检索结果-南通市图书馆

武汉工业大学学报 2001年第2期23卷 69-71页

作者：陈祁岩武汉理工大学

在探讨了广告设计艺术的理论基础和广告设计艺术风格的涵义的基础上 ,进一步研究了广告艺术风格的地域特征和时代特征。

关键词：广告设计艺术风格数字化地域特征

对标准《疟原虫检测血涂片镜检法》的几点思考

在线全文

学校读者我要写书评

暂无评论

中国卫生标准管理 2019年第9期10卷 24-27页

作者：孙晓东吕全赵晓涛许时燕林祖锐周耀武段凯霞丁春丽陈柒言田鹏云南省寄生虫病防治所疟疾防制科/云南省疟疾研究中心/云南省虫媒传染病防控研究重点实验室云南普洱665000

《疟原虫检测血涂片镜检法》(WS/T 569—2017)标准的颁布与实施,为我国消除疟疾血涂片显微镜检测提供了统一的操作流程和技术规范,保障了血涂片镜检质量。本文通过对比我国标准和WHO推荐方法,结合云南现场实际,从血涂片制作、薄血膜固... 详细信息

《疟原虫检测血涂片镜检法》(WS/T 569—2017)标准的颁布与实施,为我国消除疟疾血涂片显微镜检测提供了统一的操作流程和技术规范,保障了血涂片镜检质量。本文通过对比我国标准和WHO推荐方法,结合云南现场实际,从血涂片制作、薄血膜固定和血片染色三个方面探讨标准的应用。

关键词：疟原虫血涂片显微镜检测标准应用

在线全文

学校读者我要写书评

暂无评论

软骨母细胞瘤9例报告

解放军医学杂志 1985年第2期 110-112页

作者：钟国荣马义太王隐村卢起棪温端生陈三立阎桂莲曾万铮福州军区总医院骨科

本文报告了9例软骨母细胞瘤。男7例,女2例。发病年龄6个月～23岁。其中1例发病年龄为6个月者,且发病部位在左颞骨,实属罕见。9例均采用手术治疗。随访5个月～14年5个月。除1例截肢术后5个月尚需继续随访观察外,其余8例愈合良好,未见复发。

关键词：良性软骨母细胞瘤骨母细胞股骨下端胫骨近端刮除植骨

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

云南城市经济影响区空间组织演变规律

地理学报 2007年第12期62卷 1244-1252页

作者：吴启焰陈浩云南大学城市建设与管理学院

对1990-2004年云南省城镇发展差异进行分析,发现自20世纪90年代以来云南省城市综合实力总体呈差异扩大的趋势,表现出小城市发展缓慢且分化不明显,少数高位城市极化,在空间呈现明显的核心—边缘倾向等特征。其后,进一步展示云南省城市经... 详细信息

对1990-2004年云南省城镇发展差异进行分析,发现自20世纪90年代以来云南省城市综合实力总体呈差异扩大的趋势,表现出小城市发展缓慢且分化不明显,少数高位城市极化,在空间呈现明显的核心—边缘倾向等特征。其后,进一步展示云南省城市经济影响区空间演化的阶段性规律:①20世纪90年代以前云南省城市经济影响区被特殊的地理环境分割成破碎且难以整合的小型离散化的格局;②自20世纪90年代以来,随着地区工业化和城市化加速进行,交通通讯网络的发育和辐射,中小城市得以发育,伴随于城市经济影响区空间扩张与收缩,云南省城市经济影响区逐渐从单层离散分布演变为三层嵌套结构,并不断朝更高级的结构形态演进,即云南省城市经济影响区空间呈现显著的、由小规模离散分布阶段、过渡转型阶段到嵌套复合阶段的时空演化序列。最后,针对这种时空演化序列,笔者解析出云南省城市经济影响区在不同时空条件组合下的三种空间扩展类型:单向拓展类型、多向拓展类型和邻接扩展类型。

关键词：城市经济影响区空间演化规律云南

An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2015年第4期13卷 258-270页

作者： qiyan Wang Jian Bai Amir Abliz Ying Liu Kenan Gong Jingjing Li Wenjie Shi Yaqi Pan Fangfang Liu Shujuan Lai Haijun Yang Changdong Lu Lixin Zhang Wei chen Ruiping Xu Hong Cai Yang Ke Changqing Zeng MOE Key Laboratory of Carcinogenesis and Translational Research Laboratory of Genetics Peking UniversityCancer Hospital & Institute Beijing University of Chinese Medicine CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics Chinese Academy of Sciences University of Chinese Academy of Sciences Anyang Cancer Hospital

