检索结果-南通市图书馆

Malaria from hyperendemicity to elimination along international borders in Yunnan, China during 2003‒2020: a case study

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2022年第3期11卷 69-80页

作者： Hui Liu Yaowu Zhou Yan Deng Zurui Lin Canglin Zhang Qiyan Chen Chun Wei Kaixia Duan Peng Tian Hongning Zhou Jianwei Xu Yunnan Institute of Parasitic Diseases Yunnan Provincial Centre of Malaria ResearchYunnan Provincial Key Laboratory of Vector-Borne Diseases Control and ResearchYunnan Institute of Parasitic Diseases Innovative Team of Key Techniques for Vector Borne Disease Control and PreventionTraining Base of International Scientific Exchange and Education in Tropical Diseases for South and Southeast AsiaPuer665000China

Background: Border malaria is one of the most intractable problems hindering malaria elimination worldwide.Movement of both the human population and anopheline mosquitoes infected with Plasmodium spp.can cause cross-border malaria transmission.The Yunnan border area was still hyperendemic for malaria in the early part of this century.The objective of this case study was to analyze the strategies,interventions and impacts of malaria control and elimination in the Yunnan border area.Main text: A total of 10,349 malaria cases and 17.1 per 10,000 person-years of annual parasite incidence(API)were reported in the border area in 2003.Based on natural village-based stratification,integrated interventions,including mass drug administration for radical cures and preventive treatment,clinically presumptive treatment of all febrile patients for malaria and indoor residual spraying or dipping bed nets with insecticides were successfully carried out from 2003 to 2013.The overall API was reduced to 0.6 per 10,000 person-years by 2013,while effective cross-border collaboration interventions dramatically reduced the malaria burden in the neighbouring border areas of Myanmar.From 2014 forward,the comprehensive strategy,including universal coverage of surveillance to detect malaria cases,a rapid response to possible malaria cases and effective border collaboration with neighbouring areas,successfully eliminated malaria and prevented reintroduction of malaria transmission in the Yunnan border area.Conclusions: In Yunnan malaria burden has successfully reduced by dynamically accurate stratification and comprehensive interventions;and then the region achieved elimination and prevented reintroduction of malaria transmission through intensive surveillance,rapid response and border collaboration.Other border areas should perform their own intervention trials to develop their own effective strategy.

关键词： Malaria Control Elimination Border area International collaboration Yunnan China

HY-1C Coastal Zone Imager observations of the suspended sediment content distribution details in the sea area near Hong Kong-Zhuhai-Macao Bridge in China

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2022年第11期41卷 126-138页

作者： Lina Cai Minrui Zhou Xiaojun Yan Jianqiang Liu qiyan Ji Yuxiang chen Juncheng Zuo Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316004China Key Laboratory of Space Ocean Remote Sensing and Application Ministry of Natural ResourcesBeijing 100081China South China Sea Fisheries Research Institute Chinese Academy of Fishery SciencesGuangzhou 510300China College of Marine Sciences Shanghai Ocean UniversityShanghai 201306China

The impacts of the Hong Kong-Zhuhai-Macao Bridge(HKZMB)on suspended sediment content(SSC)were analysed in the Zhujiang River Estuary based on data from HY-1C,which was launched in September 2018 in China,carrying Coastal Zone Imager(CZI)and Chinese Ocean Color and Temperature Scanner on it.A new SSC inversion model was established based on the relationship between in-situ SSC and the remote sensing reflectance in red and near-infrared bands of CZI image.HY-1C satellite data obtained from October to December 2019 were applied to retrieve SSC in the Zhujiang River Estuary.The results show that SSC around the HKZMB is ranging from 20 mg/L to 95 mg/L.SSC change obviously on two sides of the bridge.During flooding and ebbing period,SSC increases obviously downstream of the bridge.SSC difference between upstream and downstream is ranging from 5 mg/L to 20 mg/L.Currents flowing across the HKZMB,the change trend of SSC in most places upstream and downstream is almost the same that SSC downstream of the bridge is higher than SSC upstream.The tidal currents interact with bridge piers,inducing vortexes downstream,leading the sediment to re-suspend downstream of the bridge piers.Other factors,including seafloor topography and wind,can also contribute to the distribution of SSC in the Zhujiang River Estuary.

