19/miR-491-5p/HMGA2 axis in the development of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3559-3584页

作者： Li-Xiang Zhang Pan-quan Luo Zhi-Jian Wei A-Man Xu tao Guo Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Provincial Key Laboratory of Digestive Disease Hefei 230031Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Public Health Clinical Center Hefei 230000Anhui ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignant tumor,long non-coding RNA and microRNA(miRNA)are important regulators that affect tumor proliferation,metastasis and chemotherapy resistance,and thus participate in tumor ***19 is a new bio-marker which can promote tumor invasion and ***,the mechanism by which CASC19 affects the progression of GC through miRNA is not *** To explore the role of the CASC19/miR-491-5p/HMGA2 regulatory axis in *** To explore the expression and prognosis of CASC19 in GC through clinical samples,and investigate the effects of inhibiting CASC19 on the proliferation,migration,invasion and other functions of GC cells through cell counting Kit-8(CCK-8),ethynyldeoxyuridine,Wound healing assay,Transwell,Western blot and flow cytometry *** effect of miR-491-5p and HMGA2 in GC were also *** regulatory relationship between CASC19 and miR-491-5p,miR-491-5p and HMGA2 were validated through Dual-luciferase reporter gene assay and reverse transcription *** CCK-8,Transwell,Wound healing assay,flow cytometry and animal experiments verify the role of CASC19/miR-491-5p/HMGA2 regulatory *** The expression level of CASC19 is related to the T stage,N stage,and tumor size of *** of the expression of CASC19 can inhibit the ability of proliferation,migration,invasion and EMT conversion of GC cells,and knocking down the expression of CASC19 can promote the apoptosis of GC *** the expression of miR-491-5p can inhibit the proliferation of GC cells,miR-491-5p mimics can inhibit EMT conversion,and promote the apoptosis of GC cells,while decreasing the expression of miR-491-5p can promote the proliferation and EMT conversion and inhibit the apoptosis of GC *** expression of HMGA2 in GC tissues is higher than that in adjacent *** the same time,the expression level of HMGA2 is related to the N and T stages of the *** the level of HMGA2 can pr

关键词： Gastric cancer Long non-coding RNA CASC19 miR-491-5p HMGA2 Prognosis

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Strain sensor on a chip for quantifying the magnitudes of tensile stress on cells

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Microsystems & Nanoengineering 2024年第3期10卷 305-315页

作者： Yuyin Zhang Yue Wang Hongze Yin Jiahao Wang Na Liu Songyi Zhong Long Li quan Zhang tao Yue School of Mechatronics Engineering and Automation Shanghai UniversityShanghaiChina School of Future Technology Shanghai UniversityShanghaiChina Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhouChina Shanghai Key Laboratory of Intelligent Manufacturing and Robotics Shanghai UniversityShanghaiChina Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghaiChina

During cardiac development,mechanotransduction from the in vivo microenvironment modulates cardiomyocyte growth in terms of the number,area,and arrangement ***,the response of cells to different degrees of mechanical stimuli is ***-on-a-chip,as a platform for investigating mechanical stress stimuli in cellular mimicry of the in vivo microenvironment,is limited by the lack of ability to accurately quantify externally induced ***,previous technology lacks the integration of external stimuli and feedback sensors in microfluidic platforms to obtain and apply precise amounts of external ***,we designed a cell stretching platform with an in-situ *** in-situ liquid metal sensors can accurately measure the mechanical stimulation caused by the deformation of the vacuum cavity exerted on *** platform was applied to human cardiomyocytes(AC16)under cyclic strain(5%,10%,15%,20 and 25%),and we found that cyclic strain promoted cell growth induced the arrangement of cells on the membrane to gradually unify,and stabilized the cells at 15%amplitude,which was even more effective after 3 days of *** platform’s precise control and measurement of mechanical forces can be used to establish more accurate in vitro microenvironmental models for disease modeling and therapeutic research.

