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Science China(life Sciences) 2021年第4期64卷 660-663页

作者： qiuyu li Cheng Cui Fei Xu Jianping Zhao Nan li Haichao li Tianbing Wang Hua Zhang Na liu Yudong Wei Xiaoye Niu Yan Xu Jianping Dong Xueting Yao Xiaohong Wang Yahong Chen Haiyan li Chunli Song Jie Qiao Dongyang liu Ning Shen Department of Respiratory and Critical Care Medicine Peking University Third HospitalBeijing 100191China Drug Clinical Trial Center Peking University Third HospitalBeijing 100191China Deparment of Respiratory and Critical Care Medicine the First Afiliated Hospital of Nanchang UniversirNanchang 300060 China Department of Respiratory and Critical Care Medicine Tongi HospitalTongii Medical CollegeHuazhong Universiy of Science and TechnologyWuhan 430030China Research Center of Clinical Epidemiology Peking University Third HospitalBejing 100191China Department of Respiratory and Critical Care Medicine Peking University First HospitalBeijing 100034China Trauma Center Peking University People's HospitalBeijing 100044China Beijing Haidian Hospital Haidian Section of Peking University Third HospitalBeijing 100080Chima Deparment of Cardiology Peking University Third Hospital Beijing 100191China Instiute of Medical Innovation Peking University Third HospitalBejing 100191China

Dear Editor,Since December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has been rapidly spreading *** and chloroquine are candidates for the treatment of coronavirus disease 2019(COVID-19)owing to ... 详细信息

关键词： acute respiratory patients

《吉姆爷》中的弃船事件与英国性的衰落、修正及改写

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东北大学学报（社会科学版） 2023年第1期25卷 145-150页

作者：李秋宇南京大学外国语学院江苏南京210023

康拉德的作品《吉姆爷》改编自1880年“圣吉达号”轮船上数名英国船员面临沉船危机时抛下乘客弃船逃生的真实事件。船龄仅八年的“圣吉达号”在小说中变成了生锈后经过粉饰继续航行的旧船“帕特纳号”,康拉德似乎试图通过涉事船只的“... 详细信息

康拉德的作品《吉姆爷》改编自1880年“圣吉达号”轮船上数名英国船员面临沉船危机时抛下乘客弃船逃生的真实事件。船龄仅八年的“圣吉达号”在小说中变成了生锈后经过粉饰继续航行的旧船“帕特纳号”,康拉德似乎试图通过涉事船只的“生锈”隐喻弃船行为背后英国商船队精神和绅士精神等英国性特质的衰落,以该船的命运警醒国人,并给出了自己的解决方案——对“生锈”的英国性先后进行“抛光”和“粉饰”,亦即通过改写真实事件,对衰落的英国性进行美化。《吉姆爷》中的改编、书写及再创作反映出了康拉德对大英帝国前途命运的忧虑与希望。

关键词：《吉姆爷》英国性英国商船队精神绅士精神

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康拉德殖民地小说中的饮食书写与英国性建构

外语与外语教学 2022年第1期 125-134,151页

作者：李秋宇南京大学外国语学院江苏南京210023

饮食在康拉德作品中占据着举足轻重的地位,在他的殖民地小说中自然也是如此。其中康拉德的饮食书写不仅反映了不同种族及国族迥异的饮食文化习惯,也是他建构英国性的重要途径。通过饮食书写,康拉德在作品中塑造了具备他心目中理想英国... 详细信息

饮食在康拉德作品中占据着举足轻重的地位,在他的殖民地小说中自然也是如此。其中康拉德的饮食书写不仅反映了不同种族及国族迥异的饮食文化习惯,也是他建构英国性的重要途径。通过饮食书写,康拉德在作品中塑造了具备他心目中理想英国性品质的英国公民形象:无私地帮助陷入饥饿的其他人、高尚且仁慈的救世者;适度饮食、节制又负责的好公民;注重饮食礼仪、体面而优雅的英国绅士。康拉德关于英国性的这些书写既是时代的产物,也带有其自身独特的烙印,反映了他对国家未来的忧虑与希望。

关键词：康拉德殖民地小说饮食英国性

抗C反应蛋白自体抗体在系统性红斑狼疮中的研究进展

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中国医学科学院学报 2019年第5期41卷 678-684页

