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Metabolic reprogramming: a new option for the treatment of spinal cord injury

Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie chen Jinyang chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang qixin chen chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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Locational Pricing of Uncertainty Based on Robust Optimization

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CSEE Journal of Power and Energy Systems 2021年第6期7卷 1345-1356页

作者： Xichen Fang Ershun Du Kedi Zheng Jiajia Yang qixin chen the State Key Laboratory of Power Systems Department of Electrical EngineeringTsinghua UniversityBeijing 100084China the School of Electrical Engineering and Telecommunications UNSWSydneyNSW 2052Australia

With the increasing penetration of renewables,power systems have to operate with greater flexibility to address the uncertainties of renewable *** paper develops an uncertainty locational marginal price(ULMP)mechanism to price these *** are denoted as box deviation intervals as suggested by the market *** ULMP model solves a robust optimal power flow(OPF)problem to clear market bids,aiming to minimize the system cost as a prerequisite that the reserve margin can address all the relevant *** ULMP can be obtained as a by-product of the optimization problem from the Lagrange *** the ULMP mechanism,renewables and consumers with uncertainty will make extra payments,and the thermals and financial transmission right(FTR)holders will be *** is further shown that the proposed mechanism has preferable properties,such as social efficiency,budget balance and individual *** tests are conducted on the modified IEEE 5-bus and 118-bus systems to demonstrate the merits and applicability of the proposed mechanism.

关键词： Electricity market locational marginal price(LMP) mechanism design robust optimization uncertainty pricing

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Guest Editorial:Special Section on Active Distribution Networks:Markets,Operations,Planning,and Regulation

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Journal of Modern Power Systems and Clean Energy 2023年第1期11卷 1-2页

作者： Peter Palensky qixin chen Marcos J.Rider Delft University of Technology DelftNetherlands Tsinghua University BeijingChina University of Campinas Sao PauloBrazil

THE power system is in change,and the most fundamental changes are happening in the distribution *** passive consumers get active and smart,energy storage and distributed generation appears,and the“grid edge”is upgraded with Intenet of Things(IoT).Gone are the days where distribution infrastructure consisted of passive assets,dimensioned for the worst case of load.

关键词： passive IoT distribution

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Low-Carbon Dispatching for Virtual Power Plant with Aggregated Distributed Energy Storage Considering Spatiotemporal Distribution of Cleanness Value

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 346-358页

作者： Hongchao Gao Tai Jin Guanxiong Wang qixin chen Chongqing Kang Jingkai Zhu State Key Laboratory of Power System Operation and Control Department of Electrical EngineeringTsinghua UniversityBeijing 100084China Sichuan Energy Internet Research Institute Tsinghua University Chengdu 200016China Power Dispatching and Control Center of Shanghai Municipal Electric Power Company Shanghai 200122China IEEE

The scale of distributed energy resources is increasing,but imperfect business models and value transmission mechanisms lead to low utilization ratio and poor *** address this issue,the concept of cleanness value of distributed energy storage(DES)is proposed,and the spatiotemporal distribution mechanism is discussed from the perspectives of electrical energy and *** on this,an evaluation system for the environmental benefits of DES is constructed to balance the interests between the aggregator and the power system ***,an optimal low-carbon dispatching for a virtual power plant(VPP)with aggregated DES is constructed,where-in energy value and cleanness value are both *** achieve the goal,a green attribute labeling method is used to establish a correlation constraint between the nodal carbon potential of the distribution network(DN)and DES behavior,but as a cost,it brings multiple nonlinear ***,a solution method based on the convex envelope(CE)linear re-construction method is proposed for the multivariate nonlinear programming problem,thereby improving solution efficiency and ***,the simulation verification based on the IEEE 33-bus DN is *** simulation results show that the multidimensional value recognition of DES motivates the willingness of resource users to ***,resolving the impact of DES on the nodal carbon potential can effectively alleviate overcompensation of the cleanness value.

关键词： Distributed energy storage virtual power plant(VPP) spatiotemporal distribution low-carbon dispatching

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Optimal operation strategy for distributed battery aggregator providing energy and ancillary services

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Journal of Modern Power Systems and Clean Energy 2018年第4期6卷 722-732页

作者： Kangning LIU qixin chen Chongqing KANG Wei SU Guobin ZHONG Department of Electrical Engineering Tsinghua University Guangdong Electric Power Research Institute

The high penetration of distributed renewable energy raises a higher concern for the safe and economic operation of the smart grid. Distributed batteries equipped in demand-side can not only contribute to the reliability and security of the grid, but also make profits by participating in the electricity market, especially when distributed batteries are combined and operated by an *** the well-operated mechanism of performance based regulation(PBR) in the U.S. electricity market, it becomes increasingly lucrative for batteries to participate not only in energy markets for energy arbitrage, but also in ancillary service markets to provide regulation and peakload shaving services. In this study, distributed batteries are operated and coordinated by the aggregator, which simultaneously submits offers to the energy and the ancillary service markets as an individual entity. An optimaldecision model is formulated for the aggregator to determine the operation and bidding strategy for the distributed batteries by considering the characteristics of batteries,including the terms of capacity, efficiency and degradation cost. Finally, a numerical case is conducted to evaluate the benefits of the decision model.

