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在“实感”与“知识”之间驻足往返——铃木将久教授访谈录

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现代中文学刊 2024年第1期 21-31页

作者：铃木将久马勤勤宋声泉东京大学文学部中国社会科学院文学研究所中国人民大学文学院

访谈人:马勤勤、宋声泉访谈时间:2023年8月17日、8月23日访谈地点:东京大学本乡校区、驹场校区一、我的驹场时代马勤勤、宋声泉(以下简称访谈人):铃木老师您好,感谢您接受我们的访问。我们看到一些有关您的访谈,拟在未能详尽之处展开新... 详细信息

访谈人:马勤勤、宋声泉访谈时间:2023年8月17日、8月23日访谈地点:东京大学本乡校区、驹场校区一、我的驹场时代马勤勤、宋声泉(以下简称访谈人):铃木老师您好,感谢您接受我们的访问。我们看到一些有关您的访谈,拟在未能详尽之处展开新的提问。您在1987年考入东京大学之前,对中国或汉语有哪些最初的印象吗?记得您曾提过,高中时代接触到中岛敦1的作品,从而对中国产生了兴趣。

关键词：东京大学铃木中岛敦访谈时间校区访谈录

Recent progress in background-free latent fingerprint imaging

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Nano Research 2018年第10期11卷 5499-5518页

作者： Yingqian Wang Jie Wang qinqin ma Zhihao Li Quan Yuan Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) College of Chemistry and MolecularSciences Wuhan University Wuhan 430072 China

Owing to their unique pattern and abundant chemical composition, latent fingerprints （LFPs） can serve as ＂ID cards＂ and ＂information banks＂ of donors and therefore are valuable for forensic investigation, access control, and even medical diagnosis. LFP imaging has attracted considerable attention, and a great variety of contrast agents has been developed. In LFP imaging, background signals such as background fluorescence from the underlying surface can seriously blur the LFP images and decrease imaging sensitivity; thus, great efforts have been made to eliminate background interference. Here, we stratify the recent progress in background-free LFP imaging by making use of the difference in properties between contrast agents and background compounds. For example, near-infrared （NIR） light-activatable contrast agents can efficiently remove background signals in LFP imaging because the background compounds cannot be excited by NIR light, showing that the difference in excitation properties between contrast agents and background compounds can be employed to eliminate background interference. This review is organized around background-free LFP imaging based on the difference in optical properties between contrast agents and background compounds：（i） different excitation wavelengths, （ii） different emission wavelengths, （iii） different luminescence lifetime values, （iv） different plasmonic properties, （v） different photothermal properties, and （vi） different electrochemiluminescence properties.

关键词： latent fingerprints background interference upconversion persistent luminescence nanoparticles

宫腔灌注粒细胞集落刺激因子改善薄型子宫内膜患者内膜及血流参数的前瞻性临床对照试验

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四川大学学报（医学版） 2024年第3期55卷 574-579页

作者：徐少蓉马黔红张耀安银华何玮马瑛李俊林李丹路巍马琴芹雍佳嘉赖婷苏莲向鸿电子科技大学医学院附属绵阳医院·绵阳市中心医院生殖中心绵阳621000 出生缺陷与相关妇儿疾病教育部重点实验室(四川大学) 成都610041

目的探究粒细胞集落刺激因子(granulocyte colony-stimulating factor, G-CSF)宫腔灌注对薄型子宫内膜患者内膜厚度、容积、血流参数及临床结局的影响。方法本研究为前瞻性非随机同期对照试验,将2021年9月1日至2023年9月1日于绵阳市... 详细信息

