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Tissue optical clearing enhances efficacy of vascular targeted photodynamic therapy of mouse dorsal skin

Journal of Innovative Optical Health Sciences 2024年第2期17卷 67-78页

作者： Ying Liu qiushi Wang Yidi Liu Ying Wang Haixia qiu Dan zhu Ying Gu Defu Chen School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081P.R.China School of Medical Technology Beijing Institute of TechnologyBeijing 100081P.R.China Department of Laser Medicine First Medical Center of PLA General HospitalBeijing 100853P.R.China Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics A duanced Biomedical Imaging FacilityWuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074HubeiP.R.China Precision Laser Medical Diagnosis and Treatment Innovation Unit Chinese A cademy of Medical SciencesBeijing 100000P.R.China

Vascular-targeted photodynamic therapy(V-PDT)is an effective treatment for port wine stains(PWS).However,repeated treatment is usually needed to achieve optimal treatment outcomes,possibly due to the limited treatment light penetration depth in the PWS *** optical clearing technique can increase light penetration in depth by reducing light *** study aimed to investigate the V-PDT in combination with an optical clearing agent(OCA)for the therapeutic enhancement of V-PDT in the rodent skinfold window chamber *** responses were closely monitored with laser speckle contrast imaging(LSCI),optical coherence tomography angiography,and stereo microscope before,during,and after the *** further quantitatively demonstrated the effects of V-PDT in combination with OCA on the blood flow and blood vessel size of skin *** combination of OCA and V-PDT resulted in significant vascular damage,including vasoconstriction and the reduction of blood *** results indicate the promising potential of OCA for enhancing V-PDT for treating vascular-related diseases,including PWS.

关键词： Vascular-targeted photodynamic therapy(V-PDT) optical clearing agent(OCA) treatment efficacy enhancement skin-fold window chamber port wine stains

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A highly selective electrochemical impedimetric sensor for imidacloprid determination based on WO_(3)/MoS_(2)nanosheets/molecularly imprinted polymer composite

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Rare Metals 2024年第3期43卷 1309-1315页

作者： Long-Hua Ding Ya-Wen Wang qiu-Wen Li Li-Li Zhang Ai-zhu Wang Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China HCA Florida Healthcare Westside/Northwest Hospital Internal Medicine PlantationFL33324USA

In this study,an electrochemical impedimetric sensor was established for imidacloprid(IMI)detection based on WO_(3)/MoS_(2)and molecular imprinted polymer(MIP)*** layer was prepared on electrode surface by electropolymerization of o-phenylenediamine(o-PD)in the presence of IMI template,which ensured the specific rec-ognization toward IMI.

关键词： electrochemical polymer polymerization

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From common biomass materials to high-performance tissue engineering scaffold: Biomimetic preparation, properties characterization, in vitro and in vivo evaluations

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Journal of Bioresources and Bioproducts 2024年第2期9卷 185-196页

作者： Zongpu Xu Fang He Jing Yu Zhangze Yang Yu zhu Rong Liao Ruyin Lyu mei Yang Liangjun zhu Mingying Yang Institute of Applied Bioresources College of Animal SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Silkworm and Bee Resource Utilization and Innovation of Zhejiang Province Zhejiang UniversityHangzhou 310058China Department of Neurosurgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Converting common biomass materials to high-performance biomedical products could not only reduce the environmental pressure associated with the large-scale use of synthetic materials,but also increase the economic *** as a very promising candidate has drawn considerable attention owing to its abundant sources and remarkable ***,pure chitosan materials usually exhibit insufficient mechanical properties and excessive swelling ratio,which seriously affected their in vivo stability and integrity when applied as tissue engineering ***,simultaneously improving the mechanical strength and biological compatibility of pure chitosan(CS)scaffolds becomes very ***,inspired by the fiber-reinforced con-struction of natural extracellular matrix and the porous structure of cancellous bone,we built silk microfibers/chitosan composite scaffolds via ice-templating *** biomimetic strategy achieved 500%of mechanical improvement to pure chitosan,and meanwhile still maintaining high porosity(>87%).In addition,the increased roughness of chitosan pore walls by embedded silk microfibers significantly promoted cell adhesion and *** importantly,after subcutaneous implantation in mice for four weeks,the composite scaffold showed greater struc-tural integrity,as well as better collagenation,angiogenesis,and osteogenesis abilities,suggesting its great potential in biomedicine.