关键词： Distributed storage Electricity market Optimal operation Ancillary service

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Load Profiling and Its Application to Demand Response: A Review

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Tsinghua Science and Technology 2015年第2期20卷 117-129页

作者： Yi Wang qixin chen Chongqing Kang Mingming Zhang Ke Wang Yun Zhao Department of Electrical Engineering Tsinghua University Electric Power Research Institute China Southern Power Grid Co.Ltd.

The smart grid has been revolutionizing electrical generation and consumption through a two-way flow of power and information. As an important information source from the demand side, Advanced Metering Infrastructure （AMI） has gained increasing popularity all over the world. By making full use of the data gathered by AMI, stakeholders of the electrical industry can have a better understanding of electrical consumption behavior. This is a significant strategy to improve operation efficiency and enhance power grid reliability. To implement this strategy, researchers have explored many data mining techniques for load profiling. This paper performs a state-of-the-art, comprehensive review of these data mining techniques from the perspectives of different technical approaches including direct clustering, indirect clustering, clustering evaluation criteria, and customer segmentation. On this basis, the prospects for implementing load profiling to demand response applications, price-based and incentivebased, are further summarized. Finally, challenges and opportunities of load profiling techniques in future power industry, especially in a demand response world, are discussed.

关键词： load profiling demand response data mining customer segmentation Advanced Metering Infrastructure (AMI)

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Full-Dimensional Potential Energy Surfaces of Ground(X^(2)A′)and Excited(A^(2)A″)Electronic States of HCO and Absorption Spectrum

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Chinese Journal of Chemical Physics 2022年第2期35卷 303-310,I0002页

作者： qixin chen Shanyu Han Xixi Hu Daiqian Xie Institute of Theoretical and Computational Chemistry Key Laboratory of Mesoscopic ChemistrySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Department of Chemistry and Chemical Biology University of New MexicoNew Mexico 87131USA Kuang Yaming Honors School Institute for Brain SciencesNanjing UniversityNanjing 210023China

In this work,high-fidelity full-dimensional potential energy surfaces(PESs)of the ground(X^(2)A′)and first doublet excited(A^(2)A″)electronic states of HCO were constructed using neural network *** total,4624 high-level ab initio points have been used which were calculated at Davidson corrected internally contracted MRCI-F12 level of theory with a quite large basis set(ACV5Z)without any scaling *** with the results obtained from the scaled PESs of Ndenguéet al.,the absorption spectrum based on our PESs has slightly larger intensity,and the peak positions are shifted to smaller energy for dozens of *** is indicated that the scaling of potential energy may make some unpredictable difference on the dynamical ***,the resonance energies based on those scaled PESs are slightly closer to the current available experimental values than ***,the unscaled high-level PESs developed in this work might provide a platform for further experimental and theoretical photodissociation and collisional dynamic studies for HCO system.

关键词： Potential energy surface Photodissociation process Absorption spectrum Neural network Excited state

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Super-resolution imaging for in situ monitoring sub-cellular micro-dynamics of small molecule drug

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1864-1877页

作者： Huimin chen Guiqian Fang Youxiao Ren Weiwei Zou Kang Ying Zhiwei Yang qixin chen School of Pharmaceutical Sciences&Institute of Materia Medica Medical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter School of PhysicsXi'an Jiaotong UniversityXi'an 710049China Reproductive Medicine Center Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China