目的探究粒细胞集落刺激因子(granulocyte colony-stimulating factor, G-CSF)宫腔灌注对薄型子宫内膜患者内膜厚度、容积、血流参数及临床结局的影响。方法本研究为前瞻性非随机同期对照试验,将2021年9月1日至2023年9月1日于绵阳市中心医院生殖中心行冻胚移植(frozen-thawed embryo transfer, FET)的薄型子宫内膜患者,分为实验组(行G-CSF宫腔灌注)和对照组(未行G-CSF宫腔灌注)。将两组患者的一般资料和临床结局进行统计分析,将实验组患者G-CSF灌注前后的内膜厚度、容积及血流参数进行统计分析。结果共纳入83例患者,实验组51例,对照组32例,两组患者基线资料无明显差异。实验组患者临床妊娠率(56.86%)高于对照组(50.00%),自然流产率(27.59%)低于对照组(37.50%),但差异无统计学意义(P>0.05)。实验组患者G-CSF宫腔灌注后的内膜厚度[(0.67±0.1) cm]大于灌注前[(0.59±0.09) cm],灌注后的子宫内膜容积[(1.84±0.81) cm~3]大于灌注前[(1.54±0.69) cm~3],灌注后的VFI(1.97±2.82)大于灌注前(0.99±1.04),差异均有统计学意义(P<0.05)。结论宫腔灌注G-CSF可改善薄型子宫内膜患者的内膜厚度、容积及部分血流参数。

关键词：宫腔灌注粒细胞集落刺激因子薄型子宫内膜内膜容受性

Highly efficient and multidimensional extraction of targets from complex matrices using aptamer-driven recognition

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Nano Research 2017年第1期10卷 145-156页

作者： Jie Wang Haijing Shen Chi Huang qinqin ma Yaning Tan Fenglei Jiang Chao ma Quan Yuan Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Hefei 230026 China

Adsorbents are widely employed in both fundamental and applied research areas such as separation technology, biotechnology, and environmental science. Selectivity and reusability are two most important requirements for adsorbents. Aptamers exhibit perfect selectivity and easy regeneration, which make them uniquely effective adsorption materials. Herein, we have rationally designed novel aptamer-based adsorbents and investigated their performance in extraction/ separation of targets from an aqueous solution. These adsorbents can selectively extract targets from complicated sample matrices containing background compounds. Moreover, they can also be easily recycled without a significant loss of adsorption capacity. Notably, the adsorbents did not affect the activity of isolated biological samples, revealing their potential for the purification/separation of biomolecules. Composite adsorbents were constructed using aptamer-based adsorbents and a porous polymer, displaying highly efficient target separation from aqueous solution. Finally, separation columns were constructed, and targets in the aqueous solution were efficiently separated by these columns. The aptamerbased adsorbents described here exhibit great promise for potential applications in separation technology, biotechnology, and environment-related areas.

关键词： aptamer adsorbent selectivity separation extraction

Recent progress in engineering near-infrared persistent luminescence nanoprobes for time-resolved biosensing/bioimaging

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Nano Research 2019年第6期12卷 1279-1292页

作者： Ling Liang Na Chen Yiyi Jia qinqin ma Jie Wang Quan Yuan Weihong Tan Molecular Science and Biomedicine Laboratory Institute of Chemical Biology and NanomedicineCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education) College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China

Persistent luminescence nanoprobes (PLNPs) can remain luminescent after ceasing *** to the ultra-long decay time of persistent luminescence (PersL),autofluorescence interference can be efficiently eliminated by collecting PersL signal after autofluorescence decays completely,thus the imaging contrast and sensing sensitivity can be significantly *** near-infrared (NIR) light shows reduced scattering and absorption coefficient in penetrating biological organs or tissues,near-infrared persistent luminescence nanoprobes (NIR PLNPs) possess deep tissue penetration and offer a bright prospect in the areas of in vivo biosensing/*** this review,we firstly summarize the design of different types of NIR PLNPs for biosensing/bioimaging,such as transition metal ions-doped NIR PLNPs,lanthanide ions-doped NIR PLNPs,organic molecules-based NIR PLNPs,and semiconducting polymer self-assembled NIR ***,organic molecules-based NIR PLNPs and semiconductor self-assembled NIR PLNPs,for the first time,were introduced to the review of ***,the effects of different types of charge carriers on NIR PersL and luminescence decay of NIR PLNPs are significantly emphasized so as to build up an in-depth understanding of their luminescence *** includes the regulation of valence band and conduction band of different host materials,alteration of defect types,depth and concentration changes caused by ion doping,effective radiation transitions and energy transfer generated by different luminescence *** the design and potential of NIR PLNPs as long-lived luminescent materials,the current challenges and future perspective in this rapidly growing field are also discussed.