Esophageal squamous cell carcinoma （ESCC） has a high mortality rate. To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exonic mutations and structural alterations. The clinical implications of these genetic alterations were also analyzed. Exome sequencing and verification were performed for nine pairs of ESCC and the matched blood samples, followed by validation with additional sam- ples using Sanger sequencing. Whole-genomc SNP arrays were employed to detect copy number alteration （CNA） and loss of heterozygosity （LOH） in 55 cases, including the nine ESCC samples subjected to exome sequencing. A total of 108 non-synonymous somatic mutations （NSSMs） in 102 genes were verified in nine patients. The chromatin modification process was found to be enriched in our gene ontology （GO） analysis. Tumor genomes with TP53 mutations were signifi- cantly more unstable than those without TP53 mutations. In terms of the landscape of genomic alterations, deletion of 9p21.3 covering CDKN2A/2B （30.9%）, amplification of 1 1q13.3 covering CCND1 （30.9%）, and TP53 point mutation （50.9%） occurred in two-thirds of the cases. These results suggest that the deregulation of the G1 phase during the cell cycle is a key event in ESCC. Furthermore, six minimal common regions were found to be significantly altered in ESCC samples and three of them, 9p21.3, 7p 11.2, and 3p 12.1, were associated with lymph node metastasis. With the high correlation of TP53 mutation and genomic instability in ESCC, the amplification of CCND1, the deletion of CDKN2A/2B, and the somatic mutation of TP53 appear to play pivotal roles via G1 deregulation and therefore helps to classify this cancer into different genomic subtypes. These findings provide clinical significance that could be useful in future molecular diagnoses and therapeutic targeting.

关键词： Esophageal squamous cell carcinoma Genomic subtype somatic mutation Copy number alteration Cell cycle deregulation

Estimating Costs of the HIV Comprehensive Intervention Using the Spectrum Model--China,2015-2019

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2022年第25期4卷 554-559,I0002页

作者： Youran Zhang Lili Wang Zhen Jiang Hongjing Yan Xiaoxia Liu Jing Gu Guoyong Wang Xiaosong cheng qiyan Leng Qisui Long Zimian Liang Jing Wang Liang Liang Yanchao Qiu Lin chen Hang Hong School of Health Service Management Anhui Medical UniversityHefei CityAnhui ProvinceChina Division of Prevention and intervention National Center for AIDS and STD Control and PreventionChinese Center for Disease Control and PreventionBeijing MunicipalityChina Jiangsu Provincial Center for Disease Control and Prevention Nanjing CityGuangxi Zhuang Autonomous RegionChina Zhenjiang Center for Disease Control and Prevention Zhenjiang CityJiangsu ProvinceChina Wuxi Center for Disease Control and Prevention Wuxi CityJiangsu ProvinceChina Shandong Provincial Center for Disease Control and Prevention Jinan CityJiangsu ProvinceChina Yantai Center for Disease Control and Prevention Yantai CityShandong ProvinceChina Guangdong Provincial Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Foshan Center for Disease Control and Prevention Foshan CityGuangdong ProvinceChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang CityHebei ProvinceChina Shijiazhuang Center for Disease Control and Prevention Shijiazhuang CityHebei ProvinceChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Ningbo Center for Disease Control and Prevention Ningbo CityZhejiang ProvinceChina

Introduction:In order to facilitate human immunodeficiency virus(HIV)treatment and prevention,the resource needs for HIV national strategic planning in developing regions were estimated based on Spectrum,the universal HIV costeffectiveness analysis ***:Based on the theoretical framework of Spectrum,the study developed a cost measurement tool for HIV,and calculated the cost of HIV prevention and control in 6 sampled cities in China during 2015–2019 using the Spectrum ***:From 2015 to 2019,the average annual costs for HIV prevention and control for Shijiazhuang,Yantai,Ningbo,Zhenjiang,Foshan,and Wuxi cities were 46.78,47.55,137.49,24.73,74.37,and 58.30 million Chinese yuan(CNY),*** per capita costs were 4.37,6.73,17.33,7.77,17.56,and 8.91 CNY,*** terms of the cost structure,the ratio of preventive intervention funds to therapeutic intervention funds(antiviral treatment)varied in sampled ***:Developing comprehensive and systematic HIV fund calculation methods can provide a research basis for rational resource allocation in the field of HIV.

关键词： prevention Ningbo rational

Classifications and Functions of Vitreoretinal Surgery Assisted Robots——A Review of the State of the Art

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Classifications and Functions of Vitreoretinal Surgery Assis...

作者： XIAO Jingjing WU qiyan SUN Daoheng HE Changyan chen Yiqi School of Aerospace Engineering Xiamen University Xiamen Hongfa Electroacoustic Co. Ltd School of Mechanical Engineering and Automation Beihang University The Eye Hospital of Wenzhou Medical University

To overcome the surgeon’s manual operation limitations in vitreoretinal microsurgery,many kinds of robots are developed to enhance the operation accuracy,including Master-Slave Teleoperation Robot（MSTR）,Hand-Held Robot（HHR）,Cooperative Robot（CR） and Micro Robot（MR）.With the introduction of vitreoretinal surgical assisted robots（VRSARs）,the surgeon’s operation skills can be improved through various functions of the robots,such as depth information perception,improvement of the surgical precision,and micro-force perception and *** description and classification of the latest research progress of VRSARs,the current problems of each type of VRSARs were discussed and future works summarized for further research.

