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Nano-Medicine for Thrombosis:A Precise Diagnosis and Treatment Strategy

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Nano-Micro Letters 2020年第8期12卷 25-45页

作者： Min Su qixuan Dai Chuan Chen Yun Zeng Chengchao Chu Gang Liu State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102People’s Republic of China State Key Laboratory of Physical Chemistry of Solid Surfaces The MOE Key Laboratory of Spectrochemical Analysis and InstrumentationCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005People’s Republic of China Department of Pharmacy Xiamen Medical CollegeXiamen 361023People’s Republic of China Xiamen Cardiovascular Hospital Xiamen UniversityXiamen 361102People’s Republic of China

Thrombosis is a global health issue and one of the leading factors of ***,its diagnosis has been limited to the late stages,and its therapeutic window is too narrow to provide reasonable and effective *** addition,clinical thrombolytics suffer from a short half-life,allergic reactions,inactivation,and unwanted tissue ***-medicines have gained extensive attention in diagnosis,drug delivery,and photo/sound/magnetic-theranostics due to their convertible ***,diagnosis and treatment of thrombosis using nano-medicines have also been widely *** review summarizes the recent advances in this area,which revealed six types of nanoparticle approaches:(1)in vitro diagnostic kits using“synthetic biomarkers”;(2)in vivo imaging using nano-contrast agents;(3)targeted drug delivery systems using artificial nanoparticles;(4)microenvironment responsive drug delivery systems;(5)drug delivery systems using biological nanostructures;and(6)treatments with external *** investigations of nano-medicines are believed to be of great significance,and some of the advanced drug delivery systems show potential applications in clinical theranotics.

关键词： Thrombosis Nano-medicine Diagnosis Thrombolytic therapy

高级氧化技术去除水中药物和个人护理品的研究进展

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辽宁化工 2024年第3期53卷 434-438页

作者：孙宁宁林英姿刘成宇翁启暄陈静王梦实曹炼吉林建筑大学市政与环境工程学院吉林长春130118 吉林建筑大学松辽流域水环境教育部重点实验室吉林长春130118

随着人们生活水平的提高,药物和个人护理品(PPCPs)的用量不断增加,常规水处理工艺中对PPCPs的去除效果不佳,导致其在水体中频繁被检出,对生态环境和人体健康产生潜在风险。因此,迫切需要更先进的水处理技术去除PPCPs。介绍了含有PPCPs... 详细信息

随着人们生活水平的提高,药物和个人护理品(PPCPs)的用量不断增加,常规水处理工艺中对PPCPs的去除效果不佳,导致其在水体中频繁被检出,对生态环境和人体健康产生潜在风险。因此,迫切需要更先进的水处理技术去除PPCPs。介绍了含有PPCPs的水质特征,回顾了传统的水处理方法优缺点,重点介绍了高级氧化法去除水中PPCPs的最新动态和研究进展,总结高级氧化法降解PPCPs存在的问题并对未来的发展提出展望。

关键词：高级氧化药物和个人护理品催化剂水污染控制

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Indocyanine green-based nanodrugs: A portfolio strategy for precision medicine

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Progress in Natural Science:Materials International 2020年第5期30卷 577-588页

作者： qixuan Dai En Ren Dazhuang Xu Yun Zeng Chuan Chen Gang Liu Department of Pharmacy Xiamen Medical College State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Amoy Hopeful Biotechnology Co. Ltd.

As the sole cyanine dye approved by the Food and Drug Administration(FDA), indocyanine green(ICG) has been widely applied in solid tumor and metastases surgical navigation as well as malignant tissue destruction. The great performance of ICG benefits from excellent fluorescent properties in the near infrared region(NIR) and reactive oxygen species(ROS) or hyperthermia effects under irradiation. Nevertheless, some intrinsic limitations, such as unstable optical properties, concentration-dependent aggregation, proneness to photo-bleaching, and poor aqueous stability in vivo, severely restrict its further applications. To overcome these challenges, ICG-based nanodrugs(nanoICG), as one kind of portfolio strategy, could bridge the efficient cargo-carriers and ICG molecules to artificially improve their existing performance. In this mini-review, we will focus on the developed engineering strategies for nano-ICG formulation synthesis and their desired performance in tumor tracing and eradication. A critical analysis of assembly mechanisms, excellent performance, and further improvement tactics will be examined.