关键词： Chitosan Biomimetic strategy Fiber-reinforced composite Mechanical property Biocompatibility

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Spatial-and spin-resolution ARPES and magnetism beamline at SSRF

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Nuclear Science and Techniques 2024年第8期35卷 23-37页

作者： Fang‑Yuan zhu Jie‑Feng Cao Xiang‑Yu Meng Jun‑Qin Li Rui Yu Ya‑mei Wang Shan Qiao Bo Zhao Ming‑zhu Zhang Zhong‑Kai Liu mei‑Xiao Wang Yong Wang Ren‑Zhong Tai Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China ShanghaiTech Laboratory for Topological Physics School of Physical Science and TechnologyShanghai Tech UniversityShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China

The BL07U beamline is a new extreme ultraviolet and soft X-ray beamline housed in the Shanghai Synchrotron Radiation Facility. Beamlines are used in nano-resolved angle-resolved photoemission spectroscopy(nano-ARPES), spin-resolved angle-resolved photoemission spectroscopy(spin-ARPES), X-ray magnetic circular dichroism spectroscopy, and X-ray magnetic linear dichroism spectroscopy for certain scientific research. The BL07U beamline, which is based on a pair of elliptical polarized undulators and a variable-included-angle plane-grating monochromator, delivers circularly or linear polarized X-rays within the energy range of 50–2000 eV. The beamline features two branches: One dedicated to nano-ARPES,which has a minimum spot size of only ~ 200 nm, and another branch comprising spin-ARPES, a vector magnetic field, and superconductive magnetic end-station.

关键词： Soft X-ray beamline Nano-ARPES Spin-ARPES XMCD/XMLD

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Impact of EnKF assimilating Himawari-8 all-sky infrared radiance on the forecasting of a warm-sector rainstorm event

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Science China Earth Sciences 2024年第10期67卷 3110-3127页

作者： Shanshan LOU Lei zhu Xuexing qiu Guangzhou CHEN Song YUAN Shengnan ZHOU Anhui Meteorological Observatory Anhui Province Key Laboratory of Atmospheric Science and Satellite Remote Sensing Key Laboratory of Meteorological Disaster Ministry of Education (KLME) Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters (CIC-FEMD) Joint International Research Laboratory of Climate and Environment Change (ILCEC) Nanjing University of Information Science & Technology Huaihe River Basin Meteorological Center Shouxian National Climatology Observatory Huaihe River Basin Typical Farm Eco-Meteorological Experiment Field of CMA Shouxian National Comprehensive Meteorological Observation Special Experimental Outfield

Warm-sector rainstorms are highly localized events, with weather systems and triggering mechanisms are not obvious,leading to limited forecasting capabilities in numerical models. Based on the ensemble Kalman filter(PSU-En KF) assimilation system and the regional mesoscale model WRF, this study conducted a simulation experiment assimilating all-sky infrared(IR)radiance for a warm-sector rainstorm in East China and investigated the positive impact of assimilating the Himawari-8 moisture channel all-sky IR radiance on the forecast of the rainstorm. Results indicate that hourly cycling assimilation of all-sky IR radiance can significantly improve the forecast accuracy of this warm-sector rainstorm. There is a notable increase in the Threat Score(TS), with the simulated location and intensity of the 3-hour precipitation aligning more closely with observations. These improvements result from the assimilation of cloud-affected radiance, which introduces more mesoscale convective information into the model's initial fields. The adjustments include enhancements to the moisture field, such as increased humidity and moisture transport, and modifications to the wind field, including the intrusion of mid-level cold air and the strengthening of lowlevel convergent shear. These factors are critical in improving the forecast of this warm-sector rainstorm event.