关键词： Vitreoretinal Surgery Assisted Robots(VRSARs) Depth Information Perception Improvement of Surgical Precision Micro-force Perception and Feedback

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

男性理想体型变化及其影响因素

心理科学进展 2017年第4期25卷 627-638页

作者：施启琰寇慧陈红西南大学心理学部认知与人格教育部重点实验室重庆400715

现代男性对自身体型的关注程度日益升高,理想体型也发生变化,从单一的肌肉发达体型发展为低体脂高肌肉的双维度体型。影响男性理想体型的因素主要分为两类:生物因素和社会文化因素。生物因素方面,不同性别、年龄和性取向的群体拥有不同... 详细信息

现代男性对自身体型的关注程度日益升高,理想体型也发生变化,从单一的肌肉发达体型发展为低体脂高肌肉的双维度体型。影响男性理想体型的因素主要分为两类:生物因素和社会文化因素。生物因素方面,不同性别、年龄和性取向的群体拥有不同的男性理想体型;社会文化方面,社会文化通过家庭、同伴和媒体三个渠道向理想体型施加影响。未来的研究应该进一步通过实验确立体脂与肌肉双维度的男性理想体型,并结合纵向研究验证生物及社会文化因素的影响,完善男性理想体型的理论系统,为政府制定身体意象相关的干预措施和政策提供详实有力的理论依据。

关键词：男性理想体型生物因素社会文化因素

在线全文

学校读者我要写书评

暂无评论

猪腹膜间皮细胞的分离培养及初步应用

畜牧兽医学报 2024年第3期55卷 1249-1256页

作者：黄媛媛王佳陈嘉瑜甘源袁厅冯志新邵国青王先炜熊祺琰南京农业大学动物医学院南京210095 江苏省农业科学院兽医研究所/农业部兽用生物制品工程技术重点实验室南京210014 兽用生物制品(泰州)国泰技术创新中心泰州225300

本研究旨在建立猪原代腹膜间皮细胞(peritoneal mesothelial cell, PMC)的分离和体外培养方法,并将其初步应用于猪鼻支原体(Mycoplasma hyorhinis,Mhr)体外感染细胞模型。采用0.1%Ⅰ型胶原酶消化猪大网膜组织分离猪PMC细胞,通过形态学... 详细信息

本研究旨在建立猪原代腹膜间皮细胞(peritoneal mesothelial cell, PMC)的分离和体外培养方法,并将其初步应用于猪鼻支原体(Mycoplasma hyorhinis,Mhr)体外感染细胞模型。采用0.1%Ⅰ型胶原酶消化猪大网膜组织分离猪PMC细胞,通过形态学、免疫学方法鉴定细胞。使用Mhr感染PMC细胞,观察细胞形态变化,并利用乳酸脱氢酶(lactate dehydrogenase, LDH)法检测细胞活性损伤情况。结果显示,倒置相差显微镜观察显示,分离培养的细胞早期呈拉网状,5~8 d后生长可达融合状态,细胞大小均一,呈多边形铺路石状;间接免疫荧光试验结果显示,细胞波形蛋白、角蛋白-18抗原呈阳性,第Ⅷ因子相关抗原、白细胞CD45抗原呈阴性;扫描电镜下可见细胞表面微绒毛。结果证实分离培养的细胞为猪PMC细胞,纯度达95%以上。Mhr感染后,光镜下可观察到细胞发生明显皱缩,感染组细胞的LDH释放量较对照组细胞显著升高。本研究成功建立了猪原代PMC细胞的分离培养方法,并初步用于Mhr体外感染,为研究Mhr等引起浆膜炎的病原与宿主的互作机制提供了体外细胞模型。

关键词：腹膜间皮细胞原代培养猪猪鼻支原体

Pressure-induced strongadhesion between chitosan nanofilms

在线全文

学校读者我要写书评

暂无评论

Journal of Southeast University(English Edition) 2015年第1期31卷 113-117页

作者：谭启檐阚亚鲸赵古田裘英华陈云飞东南大学机械工程学院南京211189 江苏省微纳生物医疗器械设计与制造重点实验室南京211189

The surface and adhesion forces between chitosan- coated mica surfaces in an acetic acid buffer solution were measured using a surface force apparatus （SFA）. The force- distance profiles were obtained under different pressure conditions. It was found that the chitosan was adsorbed on the mica surface and formed a stable nanofilm under acid conditions. The adsorbed chitosan nanofilms induced a short- range monotonically steric force when two such surfaces came close in the acid buffer. The adhesion forces between the two chitosan-coated mica surfaces varied with the loads. Strong adhesion between the two chitosan-coated mica surfaces was observed at high pressure. Such pressure-dependent adhesion properties are most likely related to the molecular configurations and hydrogen bonds reordering under high confinement.

关键词： surface force apparatus (SFA) chitosan adhesion pressure mica surface