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B Vitamins Supplementation Can Improve Cognitive Functions and May Relate to the Enhancement of Transketolase Activity in A Rat Model of Cognitive Impairment Associated with High-fat Diets

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Current Medical Science 2021年第5期41卷 847-856页

作者： Ying zhenG Zhi-yong CHEN Wen-jun MA qiu-zhen wang Hui LIANG Ai-guo MA Department of Nutrition Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510080China Institute of Nutrition and Health Medical College of Qingdao UniversityQingdao 266021China

Objective:To determine whether B vitamin treatment was sufficient to reduce cognitive impairment associated with high-fat diets in rats and to modulate transketolase(TK)expression and ***:To test this,we separated 50 rats into five groups that were either fed a standard chow diet(controls)or a high-fat diet(experimental groups HO,HI,H2,and H3).HO group animals received no additional dietary supplementation,while H1 group animals were administered 100 mg/kg body weight(BW)thiamine,100 mg/kg BW riboflavin,and 250 mg/kg BW niacin each day,and group H2 animals received daily doses of 100 mg/kg BW pyridoxine,100 mg/kg BW cobalamin,and 5 mg/kg BW *** in the H3 group received the B vitamin regimens administered to both H1 and H2 each ***:Over time,group HO exhibited greater increases in BW and fat mass relative to other *** spatial and memory capabilities in these animals were evaluated via conditioned taste aversion(CTA)and Morris Water Maze(MWM),we found B vitamin treatment was associated with significant improvements relative to untreated HO ***,B vitamin supplementation was associated with elevated TK expression in erythrocytes and hypothalamus of treated animals relative to those in HO(P<0.05).Conclusion:Together,these findings suggest B vitamin can modulate hypothalamic TK activity to reduce the severity of cognitive deficits in a rat model of *** such,B vitamin supplementation may be a beneficial method for reducing cognitive dysfunction in clinical settings associated with high-fat diets.

关键词： B vitamins obesity conditioned taste aversion Morris water maze cognition transketolase

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Ruthenium-lead oxide for acidic oxygen evolution reaction in proton exchange membrane water electrolysis

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Nano Research 2024年第10期17卷 8671-8677页

作者： Feng-Yang Chen Chang qiu zhen-Yu Wu Tae-Ung Wi YZou Finfrock Haotian wang Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX 77005USA Structural Biology Center X-ray Science DivisionArgonne National LaboratoryLemontIL 60439USA Department of Materials Science and NanoEngineering Rice UniversityHoustonTX 77005USA Department of Chemistry Rice UniversityHoustonTX 77005USA

Developing an active and stable anode catalyst for the proton exchange membrane water electrolyzer(PEM-WE)is a critical objective to enhance the economic viability of green hydrogen ***,the expensive iridium-based electrocatalyst remains the sole practical material with industrial-level stability for the acidic oxygen evolution reaction(OER)at the ***-based catalysts have been proposed as more cost-effective alternatives with improved activity,though their stability requires *** current urgent goal is to reduce costs and noble metal loading of the OER catalyst while maintaining robust activity and *** this study,we design a Ru-based OER catalyst incorporating Pb as a supporting *** electrocatalyst exhibits an OER overpotential of 201 mV at 10 mA·cm^(-2),simultaneously reducing Ru noble metal loading by~40%.Normalization of the electrochemically active surface area unveils improved intrinsic activity compared to the pristine RuO_(2) *** a practical stability test in a PEM-WE setup,our developed catalyst sustains stable performance over 300 h without notable degradation,underscoring its potential for future applications as a reliable anodic catalyst.

