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World Journal of Traditional Chinese Medicine 2022年第1期8卷 87-91页

作者： Luo-Qi Lin Bing-Xin Wu Miao-Yang Lin qiu-xiong chen Dan-Ping Xu The Second Clinical Medical College Guangzhou University of Chinese Medicine Department of Cardiology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou Postdoctoral Research Station Institute of Integrative Chinese and Western MedicineFujian University of Traditional Chinese MedicineFuzhouChina

Objective: The objective is to observe the effect of Kuanxiong aerosol(KXA) on angina and the quality of life of patients after percutaneous coronary intervention(PCI). Materials and Methods: Six hundred patients with angina after PCI(AAP) were randomly assigned to an experimental group and a control group(n = 300 in each group) and received basic treatment with KXA or basic treatment(respectively) for 8 weeks. The Seattle Angina Questionnaire(SAQ) and visual analog scale(VAS) scores of the two groups during the screening period and five follow-up periods were compared. Results: A total of 179 patients were included in this interim report, including 85 in the experimental group and 94 in the control group. Among the five-dimensional scores of the SAQ, the improvement in the angina frequency and quality of life scores in the experimental group was better than those in the control group after treatment(P 0.01). The difference in VAS scores between the two groups was not statistically significant(P > 0.01). No obvious adverse reactions were observed between the two groups. Conclusions: KXA can reduce the frequency of AAP and improve patients’ quality of life.

关键词： Angina Kuanxiong aerosol percutaneous coronary intervention quality of life

Coaxial Wet Spinning of Boron Nitride Nanosheet‑Based Composite Fibers with Enhanced Thermal Conductivity and Mechanical Strength

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Nano-Micro Letters 2024年第2期16卷 126-138页

作者： Wenjiang Lu Qixuan Deng Minsu Liu Baofu Ding Zhiyuan xiong Ling qiu Tsinghua Shenzhen International Graduate School(TSIGS) Tsinghua UniversityShenzhen 518055People’s Republic of China Monash Suzhou Research Institute(MSRI) Monash UniversitySuzhou 215000People’s Republic of China Faculty of Materials Science and Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Shenzhen Key Laboratory of Energy Materials for Carbon Neutrality Shenzhen 518055People’s Republic of China School of Light Industry and Engineering South China University of TechnologyGuangzhou 510614People’s Republic of China

Hexagonal boron nitride nanosheets(BNNSs)exhibit remarkable thermal and dielectric properties.However,their self-assembly and alignment in macroscopic forms remain challenging due to the chemical inertness of boron nitride,thereby limiting their performance in applications such as thermal management.In this study,we present a coaxial wet spinning approach for the fabrication of BNNSs/polymer composite fibers with high nanosheet orientation.The composite fibers were prepared using a superacid-based solvent system and showed a layered structure comprising an aramid core and an aramid/BNNSs sheath.Notably,the coaxial fibers exhibited significantly higher BNNSs alignment compared to uniaxial aramid/BNNSs fibers,primarily due to the additional compressive forces exerted at the core-sheath interface during the hot drawing process.With a BNNSs loading of 60 wt%,the resulting coaxial fibers showed exceptional properties,including an ultrahigh Herman orientation parameter of 0.81,thermal conductivity of 17.2 W m^(-1)K^(-1),and tensile strength of 192.5 MPa.These results surpassed those of uniaxial fibers and previously reported BNNSs composite fibers,making them highly suitable for applications such as wearable thermal management textiles.Our findings present a promising strategy for fabricating high-performance composite fibers based on BNNSs.

关键词： Boron nitride nanosheets Coaxial fiber Interfacial compression Nanosheet aligning Wearable thermal management

Transcatheter aortic valve replacement: A journey of two decades and beyond

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中华医学杂志(英文版) 2024年第9期137卷 1012-1015页

作者： xiong Tianyuan chen Mao Department of Cardiology West China Hospital Sichuan University Chengdu Sichuan China Laboratory of Cardiac Structure and Function Institute of Cardiovascular Diseases West China Hospital Sichuan University Chengdu Sichuan China

The number of patients with calcific aortic stenosis (AS) is 9.4 million according to 2019 Global Disease Burden estimates,which will continue to increase as the population ages.For the treatment of symptomatic severe AS,transcatheter aortic valve replacement (TAVR) has evolved to be a well-established option across all risk spectra,with a rapid growth of procedures worldwide.The rise of TAVR initiates the revolution of the management of valvular heart diseases,from patient surveillance,the staging of disease,the use of multimodality imaging,the concept of the Heart Team,new designs and iterations of devices to technical innovations and the discovery of unmet clinical needs.As a consequence of the global adoption of TAVR,geographical differences in the epidemiology of AS and patient characteristics have also been further identified.An examination of the changing patient population,current applications and breakthroughs,and remaining challenges are crucial for the future of this technique.Herein,we discuss the temporal utilization of TAVR,the accumulation of evidence and progress of devices,the selection of patients,and some ongoing topics concerning the improvement of TAVR.

