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Sclerosing epithelioid fibrosarcoma of the pancreas:A case report

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World Journal of Clinical Cases 2024年第26期12卷 5983-5989页

作者： Meng-Qing Sun Li-Na Guo Yan You Yan-Yu qiu Xiao-Dong He Xian-Lin han Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China

BACKGROUND A sclerosing epithelioid fibrosarcoma(SEF)is a rare malignant fibroblastic soft tissue tumor that rarely occurs in intra-abdominal organs.A case of a SEF in the pancreatic head is reported herein,including its clinical manifestations,preoperative imaging features,gross specimen and pathological *** SUMMARY A 33-year-old male patient was admitted to Peking Union Medical College Hospital in December 2023 due to a one-year history of intermittent upper abdominal pain and the discovery of a pancreatic *** patient underwent an enhanced computed tomography scan of the abdomen,which revealed a welldefined,round mass with clear borders and calcifications in the pancreatic *** mass exhibited progressive,uneven mild enhancement,measuring approximately 6.6 cm×6.3 *** patient underwent laparoscopic pylorus-preserving *** pathological examination revealed that the lesion was consistent with a *** the 3-month postoperative follow-up,the patient did not report any short-term complications,and there were no signs of tumor *** SEFs are rare malignant fibrous soft tissue *** rarely develop in the pancreas,and its preoperative diagnosis depends on imaging findings,with confirmation depending on pathological examination and ***,only four cases of pancreatic SEF have been reported in studies written in *** case is the first reported case of a pancreatic SEF by a clinical physician.

关键词： Sclerosing epithelioid fibrosarcoma of the pancreas Abdominal malignant fibroblastic soft tissue tumor Abdominal enhanced computed tomography Laparoscopic pancreaticoduodenectomy Case report

A genomic association study revealing subphenotypes of childhood steroid-sensitive nephrotic syndrome in a larger genomic sequencing cohort

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Genes & Diseases 2024年第4期11卷 400-410页

作者： han Chan Fenfen Ni Bo Zhao Huimin Jiang juanjuan Ding Li Wang Xiaowen Wang Jingjing Cui Shipin Feng Xiaojie Gao Xueying Yang Huan Chi Hao Lee Xuelan Chen Xiaoqin Li Jia Jiao Daoqi Wu Gaofu Zhang Mo Wang Yupeng Cun Xiongzhong Ruan Haiping Yang qiu Li Department of Nephrology Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqing 400014China Department of Nephrology Shenzhen Children's HospitalShenzhenGuangdong 518034China Department of Nephrology Kunming Children's HospitalKunming Medical UniversityKunmingYunnan 650228China Department of Nephrology Wuhan Children's HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhanHubei 430015China Department of Nephrology Chengdu Women and Children Central HospitalChengduSichuan 610073China Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Department of Nephrology John Moorhead Research LaboratoryUniversity College London Medical SchoolRoyal Free CampusUniversity College LondonLondon NW32PFUnited Kingdom

Dissecting the genetic components that contribute to the two main subphenotypes of steroid-sensitive nephrotic syndrome(SSNS)using genome-wide association studies(GWAS)strategy is important for understanding the *** conducted a multicenter cohort study(360 patients and 1835 controls)combined with a GWAS strategy to identify susceptibility var-iants associated with the following two subphenotypes of ssNS:steroid-sensitive nephrotic syn-drome without relapse(SSNswR,181 patients)and steroid-dependent/frequent relapse nephrotic syndrome(SDNS/FRNS,179 patients).The distribution of two single-nucleotide poly-morphisms(SNPs)in ANKRD36 and ALPG was significant between SSNSWR and healthy controls,and that of two SNPs in GAD1 and HLA-DQA1 was significant between SDNS/FRNS and healthy ***,rs1047989 in HLA-DQA1 was a candidate locus for SDNS/FRNS but not for *** significant SNPs were observed between SSNSWR and SDNS/***,chromosome 2:171713702 in GAD1 was associated with a greater steroid dose(>0.75 mg/kg/d)upon relapse to first remission in patients with SDNS/FRNS(odds ratio=3.14;95%confidence interval,0.97-9.87;P=0.034).rs117014418 in APOL4 was significantly associated with a decrease in eGFR of greater than 20%compared with the baseline in SDNS/FRNS patients(P=0.0001).Protein-protein intersection network construction suggested that HLA-DQA1 and HLA-DQB1 function together through ***,SSNSWR belongs to non-HLA region-dependent nephropathy,and the HLA-DQA/DQB region is likely strongly associated with dis-ease relapse,especially in SDNS/*** study provides a novel approach for the GWAS strategy of SsNS and contributes to our understanding of the pathological mechanisms of SSNSWRandSDNS/FRNS.

