检索结果-南通市图书馆

Abnormality of peripheral nerve conduction velocity associated with illness course, symptoms and fasting blood glucose in patients with type 2 diabetes mellitus

引用

Neural Regeneration Research 2006年第9期1卷 862-864页

作者： Suijing Cui jinhua qiu Weiliang Luo Department of Neurology Central People''s Hospital of Huizhou City Huizhou 516001Guangdong Province China Department of NeurologyCentral People''s Hospital of Huizhou City Huizhou 516001Guangdong Province China Department of NeurologyCentral People''s Hospital of Huizhou City Huizhou 516001Guangdong Province China

BACKGROUND: It has shown that abnormality of peripheral nerve conduction velocity during onset of diabetes mellitus is not related to age and sex, but to symptoms, illness course and level of fasting blood glucose. OBJECTIVE: To measure correlation of abnormality of peripheral nerve conduction velocity with various illness courses, symptoms and levels of fasting blood glucose of patients with type 2 diabetes mellitus. DESIGN: Case analysis. SETTING: Department of Neurology, Central People's Hospital of Huizhou. PARTICIPANTS: A total of 128 patients who were diagnosed as type 2 diabetes mellitus were selected from Central People's Hospital of Huizhou from September 2001 to October 2005. There were 75 males and 53 females aged 32-83 years and the illness course ranged from 1 month to 20 years. METHODS: All 128 patients with type 2 diabetes mellitus received neuro-electrophysiological study and their clinical data were retrospectively analyzed to measure peripheral nerve conduction velocity and fasting blood glucose so as to investigate the correlation of peripheral nerve conduction velocity with clinical symptoms, illness course and levels of fasting blood glucose. MAIN OUTCOME MEASURES: Correlation of peripheral nerve conduction velocity with clinical symptoms, illness course and levels of fasting blood glucose. RESULTS: All 128 patients with type 2 diabetes mellitus were involved in the final analysis. ① Among 128 patients, 114 patients had abnormality of peripheral nerve conduction velocity; 110 patients had clinical symptoms, including 102 patients having abnormality of peripheral nerve conduction velocity; 18 patients did not have clinical symptoms, including 12 patients having abnormality of peripheral nerve conduction velocity. There were significant differences between them (χ 2=8.275, P =0.04). ② Among 128 patients, illness course of 75 patients was equal to or less than 5 years, including 27 patients having abnormality of peripheral nerve conduction velocity

关键词： type symptoms and fasting blood glucose in patients with type 2 diabetes mellitus Abnormality of peripheral nerve conduction velocity associated with illness course

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway

引用

Signal Transduction and Targeted Therapy 2020年第1期5卷 1049-1051页

作者： Huiyu Chen Yuhan Ye Yan Yang Mengya Zhong Lei Gu Zhaopu Han jinhua qiu Zhongchen Liu Xingfeng qiu Guohong Zhuang Cancer Research Center School of MedicineXiamen UniversityXiamenFujianChina Department of Pathology Zhongshan Hospital Affiliated to Xiamen UniversityXiamenFujianChina Department of General Surgery Shanghai 10th People’s Hospital Affiliated to Tongji UniversityShanghaiChina Department of Gastrointestinal Surgery Zhongshan Hospital Affiliated to Xiamen UniversityXiamenFujianChina Organ Transplantation Institute of Xiamen University Fujian Provincial Key Laboratory of Organ and Tissue RegenerationSchool of MedicineXiamen UniversityXiamenFujianChina

Dear Editor,Colorectal cancer(CRC)is the third most common malignant tumor in human,ranking third in cancer-related mortality.1 Most colon cancer patients die of metastasis.2 Intriguingly,the deregulation of tumor necrosis factorα‑induced protein 8(TIPE)has been shown to play a vital regulatory role in tumor cell growth,proliferation,invasion,and metastasis.3 TIPE is a kind of cytoplasmic protein of 23 kDa.A large number of studies have shown that TIPE is closely related to the development of colon cancer.4 In addition,decreased expression of TIPE was linked to down-regulation of matrix metallopeptidase-1(MMP-1),MMP-9,and vascular endothelial growth factor receptor-2 in breast cancer.

