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A novel method for identifying SARS-CoV-2 infection mutants via an epitope-specific CD8^(+)T cell test

Biosafety and Health 2024年第3期6卷 143-152页

作者： Congling Qiu Bo Peng Chanchan Xiao Pengfei Chen Lipeng Mao Xiaolu Shi Zhen Zhang Ziquan lv qiuying lv Xiaomin Zhang Jiaxin Li Yanhao Huang Qinghua Hu Guobing Chen Xuan Zou Xiaofeng Liang Department of Public Health and Preventive Medicine School of MedicineJinan UniversityKangtai Biological Vaccine Industry Research Institute/Disease Prevention and Control Institute of Jinan UniversityGuangzhou 510632China Shenzhen Center for Disease Control and Prevention Shenzhen 518020China Department of Microbiology and Immunology Institute of Geriatric ImmunologySchool of MedicineJinan UniversityGuangzhou 510632China Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(Jinan University) Ministry of EducationGuangzhou 510632China The Sixth Affiliated Hospital Jinan UniversityGuangzhou 510632China Department of Systems Biomedical Sciences School of MedicineJinan UniversityGuangzhou 510632China Microbiology Laboratory Shenzhen Center for Disease Control and PreventionShenzhen 518020China Department of Communicable Diseases Control and Prevention Shenzhen Center for Disease Control and PreventionShenzhen 518020China Central Laboratory Shenzhen Center for Disease Control and PreventionShenzhen 518020China

Since the outbreak of the coronavirus disease 2019(COVID-19)epidemic in 2019,the public health system has faced enormous *** the individuals who test positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a key step for interrupting chains of transmission of SARS-CoV-2 and reducing COVID-19-associated *** the increasing of asymptomatic infections,it is difficult to track asymptomatic infections through epidemiological surveys and virus whole-genome ***,due to the cross-reactivity of neutralizing antibodies produced by multiple virus subtypes,neutralizing antibody detection cannot be used to determine whether an individual has a history of infection with a specific subtype of *** recruited 4 human leukocyte antigen A2(HLA-A2)infections,15 individuals who received three doses of inactivated vaccines,and 30 breakthrough infections after vaccination and discussed a case-tracking approach to detect epitope-specific CD8^(+)T cells in the peripheral blood of close contacts,including accurate HLA typing based on ribonucleic acid(RNA)-sequencing and flow cytometry data and the comparison and characterization of SARS-CoV-2 HLA-A2 and HLA-A24 epitope-specific CD8^(+)T *** individuals who received three doses of inactivated vaccine,we observed that the CD8^(+)T cell specificity for ancestral epitopes was significantly higher than for mutated epitopes,and the fold change of CD8^(+)T cells corresponding to mutated epitopes relative to ancestral epitopes was less than *** enzyme-linked immunospot(ELISpot)results further validate this *** study forms a“method for understanding the infection history of SARS-CoV-2 subtypes based on the proportion of epitope-specific CD8^(+)T cells in the peripheral blood of subjects”,covering up to 46%of the population,including HLA-A2+and HLA-A24+donors,providing a novel method for SARS-CoV-2 infected case tracing.

关键词： Asymptomatic coronavirus disease 2019 (COVID-19) Epitopes Specific CD8^(+)T cell ELISpot

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Distinct and relatively mild clinical characteristics of SARS-CoV-2 BA.5 infections against BA.2

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2072-2074页

作者： Liping Guo Xue Liu Yuchen Gu Jinyan Jiang Ziyue Yang qiuying lv Deyin Guo Yang Yang Hongzhou Lu Jing Yuan Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina Centre for Infection and Immunity Study(CIIS) School of Medicine(Shenzhen)Shenzhen Campus of Sun Yat-sen UniversitySun Yat-sen UniversityShenzhenChina Shenzhen Center for Disease Control and Prevention ShenzhenChina

Dear Editor,The global pandemic of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant has resulted in its continuous evolution and the emergence of numerous subvariants of Omicron(https://***/).Currently,possibly owing to the increased evasion of neutralizing antibodies elicited by previous infection and vaccination and the higher transmissibility,the BA.5 variant has replaced BA.2 variant and dominated the pandemic.