关键词： HY-1C Coastal Zone Imager(CZI) Hong Kong-Zhuhai-Macao Bridge suspended sediment content Zhujiang River Estuary

Recent applications of radical cascade reaction in the synthesis of functionalized 1-indenones

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2019年第7期30卷 1361-1368页

作者： Yinli Zhang Kai Sun qiyan Lv Xiaolan chen Lingbo Qua Bing Yu College of Chemistry and Molecular Engineering Zhengzhou University Zhengzhou 450001 China Henan Nonferrous Metals Geological Exploration Institute Zhengzhou 450052 China

1-Indenones are important scaffolds in natural products, biologically active molecules as well as functional materials. Recently, radical cascade cyclization has emerged as an efficient and powerful strategy for the construction of valuable and versatile functionalized 1-indenones. In this review, the recent advances of this rapidly growing area were summarized. The selected examples have been classified according to the type of reaction substrates such as 1,3-diarylpropynones, 2-alkynylbenzonitriles, arylpropynols, 1,5-enynes and 2-alkynylated bromocinnamates.

关键词： Radical cascade reaction 1,3-Diarylpropynones 2-Alkynylbenzonitriles Arylpropynols 1-Indenones

Characteristics of water contamination in abandoned coal mines:a case study on Yudong River area,Kaili,Guizhou Province,China

在线全文

学校读者我要写书评

暂无评论

International Journal of Coal Science & Technology 2021年第6期8卷 1491-1503页

作者： Xiangdong Li Jieying Cai Di chen qiyan Feng School of Environment Science and Spatial Informatics China University of Mining and TechnologyXuzhou 221116China Low Carbon Energy Institute China University of Mining and TechnologyXuzhou 221116China

The seasonal and spatial changes in the chemical composition of the water in abandoned mine drainages and rivers in Yudong River area in the years of 2017-2018 were analyzed.The effects of mine water drainage on the seasonality and physicochemical properties of the river water after mine closure were evaluated,and the feasibility of irrigation using river water and the degree of pollution to farmland were assessed using the Water Quality Standard for Farmland Irrigation.The results show that the mine water has low pH value(<3.5-4)and high levels of total hardness,SO_(4)^(2−),Fe,Al,and Zn.In addition,the pH of the mine water is negatively correlated with the presence of other metal ions.The correlation coefficient between the chemical oxygen demand(COD)and Fe reached 0.989.While the pollution levels of Pinglu and Baishui rivers were low,the confluence region of the two rivers was seriously polluted.However,only the levels of Fe and Cd slightly exceeded the Surface Water Environmental Quality Standard after the confluence of Yudong and Chongan rivers.Overall,the heavy pollution type of the confluent river is consistent with mine water pollution.The water quality is slightly better in the dry season compared than in the high-water period.Sulfate and Fe content decreased by 39 and 16 mg/L,respectively,and Cd content decreased two-fold.Despite these findings,this study shows that from 2017 to 2018,the pH and Cd content of the rivers at the confluence exceeded the irrigation limit and the water quality continued to deteriorate,which may pose a soil contamination risk.Long-term use of the river for irrigation water may cause toxic elements such as Cd,Fe,Mn,SO_(4)^(2−),Al,and F-to enter the food chain,thereby endangering the life and health of villagers in Yudong River area.

关键词： Yudong River(Guizhou) Closed coal mine Surface water pollution Irrigation water quality Soil and crop hazards

Analyses of a Glycine max Degradome Library Identify microRNA Targets and MicroRNAs that Trigger Secondary SiRNA Biogenesis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2013年第2期55卷 160-176页

作者： Zheng Hu qiyan Jiang Zhiyong Ni Rui chen Shuo Xu Hui Zhang The National Key Facilities for Crop Genetic Resources and Improvement Institute of Crop Sciences Chinese Academy of Agricultural Sciences Central Laboratory of Tianjin Academy of Agricultural Sciences

