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Current development in wearable glucose meters

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Chinese Chemical Letters 2021年第12期32卷 3705-3717页

作者： qiuyuan chen Yan Zhao Yunqi Liu Department of Materials Science Fudan UniversityShanghai 200433China

Diabetes is one of the most disturbing chronic diseases in the world. The improvement of treatment efficiency brought by self-monitoring of blood glucose can relieve symptoms and reduce complications,which is considered as the gold standard of diabetes diagnosis and nursing. Compared to the traditional finger pricking measurement with painful and discontinuous processes, continuous blood glucose monitoring(CGM) presents superior advantages in wearable and continuous assessment of blood glucose levels. However, widely used implantable CGM systems at present require implantation operation and are highly invasive, so it is hard to be accepted by users. Except for the blood, available fluids in humans,such as interstitial fluid(ISF), sweat, tears and saliva, also contain glucose associated with blood sugar and can be extracted more easily. Therefore, these more accessible fluids are expected to realize minimized traumatic blood glucose monitoring. This review introduces the latest development of wearable minimally-/non-invasive CGM device, focusing on the types of blood substitute biological fluid and suitable monitoring approaches. We also analysis the merits and drawbacks of each method, and discuss the properties such as sensitivity, stability and convenience of each meter. Beyond highlighting recent key work in this field, we discuss the future development trend of wearable minimally-/non-invasive glucose meters.

关键词： Diabetes Glucose sensors Noninvasive Electrochemical Healthcare systems Wearable devices

妊娠期糖尿病患者产后6~8周糖代谢异常转归及其影响因素分析

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糖尿病新世界 2024年第1期27卷 35-38页

作者：陈秋鸳赖娟娟柯敏莆田九十五医院产科福建莆田351100

目的探讨妊娠期糖尿病患者产后6~8周糖代谢异常的转归情况及影响因素。方法选取2020年1月—2022年12月莆田九十五医院确诊为妊娠期糖尿病并成功分娩的130例患者作为研究对象,均于患者产后6~8周开展口服葡萄糖耐量试验,根据试验结果分... 详细信息

目的探讨妊娠期糖尿病患者产后6~8周糖代谢异常的转归情况及影响因素。方法选取2020年1月—2022年12月莆田九十五医院确诊为妊娠期糖尿病并成功分娩的130例患者作为研究对象,均于患者产后6~8周开展口服葡萄糖耐量试验,根据试验结果分为对照组和研究组,其中糖代谢状态正常的87例纳入对照组,糖代谢状态异常的43例纳入研究组。收集患者产前、产后资料,检测脂联素、胰岛素、瘦素水平,并进行对比分析。结果研究组患者产后空腹血糖水平、产后脂联素水平、糖尿病家族史占比均明显高于对照组,确诊时孕周较对照组更早,产后胰岛素抵抗指数、产后空腹胰岛素、产后瘦素水平较对照组降低,差异有统计学意义(P均<0.05)。Logistic多因素分析结果显示:有糖尿病家族史、确诊时孕周更早、产后瘦素水平低是妊娠期糖尿病患者产后糖代谢异常的独立危险因素(P均<0.05)。结论妊娠期糖尿病患者产后6~8周发生糖代谢异常转归的风险较高,其中有糖尿病家族史、确诊时孕周早、产后瘦素水平低为独立危险因素。

关键词：妊娠期糖尿病糖代谢异常影响因素分析

2004至2021年中国肺结核发病趋势及空间分布特征

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郑州大学学报（医学版） 2024年第2期59卷 274-279页

作者：余海茹闫晔鑫杨娇张惠陈秋缘牛卫理叶鹏孙亮郑州大学公共卫生学院社会医学与卫生事业管理学教研室郑州450001 鹤壁市传染病医院感染科河南鹤壁458000

目的:探讨2004至2021年中国肺结核发病的流行趋势和空间分布特征,为制定区域化肺结核防治措施提供参考。方法:通过公共卫生科学数据中心和《中国卫生健康统计年鉴》收集2004至2021年肺结核发病数据资料,应用空间自相关及冷热点分析等方... 详细信息

