A multi-center randomized controlled trial to evaluate efficacy and safety of early conversion to a low-dose calcineurin inhibitor combined with sirolimus in renal transplant patients

作     者：Xiang Zheng Weijie Zhang Hua Zhou Ronghua Cao Zhangfei Shou Shuwei Zhang Ying Cheng Xuchun Chen Chenguang Ding Ning Li Shaohua Shi Qiang Zhou Qiuyuan Chen Gang Chen Zheng Chen Peijun Zhou Xiaopeng Hu Wujun Xue Xiaodong Zhang Ning Na Wei Wang 

作者机构：Department of UrologyCapital Medical University Beijing Chaoyang HospitalBeijing 100020China Institute of Organ TransplantationTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430032China Kidney Transplantation Dialysis CenterThe Second People’s Hospital of Shanxi ProvinceTaiyuanShanxi 030012China Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhouGuangdong 510120China Department of NephrologyShulan(Hangzhou)HospitalHangzhouZhejiang 310000China Department of UrologyNingbo Yinzhou Number.2 HospitalNingboZhejiang 315000China Department of Organ TransplantationThe First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China Institute of Kidney TransplantationThe First Affiliated HospitalMedical College of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Kidney DepartmentSouthwest HospitalThe First Hospital Affiliated to The Third Military Medical University(Army Medical University)Chongqing 400000China Organ Transplant CenterThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510260China Department of UrologyKidney Transplantation CenterRuijin HospitalShanghai Jiaotong University School of MedicineShanghai 200000China Department of UrologyThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China. 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2023年第136卷第5期

页      面：607-609页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100602[医学-中西医结合临床] 10[医学] 

基　　金：China International Medical Foundation(No.RUPUS-ISRT-20180114) 

主　　题：prognosis regimen graft 

摘      要：Although the triple immunosuppressive regimen based on calcineurin inhibitors(CNIs)has greatly improved the short-term prognosis of renal transplantation,the longterm prognosis of renal transplantation has not significantly *** associated nephrotoxicity is a major risk factor affecting the graft survival.[1]It is feasible to improve the long-term prognosis by reducing the dose of CNIs or removing the *** have demonstrated that the combination of sirolimus(SRL)with low-dose CNIs can both reduce CNI-related nephrotoxicity and improve graft function without increasing the risk of acute rejection(AR),which helps to improve long-term graft survival.[2]However,the validation of mammalian target of rapamycin inhibitor as an immunosuppression regimen and the timing of its application in renal transplantation is still *** aim of this study was to investigate the effects of early conversion to low-dose CNIs and SRL on the long-term prognosis of renal transplantation.