关键词： ICG Nanomedicine Self-assembly Tumor theranostics Tumor synergistic treatment

An Ultra‑Durable Windmill‑Like Hybrid Nanogenerator for Steady and Efficient Harvesting of Low‑Speed Wind Energy

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Nano-Micro Letters 2020年第12期12卷 228-238页

作者： Ying Zhang qixuan Zeng Yan Wu Jun Wu Songlei Yuan Dujuan Tan Chenguo Hu Xue Wang Department of Applied Physics State Key Laboratory of Power Transmission Equipment and System Security and New TechnologyChongqing UniversityChongqing 400044People’s Republic of China Chongqing Key Laboratory of Soft Condensed Matter Physics and Smart Materials Chongqing UniversityChongqing 400044People’s Republic of China

Wind energy is one of the most promising and renewable energy sources;however,owing to the limitations of device structures,collecting low-speed wind energy by triboelectric nanogenerators(TENGs)is still a huge *** solve this problem,an ultra-durable and highly efficient windmill-like hybrid nanogenerator(W-HNG)is ***,the W-HNG composes coupled TENG and electromagnetic generator(EMG)and adopts a rotational contact-separation *** unique design efficiently avoids the wear of friction materials and ensures a prolonged service ***,the generator group is separated from the wind-driven part,which successfully prevents rotation resistance induced by the friction between rotor and stator in the conventional structures,and realizes low-speed wind energy ***,the output characteristics of TENG can be complementary to the different performance advantages of EMG to achieve a satisfactory power *** device is successfully driven when the wind speed is 1.8 m s−1,and the output power of TENG and EMG can achieve 0.95 and 3.7 mW,*** power management,the W-HNG has been successfully applied as a power source for electronic *** work provides a simple,reliable,and durable device for improved performance toward large-scale low-speed breeze energy harvesting.

关键词： Triboelectric nanogenerator Windmill-like structure Rotational contact-separation mode Low-speed wind energy harvesting

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生物性添加剂在青贮饲料中的研究进展

动物营养学报 2023年第3期35卷 1475-1488页

作者：易启轩王鹏吉林大学动物科学学院长春130062

生物性添加剂能改善青贮饲料的青贮品质,提高青贮饲料的利用率,解决饲料供应不平衡问题,从而进一步推动畜牧业可持续发展。生物性添加剂主要包括微生物添加剂和酶制剂。如何发挥出生物性添加剂各自优点,形成协同作用,成为目前高效利用... 详细信息

生物性添加剂能改善青贮饲料的青贮品质,提高青贮饲料的利用率,解决饲料供应不平衡问题,从而进一步推动畜牧业可持续发展。生物性添加剂主要包括微生物添加剂和酶制剂。如何发挥出生物性添加剂各自优点,形成协同作用,成为目前高效利用青贮饲料的关键。基于此,本文对目前国内外生物性添加剂在青贮饲料中的应用进行了分析归纳,总结了其对青贮饲料发酵品质、营养价值、有氧稳定性及动物生产性能的影响,提出了未来生物性添加剂应向复合生物性添加剂(菌种组合和菌酶组合)方向重点发展的观点,以期为研发出具备高效、环保、低成本等优势的新型复合生物性添加剂提供科学性依据。

关键词：青贮饲料生物性添加剂发酵品质有氧稳定性生产性能

Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy

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Cancer Biology & Medicine 2023年第4期20卷 297-316页

作者： Hongxia Chen Luxi Yin Jie Yang Ningxin Ren Jinna Chen qixuan Lu Ying Huang Yanru Feng Weihu Wang Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin Wen Tan Dongxin Lin State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisBeijing Key Laboratory for Carcinogenesis and Cancer PreventionNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

Objective:The identification of biomarkers for predicting chemoradiotherapy efficacy is essential to optimize personalized *** study determined the effects of genetic variations in genes involved in apoptosis,pyroptosis,and ferroptosis on the prognosis of patients with locally advanced rectal cancer receiving postoperative chemoradiotherapy(CRT).Methods:The Sequenom MassARRAY was used to detect 217 genetic variations in 40 genes from 300 patients with rectal cancer who received postoperative *** associations between genetic variations and overall survival(OS)were evaluated using hazard ratios(HRs)and 95%confidence intervals(CIs)computed using a Cox proportional regression *** experiments were performed to determine the functions of the arachidonate 5-lipoxygenase(ALOX5)gene and the ALOX5 rs702365 ***:We detected 16 genetic polymorphisms in CASP3,CASP7,TRAILR2,GSDME,CASP4,HO-1,ALOX5,GPX4,and NRF2 that were significantly associated with OS in the additive model(Phere was a substantial cumulative effect of three genetic polymorphisms(CASP4 rs571407,ALOX5 rs2242332,and HO-1 rs17883419)on *** variations in the CASP4 and ALOX5 gene haplotypes were associated with a higher *** demonstrated,for the first time,that rs702365[G]>[C]represses ALOX5 transcription and corollary experiments suggested that ALOX5 may promote colon cancer cell growth by mediating an inflammatory ***:Polymorphisms in genes regulating cell death may play essential roles in the prognosis of patients with rectal cancer who are treated with postoperative CRT and may serve as potential genetic biomarkers for individualized treatment.