关键词： Ensemble Kalman filter WRF model Himawari-8 All-sky radiance Warm-sector rainstorm

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Multi-Branch Fault Line Location Method Based on Time Difference Matrix Fitting

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Energy Engineering 2024年第1期121卷 77-94页

作者： Hua Leng Silin He Jian qiu Feng Liu Xinfei Huang Jiran zhu School of Electrical and Information Engineering Hunan UniversityChangsha410082China Distribution Network Technical Center State Grid Hunan Electric Power Research InstituteChangsha410007China Technical Center China Energy Construction Group Hunan Thermal Power ConstructionZhuzhou412011China School of Electrical and Information Engineering Changsha University of Science and TechnologyChangsha410076China

The distribution network exhibits complex structural characteristics,which makes fault localization a challenging *** when a branch of the multi-branch distribution network fails,the traditional multi-branch fault location algorithm makes it difficult to meet the demands of high-precision fault localization in the multi-branch distribution network *** this paper,the multi-branch mainline is decomposed into single branch lines,transforming the complex multi-branch fault location problem into a double-ended fault location *** on the different transmission characteristics of the fault-traveling wave in fault lines and non-fault lines,the endpoint reference time difference matrix S and the fault time difference matrix G were *** time variation rule of the fault-traveling wave arriving at each endpoint before and after a fault was comprehensively *** realize the fault segment location,the least square method was *** was used to find the first-order fitting relation that satisfies the matching relationship between the corresponding row vector and the first-order function in the two matrices,to realize the fault segment ***,the time difference matrix is used to determine the traveling wave velocity,which,combined with the double-ended traveling wave location,enables accurate fault location.

关键词： Multi-branch lines distribution network fault location double-ended traveling wave positioning least square method

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Effect of alumina occurrence form on metallurgical properties of hematite and magnetite pellets

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Journal of Iron and Steel Research International 2024年第4期31卷 797-809页

作者： Jian Pan Chen-mei Tang Cong-cong Yang De-qing zhu Zheng-qi Guo Wei-qun Huang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Exploration and Development of Geology and Mineral Resources Co. Ltd.Nanchang 330030JiangxiChina

The effect of alumina occurrence form on the metallurgical properties of both hematite and magnetite pellets was investigated at the same Al_(2)O level of 2 wt.%,including reduction index(RI),low-temperature reduction disintegration index(RDI),reduction swelling index(RSI),and high-temperature softening-dripping *** mineralogy of fired pellets was also studied to reveal the influence of alumina occurrence form on the phase composition and *** the results,the alumina occurrence form presents tremendous impacts on the metallurgical perfor-mance of both magnetite and hematite *** of all alumina occurrence forms contributes to inferior reducibility of pellets,especially in the case of gibbsite for magnetite pellets with a RI of 58.4%and kaolinite for hematite pellets with a RI of 56.8%.However,addition of all alumina occurrence forms improves the RDI of magnetite pellets,while there is no significant difference among various alumina occurrence *** contrast,alumina occurrence forms have little influence on the RDI of hematite *** presence of free alumina,gibbsite,and kaolinite tends to improve the RSI of hematite and magnetite pellets,whereas hercynite gives the opposite trend with a RSI of 25.6%.For softening-dripping performance of magnetite pellets,all alumina occurrence forms contribute to narrower softening-melting ***,alumina,gibbsite,and kaolinite give narrower softening-dripping interval,at 229,217,and 88℃,respectively,whereas addition of hercynite results in the largest melting range at 276℃ due to its high melting *** hematite pellets,free alumina,gibbsite,and hercynite tend to enlarge melting range,whereas kaolinite contributes to lower dripping temperature of 1148℃ and narrow softening-dripping interval of 88℃ due to the formation of a greater amount of slag phase at high temperatures.

关键词： Oxidized pellet Magnetite Hematite Alumina occurrence form Metallurgical performance Blast furnace

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Dating Kimberlite Using Apatite U-Pb Geochronology: A Case Study from Diamond-Bearing Dikes in South China

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Journal of Earth Science 2024年第3期35卷 1059-1062页

作者： Jiawei Zhang Huan Wang Defeng He Yuhua zhu Kun Wang Yuan qiu Guizhou Geological Survey Bureau of Geology and Mineral Exploration and Development of Guizhou ProvinceGuiyang 550081China College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China Yanduzhongshi Geological Analysis Laboratory Ltd. Beijing 100080China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

