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基于创造性战略理念的创新思维与实践教学探索

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艺术与设计（理论版） 2024年第1期 138-141页

作者：甘伟李绳彪邱岚李若兮华中科技大学建筑与城市规划学院、光影交互服务技术文化和旅游部重点实验室、数字光影技术湖北省工程研究中心武汉430074 华中科技大学建筑与城市规划学院武汉430074 武汉市华中科大建筑规划设计研究院有限公司武汉430000

近年来,创新教育已成为推动国家发展的重要战略,为适应现代社会对创新人才的需求,国内高校正进行对教育方法的改革。此次设计专业创新思维课程以“地图”为主题并引入创造性战略理念(Creative Strategic Concept)的研究方法。文章将介... 详细信息

近年来,创新教育已成为推动国家发展的重要战略,为适应现代社会对创新人才的需求,国内高校正进行对教育方法的改革。此次设计专业创新思维课程以“地图”为主题并引入创造性战略理念(Creative Strategic Concept)的研究方法。文章将介绍“感官地图”和“行为地图”的学生通过创造性战略理念中“快速评估”“有效范例搜索”和“创意组合”的研究方法,获取丰富的设计要素和多样的表达方式,从而促进了创新想法产生的思维过程。这对以培养创新型人才为目标的创新思维课具有积极的作用。

关键词：创造性战略理念战略直觉创新设计教学实践

单形性嗜上皮性肠道T细胞淋巴瘤3例临床病理观察

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诊断病理学杂志 2024年第2期31卷 110-113,118页

作者：兰秋霞马强肖华亮中国人民解放军陆军特色医学中心病理科重庆400042

目的探讨单形性嗜上皮性肠道T细胞淋巴瘤(MEITL)的临床病理特征、诊断与鉴别诊断,以提高对单形性嗜上皮性肠道T细胞淋巴瘤的认识。方法收集本院诊断的3例MEITL的临床资料,进行组织学及免疫组化观察,并复习相关文献,归纳该肿瘤的诊断和... 详细信息

目的探讨单形性嗜上皮性肠道T细胞淋巴瘤(MEITL)的临床病理特征、诊断与鉴别诊断,以提高对单形性嗜上皮性肠道T细胞淋巴瘤的认识。方法收集本院诊断的3例MEITL的临床资料,进行组织学及免疫组化观察,并复习相关文献,归纳该肿瘤的诊断和鉴别诊断要点。结果镜下见淋巴细胞弥漫浸润肠壁全层,肠黏膜糜烂伴溃疡形成,可见淋巴上皮病变,肿瘤细胞大小较为一致,细胞中等大小,核仁可见,细胞膜不规则,胞质淡染,可见核分裂象及核碎裂。免疫组化:3例均表达CD3、CD2、CD7、CD8、CD56、TIA-1,均不表达CD20、PAX-5、CD30、EBER、H3k36me,Ki-67增殖指数约70%,p53散在弱阳。结论MEITL较为罕见,临床症状不特异,早期易漏诊,晚期易与其他恶性肿瘤混淆,大多为术后病理诊断明确。

关键词：单形性嗜上皮性肠道T细胞淋巴瘤诊断鉴别诊断淋巴瘤治疗

米索前列醇联合芬太尼、丙泊酚应用于绝经后宫内节育器取出术的效果分析

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四川解剖学杂志 2024年第2期32卷 62-65页

作者：邱玉兰周天资刘佳佳栾川县栾川乡卫生院妇产科洛阳471500

目的:探讨米索前列醇联合芬太尼、丙泊酚,在绝经妇女宫内节育器(IUD)取出术中的应用效果.方法:选取2022年1月至2022年12月于本院就诊并进行IUD取出术的80例绝经妇女作为研究对象.按照随机数字表法,将其分为观察组(n=40,术前采用米索前... 详细信息

目的:探讨米索前列醇联合芬太尼、丙泊酚,在绝经妇女宫内节育器(IUD)取出术中的应用效果.方法:选取2022年1月至2022年12月于本院就诊并进行IUD取出术的80例绝经妇女作为研究对象.按照随机数字表法,将其分为观察组(n=40,术前采用米索前列醇联合芬太尼与丙泊酚处理)和常规组(n=40,术前采用利多卡因处理).比较两组妇女宫颈软化率、术中指标、IUD取出成功率及不良反应率.结果:观察组妇女宫颈软化总有效率为95%(34/40),高于常规组的72.5%(29/40),差异有统计学意义(P0.05).结论:米索前列醇联合芬太尼、丙泊酚,可以明显改善绝经妇女的宫颈软化效果,提高IUD取出成功率,而且是一种安全性较高的方法,值得临床推广应用.