关键词： metastasis TIP p38

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carotid Doppler and transcranial Doppler in diagnosing transient ischemic attack: A healthy control

引用

Neural Regeneration Research 2006年第3期1卷 283-285页

作者： Huiling Chen jinhua qiu Hongying Liu Department of Neuroelectrophysiology Central People＇s Hospital of Huizhou Huizhou 516001 Guangdong Province China

BACKGROUND： If changes of hemodynamics in internal or external cranial artery and stenosis of atherosclerosis are found eady, patients with transient ischemic attack （TIA） may be treated at an eady phase so as to prevent and decrease the onset of cerebral infarction. Carotid Doppler can analyze carotid canal wall, hemodynamic properties and stenosis, and changes of plaque morphology; however, transcranial Doppler （TCD） can evaluate vascular stenosis and occlusion and judge collateral circulation in cranium through detecting velocity and direction of blood flow. Can the association of them increase the diagnostic rate of TIA？ OB3ECTIVE： To evaluate the effect of the association of carotid Doppler and TCD on TIA in internal carotid artery. DESIGN： Contrast observational study SETTING： Department of Neuroelectrophysiology, Central People＇s Hospital of Huizhou PARTICIPANTS： A total of 54 patients with TIA in internal carotid artery were selected from the Department of Neurology of Huizhou Central People＇s Hospital from May 2004 to June 2005. There were 35 males and 24 females aged 46-81 years. The clinical situation was asthenia of single limb, hemiplegia, anaesthesia of single upper or lower limb, hemianesthesia, sensory disorder and aphasia. The symptoms lasted for less than 2 hours. All cases were diagnosed with CT, and those who had pathological changes of acute cerebral infarction and history of cardiac disease were excluded. Additionally, 50 healthy subjects who were regarded as control group were selected from the Department of Neurology of Huizhou Central People＇s Hospital. There were 30 males and 20 females aged 45-80 years. All subjects were consent. METHODS： HD15000 color Doppler ultrasound （Philips Company, USA） and Muliti-DopX2 TCD （DWL Company, Germany） were used to detect hemodynamics, stenosis and distribution of atherosclerosis in carotid artery and internal carotid artery. Evaluation of marker： Stenosis was calculated by the ratio between the minimal c

关键词： TIA Carotid Doppler and transcranial Doppler in diagnosing transient ischemic attack A healthy control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Combination of Human Fas （CD95/Apo-1） Ligand with Adriamycin Significantly Enhances the Efficacy of Antitumor Response

引用

Cellular & Molecular Immunology 2009年第3期6卷 167-174页

作者： Zhongchen Liu Ruizhen Liu jinhua qiu Ping Yin Fanghong Luo jinhua Su Wenzhu Li Caixia Chen Xin Fan Jiakai Zhang Guohong Zhuang Anti-Cancer Research Center Medical College Xiamen University 422 Siming South Road Xiamen Fujian 361005 China Zhongshan Hospital Xiamen University 201-209 Lakeside South Xiamen Fujian 361004 China College of Life Science Xiamen University 422 Siming South Road Xiamen Fujian 361005 China These authors contributed equally to this work

The prognosis of hepatocellular carcinoma （HCC） is poor, even with the combined treatment of curative resection and adjuvant chemoradiotherapy. To solve this problem, many biologic therapies have been investigated. Fas ligand （FasL, CD95L） is mainly expressed in activated T lymphocytes and natural killer （NK） cells, and plays a central role in both cell-mediated immunity and immune downregulation. Several studies have shown that FasL is expressed in HCC. In the present report, we prepared recombinant human pET-22b（＋）/FasL protein and investigated the effect of FasL on HCC cells in vitro and on tumor growth in a murine HCC tumor model. The well-known cytotoxic chemotherapeutic reagent adriamycin （ADM） served as a control. We found that FasL effectively suppressed the viability of H22 tumor cells and significantly induced the apoptosis of H22 cells. The apoptotic levels of cells treated with FasL-ADM were significantly higher than those treated with FasL or ADM alone, and the FasL-ADM combination resulted in a more than additive effect on tumor growth delay in this model. The results suggested that combined treatment of FasL and other chemotherapeutic agents may be a new approach to improve the efficacy of chemotherapy for HCC.