Small molecule drugs play a pivotal role in the arsenal of anticancer pharmacological agents. Nonetheless, their small size poses a challenge when directly visualizing their localization, distribution, mechanism of action (MOA), and target engagement at the subcellular level in real time. We propose a strategy for developing triple-functioning drug beacons that seamlessly integrate therapeutically relevant bioactivity, precise subcellular localization, and direct visualization capabilities within a single molecular entity. As a proof of concept, we have meticulously designed and constructed a boronic acid fluorescence drug beacon using coumarin–hemicyanine (CHB). Our CHB design includes three pivotal features: a boronic acid moiety that binds both adenosine triphosphate (ATP) and adenosine diphosphate (ADP), thus depleting their levels and disrupting the energy supply within mitochondria;a positively charged component that targets the drug beacon to mitochondria;and a sizeable conjugated luminophore that emits fluorescence, facilitating the application of structured illumination microscopy (SIM). Our study indicates the exceptional responsiveness of our proof-of-concept drug beacon to ADP and ATP, its efficacy in inhibiting tumor growth, and its ability to facilitate the tracking of ADP and ATP distribution around the mitochondrial cristae. Furthermore, our investigation reveals that the micro-dynamics of CHB induce mitochondrial dysfunction by causing damage to the mitochondrial cristae and mitochondrial DNA. Altogether, our findings highlight the potential of SIM in conjunction with visual drug design as a potent tool for monitoring the in situ MOA of small molecule anticancer compounds. This approach represents a crucial advancement in addressing a current challenge within the field of small molecule drug discovery and validation.

关键词： Mitochondrial Drug beacon Sub-cellular Small molecule Energy supply Anti-tumor

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Super-resolution imaging reveals the subcellular distribution of dextran at the nanoscale in living cells

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Chinese Chemical Letters 2022年第4期33卷 1865-1869页

作者： Huimin chen Han Wang Yongchun Wei Maomao Hu Bo Dong Hongbao Fang qixin chen Institute of Materia Medica Shandong First Medical University&Shandong Academy of Medical SciencesJi’nan 250062China Department of Cardiology Shandong Provincial Hospital Affiliated to Shandong UniversityJi’nan 250012China State Key Laboratory of Coordination Chemistry Chemistry and Biomedicine Innovation Center(ChemBIC)School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Theranostic visualization of dextran at the nanoscale is beneficial for understanding the bioregulatory mechanisms of this molecule. In this study, we applied structured illumination microscopy(SIM) to capture the distribution of Cy5-Dextran at different incubation periods in living cells. The results showed that Cy5-Dextran could be absorbed by He La cells. In addition, we clarified that Cy5-Dextran exhibited differential organelle distribution(lysosomal or mitochondrial) in a time-dependent manner. Moreover,lysosomal Cy5-Dextran localization was found to be independent of the autophagy process, while Cy5-Dextran localized to the mitochondria triggered a pro-apoptotic event, upregulating the levels of reactive oxygen species(ROS) to accelerate mitochondrial fragmentation. This work uses a visualized strategy to reveal the anti-tumor bioactivity of dextran, which was achieved by regulating apoptosis and autophagy.

关键词： Dextran Subcellular distribution Super-resolution imaging Structured illumination microscopy

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Nanoscale monitoring of mitochondria and lysosome interactions for drug screening and discover

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Nano Research 2019年第5期12卷 1009-1015页

作者： qixin chen Xintian Shao Zhiqi Tian Yang chen Payel Mondal Fei Liu Fengshan Wang Peixue Ling Weijiang He Kai Zhang Zijian Guo Jiajie Diao School of Pharmaceutical Sciences Shandong UniversityJinan 250101China Shandong Academy of Pharmaceutical Science Key Laboratory of BiopharmaceuticalsEngineering Laboratory of Polysaccharide DrugsNational-Local Joint Engineering Laboratory of Polysaccharide DrugsJinan 250101China Department of Cancer Biology University of Cincinnati College of MedicineCincinnatiOH 45267USA Department of Biochemistry University of Illinois at Urbana-ChampaignUrbanaIL 61801USA State Key Laboratory of Coordination Chemistry Coordination Chemistry InstituteSchool of Chemistry and Chemical EngineeringNanjing University Nanjing 210093China

Technology advances in genomics,proteomics,and metabolomics largely expanded the pool of potential therapeutic *** with the in vitro setting,cell-based screening assays have been playing a key role in the processes of drug discovery and *** the commonly used strategies based on colorimetric and cell viability,we reason that methods that capture the dynamic cellular events will facilitate optimal hit identification with high sensitivity and ***,we propose a live-cell screening strategy using structured illumination microscopy (SIM) combined with an automated cell colocalization analysis software,CellprofilerTM,to screen and discover drugs for mitochondria and lysosomes interaction at a nanoscale resolution in living *** strategy quantitatively benchmarks the mitochondria-lysosome interactions such as mitochondria and lysosomes contact (MLC) and *** automatic quantitative analysis also resolves fine changes of the mitochondria-lysosome interaction in response to genetic and pharmacological ***-resolution live-cell imaging on the basis of quantitative analysis opens up new avenues for drug screening and development by targeting dynamic organelle interactions at the nanoscale resolution,which could facilitate optimal hit identification and potentially shorten the cycle of drug discovery.

关键词： drug screening mitochondria lysosome mitophagy structured illumination microscopy

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