关键词： stress deformation arrangement

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基于民族学生心理语言距离的英语教育策略

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贵州民族研究 2016年第3期37卷 232-235页

作者：全涛中南林业科技大学外国语学院湖南长沙410004

语言距离分为客观语言距离和心理语言距离,两种语言距离都对英语学习有重要影响,因此民族地区英语教育不仅要从客观语言距离出发,进行教材、教学方式方法等方面的调整和完善,同时也要从改善民族学生对语言之间距离的主观感知着手,促进... 详细信息

语言距离分为客观语言距离和心理语言距离,两种语言距离都对英语学习有重要影响,因此民族地区英语教育不仅要从客观语言距离出发,进行教材、教学方式方法等方面的调整和完善,同时也要从改善民族学生对语言之间距离的主观感知着手,促进民族学生对英语语言差异的正确认知,加强民族学生对英语文化的了解,培养民族学生建立开放的文化心态。

关键词：民族英语教育语言距离

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Anti-tumor and Phenotypic Regulation Effect of Matrine on Dendritic Cells through Regulating TLRs Pathway

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Chinese Journal of Integrative Medicine 2021年第7期27卷 520-526页

作者： WANG Jing-kang ZHAO Bao-sheng WANG Min LIU Chen-yue LI Ya-qi MA quan-tao LI Peng-fei WANG Tie-shan WANG Chun-guo ZHOU Yong-ming School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing100029China Beijing Research Institute of Chinese Medicine Beijing University of Chinese MedicineBeijing100029China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029China Department of Oncology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China

Objective To investigate the effects of matrine on antigen presentation of dendritic cells(DCs),and to explore the pharmacological mechanism of matrine on anti-tumor *** Different concentrations(0,1,2,4,8 and 16µg/mL)of matrine were co-cultured with DCs,the harvested DCs were co-cultured with antigens of Lewis lung cancer(LLC)cells,and then DCs and T cells were co-cultured to produce DCs-activated killer(DAK)cells,which have significant tumor-killing *** expression of cytokines,mRNA and protein of toll-like receptors(TLRs)in DCs were detected by enzyme linked immunosobent assay,polymerase chain reaction and Western blot,*** the killing effect of DAK were measured by MTT *** Matrine significantly increased the mRNA expression of TLR7,TLR8,myeloid differentiation factor 88(MyD88),tumor necrosis factor receptor-associated factor 6(TRAF-6)and IκB kinase(IKK),as well as the protein expression of TLR7 and TLR8,and up-regulated the levels of interleukin-12(IL-12),IL-6 and tumor necrosis factor-α(TNF-α),meanwhile,it also increased the expressions of MHC-II,CD54,CD80 and CD86 in ***-activated effector T cells had significant tumor-killing *** the concentration of matrine was more than 4µg/mL,all indices had significant difference(P<0.01 or P<0.05).Conclusion Matrine plays an anti-tumor role by regulating TLRs signal transduction pathway,promoting the secretion of inflammatory cytokines and enhancing immune function.

关键词： matrine Chinese medicine dendritic cells tumors toll-like receptors inflammatory cytokines

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Effects of Cinnamon Acid on Respiratory Rate and Its Related Enzymes Activity in Roots of Seedlings of Malus hupehensis Rehd.

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Agricultural Sciences in China 2010年第6期9卷 833-839页

作者： GAO Xiang-bin,ZHAO Feng-xia,SHEN Xiang,HU Yan-li,HAO Yun-hong,YANG Shu-quan,SU Li-tao and MAO Zhi-quan State Key Laboratory of Crop Biology/College of Horticultural Science and Engineering,Shandong Agricultural University,Tai’an 271018,P.R.China State Key Laboratory of Crop Biology/College of Horticultural Science and Engineering Shandong Agricultural University Tai'an 271018 P.R.China

This paper studied the effects of cinnamon acid treatments on the respiratory rate and related enzymes activity in the seedling roots of Malus hupehensis *** would provide information for understanding the mechanisms of inhibition damage caused by continuous cultivation of apple tree.20 mL of solution containing different concentrations of cinnamon acid was added into container with the tested *** treatment,the samples were taken periodically and the respiratory rates were measured by OXY-LAB oxygen electrodes under 25°C stable temperature and then the activities of related enzymes were *** rates of total respiration and other 2 pathways [tricarboxylic acid cycle （TCA） and pentose phosphate pathway （PPP）] appeared initially an increasing treads and late （on the 3rd d） began to ***,they again appeared an increase trend at the end period,on the contrast,the respiratory rate of embden-meyer- hot-parnas （EMP） pathway appeared a stead decline tread but it had a recover on the last *** respiratory rate of total and 3 pathways were decreased under 125 mg kg-1 （soil）.The dynamic trends of the enzymes activities of pyrophosphate-dependent phosphofructokinase （PFK）,glucose-6-phosphate dehydrogenase （G-6-PDH） and malate dehydrogenase （MDH） showed *** conclusion,treatments of certain concentration of cinnamon acid would inhibit the respiratory rate and related enzymes activity of roots of *** *** the inhibition degrees were positively related with concentration of cinnamon acid treatments.

