Nano-Medicine for Thrombosis:A Precise Diagnosis and Treatment Strategy

作     者：Min Su Qixuan Dai Chuan Chen Yun Zeng Chengchao Chu Gang Liu Min Su;Qixuan Dai;Chuan Chen;Yun Zeng;Chengchao Chu;Gang Liu

作者机构：State Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsCenter for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102People’s Republic of China State Key Laboratory of Physical Chemistry of Solid SurfacesThe MOE Key Laboratory of Spectrochemical Analysis and InstrumentationCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005People’s Republic of China Department of PharmacyXiamen Medical CollegeXiamen 361023People’s Republic of China Xiamen Cardiovascular HospitalXiamen UniversityXiamen 361102People’s Republic of China 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2020年第12卷第8期

页      面：25-45页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100602[医学-中西医结合临床] 10[医学] 0702[理学-物理学] 

基　　金：supported by the Major State Basic Research Development Program of China(2017YFA0205201 and 2018YFA0107301) the National Natural Science Foundation of China(81901876,81925019,81603015,81871404,81801817,and U1705281) Xiamen science and technology program(3502Z20173012) the Fundamental Research Funds for the Central Universities(20720190088 and 20720200019) the Program for New Century Excellent Talents in University,China(NCET-13-0502) 

主　　题：Thrombosis Nano-medicine Diagnosis Thrombolytic therapy 

摘      要：Thrombosis is a global health issue and one of the leading factors of ***,its diagnosis has been limited to the late stages,and its therapeutic window is too narrow to provide reasonable and effective *** addition,clinical thrombolytics suffer from a short half-life,allergic reactions,inactivation,and unwanted tissue ***-medicines have gained extensive attention in diagnosis,drug delivery,and photo/sound/magnetic-theranostics due to their convertible ***,diagnosis and treatment of thrombosis using nano-medicines have also been widely *** review summarizes the recent advances in this area,which revealed six types of nanoparticle approaches:(1)in vitro diagnostic kits using“synthetic biomarkers;(2)in vivo imaging using nano-contrast agents;(3)targeted drug delivery systems using artificial nanoparticles;(4)microenvironment responsive drug delivery systems;(5)drug delivery systems using biological nanostructures;and(6)treatments with external *** investigations of nano-medicines are believed to be of great significance,and some of the advanced drug delivery systems show potential applications in clinical theranotics.