关键词：装置取出米索前列醇芬太尼丙泊酚宫内避孕器宫颈软化绝经期女性

Major complications after radiofrequency ablation for liver tumors:Analysis of 255 patients

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World Journal of Gastroenterology 2009年第21期15卷 2651-2656页

作者： Wen-Tao Kong Wei-Wei Zhang Yu-Dong qiu Tie Zhou Jun-lan qiu Wei Zhang Yi-Tao Ding Department of Hepatobiliary Surgery Drum Tower Hospital Medical College of Nanjing University Nanjing 210008 Jiangsu Province China

AIM:To investigate the major complications after radiofrequency ablation(RFA) for the treatment of liver tumors and analyze possible risk factors that precipitate these ***:From March 2001 to April 2008,255 patients with liver tumors(205 male,50 female;age range,18-89 years;mean age,56.0 years) who received RFA were enrolled in this *** these patients,212 had hepatocellular carcinoma,39 had metastatic liver tumors and four had cholangiocellular *** hundred and forty eight patients had a single tumor,and 107 had multiple *** diameter of the tumors ranged 1.3-20 cm(mean,5.1 cm).All patients were treated with a cooled-tip perfusion electrode attached to a radiofrequency generator(Radionics,Burlington,MA,USA).RFA was performed via the percutaneous approach(n = 257),laparoscopy(n = 7),or open surgical treatment(n = 86).The major complications related to RFA were *** resultant data were analyzed to determine risk factors associated these ***:Among the 255 patients,425 liver tumors were treated and 350 RFA sessions were ***-seven(10%) major complications were observed which included 13 cases of liver failure,10 cases of hydrothorax requiring drainage,three casesof tumor seeding,one case of upper gastrointestinal bleeding,one case ofintrahepatic abscess,one case of bile duct injury,one case of cardiac arrest,and five cases of *** patients had more than two *** failure was the most severe complication and was associated with the highest *** patients died due to worsening liver ***-Pugh classification(P = 0.001) and choice of approach(P = 0.045) were related to post-treatment liver failure,whereas patient age,tumor size and number were not significant factors precipitating this ***:RFA can be accepted as a relatively safe procedure for the treatment of liver ***,attention should be paid to possible com

关键词： Complication Hepatocellular carcinoma Metastatic liver tumor Radiofrequency ablation Liverfailure

Strong Converse Inequality for the Meyer-Knig and Zeller-Durrmeyer Operators

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Communications in Mathematical Research 2012年第1期28卷 1-9页

作者： QI qiu-lan LIU JUAN College of Mathematics and Information Science Hebei Normal University Shijiazhuang 050016 No.1 Middle Shcool of Handan Handan Hebei 056002

In this paper we give a strong converse inequality of type B in terms of unified K-functional Kλα （f, t2）（0 ≤λ≤ 1, 0 〈 α 〈 2） for the Meyer-Knig and Zeller-Durrmeyer type operators.

关键词： Meyer-Konig and Zeller-Durrmeyer type operator moduli of smooth-ness,K-functional strong converse inequality HOder's inequality

Correction: Efficacy of activating blood and resolving stasis therapy for IgA nephropathy: a systematic review and meta-analysis

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Medical Data Mining 2024年第3期7卷 53-53页

作者： qiu-Mei lan Jie Li Han-Qing Zang Zi-Jun Zhou Ya-Xuan Fang Yun-Ze Xing Bo Yang Department of Nephrology the First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China

Medical Data Mining published an article entitled Efficacy of activating blood and resolving stasis therapy for IgA nephropathy:a systematic review and meta-analysis on 16 January *** author confirmed this article’s proof on 15 January 2024 without any *** on 15 April 2024,the authors contacted the editorial office to state that the name of the corresponding author is mis-spelled as“Han-Qing Zang”.Hence the mis-spelled name“Han-Qing Zang”is corrected as“Han-Qing Zhang”.“Han-Qing Zhang”is the third author of this article.

关键词： stasis Medical analysis

Efficacy of activating blood and resolving stasis therapy for IgA nephropathy:a systematic review and meta-analysis

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Medical Data Mining 2024年第2期7卷 9-16页

Background:To systematically evaluate the efficacy and safety of activating blood and resolving stasis in patients with IgA ***:From inception to May 2022,databases including PubMed,Embase,the Cochrane Library,Web of Science,WanFang database,Chinese Biomedical Database,VIP,and China National Knowledge Infrastructure were searched for randomized controlled trials about enhancing blood circulation and removing stasis for IgA *** the articles that satisfied the requirements,quality assessment and meta-analysis were ***:Seventeen randomized controlled trials with a total of 1653 patients were ***-analysis showed that activating blood and resolving stasis could increase therapeutic effectiveness(risk ratio(RR)=-0.47,95%confidence interval(CI)(-0.37,-0.2),P=0.0006)and decrease levels of serum creatinine(RR=-0.47,95%CI(-0.37,-0.2),P=0.0006),urea nitrogen(RR=0.85,95%CI(1.44,0.26),P=0.005),24-hour urinary protein quantification(RR=1.6,95%CI(2.44,0.95).P=0.00001),and urine red blood cell count(RR=1.7,95%CI(2.57,0.82),P=0.0001).There was no significant difference between the two groups in terms of security(RR=0.6,95%CI(0.36,1.01),P=0.05).Conclusion:Western medicine combined activating blood and resolving stasis is more efficient than Western medicine therapy alone in treating IgA nephropathy,but it still needs to be supported by additional large-scale,multi-center randomized controlled clinical trials due to the poor quality of the included trials.