关键词： cinnamon acid Malus hupehensis Rehd. roots respiratory rate enzymes activity

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Electro-reductive carboxylation of acyclic C(sp^(3))–C(sp^(3))bonds in aromatic hydrocarbons with CO_(2)

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Science China Chemistry 2024年第10期67卷 3366-3372页

作者： Chuan-Kun Ran quan Qu Yang-Yi tao Yi-Fei Chen Li-Li Liao Jian-Heng Ye Da-Gang Yu Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu 610064China

Despite the recent advances in the selective functionalization of C–C bonds in specific substrates,cleavage and functionalization of C–C bonds in acyclic substrates,such as ethane derivatives,remains *** contrast to the well-developed functionalization of one carbon fragment after C–C bond cleavage,herein,we report a novel electro-reductive carboxylation of C(sp^(3))–C(sp^(3))bond in multi-aryl ethanes with carbon dioxide(CO_(2))by utilizing both carbon ***,this reaction exhibits an atom-,step-economic approach for the synthesis of carboxylic acids,fulfilling principal aspirations of organic ***,this method features mild reaction conditions,broad substrate scope,and good functional group *** and asymmetric substrates bearing primary,secondary,or tertiary C(sp^(3))–C(sp^(3))bonds are all amenable to this strategy,enabling one or two structurally different carboxylic acids to be facilely constructed at the same *** investigations indicate that carbanions might be the key intermediates in this reaction,which could be captured by CO_(2)efficiently.

关键词： carbon dioxide electrochemistry C(sp^(3))–C(sp^(3))bonds cleavage reductive carboxylation

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制造业开放式科技创新模式的灰色关联分析

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科技管理研究 2020年第6期40卷 7-14页

作者：陶权江汉大学商学院湖北武汉430056

我国采取以生产总值增长为目的的激励机制是影响制造业开放式自主创新的一个重要因素。选取《中国统计年鉴》和中国经济信息网(中经专网)统计数据库2007—2018年的数据,对我国制造业开放式科技创新与各相关指标进行灰色关联分析。研究表... 详细信息

我国采取以生产总值增长为目的的激励机制是影响制造业开放式自主创新的一个重要因素。选取《中国统计年鉴》和中国经济信息网(中经专网)统计数据库2007—2018年的数据,对我国制造业开放式科技创新与各相关指标进行灰色关联分析。研究表明:地区经济增长是影响制造业开放式科技创新效率的主要因素,城镇化率提高也对促进制造业开放式科技创新有着重要影响,人口数量增加、价格变动、产业结构调整及技术进步等都对制造业开放式科技创新效率的提升具有正相关影响。最后提出进一步扩大制造业科技创新开放度、提高资源配置效率和开放创新效率,加大自主研发力度并加强消化吸收外部技术、提高新技术利用率等相关建议,以促进我国制造业企业提升科技创新效率。

关键词：制造业开放式创新创新模式灰色关联

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利益集团游说博弈对贸易制度的影响

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商业研究 2015年第7期 86-91页

作者：陶权江汉大学武汉城市圈制造业发展研究中心武汉430056

目前,各国在制定贸易制度时不可避免地受到利益集团为了自身利益而采用各种方式直接或间接地游说政府相关部门,使之制定有利于利益集团利益的贸易政策或制度。本文应用30个国家的数据资料,就利益集团如何通过游说政府制定有利于自身利... 详细信息

目前,各国在制定贸易制度时不可避免地受到利益集团为了自身利益而采用各种方式直接或间接地游说政府相关部门,使之制定有利于利益集团利益的贸易政策或制度。本文应用30个国家的数据资料,就利益集团如何通过游说政府制定有利于自身利益的贸易制度进行分析,并发现了利益集团游说博弈内生决定贸易制度的重要性。

关键词：利益集团游说博弈贸易制度

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