Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats

作     者：Maojun Yao Hui Teng Qiyan Lv Huifang Gao Tengming Guo Yiwen Lin Sihai Gao Meihu Ma Lei Chen Maojun Yao;Hui Teng;Qiyan Lv;Huifang Gao;Tengming Guo;Yiwen Lin;Sihai Gao;Meihu Ma;Lei Chen

作者机构：College of Chemistry and Chemical EngineeringJishou UniversityJishou416000China College of Food ScienceFujian Agriculture and Forestry UniversityFuzhouFujian 350002China National Research and Development Center for Egg ProcessingCollege of Food Science and TechnologyHuazhong Agricultural UniversityWuhanHubei430070China Department of Cardiothoracic and Vascular SurgeryTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei430070China College of Food Science and TechnologyGuangdong Ocean UniversityZhanjiang 524025China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2021年第10卷第2期

页      面：155-162页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 083201[工学-食品科学] 

基　　金：the National Natural Science Foundation of China(NSFC,Grant No.31801459,31701520) Science and Technology General Projects of Fujian Province(2019J01393) Educational research project for young and middleaged teachers in Fujian Province(JT180116). 

主　　题：Dihy dromyricetin Type 2 diabetes Hypolipidemic Hypoglycemic AMPK/Akt/GSK-3βsignaling pathway 

摘      要：Dihydromyricetin(DHM),as a bioactive flavanonol compound,is mainly found in“Tengcha(Ampelopsis grossedentata)cultivated in south of China.This study aimed to investigate the anti-hyperglycemic and antidyslipidemic activities of DHM using type 2 diabetes mellitus(T2D)rats,which was induced by feeding with high fat and fructose diet for 42 days and intraperitoneal administration of streptozocin.Forty-eight freshlyweaned rats were randomly assigned into the negative control(Blank),low dose(100 mg/kg),medium dose(200 mg/kg),high dose(400 mg/kg),and positive(40 mg/kg,met)groups.Fasting blood glucose and body weight were measured at weekly interval.Oral glucose tolerance tests were performed on days 42.The results revealed that DHM possessed significant antihyperglycaemic and antihyperinsulinemic effects.Moreover,after the DHM treatment,p-Akt and p-AMPK expression was upregulated,and glycogen synthase kinase-3β(GSK-3β)expression was downregulated,indicating that the potential anti-diabetic mechanism of DHM might be due to the regulation of the AMPK/Akt/GSK-3βsignaling pathway.