Kimberlite,one of the deepest known magmatic rocks on Earth,offers valuable glimpses into the deep mantle composition(Woodhead et al.,2019),craton structure(Gardiner et al.,2020),global geodynamic variation(Tappe et al.,2018),and diamond formation(Giuliani et al.,2023).The accurate determination of the emplacement of this special rock is crucial for revealing such ***,dating kimberlite is challenging due to its silica-poor,volatile-rich,strongly altered,and hybrid nature(Mitchell et al.,2019).Zircon is unsuitable for dating kimberlite and related rocks due to its preference for crystallizing in intermediate to felsic melts(Gervasoni et al.,2016)rather than silica-poor *** if present,zircon is prone to Pb loss through hydrothermal alteration(Zi et al.,2022)in a volatile-rich system like kimberlitic magmas.

关键词： dating magma alteration

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Insights into the dwarfing mechanism of pear(Pyrus betulaefolia) based on anatomical and structural analysis using X-ray scanning

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Horticultural Plant Journal 2024年第2期10卷 355-366页

作者： Lili Dong Chuxuan Yang Jing Wang Jingjing Li mei Zhao Dingli Li Zhiyun qiu Chunhui Ma Zhenhua Cui College of Horticulture Qingdao Agricultural UniversityQingdaoShandong 266109China College of Landscape and Forestry Qingdao Agricultural UniversityQingdaoShandong 266109China

The lack of a suitable rootstock to control scion growth has limited the development of high-density plantations in pear production, which is partly attributed to poor understanding of the dwarfing mechanism. In the present study, the rootstock of the dwarf-type pear (Pyrus betulaefolia)PY-9’ was identified and used as the material for anatomical ***-9’ grew to half the tree height of the normal cultivar Zhengdu’, along with fewer internodes and shorter length. Significant differences in growth rate betweenPY-9’ andZhengdu’ were detected at approximately 30 days after full bloom, which corresponded with the time of the greatest difference in water potential between the dwarf and normal ***-9’ showed a higher photosynthetic rate thanZhengdu’. Anatomical analysis showed thatPY-9’ had higher area ratios of both phloem and xylem and more developed vascular tissues thanZhengdu’. The three-dimensional reconstructed skeleton of the xylem from X-ray computed tomography scanning revealed greater intervessel connectivity inZhengdu’ than inPY-9’, which could contribute to the more vigorous growth ofZhengdu’. This study thus provides the first comparison of the microstructural properties of xylem elements between a dwarfing-type and vigorous-type pear rootstock, providing new insights into the dwarfing mechanism in pear and facilitating breeding of dwarf pear rootstocks to increase crop productivity.

关键词： Pyrus betulaefolia Anatomical analysis Dwarfing mechanism Intervessel connectivity Rootstock

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Applications of deep learning for detecting ophthalmic diseases with ultrawide-field fundus

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 188-200页

作者： Qing-Qing Tang Xiang-Gang Yang Hong-qiu Wang Da-Wen Wu mei-Xia Zhang Department of Ophthalmology and Research Laboratory of Macular Disease West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Hong Kong University of Science and Technology(Guangzhou) Guangzhou 511400Guangdong ProvinceChina

AIM:To summarize the application of deep learning in detecting ophthalmic disease with ultrawide-field fundus images and analyze the advantages,limitations,and possible solutions common to all ***:We searched three academic databases,including PubMed,Web of Science,and Ovid,with the date of August *** matched and screened according to the target keywords and publication year and retrieved a total of 4358 research papers according to the keywords,of which 23 studies were retrieved on applying deep learning in diagnosing ophthalmic disease with ultrawide-field ***:Deep learning in ultrawide-field images can detect various ophthalmic diseases and achieve great performance,including diabetic retinopathy,glaucoma,age-related macular degeneration,retinal vein occlusions,retinal detachment,and other peripheral retinal *** to fundus images,the ultrawide-field fundus scanning laser ophthalmoscopy enables the capture of the ocular fundus up to 200°in a single exposure,which can observe more areas of the ***:The combination of ultrawide-field fundus images and artificial intelligence will achieve great performance in diagnosing multiple ophthalmic diseases in the future.

关键词： ultrawide-field fundus images deep learning disease diagnosis ophthalmic disease

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