作者：李秋钰于峰北京大学第三医院呼吸与危重医学科北京100191 北京大学第一医院肾脏内科北京100031

系统性红斑狼疮(SLE)是一种可累及多脏器系统的慢性自身免疫性疾病,其发病机制尚不明确。有研究表明,免疫炎症反应和细胞凋亡清除受损是SLE发生发展的关键事件,在此过程中,五聚蛋白家族发挥重要作用。本文总结了抗C反应蛋白自体抗体与SL... 详细信息

系统性红斑狼疮(SLE)是一种可累及多脏器系统的慢性自身免疫性疾病,其发病机制尚不明确。有研究表明,免疫炎症反应和细胞凋亡清除受损是SLE发生发展的关键事件,在此过程中,五聚蛋白家族发挥重要作用。本文总结了抗C反应蛋白自体抗体与SLE疾病的相关性研究进展。

关键词：系统性红斑狼疮狼疮性肾炎自身免疫细胞凋亡抗C反应蛋白自体抗体

基于非零和博弈的互联异构多微网系统电热碳优化调度策略

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电网技术 2024年第6期48卷 2287-2296,I0011-I0016页

作者：初壮李秋雨王议坚东北电力大学电气工程学院吉林省吉林市132012

微电网规模随着新能源渗透比例的提高与日剧增,然而由于缺乏灵活的能量转移机制,针对单个微电网的低碳经济调度优化效果有限。有效利用多微网系统内部的结构差异,实现能源在空间与时间双重维度上的流动对促进新能源电力系统低碳经济发... 详细信息

微电网规模随着新能源渗透比例的提高与日剧增,然而由于缺乏灵活的能量转移机制,针对单个微电网的低碳经济调度优化效果有限。有效利用多微网系统内部的结构差异,实现能源在空间与时间双重维度上的流动对促进新能源电力系统低碳经济发展具有重要意义。为此,该文在考虑多微网功能区差异的基础上,运用纳什谈判思想,制定了计及电、热、碳能源交易的多微网系统优化调度策略。首先,针对微网功能区差异性构建基于居民区、商业区与工业区的多微网系统运行框架;其次,根据不同功能区的负荷特性构建了计及电、热负荷可替代性的需求响应模型;最后,以纳什谈判思想为基础,结合交替方向乘子法与商业求解器达成多微网间电、热、碳互利共赢的交易策略。算例分析验证了所提方案能够在实现多微网隐私保护的前提下全面提高系统运行的低碳性与经济性。

关键词：多微网系统点对点能源交易碳配额交易需求响应交替方向乘子法

Study on the Protective Mechanism of Acupuncture Regulating ICAM-5 mRNA Expression in Rats with Ischemic Stroke

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Journal of Behavioral and Brain Science 2021年第12期11卷 313-321页

作者： Yating Shen Ximei Xie Xiu Bai Hua Bai Xiaofan Chang Yuanyuan Tang qiuyu li Xi’an Hospital of Traditional Chinese Medicine Xi’an China Shaanxi University of traditional Chinese Medicine Xianyang China

Objective: The objective is to investigate whether acupuncture can protect brain by regulating the expression of ICAM-5 mRNA in brain tissue. Methods: Male SD rats were used to construct a middle cerebral artery occlusion reperfusion injury (Middle cerebral artery occlusion, MCAO) model, and the rats were randomly divided into 4 groups, namely the normal group (group A) and the sham operation group (group B), MCAO group (group C), MCAO + acupuncture group (group D);real-time fluorescent quantitative PCR (RT-qPCR) was used to detect the expression of ICAM-5 mRNA in the brain tissue of the ischemic area, and HE staining and TUNEL were used to detect the level of neuronal apoptosis to evaluate the therapeutic effect. Results: Acupuncture can improve neuronal morphology and reduce neuronal apoptosis in rats with ischemic stroke. RT-qPCR: compared with group A and group B, the expression level of ICAM-5 mRNA in the brain tissues of group C and group D decreased, while compared with group C, The expression of ICAM-5 mRNA in the brain tissue of group D was significantly up-regulated (P 0.05). Conclusion: The effectiveness of acupuncture in the treatment of ischemic stroke may achieve neuroprotection by up-regulating the expression level of ICAM-5 mRNA.

