口服异维A酸治疗痤疮后复发危险因素的前瞻性研究
Prospective study of risk factors of relapse after treatment of acne with oral isotretinoin作者机构：Department of Dermatology - Dieu Centre Hospitalier Ré gional Universitaire de Nantes Place Alexis- Ricordeau FR- 44035 Nantes Cedex 1 FranceProf.
出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)
年 卷 期：2006年第2卷第4期
页 面：49-49页
学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学]
主 题：重度痤疮 痤疮患者 青春期前 皮脂溢 大学医院 发病年龄 南特 多变量分析
摘 要：Background: The effectiveness of oral isotretinoin against acne is undeniable. However, few data on the maintenance of effect after treatment termination have been published. Objective: The purpose of the study was to identify the risk factors of relapse after stopping isotretinoin. Method: This prospective open study examined 52 patients with moderate to severe acne at the Dermatological Clinic of the Nantes University Hospital (France). Variables likely to influence relapse were studied using the Cox model. Results: 27 patients (52% ) relapsed after stopping treatment. In multivariate analysis, severe seborrhoea and a high score of inflammatory lesions at the end of the treatment, an early age, a family history of acne, prepubertal acne and acne extended to the trunk were the factors increasing significantly the risk of relapse. Conclusion: Our data allow to define more precisely the profile of acne patients for whom the risk of relapse is highest and who should therefore be followed up quite regularly after treatment termination.
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