关键词： IgA nephropathy activating blood and resolving stasis meta-analysis randomized controlled trial blood stasi

Flavonoid-Rich Extract of Oldenlandia diffusa(Willd.)*** Gastric Cancer by Activation of Caspase-Dependent Mitochondrial Apoptosis

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Chinese Journal of Integrative Medicine 2023年第3期29卷 213-223页

作者： LING Jia-yin WANG qiu-lan LIANG Hao-nan LIU Qing-bo YIN Dong-hong LIN Li First School of Clinical Medicine Gansu University of Chinese MedicineLanzhou(730000)China Gansu Provincial Hospital Lanzhou(730000)China College of Pharmacy Gansu University of Chinese MedicineLanzhou(730000)China Institute of Chinese(Tibetan)Medicine Resources Gansu University of Chinese MedicineLanzhou(730000)China

Objective:To evaluate the apoptosis and cycle arrest effects of Oldenlandia diffusa flavonoids on human gastric cancer cells,determine the action mechanisms in association with the mitochondrial dependent signal transduction pathway that controls production of reactive oxygen species(ROS),and evaluate the pharmacodynamics of a mouse xenotransplantation model to provide a reference for the use of flavonoids in prevention and treatment of gastric ***:Flavonoids were extracted by an enzymatic-ultrasonic assisted method and purified with D-101 *** components were characterized by high-performance liquid *** lines MKN-45,AGS,and GES-1 were treated with different concentrations of flavonoids(64,96,128,and 160μg/mL).The effect of flavonoids on cell viability was evaluated by MTT method,and cell nuclear morphology was observed by Hoechst *** apoptosis rate and cell cycle phases were measured by flow cytometry,the production of ROS was detected by laser confocal microscope,the mitochondrial membrane potential(MMP)were observed by fluorescence microscope,and the expression of apoptotic proteins related to activation of mitochondrial pathway were measured by ***-45cells were transplanted into BALB/c nude mice to establish a xenograft tumor *** and eosin staining was used to reveal the subcutaneous tumor *** tumor volume and tumor weight were measured,the expression levels of proliferation markers proliferating cell nuclear antigen(PCNA)and Ki-67were detected by immunohistochemistry,and the expression levels of CA72-4 were measured by enzyme linked immunosorbent ***:Oldenlandia diffusa flavonoids inhibited proliferation of MKN-45 and AGS human gastric cancer cells,arrested the cell cycle in G1/S phase,induced accumulation of ROS in the process of apoptosis,and altered *** addition,flavonoids increased Apaf-1,Cleaved-Caspase-3,and Bax,and decreased Cyclin A,Cdk2,Bcl-2,Pro-Caspase-9,a

关键词： Chinese medicine Oldenlandia diffusa flavonoids gastric cancer apoptosis mitochondria

Flow patterns and critical criteria of thermally stratified shear flow in braided rivers

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Water Science and Engineering 2017年第3期10卷 225-235页

作者： Li Gu qiu-lan Li Bo Dai Zu-lin Hua Xiao-dong Liu Ke-jian Chu Department of Civil and Environmental Engineering University of AlbertaEdmonton T6G 2R3Canada Key Laboratory of Integrated Regulation and Resource Development of Shallow Lakes Ministry of EducationHohai UniversityNanjing 210098China Zhenjiang Urban Planning and Design Institute Zhenjiang 212000China Jiangsu Transportation Institute Nanjing 210098China National Engineering Research Center of Water Resources Efficient Utilization and Engineering Safety Hohai UniversityNanjing 210098China

Flow characteristics of thermally stratified shear flow in braided rivers are particularly complicated and poorly understood. In this study, a series of typical flow patterns was examined and their critical criteria were determined. Four flow patterns were identified: mixed, locally unstable, continuously stratified, and two-layer flow. Temperature distributions of the four types of flow patterns were analyzed and *** critical Froude numbers for unstable flow, FDcr1, and stable flow, FDcr2, were determined to be 6 and 1, respectively, and comparison of FDcr1 and FDcr2 to the peak Froude numbers, FD1 at the outer bank and FD2 at the inner bank along the anabranch, allowed the flow patterns to be assessed. Then, a discriminant based on initial Jeffreys-Keulegan stability parameters was established to distinguish the flow stages from twolayer flow to completely mixed flow. It is indicated that the three critical Jeffreys-Keulegan parameters increased with the diversion angle of braided rivers. Results also show that, compared to the stratified flow in straight and curved channels, it was more difficult for braided stratified flow to maintain as two-layer flow, and it more easily became mixed flow. Consequently, empirical expressions for stability criteria of the thermally stratified shear flow in braided rivers are presented.

关键词： Braided river Critical criterion Empirical formula Flow pattern Temperature distribution Thermally stratified flow