目的:探讨2004至2021年中国肺结核发病的流行趋势和空间分布特征,为制定区域化肺结核防治措施提供参考。方法:通过公共卫生科学数据中心和《中国卫生健康统计年鉴》收集2004至2021年肺结核发病数据资料,应用空间自相关及冷热点分析等方法分析肺结核流行趋势和空间聚集特征。结果:2004至2021年,中国肺结核发病总体呈现逐年下降趋势,空间上呈西高东低、南高北低的态势。全局Moran′s I指数从2005年的0.262逐年增大,2020年达到最大值0.522。局部空间自相关分析结果显示,2004至2008年四川、贵州、湖南、广西等地呈“高-高”聚集特征,2009至2011年西藏和广西呈“高-高”聚集特征,2012至2019年西藏和新疆呈“高-高”聚集特征,2020至2021年,除新疆和西藏外,云南和广西也呈现“高-高”聚集特征。2004至2021年“低-低”聚集集中在华北和华东地区。中国肺结核年均发病率热点区域为新疆、西藏和云南;冷点区域有北京、河北、山东、江苏等15个。结论:中国肺结核发病率不断下降,但空间聚集特征显著,应加强对新疆、西藏等热点区域的卫生资源配置。

关键词：肺结核发病率空间分布聚集特征

Nurr1通过抑制小胶质细胞NF-κB发挥抗炎作用

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宁夏医学杂志 2024年第4期46卷 281-284,F0002页

作者：王伟侯晓霖陈秋元潘晓玥彭涛王俊燕李云鸿王银宁夏医科大学总医院宁夏银川750004 宁夏医科大学基础医学院宁夏银川750004

目的探索在细菌脂多糖(LPS)诱导的小鼠小胶质细胞(BV2细胞株)炎症反应中,核受体相关蛋白1(Nurr1)是否通过抑制NF-κB的表达及核转位发挥抗炎作用。方法培养小鼠BV2小胶质细胞株,将细胞分为Ctrl组、LPS组、C-DIM12(Nurrl特异性激动剂)组... 详细信息

目的探索在细菌脂多糖(LPS)诱导的小鼠小胶质细胞(BV2细胞株)炎症反应中,核受体相关蛋白1(Nurr1)是否通过抑制NF-κB的表达及核转位发挥抗炎作用。方法培养小鼠BV2小胶质细胞株,将细胞分为Ctrl组、LPS组、C-DIM12(Nurrl特异性激动剂)组、siRNA干扰组、LPS+C-DIM12组。利用CCK-8检测LPS和C-DIM12的最适作用浓度,用Western blot观察NF-κB和Nurr1的表达变化,用酶联免疫吸附法(ELISA)检测培养液中炎症因子IL-6、IL-1β和TNF-α的水平,用免疫荧光观察siRNA干扰或C-DIM12激活Nurr1表达活性后,NF-κB及p-IκB在BV2细胞中的表达水平。结果LPS刺激BV2细胞后,NF-κB表达提高,炎症因子IL-1、IL-6、TNF-α释放量增加(P<0.05)。C-DIM12激活Nurr1后,免疫荧光染色技术和Western blot实验结果都显示NF-κB的表达显著下降,而小干扰RNA(siNurr1)沉默Nurr1表达后,NF-κB表达增加。在LPS激活的小胶质细胞中,NF-κB二聚体分子的结合分子p-IκB的磷酸化蛋白水平相对于对照组显著升高,而C-DIM12激活Nurr1后,p-IκB水平显著下降。结论Nurr1可以通过抑制小胶质细胞NF-κB表达水平并阻止NF-κB核位移发挥抗炎作用。Nurr1可能是一个新的潜在的治疗中枢神经系统炎症相关疾病的靶点。

关键词： Nurr1 NF-κB 神经炎症小胶质细胞 p-IκB

Health Inequalities during 20 Years of Rapid Economic Development in China (1980-2000):A Mortality Analysis

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Biomedical and Environmental Sciences 2011年第4期24卷 329-334页

作者： ZHENG XiaoYing SONG XinMing chen Gong YOU YunZhong REN Qiang LIU JuFen ZHANG Lei TAN LingFang WEI JiHong chen qiuyuan Institute of Population Research WHO Collaborating Center on Reproductive Health and Population SciencePeking UniversityBeijing 100871China

Objective To examine the influence of China＇s economic reforms on population health and regional mortality *** Longitudinal study measuring the mortality trends and their regional *** data from the three most recent national censuses,we used the model life table to adjust the mortality levels within the population for each census,and to calculate life *** then examined the variation in patterns of mortality and population health by economic status,region and gender from *** Life expectancy varied with economic status,province,and *** showed that,although life expectancy in China had increased overall since the early 1980s,regional differences became more *** expectancy for populations who live in the eastern coastal provinces are greater than those in the western *** Differences in life expectancy are primarily related to differences in regional economic development,which in turn exacerbate regional health ***,it is necessary to improve economic development in less developed regions and to improve health policies and the public health system that address the needs of everyone.