关键词： Ischemic Stroke Acupuncture ICAM-5 mRNA Mechanism Study

Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang qiuyu Pang Lexin Zheng Jiaxi lin Hanxi li lingbo Wan Tao Wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

Experimental Study on the Effect of Acupuncture on ERM/PI3/Akt Signal Pathway in Rats with Ischemic Stroke

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Journal of Behavioral and Brain Science 2021年第10期11卷 248-256页

作者： Xiu Bai Ximei Xie Yating Shen Hua Bai Yuanyuan Tang Xiaofan Chang qiuyu li Xi’an Hospital of Traditional Chinese Medicine Xi’an China Shaanxi University of Traditional Chinese Medicine Xianyang China

Objective: To observe the effect of acupuncture on the expression of ERM/PI3K/Akt signaling pathway in the brain tissue around the infarct focus of ischemic stroke model rats. Methods: According to the block randomization method, 80 male SD rats were divided into normal group (n = 10), sham operation group (n = 24), model group (n = 23) and acupuncture group (n = 23). The normal group was bred routinely without any intervention. In the sham operation group, only the skin was cut to find and the nerves and blood vessels were stripped and sutured. The model group and the acupuncture group were sutured to prepare the MCAO model. After the model was successfully established, acupuncture of the acupuncture group rats was given once a day, and the needles were kept for 30 minutes each time. The rats in the sham operation group and the model group only imitated capture and return, and were treated with acupuncture for 2 consecutive courses, each course was 5 days, and the two courses were rested for 2 days. After that, Western blot was used to detect ERM, changes in the concentration of PI3K and Akt proteins. Results: Compared with the normal group, the expression levels of ERM, PI3K, and Akt proteins in the sham operation group were reduced. Compared with the sham operation group, the expression levels of ERM, PI3K, and Akt proteins in the model group were significantly down-regulated. Compared with the model group, the protein expression levels of ERM, PI3K and Akt were significantly up-regulated in the acupuncture group, and the difference was statistically significant (P ling pathway in cells.

关键词： Acupuncture Ischemic Stroke ERM/PI3/Akt Signaling Pathway

对国际声乐比赛选手演唱修养的认识——以意大利阿尔卡莫国际声乐比赛为例

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音乐探索 2011年第3期 135-137,141页

作者：李秋玉广东外语外贸大学艺术学院广东广州510420

国际声乐比赛是对演唱者全面素质和修养的检测,笔者以参加阿尔卡莫国际声乐比赛的实例,分别从声部界定、作品的选择、语言的演唱规范、音乐的理解和全面的音乐修养及心理素质与演唱体态论述,具体讨论在国际声乐比赛中修养的表现及实现... 详细信息

国际声乐比赛是对演唱者全面素质和修养的检测,笔者以参加阿尔卡莫国际声乐比赛的实例,分别从声部界定、作品的选择、语言的演唱规范、音乐的理解和全面的音乐修养及心理素质与演唱体态论述,具体讨论在国际声乐比赛中修养的表现及实现的具体方法和途径,为参赛选手提供依据。

关键词：阿尔卡莫声乐比赛修养语言声部

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活性氧在果实成熟和衰老中的作用及调控机制

食品与发酵工业 2020年第17期46卷 271-276页

作者：李秋雨曾凯芳姚世响西南大学食品科学学院重庆400715 西南大学食品贮藏与物流研究中心重庆400715

活性氧在果实成熟及衰老阶段含量呈总体升高,且先后出现两个高峰的动态变化特征。近10年研究逐渐揭示了活性氧在果实成熟及衰老中扮演的重要调控功能。该文从活性氧在植物生长发育和抗逆中的作用、在果实成熟及衰老过程中的动态变化、... 详细信息

活性氧在果实成熟及衰老阶段含量呈总体升高,且先后出现两个高峰的动态变化特征。近10年研究逐渐揭示了活性氧在果实成熟及衰老中扮演的重要调控功能。该文从活性氧在植物生长发育和抗逆中的作用、在果实成熟及衰老过程中的动态变化、参与调控果实成熟与衰老、调控果实成熟与衰老的机制、稳态调控技术在延缓果实成熟及衰老中的应用等5方面进行综述。并对该领域未来的研究方向进行展望,以期给相关学者提供参考。

关键词：活性氧果实成熟衰老分子机制