Plant microRNAs （miRNAs） regulate gene expression mainly by guiding cleavage of target mRNAs. In this study, a degradome library constructed from different soybean （Glycine max （L.） Merr.） tissues was deep-sequenced. 428 potential targets of small interfering RNAs and 25 novel miRNA families were identified. A total of 211 potential miRNA targets, including 174 conserved miRNA targets and 37 soybean- specific miRNA targets, were identified. Among them, 121 targets were first discovered in soybean. The signature distribution of soybean primary miRNAs （pri-miRNAs） showed that most pri-miRNAs had the characteristic pattern of Dicer processing. The biogenesis of TAS3 small interfering RNAs （siRNAs） was conserved in soybean, and nine Auxin Response Factors were identified as TAS3 siRNA targets. Twenty- three miRNA targets produced secondary small interfering RNAs （siRNAs） in soybean. These targets were guided by five miRNAs： gma-miR393, gma-miR1508, gma-miR1510, gma-miR1514, and novel-11. Multiple targets of these secondary siRNAs were detected. These 23 miRNA targets may be the putative novel TAS genes in soybean. Global identification of miRNA targets and potential novel TAS genes will nnntrihnltp, tn r~__~nrP.h nn th~ f, mP.tinn_~ nf miRNA~ in ~nvh^n

关键词： miRNAs miRNA targets secondary siRNAs degradome Glycine max.

Effects of acid drainage from abandoned coal mines on the microbial community of Shandi River sediment,Shanxi Province

在线全文

学校读者我要写书评

暂无评论

International Journal of Coal Science & Technology 2021年第4期8卷 756-766页

作者： Di chen qiyan Feng Wenbo Li Yuan Song Chunhong Zhao Collaborative Innovation Center for Resource Utilization and Ecological Restoration of Old Industrial Base China University of Mining and TechnologyXuzhou 221116China School of Environment Science and Spatial Informatics China University of Mining and TechnologyXuzhou 221116China Institute of Karst Geology of Chinese Academy of Geology Sciences Guilin 541004China

The discharge of acid mine drainage from abandoned high sulfur(S)coal mines has caused serious pollution in the Shandi River,Yangquan,Shanxi Province.To determine the impact of long-term acid mine drainage on the microorganisms in the river,we collected river sediments from a polluted tributary(Group P)and the mainstream of Shandi River(Group R)to study the bacterial diversity and community composition.The results showed that the tributary was seriously polluted by acid drainage from abandoned coal mines,with the pH value of the sediment being<2.5,resulting in the low bacterial richness and diversity of the tributary samples.Acidophillic Fe-and S-metabolizing bacteria,such as Metallibacterium,Acidiphilium,and Acidithiobacillus,were the dominant genera in Group P samples,while the Group R was dominated by the neutral anaerobic iron-reducing bacteria Geothrix and Geobacter.Results of principal co-ordinates analysis(PCoA)revealed that the bacterial communities are significantly different between groups P and R,and the significant different species were mainly attributed to phylum Proteobacteria,Actinobacteria,and Acidobacteria.The distribution of the microbial community is mainly influenced by pH,and the Fe and Cd concentrations.Metallicactrium,the dominant genus,is negatively correlated with pH(R^(2)=-0.95)and positively correlated with Fe(R^(2)=0.99),while Geothrix and Geobacter,are mainly affected by the heavy metals.This study determined the impact of river pollution caused by abandoned coal mine drainage,especially on the microbial diversity and community composition within the river sediment.

关键词： Abandoned coal mine Acid mine drainage Bacterial community River sediment PCoA

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

数字化背景下传统产业转型升级路径研究

中国商论 2022年第21期 150-152页

作者：陈绮燕广东省佛山市南海区西樵镇人民政府广东佛山528211

纺织业是广东省佛山市南海区重要的传统产业,主要以中小企业为主,产品附加值有待提高,数字化供应链管理水平普遍偏低,且受新冠疫情、市场、资源压力等多重因素影响,大力推动传统纺织向数智化升级发展,加快纺织与现代服务业的耦合共生,... 详细信息

纺织业是广东省佛山市南海区重要的传统产业,主要以中小企业为主,产品附加值有待提高,数字化供应链管理水平普遍偏低,且受新冠疫情、市场、资源压力等多重因素影响,大力推动传统纺织向数智化升级发展,加快纺织与现代服务业的耦合共生,成为推进产业转型升级,重构双循环格局,实现纺织产业动力变革、效率变革及高质量发展的必由之路。