关键词： Economic development Health inequalities Life expectancy Model life tables Mortality

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楚雄盆地云龙凹陷石油地质特征及勘探目标

天然气工业 2001年第2期21卷 22-26页

作者：梁秋源陈坚滇黔桂石油勘探局研究院

楚雄盆地是我国南方重要的中生代沉积盆地 ,盆地具有烃源条件好、圈闭类型多、生储盖条件好、资源潜力大等特点 ,而成为滇黔桂地区中、古生代大型盆地中最有希望取得突破和发展的盆地。云龙凹陷位于楚雄盆地东缘隆后沉积区 ,其内古生界... 详细信息

楚雄盆地是我国南方重要的中生代沉积盆地 ,盆地具有烃源条件好、圈闭类型多、生储盖条件好、资源潜力大等特点 ,而成为滇黔桂地区中、古生代大型盆地中最有希望取得突破和发展的盆地。云龙凹陷位于楚雄盆地东缘隆后沉积区 ,其内古生界海相地层保留相对较完整。具有长期稳定沉降、海陆相烃源岩丰富、勘探目的层多、埋深适中等特点。中部断弯构造带圈闭发育 ,圈闭面积大 ,闭合度高 ,资源量大 ,是首选的有利勘探区带。

关键词：楚雄盆地云龙凹陷评价油气资源油气勘探地质特征

Endorepellin downregulation promotes angiogenesis after experimental traumatic brain injury

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Neural Regeneration Research 2024年第5期19卷 1092-1097页

作者： Qian Zhang Yao Jing qiuyuan Gong Lin Cai Ren Wang Dianxu Yang Liping Wang Meijie Qu Hao chen Yaohui Tang Hengli Tian Jun Ding Zhiming Xu Department of Gerontology Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurosurgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina School of Biomedical Engineering and Med-X Research Institute Shanghai Jiao Tong UniversityShanghaiChina Department of Neurology Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Endorepellin plays a key role in the regulation of angiogenesis,but its effects on angiogenesis after traumatic brain injury are *** study explored the effects of endorepellin on angiogenesis and neurobehavioral outcomes after traumatic brain injury in *** were randomly divided into four groups:sham,controlled cortical impact only,adeno-associated virus(AAV)-green fluorescent protein,and AAV-shEndorepellin-green fluorescent protein *** the controlled cortical impact model,the transduction of AAV-shEndorepellin-green fluorescent protein downregulated endorepellin while increasing the number of CD31+/Ki-67+proliferating endothelial cells and the functional microvessel density in mouse *** changes resulted in improved neurological function compared with controlled cortical impact *** blotting revealed increased expression of vascular endothelial growth factor and angiopoietin-1 in mice treated with AAV-shEndorepellin-green fluorescent *** radiation angiography showed that endorepellin downregulation promoted angiogenesis and increased cortical neovascularization,which may further improve neurobehavioral ***,an in vitro study showed that downregulation of endorepellin increased tube formation by human umbilical vein endothelial cells compared with a *** analysis found that endorepellin downregulation may mediate angiogenesis by activating vascular endothelial growth factor-and angiopoietin-1-related signaling pathways.

关键词： angiogenesis controlled cortical impact endorepellin neurological function traumatic brain injury

A randomized controlled trial to evaluate efficacy and safety of early conversion to a low-dose calcineurin inhibitor combined with sirolimus in renal transplant patients

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Chinese Medical Journal 2022年第13期135卷 1597-1603页

作者： Xiang Zheng Weijie Zhang Hua Zhou Ronghua Cao Zhangfei Shou Shuwei Zhang Ying cheng Xuchun chen chenguang Ding Zuofu Tang Ning Li Shaohua Shi Qiang Zhou qiuyuan chen Gang chen Zheng chen Peijun Zhou Xiaopeng Hu Xiaodong Zhang Ning Na Wei Wang Department of Urology Capital Medical University Beijing Chaoyang HospitalBeijing 100020China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430032China Kidney Transplantation Dialysis Center The Second People’s Hospital of Shanxi ProvinceTaiyuanShanxi 030012China Department of Organ Transplantation Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhouGuangdong 510120China Department of Nephrology Shulan(Hangzhou)HospitalHangzhouZhejiang 310000China Department of Urology Ningbo Yinzhou Number.2 HospitalNingboZhejiang 315000China Department of Organ Transplantation The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China Institute of Kidney Transplantation The First Affiliated HospitalMedical College of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Kidney The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Kidney Southwest HospitalThe First Hospital Affiliated to The Third Military Medical University(Army Medical University)Chongqing 400000China Organ Transplant Center The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510260China Kidney Transplantation Center Department of UrologyRuijin HospitalShanghai Jiaotong University School of MedicineShanghai 200000China.

