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MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang ma Jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux Ferguson Shenfeng qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang ju-Yun ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu ju-Song Yang Fu-Min Zhang Ai-jun ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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In-situ Observation of Point Defect and Precipitate Evolvement of CLAM Steel under Electron Irradiation

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Journal of materials Science & Technology 2013年第5期29卷 467-470页

作者： Yong Xin Tongda ma Xin ju Jie qiu Department of Physics University of Science and Technology Beijing General Research Institute for Nonferrous Metals Institute of Nuclear and New Energy Technology Tsinghua University

The point defect and precipitate evolution of China low activation martensitic steel （CLAM） under electron beam irradiation were characterized by high voltage electron microscopy. The process was recorded in-situ on electronsensitive films. The irradiation dose rate was 1.78 × 10-3 dpa/s and the highest dose was 2.12 dpa/s. Irradiation introduced dislocation loops into the sub-grain, which increased density when the irradiation dose was increased from 0.53 dpa to 1.59 dpa at 723 K. The precipitate, found to be an M6C type, was irradiated at 773 K at the [011] plane direction. The precipitate morphology and structure were unchanged when the irradiation dose was increased to 2.12 dpa. Compared with the irradiation at 723 K in the sub-grain, no other defects were generated at the nearby grain boundary at 773 K.

关键词： martensitic steel Electron microscopy Electron irradiation Defect Precipitate

An investigation on the wind profiles and gravity wave dynamics in MLT region based on the meteor radars from the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 29-38页

作者： Tai Liu Zhe Wang MengXi Shi Willie Soon ShiCan qiu Department of Geophysics College of the Geology Engineering and GeomaticsChang’an UniversityXi’an 710054China Center for Environmental Research and Earth Sciences(CERES) SalemMA 01970USA Institute of Earth Physics and Space Science(ELKH EPSS) 9400SopronHungary

The meteor radar can detect the zenith angle,azimuth,radial velocity,and altitude of meteor trails so that one can invert the wind profiles in the mesosphere and low thermosphere(MLT)region,based on the Interferometric and Doppler *** this paper,the horizontal wind field,gravity wave(GW)disturbance variance,and GW fluxes are analyzed through the meteor radar observation from 2012−2022,at Mohe(53.5°N,122.4°E)and Zuoling(30.5°N,114.6°E)stations of the(Chinese)Meridian *** Lomb−Scargle periodogram method has been utilized to analyze the periodic variations for time series with observational data *** results show that the zonal winds at both stations are eastward dominated,while the meridional winds are southward *** variance of GW disturbances in the zonal and meridional directions increases gradually with height,and there is a strong pattern of annual *** zonal momentum flux of GW changes little with height,showing weak annual *** meridional GW flux varies gradually from northward to southward with height,and the annual periodicity is *** both stations,the maximum values of zonal and meridional wind occur close to the peak heights of GW flux,with opposite *** observational evidence is consistent with the filtering *** horizontal wind velocity,GW flux,and disturbance variance of the GW at Mohe are overall smaller than those at Zuoling,indicating weaker activities in the MLT at *** power spectral density(PSD)calculated by the Lomb−Scargle periodogram shows that there are 12-month period and 6-month period in horizontal wind field,GW disturbance variance and GW flux at both stations,and especially there is also a 4-month cycle in the disturbance *** PSD of the 12-month and 6-month cycles exhibits maximum values below 88 km and above 94 km.

关键词： meteor radar wind field gravity wave Lomb−Scargle method

Impacts of Platform’s Omnichannel Coupons on Multichannel Suppliers

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Journal of Systems Science and Systems Engineering 2023年第1期32卷 71-99页

作者： Yue Zhang Xiaojian Hu ju Zhao ju qiu School of management Hefei University of TechnologyHefei230009China Key Laboratory of Process Optimization and Intelligent Decision-making Ministry of EducationHefei230009China