关键词： Frequentrelapse Genome-wide association study Human leukocyte antigen region Steroid-sensitive nephrotic syndrome

强制对流对高压套管油介质中乙炔分子传质过程的影响

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电机与控制学报 2024年第4期28卷 31-40页

作者：陈图南李康邱宗甲韩冬张国强中国科学院电工研究所北京100190 中国科学院大学北京100049

为优化对高压套管进行油中溶解气体分析时的取样质量,提升分析结果的代表性和准确性,提出一种对高压套管中的绝缘油施加强制对流的方法,通过向绝缘油施加速度场促进油中溶解气体的传质过程,进而改善油中溶解气体分析的取样质量。从仿真... 详细信息

为优化对高压套管进行油中溶解气体分析时的取样质量,提升分析结果的代表性和准确性,提出一种对高压套管中的绝缘油施加强制对流的方法,通过向绝缘油施加速度场促进油中溶解气体的传质过程,进而改善油中溶解气体分析的取样质量。从仿真计算和实验验证2个方面对绝缘油中溶解乙炔气体传质过程进行研究。首先分析无强制对流情况下气体的传质过程,并测量气体从故障源到取样口的时间;然后分析在强制对流情况下气体的传质过程并测量了传质时间,在此基础上讨论气体传质时间缩短的原因;最后探究不同强制对流动作周期对传质过程影响的程度。研究成果能够为高压套管在线监测装置的研发提供参考。

关键词：高压套管油中溶解气体分析乙炔传质强制对流

中国式现代化进程中主题出版的职责使命与践行路径

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编辑之友 2024年第6期 5-13页

作者：陈矩弘韩建民杭州电子科技大学融媒体与主题出版研究院浙江杭州310018

新时代主题出版承载着阐释和传播中国式现代化理论、壮大主流思想舆论、推动经济社会发展、传承创新中华文化、向世界讲好中国式现代化故事以及推进自身高质量发展的职责使命。为此,主题出版要通过转变叙事方式以提升叙事能力、强化育... 详细信息

新时代主题出版承载着阐释和传播中国式现代化理论、壮大主流思想舆论、推动经济社会发展、传承创新中华文化、向世界讲好中国式现代化故事以及推进自身高质量发展的职责使命。为此,主题出版要通过转变叙事方式以提升叙事能力、强化育人和全民阅读功能以提升民众素养、推动“走出去”以提升国际话语权、强化数字技术赋能以推进自身转型升级。在践行过程中,主题出版要统筹把握好政治性与文化性、学术性与大众性、国内市场与国际市场、传统主题图书和融媒体主题出版产品之间的平衡。

关键词：主题出版中国式现代化职责使命践行路径

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Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia:a prospective,single arm,phase I trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2250-2259页

作者： Yunfei Chen Yanmei Xu Ying Chi Ting Sun Yuchen Gao Xueqing Dou Zhibo han Feng Xue Huiyuan Li Wei Liu Xiaofan Liu Huan Dong Rongfeng Fu Mankai ju Xinyue Dai Wentian Wang Yueshen Ma Zhen Song jundong Gu Wei Gong Renchi Yang Lei Zhang State Key Laboratory of Experimental Hematology National Clinical Research Centre for Blood DiseasesHaihe Laboratory of Cell EcosystemTianjin Key Laboratory of Gene Therapy for Blood DiseasesCAMS Key Laboratory of Gene Therapy for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Tianjin Institutes of Health Science Tianjin 301600China National Clinical Research Center for Hematologic Diseases Jiangsu Institute of HematologyThe First Affiliated Hospital of Soochow UniversitySuzhou 215006China National Engineering Research Centre of Cell Products Tianjin Key Laboratory of Engineering Technologies for Cell PharmaceuticalAmCellGene Engineering Co.LtdTianjin 300457China School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College100730 BeijingChina