关键词： CEREBRAL EMBOLIC PROTECTION OUTCOMES TAVR

Local quantum Fisher information and quantum correlation in the mixed-spin Heisenberg XXZ chain

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Frontiers of physics 2024年第2期19卷 235-245页

作者： Peng-Fei Wei Qi Luo Huang-qiu-chen Wang Shao-Jie xiong Bo Liu Zhe Sun School of Physics Hangzhou Normal UniversityHangzhou 310036China Zhejiang Institute of Modern Physics and School of Physics Zhejiang UniversityHangzhou 310027China School of Information and Electrical Engineering Hangzhou City UniversityHangzhou 310015China Zhejiang Provincial Key Laboratory of Urban Wetlands and Regional Change Hangzhou 311121China

We study the local quantum Fisher information(LQFI)in the mixed-spin Heisenberg XXZ chain.Both the maximal and minimal LQFI are studied and the former is essential to determine the accuracy of the quantum parameter estimation,the latter can be well used to characterize the discord-type quantum correlations.We investigate the effects of the temperature and the anisotropy parameter on the maximal LQFI and thus on the accuracy of the parameter estimation.Then we make use of the minimal LQFI to study the discord-type correlations of different site pairs.Different dimensions of the subsystems cause different values of the minimal LQFI which reflects the asymmetry of the discord-type correlation.In addition,the site pairs at different positions of the spin chains have different minimal LQFI,which reveals the influence of the surrounding spins on the bipartite quantum correlation.Our results show that the LQFI obtained through a simple calculation process provides a convenient way to investigate the discord-type correlation in high-dimensional systems.

关键词： local quantum Fisher information quantum correlation mixed-spin Heisenberg XXZ chain

Neuronomodulation of Excitable Neurons

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Neuroscience Bulletin 2024年第1期40卷 103-112页

作者： Yizhang chen Lin Xiao Jian qiu Institute of Neuroscience Second Military Medical UniversityShanghai 200433China Institute for Brain Research and Rehabilitation Key Laboratory of BrainCognition and Education Sciences of Ministry of EducationSouth China Normal UniversityGuangzhou 510631China Department of Chemical Physiology and Biochemistry Oregon Health and Science UniversityPortlandOR 97239USA

Neuronomodulation refers to the modulation of neural conduction and synaptic transmission(i.e.,the conduction process involved in synaptic transmission)of excitable neurons via changes in the membrane potential in response to chemical substances,from spillover neuro-transmitters to paracrine or endocrine hormones circulating in the blood.Neuronomodulation can be direct or indirect,depending on the transduction pathways from the ligand binding site to the ion pore,either on the same molecule,i.***.the ion channel,or through an intermediate step on different molecules.The major players in direct neurono-modulation are ligand-gated or voltage-gated ion channels.The key process of direct neuronomodulation is the binding and chemoactivation of ligand-gated or voltage-gated ion channels,either orthosterically or allosterically,by various ligands.Indirect neuronomodulation involves metabotropic receptor-mediated slow potentials,where steroid hormones,cytokines,and chemokines can implement these actions.Elucidating neuronomodulation is of great significance for understanding the physiological mechanisms of brain function,and the occurrence and treatment of diseases.

关键词： Neuron Membrane potential Excitability Chemoactivation Neuronomodulation

Phase-field lattice-Boltzmann study on fully coupled thermal-solute-convection dendrite growth of Al-Cu alloy

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China Foundry 2024年第2期21卷 125-136页

作者： Yin-qi qiu Meng-wu Wu Xun-peng Qin Shou-mei xiong Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Longzhong Laboratory Xiangyang 441000HubeiChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