关键词： hepatocellular carcinoma combination therapy FasL ADM apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparison Test on Adaptability of Six Medicago sativa (Alfalfa) Varieties in Guangxi

引用

Agricultural Biotechnology 2020年第4期9卷 49-52页

作者： jinhua qiu Yilong HUANG Fanquan ZENG Jinyi WEI Na YAO Guangxi Institute of Animal Sciences Nanning 530001China

In order to screen the Medicago sativa(alfalfa)varieties suitable for planting in Guangxi,six domestic and foreign heat-resistant alfalfa varieties,namely WL903,WL712,WL525HQ,59N59,Elite 9 and Longwei 6010,were selected and tested for growth performance,nutritional value and over-summer rate by the random block *** results showed that the alfalfa varieties with better plant height and fresh grass yield were 59N59 and WL903,which showed the plant heights reaching 62.01 and 62.53 cm,respectively,and the fresh grass yields up to 40.93 and 38.38 t/hm 2,respectively,exhibiting extremely significant differences from the poorly performing Longwei 6010(P<0.01).The nutritional value of each tested variety was good,and the crude protein content was more than 20%.Among them,Elite 9 had a crude protein content as high as 28.43%.The over-summer rates of the six alfalfa varieties were all higher than 75%.It showed that the alfalfa varieties with fast growth,high yield,high nutritional value and high over-summer rate in this experimental area were 59N59 and WL903,which are suitable as the first varieties for planting in Guangxi.

关键词： Medicago sativa Variety comparison Production performance Nutritional value Over-summer rate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Dietary Supplementation of Fu-libao and Glutamic Acid on Finishing and Slaughter Performance and Meat Quality of Pigs

引用

Animal Husbandry and Feed Science 2020年第1期12卷 26-30页

作者： Yang Cui Luo Sicong Yang Jiahuang qiu jinhua Wu Zhuyue Guangxi Institute of Animal Science Nanning 530001China

[Objective]The paper was to investigate the effect of dietary supplementation of Fu-libao and L-glutamic acid on finishing and slaughter performances and meat quality trait of"L(Large Yorkshire)×L(Landrace)"crossbred pigs.[Method]Twelve individuals of L×L crossbred pigs with similar body weight of about 51 kg were *** pigs were randomly divided into two groups,three replicates each group,two piglets each *** pigs in control group were fed with conventional diet(control diet),and pigs in treatment group were fed with the control diet added with 0.1%Fu-libao(mainly contained soybean phospholipid)and 0.6%L-glutamic *** the pigs were under the same feeding conditions except for different diets during the *** the end of the trial,one pig with similar body weight was selected from each replicate for slaughter and determination of meat quality.[Result]Dietary supplementation of Fu-libao and L-glutamic acid had no significant impact on finishing performance of pigs between the two groups(P>0.05),but the back fat thickness of pigs in treatment group was increased(P<0.05).On the contrary,the longissimus muscle(LM)area,meat color and water-holding capacity(WHC)were reduced significantly compared with the control group(P<0.05).However,the contents of glutamic acid,glysine,alanine,threonine,proline,valine and arginine in LM were increased significantly compared with the control group(P<0.05);moreover,the total amino acid and total flavor amino acid contents in LM were increased by 5.85%(P<0.05)and 6.87%(P<0.05)*** addition,the content of intramuscular fat(IMF)in LM was improved from 5.11±0.24(control group)to 8.86±0.52(treatment group)(P<0.05).[Conclusion]Although dietary supplementation of Fu-libao and L-glutamic acid did not increase the finishing and slaughter performances of L×L crossbred pigs,it significantly enhanced the contents of total amino acid,total flavor amino acid and IMF,and significantly improved meat quality.

关键词： Fu-libao L-glutamic acid Finishing Slaughter performance Meat quality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Selenium and Cobalt on Germination of Alfalfa(Medicago sativa) at Different Temperatures

引用

Animal Husbandry and Feed Science 2019年第3期11卷 115-118,124页

作者： Shi Jing Wei Jinyi Lan Xi qiu jinhua Deng Suyuan Yao Na Animal Husbandry Research Institute of Guangxi Zhuang Autonomous Region

Taking No.3 alfalfa(Medicago sativa)as the material,the effects of selenium and cobalt elements on seed germination of alfalfa at different temperatures were studied through germination *** results showed that selenium and cobalt promoted seed germination of alfalfa,and improved germination potential,germination rate,germination index and vigor *** the increasing proportion of selenium and cobalt,the numerical value of each index first increased then *** seed germinations in A15 and B12 treatments were the best at 10℃ and 20℃,while those in A1 and B1 treatments were the worst.