关键词： near-infrared persistent luminescence nanoprobes biosensing bioimaging

Controlling disorder in host lattice by hetero-valence ion doping to manipulate luminescence in spinel solid solution phosphors

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Science China Chemistry 2018年第12期61卷 1624-1629页

作者： qinqin ma Jie Wang Wei Zheng Qian Wang Zhiheng Li Hengjiang Cong Huijun Liu Xueyuan Chen Quan Yuan Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education) College of Chemistry and Molecular SciencesWuhan University CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Key Laboratory of Nanomaterials Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education and School of Physics and Technology Wuhan University

Phosphor materials have been rapidly developed in the past decades. Developing phosphors with desired properties including strong luminescence intensity and long lifetime has attracted widespread attention. Herein, we show that hetero-valence ion doping can serve as a potent strategy to manipulate luminescence in persistent phosphors by controlling disorder in the host lattice. Specifically, spinel phosphor Zn(Ga_(1-x)Zn_x)(Ga_(1-x)Ge_x)O_4:Cr is developed by doping ZnGa_2O_4:Cr with tetravalent Ge^(^(4+)).Compared to the original ZnGa_2O_4:Cr, the doped Zn(Ga_(1-x)Zn_x)(Ga_(1-x)Ge_x)O_4:Cr possesses significantly enhanced persistent luminescence intensity and prolonged decay time. Rietveld refinements show that Ge^(4+)enters into octahedral sites to substitute Ga^(3+), which leads to the co-substitution of Ga^(3+) by Zn^(2+) for charge compensation. The hetero-valence substitution of Ga^(3+) by Ge^(4+)and Zn^(2+) enriches the charged defects in Zn(Ga_(1-x)Zn_x)(Ga_(1-x)Ge_x)O_4:Cr, making it possible to trap large amounts of charge carriers within the defects during excitation. Electron paramagnetic resonance measurement further confirms that the amount of Cr^(3+) neighboring charged defects increases with Ge^(4+)doping. Thus charge carriers released from defects can readily combine with the neighboring Cr^(3+) to produce bright persistent luminescence after excitation ceases. The hetero-valence ion doping strategy can further be employed to develop many other phosphors and contributes to lighting, photocatalysis and bioimaging.

关键词： persistent luminescence nanoparticle defect doping

Background-free latent fingerprint imaging based on nanocrystals with long-lived luminescence and pH-guided recognition

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Nano Research 2018年第12期11卷 6167-6176页

作者： Zhiheng Li Qian Wang Yingqian Wang qinqin ma Jie Wang Zhihao Li Yingxue Li Xiaobo Lv Wei Wei Lang Chen Quan Yuan Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy ofSciencesBeijing 10090China School of Basic Medical Sciences Wuhan UniversityWuhan 430072China

Latent fingerprints (LFPs) are highly specific to individuals, and LFP imaging has played an important role in areas such as forensic investigation and law enforcement. Presently, LFP imaging still faces considerable problems, including background interference and destructive and complex operations. Herein, we have designed a background-free, nondestructive, and easy-to-perform method for LFP imaging based on pH-mediated recognition of LFPs by carboxyl group-functionalized Zn2GeO4:Mn (ZGO:Mn-COOH) persistent luminescence nanorods (PLNRs). By simply adjusting the pH of the ZGO:Mn-COOH colloid dispersion to a certain acidic range, the negatively charged ZGO:Mn-COOH readily binds to protonated fingerprint ridges via electrostatic attraction. The ZGO:Mn-COOH colloid dispersion can be stored in portable commercial spray bottles, and the LFPs have been easily detected in situ by simply dropping the colloid dispersion on the LFPs. Moreover, since the ZGO:Mn-COOH can remain luminescent after excitation ceases, background color and background fluorescence interference were efficiently removed by simply capturing the luminescent LFP images after the excitation ceased. The entire LFP imaging process can be easily conducted without any destructive or complex operations. Due to the great versatility of the developed method for LFP imaging, clear LFP images with well-resolved ridge patterns were obtained. The designed background-free, nondestructive, and easy-to-perform LFP imaging strategy has great potential for future applications, such as forensic investigations and law enforcement.