关键词： electrocatalysis oxygen evolution reaction water splitting proton exchange membrane water electrolyzer

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Enhancement of vitamin A combined vitamin D supplementation on immune response to Bacille Calmette-Guerin vaccine revaccinated in Chinese infants

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Asian Pacific Journal of Tropical Medicine 2014年第2期7卷 130-135页

作者： Ying zheng Xue-Gang Li qiu-zhen wang Ai-Guo Ma Ib Christian Bygbjerg Yong-Ye Sun Yong Li Ming-Ci zheng Xi wang Institute of Human Nutrition Medical College of Qingdao Unirersity Department of International Health University of Copenhagen Department of Pediatrics.Guilin Medical College Affiliated Hospital Department of Orthopaedic Surgery The Sixth Affiliated Hospital of Sun Yat-sen University

Objective:To investigate whether there is an association between diameter of bacille CalmetteGuerin(BCG)sears and effect of purified protein derivative(PPD)reaction anil to determine whether vitamin A(VA)combined vitamin I)(VD)supplementation influences the immune response to BCG revueeinated in Chinese ***:A cross-section and 3-month community-randomised trial was conducted.A total of 5 629 infants at 3,6 and 12 months of age in Junan County of China were examined for BCG scar ***,597 revuccinated infants were randomly assigned to supplementation(n=307)and control(n=290)*** supplementation group were daily assigned to 1 500 IU VA and 500 IU VD for 3 *** all infants were subjected to skin test with ***:The diameter of BCG sears was positively con-elated with diameter of skin indurations of PPD(r=0.17,P<0.05)in the 5 629 *** rate of positive response to PP1)was higher in the supplementation group than in the control group(96.1%versus 89.7%,P<0.05,prevalence ratio 1.07.95%CI 1.02-1.12).The prevalence ralio of PPD response for the supplementation group compared with that for the control group was 1.07(95%CI 1.01-1.13)for the males and 1.08(95%CI 1.00-1.17)for the *** the supplementation group,the males got larger tuberculin induration than the females[(0.73±0.2l)cm versus(0.67±0.20)cm.P<0.05)after ***:The diameter of BCG scars was effectively correlated with PPD response,which indicates BCG scar formation may be an useful tool Io evaluate the effect of tuberculosis *** combined VD supplementation may play an immunoregulatory rale in BCG *** may contribute to the prevention of childhood tuberculosis.

关键词： Tuberculosis Bacille Calmette-Guerin Purified protein derivative Vitamin A Vitamin D Revaccination

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Normalized glandular dose coefficients for digital breast tomosynthesis using detailed Chinese breast models

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Nuclear Science and Techniques 2024年第5期35卷 42-59页

作者： Jia-Hao wang Rui qiu An-Kang Hu Ye-Qi Liu zhen Wu Hui Zhang Jun-Li Li Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging Ministry of EducationTsinghua UniversityBeijing 100084China Joint Institute of Tsinghua University Nuctech Company Limited BeijingBeijing 100084China

The rise in breast cancer diagnoses among Chinese women has necessitated the use of X-ray breast screening,which carries a radiation *** study aimed to provide a dosimetry protocol for the Chinese female population to replace the traditional standard that utilizes simplified breast models,for the accurate estimation of the mean glandular dose of a patient undergoing digital breast tomosynthesis(DBT).The first set of detailed Chinese female breast models and representative breast parameters was *** backscatter radiation and computational efficiency,we improved the combination of these models and the Chinese reference adult female whole-body voxel *** acquisition for four commercial DBT systems that are widely employed in China was simulated using the Monte Carlo method to obtain the normalized glandular dose coefficients of DBT(D_(gN)^(DBT))and the glandular depth dose(D_(g)^(dep)(z))for different breast characteristics and X-ray *** calculated a series of D_(gN)^(DBT) values for breasts with different percentage mass glandularities(5%,25%,50%,75%,and 100%)and compressed breast thicknesses(2,3,4,5,6,and 7 cm)at various tube potentials(25,28,30,32,35,and 49 kV)and target/filter combinations(W/Rh,W/Al,Mo/Mo,Rh/Rh,and Rh/Ag).The parameter dependence of the breast characteristics and beam conditions on D_(gN)^(DBT) in detailed breast models was *** D_(gN)^(DBT) results were 14.6-51.0%lower than those of the traditional dosimetry standard in *** difference in D_(gN)^(DBT) was mainly due to a decrease in the depth of the main energy deposition area caused by the glandular distribution along the depth *** results obtained in this study may be used to improve breast dosimetry in China and provide more detailed information on risk assessment during DBT.