While coupons that can be redeemed only in online channels have been issued by e-commerce platforms for decades, a new type of platform’s coupons, i.e., omnichannel coupons, which can be redeemed in both online and store channels, is gaining popularity with the rise of the omnichannel retail mode. It is interesting to explore the conditions under which omnichannel coupons are more advantageous to platforms and multichannel suppliers that sell products through platforms and physical stores. Two game models are developed in two cases where an e-commerce platform offers single channel coupons or omnichannel coupons for a multichannel supplier. Two scenarios are considered: one in which a consumer’s valuation of a product that fits his or her need is homogeneous and another in which the valuation is heterogeneous. Equilibrium outcomes show that under the homogeneous scenario, the product price and coupon face value in both coupon modes increase with the product’s fit probability when the cross-selling revenue is high, while decrease with the product’s fit probability when the cross-selling revenue is low. However, under the heterogeneous scenario, the price in both modes increases with the product’s fit probability only when the supplier’s loss from returns is low and the cross-selling revenue is high, and the coupon face value always decreases with the product’s fit probability. Compared with single channel coupons, omnichannel coupons may lead to a higher product price under certain conditions. Furthermore, omnichannel coupons can lead to higher total demand and benefit both the platform and the supplier if and only if the product’s fit probability is low and the supplier’s loss from returns is high. An extension shows that the platform’s preference for omnichannel coupons is weakened when the supplier offers a partial refund policy.

关键词： Omnichannel coupon promotion e-commerce platform game theory

Preparation of ZnO Nanoparticles from Zn-containing Rotary Hearth Furnace Dust

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Journal of Wuhan University of Technology(materials Science) 2022年第1期37卷 32-37页

作者： YAO Haiwei ma Han maO Rui qiu Jiayong CHEN Chunyu ju Dianchun School of Metallurgy and materials Engineering Jiangsu University of Science and TechnologyZhangjiagang 215600China Shagang Iron&Steel Research Institute of Jiangsu Province Zhangjiagang 215625China

To solve the problem of the low added value Zn-containing rotary hearth furnace(RHF)dust,two deep eutectic solvents(DESs)were employed,such as choline chloride-urea(ChCl-urea)and choline chloride-oxalic acid dihydrate(CC-OA)solvent and Zn-containing RHF dust(water-washed)as the research ***,we prepared ZnO nanoparticles using two DESs or their combination,namely,ChCl-urea(Method A),CC-OA(Method B),first CC-OA and then ChCl-urea(Method B-A)and first ChCl-urea and then CCOA(Method A-B),*** effects of these methods on the properties of as-obtained precursors and ZnO nanoparticles were investigated in *** results indicated that the precursor obtained by Method A was Zn_(4)CO_(3)(OH)_(6)·H_(2)O,and those by Methods B,B-A,and A-B were all ZnC_(2)O_(4)·2H_(2)***,the decomposition steps of the last three methods were *** ZnO contents of 95.486%,99.768%,99.733%,and 99.76%were obtained by Methods A,B,B-A,and A-B,*** A,B,and B-A led to the formation of spherical and agglomerated ZnO nanoparticles with normal size distributions,where Method B showed the best distribution with an average diameter 25 *** ZnO nanoparticles obtained by the Method A-B did not possess good properties.

关键词： rotary hearth furnace Zn-containing dust deep eutectic solvent ZnO nanoparticle

Motion and acceleration of electrons in high-intensity laser standing waves

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Chinese Physics B 2012年第1期21卷 171-176页

作者： Zhang qiu-ju Yu wei Luan Shi-xia ma Guang-Jin College of Physics and Electronics Shandong Normal UniversityJinan 250014China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China

The motion and the energy of electrons driven by the ponderomotive force in linearly polarized high-intensity laser standing wave fields are considered. The results show that there exists a threshold laser intensity, above which the motion of electrons incident parallel to the electric field of the laser standing waves undergoes a transition from regulation to chaos. We propose that the huge energy exchange between the electrons and the strong laser standing waves is triggered by inelastic scattering, which is related to the chaos patterns. It is shown that an electron＇s energy gain of tens of MeV can be realized for a laser intensity of 10^20 W/cm^2.

关键词： electron motion inelastic scattering laser standing wave energy exchange

Semiclassical Calculations of Recurrence Spectra for Lithium Atoms in Parallel Electric and magnetic Fields

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Chinese Physics Letters 2002年第1期19卷 29-31页

作者： Lin Sheng-Lu, Zhang qiu-ju Department of Physics Shandong Normal University Ji\'nan 250014

By using the region-splitting consistent and iterative method, we calculate the recurrence spectra of lithium atoms in parallel strong external electric and magnetic fields, and obtain the novel resonance structure in the photoabsorption spectrum above the ionization threshold with a constant scaled electric field at (F↑-)= 0.036, and a scaled energy at ε= 0.58 and ε= 0.006, respectively. The results are compared with those of hydrogen obtained by using standard closed orbit theory. It is demonstrated that the core-scattered effects exhibited in combination recurrence play a great role

关键词： Electric fields