关键词： Selenium Cobalt Alfalfa Germination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Pennisetum purpureum Schum cv. Guiminyin on Milk Yield and Quality of Jersey Cattle at Lactation Stage

引用

Animal Husbandry and Feed Science 2016年第3期8卷 143-145页

作者： Yao Na Teng Shaohua Lai Zhiqiang Yi Xianfeng qiu jinhua Deng Suyuan Lai Dawei Guangxi Institute of Animal Sciences Nanning 530001China

The study aimed to research the forage value of Pennisetum purpureum Schum *** in dairy industry and then provide scientific support for feeding jersey cattle with *** Schum *** 20 jersey cattle at lactation stage were selected and divided into two groups randomly,10 cattle each *** cattle were fed with *** Schum *** and *** ***×（***×***）*** No.1,*** results showed that *** Schum *** performed well in both nutritional value and palatability,and received remarkable effects on jersey *** milk yield was 5.4%higher than that of before test,and the average daily milk yield was（11.65±0.07）kg/*** with control group,milk fat percentage,lactoprotein content and overall milk-solid content were improved *** jersey cattle with *** Schum *** at lactation stage could increase their milk yield and milk quality.

关键词： Pennisetum purpureum Schum cv Guiminyin Jersey cattle Milk yield Milk quality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

RGD-FasL Induces Apoptosis in Hepatocellular Carcinoma

引用

Cellular & Molecular Immunology 2009年第4期6卷 285-293页

作者： Zhongchen Liu Juan Wang Ping Yin jinhua qiu Ruizhen Liu Wenzhu Li Xin Fan Xiaofeng Cheng Caixia Chen Jiakai Zhang Guohong Zhuang Anti-Cancer Research Center Medical College Xiamen University 422Siming South Road Xiamen 361005 China School of Life Science Xiamen University 422 Siming South RoadXiamen 361005 China Zhongshan Hospital Xiamen University Lakeside South 201-209 Xiamen361004 China These authors contributed equally to this work Anti-Cancer Research Center Medical College Xiamen University 422 Siming South Road Xiamen 361005 China

Despite impressive results obtained in animal models, the clinical use of Fas ligand （FasL） as an anticancer drug is limited by severe toxicity. Systemic toxicity of death ligands may be prevented by using genes encoding membrane-bound death ligands and by targeted transgene expression through either targeted transduction or targeted transcription. Selective induction of tumor cell death is a promising anticancer strategy. A fusion protein is created by fusing the extracellular domain of Fas ligand （FasL） to the peptide arginine-glycine-aspartic acid （RGD） that selectively targets avβ-integrins on tumor endothelial cells. The purpose of this study is to evaluate the effects of RGD-FasL on tumor growth and survival in a murine hepatocellular carcinoma （HCC） tumor model. Treatment with RGD-FasL displaying an obvious suppressive effect on the HCC tumor model as compared to that with FasL （p 〈 0.05） and resulted in a more additive effect on tumor growth delay in this model. RGD-FasL treatment significantly enhanced mouse survival and caused no toxic effect, such as weight loss, organ failure, or other treatment-related toxicities. Apoptosis was detected by flow cytometric analysis and TUNEL assays; those results also showed that RGD-FasL is a more potent inducer of cell apoptosis for H22 and H9101 cell lines than FasL （p 〈 0.05）. In conclusion, RGD-FasL appears to be a low-toxicity selective inducer of tumor cell death, which merits further investigation in preclinical and clinical studies. Furthermore, this approach offers a versatile technology for complexing target ligands with therapeutic recombinant proteins. To distinguish the anti-tumor effects of FasL in vivo, tumor and liver tissues were harvested to examine for evidence of necrotic cells, tumor cells, or apoptotic cells by Hematoxylin and eosin （H＆E） staining.

关键词： FasL RGD-FasL apoptosis tumor targeting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

长春瑞滨行数字减影动脉造影术化学治疗出现大片皮肤坏死1例

引用

中国新药与临床杂志 2005年第1期24卷 62-63页

作者：郑玉群马秋爱金华市中心医院浙江金华321000

长春瑞滨(vinorelbine)属长春碱类阻止细胞分裂的抗癌新药.由于其神经毒性较低,临床在治疗非小细胞性肺癌和乳腺癌等已广泛应用.

关键词：导管插入术,外周抗肿瘤药皮炎,刺激性长春瑞滨药物不良反应

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：