关键词： Digital breast tomosynthesis Normalized glandular dose coefficients Detailed breast model Monte Carlo simulation

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Endoscopic transsphenoidal approach to pituitary adenomas invading the cavernous sinus

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Chinese Medical Journal 2010年第24期123卷 3519-3523页

作者： TAO Yu-xin QU qiu-yi wang zhen-lin ZHANG qiu-hang Department of Otolaryngology-Head and Neck Surgery Xuanwu Hospital Capital Medical University Beijing 100053 China

Background Surgery of pituitary adenomas invading cavernous sinus has always been thought as a challenge due to the complex anatomical structures and high risk of complications. The purpose of this study was to evaluate endoscopic trarssphenoidal approach to pituitary adenomas invading cavernous *** The clinical data of 22 patients who admitted to Xuanwu Hospital with pituitary adenomas invading cavernous sinus were analyzed retrospectively. All patients underwent endoscopic transsphenoidal surgery. To expose the surgical field sufficiently, the opening of sellar floor was exceeded the bone overlying the invaded cavernous sinus, and synthetic dura was used to repair and strengthen the sella floor for preventing the leak of cerebrospinal *** Among 22 patients, total resection was achieved in 14, subtotal resection in 5, and partial resection in 3; no patient underwent insufficient resection. Visual symptoms improved in 7 of 9 patients. In one patient diplopia *** was relieved to various extents in all patients. No serious complications were found. Patient＇s hospital stay ranged from 7 to 20 *** These data suggest that the endoscopic transsphenoid approach is a safe, minimally invasive, and efficient surgical technique, which might be an important therapeutic strategy for the pituitary adenoms invading cavernous sinus.

关键词： endoscopy pituitary adenorna cavernous sinus invasion

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Number of Solitons Emerged in the Initial Profile of Shallow Water Using Convolutional Neural Networks

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Journal of Systems Science & Complexity 2024年第2期37卷 463-479页

作者： wang zhen CUI Shikun School of Mathematical Sciences Dalian University of TechnologyDalian 116024China School of Mathematical Sciences Beihang UniversityBeijing 100191China

The soliton resolution conjecture proposes that the initial value problem can evolve into a dispersion part and a soliton ***,the problem of determining the number of solitons that form in a given initial profile remains unsolved,except for a few specific *** this paper,the authors use the deep learning method to predict the number of solitons in a given initial value of the Korteweg-de Vries(KdV)*** leveraging the analytical relationship between Asech^(2)(x)initial values and the number of solitons,the authors train a Convolutional Neural Network(CNN)that can accurately identify the soliton count from spatio-temporal *** trained neural network is capable of predicting the number of solitons with other given initial values without any additional *** extensive calculations,the authors demonstrate the effectiveness and high performance of the proposed method.

关键词： Convolutional neural network deep learning method KdV equation soliton

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Abiotic stress treatment reveals expansin like A gene OfEXLA1 improving salt and drought tolerance of Osmanthus fragrans by responding to abscisic acid

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Horticultural Plant Journal 2024年第2期10卷 573-585页

作者： Bin Dong Qianqian wang Dan Zhou Yiguang wang Yunfeng Miao Shiwei Zhong qiu Fang Liyuan Yang zhen Xiao Hongbo Zhao School of Landscape Architecture Zhejiang Agriculture and Forestry UniversityHangzhouZhejiang 311300China Zhejiang Provincial Key Laboratory of Germplasm Innovation and Utilization for Garden Plants HangzhouZhejiang 311300China Key Laboratory of National Forestry and Grassland Administration on Germplasm Innovation and Utilization for Southern Garden Plants HangzhouZhejiang 311300China