Dendrite growth is a complex liquid-solid phase transition process involving multiple physical factors.A phase-field lattice-Boltzmann method was developed to simulate the two-and three-dimension dendrite growth of Al-Cu alloy.The effect of fully coupled thermal-solute-convection interaction on the dendrite growth was investigated by incorporating a parallel-adaptive mesh refinement algorithm into the numerical model.By accurately reproducing the latent heat release,solute diffusion and convective transport behaviors at the liquidsolid interface,the interaction mechanism among thermal-solute-convection transport as well as their coupling effects on the dendrite growth dynamics were discussed.The simulation results show that the release of latent heat slows down the dendrite growth rate,and both natural and forced convection disrupt the symmetrical growth of dendrites.Their combination makes the growth of dendrites more complex,capturing important physical aspects such as recalescence,dendrite tip splitting,dendrite tilting,dendrite remelting,and solute plume in the simulation case.Based on the robustness and powerful ability of the numerical model,the formation mechanisms of these physical aspects were revealed.

关键词： simulation phase field dendrite growth thermal-solute-convection interaction

Iodine enrichment in the groundwater in South China and its hydrogeochemical control

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Journal of Environmental Sciences 2024年第8期142卷 226-235页

作者： Fengping Zhou Qianting Xu Yuyun chen Weihua Zhang Rongliang qiu Guangdong Provincial Key Laboratory of Environmental Pollution and Remediation Technology Guangdong Provincial Engineering Research Center for Heavy Metal Contaminated Soil RemediationSchool of Environmental Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China Shenzhen Research Institute Sun Yat-sen UniversityShenzhen 518057China Guangdong Provincial Key Laboratory of Agricultural&Rural Pollution Abatement and Environmental Safety School of Natural Resources and EnvironmentSouth China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China

In North China,iodine-rich groundwater has been extensively studied,but few in South China.This study aimed to investigate the characteristics of iodine-rich groundwater in South China and identify potential contamination sources.The results revealed that the average concentration of iodine in groundwater was 890μg/L,with a maximumconcentration of 6350μg/L,exceeding the permitted levels recommended by the World Health Organization(5–300μg/L).Notably,the enrichment of iodide occurred in acidic conditions(pH=6.6)and a relatively low Eh environment(Eh=198.4 mV).Pearson correlation and cluster analyses suggested that the enrichment of iodide could be attributed to the intensified redox process involving Mn(II),iodine(I_(2)),or iodate(IO_(3)^(−))in the soil.The strong affinity between Mn(II)and I_(2)/IO_(3)^(−)facilitated their interaction,resulting in the formation and mobilization of I^(−)from the soil to the groundwater.Leaching experiments further confirmed that reducing substances(such as sodium sulfides,ascorbic acids,and fulvic acids)in the soil with low dissolved oxygen(DO)levels(3.8 mg/L)promoted the oxidation of I^(−)into I_(2)or IO_(3)^(−),leading to its stabilization.This research provides new insights into the characteristics and mechanisms of I^(−)enrichment in groundwater in South China,and emphasizes the significance of the redox reactions involving Mn(II)and I_(2)/IO_(3)^(−),as well as the influence of soil properties in regulating the occurrence and transportation of iodine species within groundwater systems.

关键词： Iodine enrichment Acid environment Groundwater South China Manganese

Diagnostic values of questionnaires of Convergence Insufficiency Symptom Survey and College of Optometrists Vision Development Quality of Life in the screening of convergence insufficiency

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 904-908页

作者： Ling xiong Qian chen Ye Wu Department of Ophthalmology West China HospitalSichuan University/Laboratory of Optometry and Vision ScienceWest China School of MedicineChengdu 610041Sichuan ProvinceChina Department of Clinical Research Management Center of BiostatisticsDesignMeasurement and EvaluationWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To compare and analyse the diagnostic efficacy of the College of Optometrists Vision Development Quality of Life Questionnaire(COVD-QOL)and the Convergence Insufficiency Symptom Survey(CISS)in detecting convergence insufficiency and to compare their diagnostic value in clinical applications.METHODS:Using the diagnostic test method,62 adult patients with convergence insufficiency(age:24.74±3.75y)and 62 normal participants(age:23.61±3.13y)who visited the Optometry Clinic of West China Hospital of Sichuan University from April 2021 to January 2023 were included.All subjects completed the CISS and COVD-QOL.Statistical analysis of the sensitivity and specificity of the CISS and COVD-QOL and comparison and joint experimental analysis of their diagnostic efficacy were performed.RESULTS:The sensitivity of the CISS and COVD-QOL for convergence insufficiency was 64.5%and 71.0%,respectively,while the specificity was 96.8%and 67.7%,respectively.Compared to the CISS alone,the combination of the CISS and COVD-QOL demonstrated lower sensitivity and specificity.The areas under the receiver operating characteristic curve of CISS,COVD-QOL and CISS combined with COVD-QOL were 0.806,0.694 and 0.782,respectively.CONCLUSION:Considering the low sensitivity of the CISS and the low specificity of the COVD-QOL,it is recommended to supplement these questionnaires with other screening tests for the detection of convergence insufficiency.