关键词： acute respiratory clinical

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Temporal dynamics of SARS-CoV-2 genome mutations that occurred in vivo on an aircraft

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Biosafety and Health 2023年第1期5卷 62-67页

作者： Yaqing He Shengyuan Dang Wentai Ma Long Chen Renli Zhang Shujiang Mei Xinyi Wei qiuying lv Bo Peng Ying Sun Dongfeng Kong Jiancheng Chen Shimin Li Xiujuan Tang Qingju Lu Can Zhu Zhigao Chen Jia Wan Xuan Zou Mingkun Li Tiejiang Feng Lili Ren Jianwei Wang Shenzhen Research Center for Communicable Disease Control and Prevention Chinese Academy of Medical SciencesShenzhen 518055China Center for Disease Control and Prevention Shenzhen 518055China National Health Commission of the People’s Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China University of Chinese Academy of Sciences Beijing 100190China Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciencesand China National Center for BioinformationBeijing 100101China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

We analyzed variations in the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)genome during a flight-related cluster outbreak of coronavirus disease 2019(COVID-19)in Shenzhen,China,to explore the characteristics of SARS-CoV-2 transmission and intra-host single nucleotide variations(iSNVs)in a confined ***-three patients with COVID-19 were sampled,and 14 were resampled 3-31 days *** 47 nasopharyngeal swabs were *** and similarities in the consensus genome sequence were *** SARS-CoV-2 variants of concern,Delta(n=31),Beta(n=1),and C.1.2(n=1),were detected among the 33 *** viral genome sequences from 30 Delta-positive patients had similar SNVs;14 of these patients provided two successive ***,the 47 sequenced genomes contained 164 *** the 14 paired(successive)samples,the second samples(T2)contained more iSNVs(median:3;95%confidence interval[95%CI]:2.77-10.22)than did the first samples(T1;median:2;95%CI:1.63-3.74;Wilcoxon test,P=0.021).38 iSNVs were detected in T1 samples,and only seven were also detectable in T2 ***,T2 samples from two of the 14 paired samples had additional mutations than the T1 *** iSNVs of the SARS-CoV-2 genome exhibited rapid dynamic changes during a flight-related cluster outbreak ***-host diversity increased gradually with time,and new site mutations occurred in vivo without a population transmission ***,we could not determine the generational relationship from the mutation site changes alone.

关键词： SARS-CoV-2 Cluster epidemic Intra-host single nucleotide variation

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网络时代的“社会式互动”行为——对中国社区零售转型发展的社会学考察

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安徽理工大学学报（社会科学版） 2023年第3期25卷 37-44页

作者：吕秋颍阜阳师范大学商学院安徽阜阳200237

基于社会行为理论,聚焦于典型案例分析,构建“社会行为-行为逻辑-行为目标”的理论分析框架,并应用该分析框架探究了由社会参与、社会化服务、社会控制和相互支持等要素共同构成的社区零售中出现的“社会式互动”行为。研究发现,“社会... 详细信息

基于社会行为理论,聚焦于典型案例分析,构建“社会行为-行为逻辑-行为目标”的理论分析框架,并应用该分析框架探究了由社会参与、社会化服务、社会控制和相互支持等要素共同构成的社区零售中出现的“社会式互动”行为。研究发现,“社会式互动”行为能够挖掘社区零售的核心价值,增加零售机构与所在社区利益相关者之间的相互沟通与理解,进而形成企业发展优势;强调社区共享的意义,是社区零售承载社区发展的有效途径。分析表明,“社会式互动”行为模式的应用可以有效突破零售商与社区居民的关系边界,但仍需要依靠互联网技术的支撑和地方政府及其他利益群体的参与和支持,才能真正实现社区零售的转型发展。

关键词：社会式互动社区零售分析框架互联网技术

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50 mm轴承钢球化退火工艺布料方式和最佳重量试验分析

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山东冶金 2023年第1期45卷 44-45页

作者：张涛刘廷港高文娟吕秋影山东寿光巨能特钢有限公司山东寿光262700

轴承钢(GCr15)经过球化退火,可以获得均匀分布的球粒状珠光体组织,硬度降至HB179~207,不仅便于切削加工,也为避免淬火开裂,获得优良的机械性能做必要的组织准备。本文通过对GCr15球化退火时重量及布料方式的探究,进行了4组对比实验,通... 详细信息