Patients with refractory immune thrombocytopenia(ITP)frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing *** cord-derived mesenchymal stem cells(UC-MSCs)present a promising alternative,capitalizing on their low immunogenicity and potent immunomodulatory effects for treating diverse autoimmune *** prospective phase I trial enrolled eighteen eligible patients to explore the safety and efficacy of UC-MSCs in treating refractory *** research design included administering UC-MSCs at escalating doses of 0.5×10^(6)cells/kg,1.0×10^(6)cells/kg,and 2.0×10^(6)cells/kg weekly for four consecutive weeks across three cohorts during the dose-escalation phase,followed by a dose of 2.0×10^(6)cells/kg weekly for the dose-expansion *** events,platelet counts,and changes in peripheral blood immunity were monitored and recorded throughout the administration and follow-up ***,12(with an addition of three patients in the 2.0×10^(6)cells/kg group due to dose-limiting toxicity)and six patients were enrolled in the dose-escalation and dose-expansion phase,*** patients(13/18,72.2%)experienced one or more treatment emergent adverse *** adverse events occurred in four patients(4/18,22.2%),including gastrointestinal hemorrhage(2/4),profuse menstruation(1/4),and acute myocardial infarction(1/4).The response rates were 41.7%in the dose-escalation phase(5/12,two received 1.0×10^(6)cells/kg per week,and three received 2.0×10^(6)cells/kg per week)and 50.0%(3/6)in the dose-expansion *** overall response rate was 44.4%(8/18)among all enrolled *** sum up,UC-MSCs are effective and well tolerated in treating refractory ITP(*** ID:NCT04014166).

关键词： doses immunity treatment

基于NOMA-VLC系统的GWO-DNN信道估计方法

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光通信技术 2024年第2期48卷 62-67页

作者：邱涵张峰赵黎西安工业大学电子信息工程学院西安710021

为了解决室内非正交多址(NOMA)可见光通信(VLC)信道估计方法的可靠性和用户公平性低问题,提出了一种在NOMA-VLC系统中使用灰狼优化(GWO)算法对深度神经网络(DNN)进行信号补偿和恢复的方法,即GWO-DNN信道估计方法。该方法引入非线性收敛... 详细信息

为了解决室内非正交多址(NOMA)可见光通信(VLC)信道估计方法的可靠性和用户公平性低问题,提出了一种在NOMA-VLC系统中使用灰狼优化(GWO)算法对深度神经网络(DNN)进行信号补偿和恢复的方法,即GWO-DNN信道估计方法。该方法引入非线性收敛因子和二维混沌映射,有效提升了系统可靠性和多用户传输公平性。实验结果表明:在误码率(BER)为10^(-4)时,所提方法比最小均方误差(MMSE)方法最高可获得4.3 dB的信噪比(SNR)增益,两用户的SNR差异由3.2 dB降到0.9 dB;在不同阶次的正交幅度调制下,所提方法的性能均优于MMSE方法,且调制阶次越高性能改善越明显。

关键词：可见光通信非正交多址接入神经网络灰狼算法信道估计

Preparation and Properties of Glass with High Transmittance and Intense Gamma Ray Shielding

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硅酸盐学报 2024年第10期52卷 3301-3310页

作者： ZhanG Meilun CAO Zhenbo YANG Shengyun ZhanG Yang han Yu qiu Fu ZHOU You ZHENG Jingming LIU Hui JIA Jinsheng China National Building Material Photonics Technology Co. Ltd.Zaozhuang 277000ShandongChina China Building Materials Academy Co. Ltd.Beijing 100000China