关键词： Rectal neoplasms genetic variation regulated cell death overall survival ALOX5

Biodegradable Materials as Nanocarriers for Drugs and Nutrients

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Journal of Renewable Materials 2021年第7期9卷 1189-1211页

作者： Xingran Kou qixuan Zhao Wenwen Xu Zuobing Xiao Yunwei Niu Kai Wang Key Laboratory of Textile Science&Technology Ministry of EducationCollege of TextilesDonghua UniversityShanghai201620China School of Perfume and Aroma Technology Shanghai Institute of TechnologyShanghai201418China R&D Center of China Tobacco Yunnan Industrial Co. Ltd.Kunming650231China

Several important drugs and nutritional supplements are limited by their lack of *** display unique beneficial properties that might help improve the bioavailability of drugs and nutritional supple***,nanomaterials produced from synthetic polymers and metals may have similar difficulties with bioavailability and *** occurring biopolymers are biodegradable and non-toxic and are adaptable to the synthesis of *** and other substances can be encapsulated or embedded in such particles with an increase in *** search for biodegradable nanomaterials is an active research *** review summarizes the research on nanocrystalline cellulose,starch,lignin,and other biological and environment-friendly nanocomposites which are commonly used as nanocarriers for drugs and ***,prospects for the use of biodegradable nanomaterials in targeted therapy,including environmentally responsive therapy,are discussed.

关键词： Nanomaterials biodegradation classification application

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科技自立自强与亚洲发展的内生动力

学术前沿 2023年第15期 31-44页

作者：黄琪轩上海交通大学国际与公共事务学院

亚洲发展取得了举世瞩目的成就。外来技术、外部市场均为亚洲发展作出过重要贡献。但二者都不是典型意义上的“国际公共品”。从以中日韩为代表的亚洲国家发展经验来看,在全球化时代,“自主”有着重要意义。科技自立自强构成亚洲发展的... 详细信息

亚洲发展取得了举世瞩目的成就。外来技术、外部市场均为亚洲发展作出过重要贡献。但二者都不是典型意义上的“国际公共品”。从以中日韩为代表的亚洲国家发展经验来看,在全球化时代,“自主”有着重要意义。科技自立自强构成亚洲发展的内生动力,但在发展的“追赶阶段”与“成熟阶段”,科技自立自强又有着不同侧重。在“追赶阶段”,由于后发国家对先发国家构成的竞争压力小,获得外来技术与外部市场均相对容易,培育“自主学习能力”是支撑科技自立自强,进而推动成功发展的关键。当亚洲逐步步入发展“成熟阶段”,对先发国家构成的竞争压力增大,获得外来技术与外部市场也愈发困难,此时“自主创新能力”与“自主市场规模”相互补充支撑着“高水平科技自立自强”,推动着亚洲持续发展。新时代的中国致力于实现“高水平科技自立自强”,积极向亚洲分享技术与市场,推动亚洲共同发展。

关键词：科技自立自强亚洲发展自主学习能力自主创新能力自主市场规模

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地缘政治的复兴与大国的技术竞争

国际政治研究 2023年第6期44卷 54-69,M0004页

作者：黄琪轩上海交通大学国际与公共事务学院 200030 上海市创新政策评估研究中心

国际政治经济学中的技术竞争从经济、安全与声誉等多维度展开。全球市场扩张促发着两类“双重运动”,一是社会会伴随全球市场扩张而反弹,二是地缘政治随着全球市场扩张而回归。国际政治经济学中对技术议题的讨论日益从关注制度差异转向... 详细信息

国际政治经济学中的技术竞争从经济、安全与声誉等多维度展开。全球市场扩张促发着两类“双重运动”,一是社会会伴随全球市场扩张而反弹,二是地缘政治随着全球市场扩张而回归。国际政治经济学中对技术议题的讨论日益从关注制度差异转向地缘政治。当经济竞争占主导时,各国对技术发展的介入以市场导向为政策调整方向;随着安全竞争压力增大,各国对技术发展的介入模式日渐呈现集中化趋势,国家战略日益显现。地缘政治竞争驱使各国避免落入“武器化的相互依赖”困境,更加强调技术自主。在全球化发展水平较低的情况下,国家可能靠闭关自守来实现技术自主;而在全球化发展水平较高的情况下,与世界经济的孤立与隔离面临巨大机会成本。此时,通过再全球化来推动技术国际分工,进而增强技术能力,才能更好实现技术自主。随着大国技术竞争在经济、安全与声誉等多维度展开,对技术议题的研究将带动国际政治经济学与国际安全走向新一轮的综合和融合。

关键词：国际政治经济学技术竞争地缘政治国家战略再全球化国际安全