关键词：数字化传统产业转型升级纺织业现代服务业

Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2021年第2期10卷 155-162页

作者： Maojun Yao Hui Teng qiyan Lv Huifang Gao Tengming Guo Yiwen Lin Sihai Gao Meihu Ma Lei chen College of Chemistry and Chemical Engineering Jishou UniversityJishou416000China College of Food Science Fujian Agriculture and Forestry UniversityFuzhouFujian 350002China National Research and Development Center for Egg Processing College of Food Science and TechnologyHuazhong Agricultural UniversityWuhanHubei430070China Department of Cardiothoracic and Vascular Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei430070China College of Food Science and Technology Guangdong Ocean UniversityZhanjiang 524025China

Dihydromyricetin(DHM),as a bioactive flavanonol compound,is mainly found in“Tengcha”(Ampelopsis grossedentata)cultivated in south of China.This study aimed to investigate the anti-hyperglycemic and antidyslipidemic activities of DHM using type 2 diabetes mellitus(T2D)rats,which was induced by feeding with high fat and fructose diet for 42 days and intraperitoneal administration of streptozocin.Forty-eight freshlyweaned rats were randomly assigned into the negative control(Blank),low dose(100 mg/kg),medium dose(200 mg/kg),high dose(400 mg/kg),and positive(40 mg/kg,met)groups.Fasting blood glucose and body weight were measured at weekly interval.Oral glucose tolerance tests were performed on days 42.The results revealed that DHM possessed significant antihyperglycaemic and antihyperinsulinemic effects.Moreover,after the DHM treatment,p-Akt and p-AMPK expression was upregulated,and glycogen synthase kinase-3β(GSK-3β)expression was downregulated,indicating that the potential anti-diabetic mechanism of DHM might be due to the regulation of the AMPK/Akt/GSK-3βsignaling pathway.

关键词： Dihy dromyricetin Type 2 diabetes Hypolipidemic Hypoglycemic AMPK/Akt/GSK-3βsignaling pathway

Current state and future of co-inhibitory immune checkpoints for the treatment of glioblastoma

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2020年第3期17卷 555-568页

作者： Shaoping Shen Ling chen Jialin Liu Lin Yang Mengna Zhang Lingxiong Wang Rong Zhang Yasushi Uemura qiyan Wu Xinguang Yu Tianyi Liu Department of Neurosurgery Chinese PLA General HospitalBeijing 100853China Pediatric Center Chinese PLA General HospitalBeijing 100853China Key Laboratory of Cancer Center Chinese PLA General HospitalBeijing 100853China Division of Cancer Immunotherapy Exploratory Oncology Research and Clinical Trial CenterNational Cancer CenterKashiwa 277-8577Japan

In the interaction between a tumor and the immune system,immune checkpoints play an important role,and in tumor immune escape,co-inhibitory immune checkpoints are important.Immune checkpoint inhibitors(ICIs)can enhance the immune system's killing effect on tumors.To date,impressive progress has been made in a variety of tumor treatments;PD1/PDL1 and CTLA4 inhibitors have been approved for clinical use in some tumors.However,glioblastoma(GBM)still lacks an effective treatment.Recently,a phase III clinical trial using nivolumab to treat recurrent GBM showed no significant improvement in overall survival compared to bevacizumab.Therefore,the use of immune checkpoints in the treatment of GBM still faces many challenges.First,to clarify the mechanism of action,how different immune checkpoints play roles in tumor escape needs to be determined;which biomarkers predict a benefit from ICIs treatment and the therapeutic implications for GBM based on experiences in other tumors also need to be determined.Second,to optimize combination therapies,how different types of immune checkpoints are selected for combined application and whether combinations with targeted agents or other immunotherapies exhibit increased efficacy need to be addressed.All of these concerns require extensive basic research and clinical trials.In this study,we reviewed existing knowledge with respect to the issues mentioned above and the progress made in treatments,summarized the state of ICIs in preclinical studies and clinical trials involving GBM,and speculated on the therapeutic prospects of ICIs in the treatment of GBM.

关键词： Immunotherapy glioblastoma co-inhibitory immune checkpoint checkpoint inhibitors combination therapy