轴承钢(GCr15)经过球化退火,可以获得均匀分布的球粒状珠光体组织,硬度降至HB179~207,不仅便于切削加工,也为避免淬火开裂,获得优良的机械性能做必要的组织准备。本文通过对GCr15球化退火时重量及布料方式的探究,进行了4组对比实验,通过对不同方案下的球化组织进行评级,确定了最佳热处理方案为单层布料的退火方式,重量控制在50~65 t时效果最佳。

关键词：轴承钢退火炉球化退火单层布料重量控制

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社会功能重塑:公共危机应对中的城市社区商业转型研究——以F市地方传统商超为例

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安徽农业大学学报（社会科学版） 2021年第4期30卷 106-110页

作者：吕秋颍阜阳师范大学商学院安徽阜阳236000 华东理工大学社会与公共管理学院上海200237

在突发公共危机事件背景下,城市社区商业积极参与抗疫防控行为引发社会对其社会功能的重新思考。调研发现,危机前后城市社区商业行为有了明显改变,由社会规范、聚集人群、社会化和社区意识组成的社区商业的社会功能从弱变强。危机中城... 详细信息

在突发公共危机事件背景下,城市社区商业积极参与抗疫防控行为引发社会对其社会功能的重新思考。调研发现,危机前后城市社区商业行为有了明显改变,由社会规范、聚集人群、社会化和社区意识组成的社区商业的社会功能从弱变强。危机中城市社区商业行为的变化不仅促进了零售机会的增加,还加强了与所属社区利益相关者之间的理解与沟通。因此,告别单一的经济功能,进一步推动城市商业社区社会功能的重塑,是实现城市社区商业转型的关键。

关键词：公共危机城市社区商业社会功能重塑

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网络环境下应用化学实验教学研究性学习模式的研究与应用

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广东化工 2016年第23期43卷 146-147页

作者：吴福芳王倩吕秋颖盛良全夏娟阜阳师范学院化学与材料工程学院安徽阜阳236041

从网络环境下应用化学专业研究性学习的意义、原则及模式三个方面进行探讨研究,为培养应用型化学人才提供一种新的教学、学习模式。

关键词：网络环境应用化学实验研究性学习

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Mesoporous H-ZSM-5 nanocrystals with programmable number of acid sites as ＂solid ligands＂ to activate Pd nanoparticles for C-C coupling reactions

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Nano Research 2018年第2期11卷 874-881页

作者： Wenyu Ke Tianlu Cui qiuying Yu Mengying Wang Libing lv Honghui Wang Zhidong Jiang XinhHao Li Jiesheng Chen School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai China

In this work, we described a proof-of-concept method to promote the activity and selectivity of Pd nanoparticles for heterogeneous catalysis （exemplified by C-C coupling reactions） by using acid sites within a zeolite framework. The Pd nanoparticles were encapsulated inside the crystalline walls of mesoporous H-ZSM-5 leading to hybrid samples （denoted as Pd@mZ-x-H） with controlled number of acid sites. A linear relationship between the number of acid sites of the zeolite nanocrystals and the catalytic activities of the Pd nanoparticles in organic reactions was established. Moreover, the shape-dependent selectivity of Pd@mZ-x-H was not sacrificed when the final activity was enhanced.

关键词： Brgnsted acidity palladium HZSM-5 mesopores Suzuki coupling

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Synthesis and Characterization of the Amorphous SiO2 Nanowires

Synthesis and Characterization of the Amorphous SiO2 Nanowir...

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第十八届中国高压科学学术会议

作者：徐菁 qiuying Liu Xibao Yang Hang lv College of New Energy Bohai University Laboratory Management Center Bohai University

After entering the 21 century,nano science and technology led the new stage of the development of materials,and it also expand the new vision of the *** a new type of one-dimensional semiconductor materials,the unique physical and chemical properties of Si O2 nanowires have been widespread ***,as a photoluminescence material,Si O2 nanowires have a very broad

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THE PERMANENCE OF A DISCRETE PREDATOR-PREY SYSTEM WITH TIME DELAYS

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Annals of Differential Equations 2011年第2期27卷 176-182页

作者： qiuying Li, Fengqin Zhang, Hanwu Liu, Jiang lv (Dept. of Math., Yuncheng University, Yuncheng 044000, Shanxi)

In this paper, a discrete predator-prey system with time delay is considered. Sufficient conditions which guarantee the permanence of all positive solutions to this discrete system are obtained.

关键词： permanence predator-prey discrete delay

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