Introduction As a kind of high-energy electromagnetic radiation,gamma rays can lead to radiation effect and environmental *** ensure the reliability and safety utilization of gamma radiations in different areas,materials with reliable gamma shielding performances should be *** existing efforts are to use glasses as alternative for the conventional radiation shielding *** a typical window material,glass itself has attracted wide attention due to its unique chemical and physical *** them,lead-based radiation shielding materials are widely used in the field of ionizing radiation protection due to their reliable physical *** the nuclear industry and high energy physics laboratories,different materials can be used for temporary or permanent *** lead-based glass doped with heavy metal oxide PbO is widely used in the field of radiation shielding for a long time with reliable light transmission properties,which facilitates the observation and monitoring of radiation *** this paper,three kinds of transparent silicate glass with different PbO contents were prepared by a high-temperature melting forming *** gamma-rays protection abilities of the three kinds of glass were investigated through experimental and thermotical *** chemical and thermal stability of the glass were also *** addition,the influence mechanism of the structure and performance differences of the three kinds of glass was also *** Analytical pure quartz sand(SiO_(2),purity 99.5%,in mass,the same below),lead monoxide(PbO,purity 99.0%),potassium nitrate(KNO3,purity 99.0%)and sodium nitrate(NaNO3,purity 99.0%)were selected as raw materials for preparation of three kinds of gamma-rays shielding glass materials by a high-temperature melting *** appropriate amount of raw materials was thoroughly mixed and added to 3 L quartz crucible and heated in air at 1200℃.Then the raw materials were melted at 1250℃for 14

关键词： transmittance gamma rays radiation shielding glass

基于耳石微化学的珠江水系日本鳗鲡洄游特征研究

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水生生物学报 2024年第10期48卷 1758-1765页

作者：贾秋菊帅方敏李捷上海海洋大学海洋生物资源与管理学院上海201306 中国水产科学研究院珠江水产研究所广州510380 国家渔业资源环境广州观测实验站广州510380 农业农村部外来入侵水生生物防控重点实验室广州510380 广东省水产动物免疫与绿色养殖重点实验室广州510380

为了解珠江水系日本鳗鲡(Anguilla japonica)洄游生态特征,有效保护鳗鲡野生种群,采集了柳州、合山、武宣、桂平、梧州等11个淡水生境以及珠海1个河口生境共155尾日本鳗鲡,利用电子探针微区分析仪测定耳石中的Sr、Ca元素比值,对耳石微化... 详细信息

为了解珠江水系日本鳗鲡(Anguilla japonica)洄游生态特征,有效保护鳗鲡野生种群,采集了柳州、合山、武宣、桂平、梧州等11个淡水生境以及珠海1个河口生境共155尾日本鳗鲡,利用电子探针微区分析仪测定耳石中的Sr、Ca元素比值,对耳石微化学Sr/Ca进行分析,结果发现珠江水系日本鳗鲡具有“海水–淡水”、“海水–河口–淡水”、“海水–河口–海水–河口–淡水”、“海水–河口–淡水–河口–淡水”等多种洄游模式。但总体而言,最终都会洄游到淡水中育肥。这说明珠江水系的日本鳗鲡具有适应不同栖息地和盐度的能力,在不同水域之间表现出灵活的洄游策略,同时也说明了淡水栖息地保护的重要性。

关键词：降河洄游耳石微化学 Sr/Ca 珠江日本鳗鲡

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自媒体语境下海外受众对中国的地理想象建构——以YouTube李子柒短视频受众为例

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人文地理 2024年第1期39卷 8-16,67页

作者：杨位擎罗秋菊中山大学旅游学院珠海519082 中山大学旅游发展与规划研究中心广州510275

地理想象是对地方和地方知识进行信息加工或改造以塑造新形象的心理过程。本研究将地理想象运用到社交媒体研究,以李子柒You Tube频道的海外受众为研究对象,通过分析网络评论和开展半结构访谈,阐释由自媒体生产的地方性知识在国际社交... 详细信息

地理想象是对地方和地方知识进行信息加工或改造以塑造新形象的心理过程。本研究将地理想象运用到社交媒体研究,以李子柒You Tube频道的海外受众为研究对象,通过分析网络评论和开展半结构访谈,阐释由自媒体生产的地方性知识在国际社交媒体中是如何被受众的地理想象解构、表征和再建构的社会动态实践过程。研究发现:(1)短视频社区地理想象的建构由个体想象和集体想象组成,在互动讨论中形成相似度较高的观点,为短视频赋予意义和共创价值,从而影响受众的行为意向表达;(2)李子柒短视频唤醒了受众的积极情感,其地理想象被高质量的视听感官体验激活,内容包括了微观尺度的短视频物质元素想象以及宏观尺度的中国想象。本研究拓宽了地理想象的研究视野,也为国家文旅形象和文旅项目的打造提供参考。

关键词：地理想象媒介旅游自媒体海外受众