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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 44-45页

作者： Knol A.C. quéreux g. Marques-Briand S. B. Dreno 冯义国 INSERM U601 CHU Htel-Dieu 9 quai M-oncousu 44093 Nantes Cedex 01 France

Patients exhibiting.association between vitilig. and cutaneous T-cell lymphoma (CTCL) remain rare and it is not known whether some T-cell subpopulations of CTCL in the skin are able to recog.ize specific melanocytic epitopes and thus induce vitilig.. The aim of our study was to determine whether T cells specific to melanocyte differentiation antig.ns were detectable among.tumour-infiltrating.lymphocytes (TIL) in the hypopig.ented skin of a patient with Sé zary syndrome (SS). A 71-year-old patient presented with SS and developed vitilig. during.the course of her disease. Immunohistochemical studies showed staining.with HMB45 and MelanA antibodies in the pig.ented skin biopsy, whereas no staining.was observed in the hypopig.ented skin biopsy. To analyse responses to melanocyte differentiation antig.ns, we used a transient COS transfection assay that permits an estimation of CD8 T-cell responses ag.inst a- larg. number of HLA/antig.n combinations. This technique allowed the detection of melanocyte differentiation antig.n-specific T lymphocytes, directed mainly ag.inst Melan-A/MART1 antig.n in the HLA-A 23 context. Our study supports the concept that vitilig. that has developed during.the evolution of a CTCL is related to the presence of a T-lymphocyte subpopulation reactive ag.inst melanocyte differentiation antig.ns (mainly Melan-A/MART1) present in skin lesions. The role of interferon in the induction of this T-lymphocyte subpopulation is discussed.

关键词：白癜风综合征皮肤T细胞淋巴瘤患者发病机制肿瘤浸润淋巴细胞免疫组织化学检查黑色素细胞色素减退性细胞分化抗原

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口服异维A酸治疗痤疮后复发危险因素的前瞻性研究

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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 49-49页

作者： qué reux g. Volteau C. N' g.yen J.M. Dré noB. 罗素菊徐波 Department of Dermatolog. - Dieu Centre Hospitalier Ré gional Universitaire de Nantes Place Alexis- Ricordeau FR- 44035 Nantes Cedex 1 FranceProf.

Backg.ound: The effectiveness of oral isotretinoin ag.inst acne is undeniable. However, few data on the maintenance of effect after treatment termination have been published. Objective: The purpose of the study was to identify the risk factors of relapse after stopping.isotretinoin. Method: This prospective open study examined 52 patients with moderate to severe acne at the Dermatolog.cal Clinic of the Nantes University Hospital (France). Variables likely to influence relapse were studied using.the Cox model. Results: 27 patients (52% ) relapsed after stopping.treatment. In multivariate analysis, severe seborrhoea and a hig. score of inflammatory lesions at the end of the treatment, an early ag., a family history of acne, prepubertal acne and acne extended to the trunk were the factors increasing.sig.ificantly the risk of relapse. Conclusion: Our data allow to define more precisely the profile of acne patients for whom the risk of relapse is hig.est and who should therefore be followed up quite reg.larly after treatment termination.

关键词：重度痤疮痤疮患者青春期前皮脂溢大学医院发病年龄南特多变量分析

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