关键词： convergence insufficiency symptom survey College of Optometrists Vision Development Quality of Life Questionnaire convergence insufficiency asthenopia

Intraspecific floral colour variation in three Pedicularis species

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Plant Diversity 2024年第2期46卷 274-279页

作者： qiu-Yu Zhang Zhe chen Hang Sun Yang Niu State Key Laboratory of Plant Diversity and Specialty Crops Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina University of Chinese Academy of Sciences Beijing 100049China

Flower constancy describes the phenomenon that pollinators tend to successively visit flowers of a single species during foraging,reducing reproductive interference in natural communities.The extent of flower constancy is largely determined by the floral traits of co-flowering species.Both higher inter-specific and lower intraspecific differences of floral traits should contribute to a higher level of flower constancy.However,previous studies mainly focused on interspecific difference,and the intraspecific variation(consistency)of floral traits received much less attention.We hypothesise that selection may favour lower intraspecific floral trait variation in communities composed of multiple co-flowering congeners.We investigated the floral colour variation of three focal Pedicularis species that share pollinators in 19communities composed of either single or multiple Pedicularis species.Colour was quantified using image-based colour analysis as perceived by pollinators.We found that most of the intrapopulation floral colour variation was below the colour discrimination threshold of bumblebees,implying strongly constrained by the visual selection by pollinators.Contrary to the hypothesis,there is no significant difference in intraspecific floral colour variation between different community contexts.It may be due to the relatively large interspecific floral colour differences of most co-flowering species.The influence of community context on intraspecific variation may be reflected in floral traits other than colours.

关键词： Flower constancy Floral colour variation Plantepollinator interactions Pollinator vision

Cortical activity in patients with high-functioning ischemic stroke during the Purdue Pegboard Test:insights into bimanual coordinated fine motor skills with functional near-infrared spectroscopy

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Neural Regeneration Research 2024年第5期19卷 1098-1104页

作者： Siyun chen Mengchai Mao Guangyue Zhu Yufeng chen Yuqi qiu Bin Ye Dongsheng Xu The Second Rehabilitation Hospital of Shanghai ShanghaiChina College of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina School of Statistics East China Normal UniversityShanghaiChina The Third Rehabilitation Hospital of Shanghai ShanghaiChina Tongji University ShanghaiChina Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine ShanghaiChina

After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional independence.Bilateral arm training has been proposed as a promising intervention to address these deficits.However,the neural basis of the impairment of functional fine motor skills and their relationship to bimanual coordination performance in stroke patients remains unclear,limiting the development of more targeted interventions.To address this gap,our study employed functional near-infrared spectroscopy to investigate cortical responses in patients after stroke as they perform functional tasks that engage fine motor control and coordination.Twenty-four high-functioning patients with ischemic stroke(7 women,17 men;mean age 64.75±10.84 years)participated in this cross-sectional observational study and completed four subtasks from the Purdue Pegboard Test,which measures unimanual and bimanual finger and hand dexterity.We found significant bilateral activation of the sensorimotor cortices during all Purdue Pegboard Test subtasks,with bimanual tasks inducing higher cortical activation than the assembly subtask.Importantly,patients with better bimanual coordination exhibited lower cortical activation during the other three Purdue Pegboard Test subtasks.Notably,the observed neural response patterns varied depending on the specific subtask.In the unaffected hand task,the differences were primarily observed in the ipsilesional hemisphere.In contrast,the bilateral sensorimotor cortices and the contralesional hemisphere played a more prominent role in the bimanual task and assembly task,respectively.While significant correlations were found between cortical activation and unimanual tasks,no significant correlations were observed with bimanual tasks.This study provides insights into the neural basis of bimanual coordination and fine motor skills in high-functioning patients after stroke,highlighting task-dependent neural responses.The findings also suggest that patients wh

关键词： bilateral arm training bimanual coordination cortical activity fine motor dexterity functional near-infrared spectroscopy(fNIRS) high-functioning Purdue Pegboard Test stroke