Sweet osmanthus(Osmanthus fragrans) is a having general approval aromatic tree in China that is widely applied to landscaping and gardening. However, the evergreen tree adaptability is limited by many environmental stresses. Currently, limited information is available regarding the genetic analysis and functional identification of expansin genes in response to abiotic stress in sweet osmanthus. In this study, a total of 29 expansin genes were identified and divided into four groups by genome-wide analysis from the sweet osmanthus genome. Transcriptome and quantitative Real-time PCR analysis showed that the cell wall-localized protein expansin-like A(OfEXLA1) gene was significantly induced by salt and drought treatment. Histochemical GUS staining of transgenic Arabidopsis lines in which GUS activity was driven with the OfEXLA1 promoter, GUS activity was significantly induced by salt, drought, and exogenous abscisic acid(ABA). In yeast, we found OfEXLA1overexpression significantly improved the population of cells compared with wild-type strains after NaCl and polyethylene glycol(PEG)treatment. Additionally, OfEXLA1 overexpression not only promoted plant growth, but also improved the salt and drought tolerance in Arabidopsis. To gain insight into the role of ABA signaling in the regulation of OfEXLA1 improving abiotic tolerance in sweet osmanthus, four differentially expressed ABA Insensitive 5(ABI5)-like genes(OfABL4, OfABL5, OfABL7, and OfABL8) were identified from transcriptome, and dualluciferase(dual-LUC) and yeast one hybrid(Y1H) assay showed that OfABL4 and OfABL5 might bind to OfEXLA1 promoter to accumulate the OfEXLA1 expression by responding to ABA signaling to improve abiotic tolerance in sweet osmanthus. These results provide the information for understanding the molecular functions of expansin-like A gene and molecular breeding of sweet osmanthus in future.

关键词： Osmanthus fragrans Abiotic tolerance Expansin Abscisic acid

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The First Five Years of a Phase Theory for Complex Systems and Networks

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1728-1743页

作者： Dan wang Wei Chen Li qiu Division of Decision and Control Systems KTH Royal Institute of TechnologyStockholm 10044Sweden Department of Mechanics and Engineering Science&the State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing 100871China Hong Kong University of Science and Technology Hong KongChinaand also with the Southern University of Science and TechnologyShenzhen 518055China

In this paper,we review the development of a phase theory for systems and networks in its first five years,represented by a trilogy:Matrix phases and their properties;The MIMO LTI system phase response,its physical interpretations,the small phase theorem,and the sectored real lemma;The synchronization of a multi-agent network using phase *** the end,we also summarize a list of ongoing research on the phase theory and speculate what will happen in the next five years.

关键词： Consensus and synchronization matrix phases multi-agent systems phase theory sectored real lemma small phase theorem.

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How Does Stacking Pressure Affect the Performance of Solid Electrolytes and All-Solid-State Lithium Metal Batteries?

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Energy & Environmental Materials 2024年第4期7卷 93-98页

作者： Junwu Sang Bin Tang Yong qiu Yongzheng Fang Kecheng Pan zhen Zhou Interdisciplinary Research Center for Sustainable Energy Science and Engineering (IRC4SE2) School of Chemical Engineering Zhengzhou University

All-solid-state lithium metal batteries (ASSLMBs) with solid electrolytes (SEs)have emerged as a promising alternative to liquid electrolyte-based Li-ion batteries due to their higher energy density and ***,since ASSLMBs lack the wetting properties of liquid electrolytes,they require stacking pressure to prevent contact loss between electrodes and SEs.

关键词： critical current density solid electrolyte solid-state lithium metal batteries stacking pressure

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Impact of sourdough fermentation on nutrient transformations in cereal-based foods:Mechanisms,practical applications,and health implications

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Grain & Oil Science and Technology 2024年第2期7卷 124-132页

作者： zhen wang Luyang wang State Key Laboratory of Crop Stress Adaptation and Improvement College of AgricultureHenan UniversityKaifeng 475004China

Sourdough is often considered a healthy choice and quality improver for use in cereal production due to its unique microbial composition and fermentation *** sourdough fermentation of cereals,biotransformation of nutrients occurs,resulting in notable changes to proteins,carbohydrates,fats,vitamins,and *** nutrient undergoes specific transformations,providing various advantages for human *** undergo hydrolysis to produce small molecular weight peptides and amino acids that are more easily digested and absorbed by the human *** break down to improve the digestibility and absorption of cereals and lower the glycemic *** acids experience oxidation to produce new substances with health ***,the application of sourdough fermentation can enhance the texture,flavor,and nutritional value of cereal foods while also extending their shelf life and improving food *** conclusion,sourdough fermentation has a broad range of applications in cereal food *** research is encouraged to investigate the mechanisms and processes of sourdough fermentation to develop even more nutritious,healthy,and flavorful cereal-based foods.

关键词： Sourdough fermentation Lactic acid bacteria Proteolysis Starch hydrolysis Low-GI Nutrients

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