Background:The calcineurin inhibitor(CNI)-based immune maintenance regimen that is commonly used after renal transplantation has greatly improved early graft survival after transplantation;however,the long-term prognosis of grafts has not been significantly *** nephrotoxicity of CNI drugs is one of the main risk factors for the poor long-term prognosis of ***(SRL)has been employed as an immunosuppressant in clinical practice for over 20 years and has been found to have no nephrotoxic effects on ***,the regimen and timing of SRL application after renal transplantation vary,and clinical data are *** prospective randomized controlled studies are particularly *** study aims to investigate the effects of early conversion to a low-dose CNI combined with SRL on the long-term prognosis of renal ***:Patients who receive four weeks of a standard regimen with CNI+mycophenolic acid(MPA)+glucocorticoid after renal transplantation in multiple transplant centers across China will be included in this *** week 5,after the operation,patients in the experimental group will receive an additional administration of SRL,a reduction in the CNI drug doses,withdrawal of MPA medication,and maintenance of *** addition,patients in the control group will receive the maintained standard of *** patients’vital signs,routine blood tests,routine urine tests,blood biochemistry,serum creatinine,BK virus(BKV)/cytomegalovirus(CMV),and trough concentrations of CNI drugs and SRL at the baseline and weeks 12,24,36,48,72,and 104 after conversion will be *** survival,graft survival,and estimated glomerular filtration rate will be calculated,and concomitant medications and adverse events will also be ***:The study data will be utilized to evaluate the efficacy and safety of early conversion to low-dose CNIs combined with SRL in renal transplant patients.

关键词： Calcineurin inhibitor Conversion Rapamycin Renal transplantation Sirolimus

A multi-center randomized controlled trial to evaluate efficacy and safety of early conversion to a low-dose calcineurin inhibitor combined with sirolimus in renal transplant patients

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Chinese Medical Journal 2023年第5期136卷 607-609页

作者： Xiang Zheng Weijie Zhang Hua Zhou Ronghua Cao Zhangfei Shou Shuwei Zhang Ying cheng Xuchun chen chenguang Ding Ning Li Shaohua Shi Qiang Zhou qiuyuan chen Gang chen Zheng chen Peijun Zhou Xiaopeng Hu Wujun Xue Xiaodong Zhang Ning Na Wei Wang Department of Urology Capital Medical University Beijing Chaoyang HospitalBeijing 100020China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430032China Kidney Transplantation Dialysis Center The Second People’s Hospital of Shanxi ProvinceTaiyuanShanxi 030012China Guangdong Provincial Hospital of Traditional Chinese Medicine GuangzhouGuangdong 510120China Department of Nephrology Shulan(Hangzhou)HospitalHangzhouZhejiang 310000China Department of Urology Ningbo Yinzhou Number.2 HospitalNingboZhejiang 315000China Department of Organ Transplantation The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China Institute of Kidney Transplantation The First Affiliated HospitalMedical College of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Kidney Department Southwest HospitalThe First Hospital Affiliated to The Third Military Medical University(Army Medical University)Chongqing 400000China Organ Transplant Center The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510260China Department of Urology Kidney Transplantation CenterRuijin HospitalShanghai Jiaotong University School of MedicineShanghai 200000China Department of Urology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China.

Although the triple immunosuppressive regimen based on calcineurin inhibitors(CNIs)has greatly improved the short-term prognosis of renal transplantation,the longterm prognosis of renal transplantation has not significantly *** associated nephrotoxicity is a major risk factor affecting the graft survival.[1]It is feasible to improve the long-term prognosis by reducing the dose of CNIs or removing the *** have demonstrated that the combination of sirolimus(SRL)with low-dose CNIs can both reduce CNI-related nephrotoxicity and improve graft function without increasing the risk of acute rejection(AR),which helps to improve long-term graft survival.[2]However,the validation of mammalian target of rapamycin inhibitor as an immunosuppression regimen and the timing of its application in renal transplantation is still *** aim of this study was to investigate the effects of early conversion to low-dose CNIs and SRL on the long-term prognosis of renal transplantation.

关键词： prognosis regimen graft