关键词： fingerprint persistent luminescence background interference nanoparticle imaging

基于全病变MRI动态增强扫描直方图分析对小乳腺癌腋窝淋巴结转移的预测价值

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中国中西医结合影像学杂志 2024年第4期22卷 424-429页

作者：马芹芹卢星如李芷凡刘春翠冯雯雷军强兰州大学第一临床医学院甘肃兰州730000 兰州大学第一医院放射科甘肃兰州730000 甘肃省智能影像医学工程研究中心甘肃兰州730000 甘肃省放射影像医学临床医学研究中心甘肃兰州730000

目的:基于小乳腺癌全病变MRI动态增强扫描(DCE-MRI)直方图分析及临床特征预测腋窝淋巴结(ALN)转移。方法:回顾性分析93例小乳腺癌患者临床病理资料,其中30例发生ALN转移(转移组),63例ALN无转移(无转移组)。患者术前或治疗前均行MRI检查... 详细信息

目的:基于小乳腺癌全病变MRI动态增强扫描(DCE-MRI)直方图分析及临床特征预测腋窝淋巴结(ALN)转移。方法:回顾性分析93例小乳腺癌患者临床病理资料,其中30例发生ALN转移(转移组),63例ALN无转移(无转移组)。患者术前或治疗前均行MRI检查。采用FireVoxel软件勾画ROI并行直方图分析,采用t检验及mann-WhitneyU检验分析比较2组的直方图参数。采用Pearson及Spearman相关检验分析ALN转移与直方图参数之间的相关性,采用二元logistic回归分析对筛选出ALN转移组和无转移组间差异有统计学意义的参数构建联合模型,并利用ROC曲线分析直方图参数对ALN状态的诊断效能。结果:年龄和绝经状态均与ALN转移存在相关性(均P<0.05)。直方图参数中最小值、第5百分位数、变异系数、体积均与ALN转移显著相关(均P<0.05)。在直方图参数中,体积预测ALN状态的AUC最大,为0.729,最佳阈值为1.765。最小值、第5百分位数、变异系数、体积和年龄构建的联合模型的AUC最高,为0.780。结论:基于全病变DCE-MRI直方图分析可用于预测小乳腺癌的ALN转移,且最小值、第5百分位数、变异系数和体积是预测ALN状态有价值的影像学指标。

关键词：小乳腺癌磁共振成像动态增强扫描直方图分析腋窝淋巴结转移

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颈动脉周围脂肪密度预测颅内斑块易损性的可行性研究

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兰州大学学报（医学版） 2024年第3期50卷 28-34页

作者：刘春翠张艳利徐静菲马芹芹王莎雷军强兰州大学第一临床医学院甘肃兰州730000 兰州大学第一医院放射科甘肃兰州730000 兰州大学第一医院甘肃省智能影像医学工程研究中心甘肃兰州730000 兰州大学第一医院精准影像协同创新甘肃省国际科技合作基地甘肃兰州730000 兰州大学第一医院甘肃省放射影像临床医学研究中心甘肃兰州730000

目的探讨颈动脉周围脂肪密度与不同类型颈动脉斑块及颅内斑块易损性的相关性。方法回顾性分析90例同时行颈动脉计算机断层成像血管造影及高分辨率血管壁磁共振成像检查并诊断为颈动脉粥样硬化斑块的患者临床资料。根据颈动脉计算机断... 详细信息

目的探讨颈动脉周围脂肪密度与不同类型颈动脉斑块及颅内斑块易损性的相关性。方法回顾性分析90例同时行颈动脉计算机断层成像血管造影及高分辨率血管壁磁共振成像检查并诊断为颈动脉粥样硬化斑块的患者临床资料。根据颈动脉计算机断层成像血管造影中斑块成分将颈动脉斑块分为钙化斑块组(n=22)、混合斑块组(n=23)和非钙化斑块组(n=45)。筛选颈动脉周围脂肪组织炎症更重的混合斑块组和非钙化斑块组中存在同侧颅内动脉斑块患者49例,根据高分辨率血管壁磁共振成像检查将其分为易损斑块组(n=36)和稳定斑块组(n=13)。使用Perivascular Fat Analysis Tool软件和手动勾画相结合方式识别和测量颈动脉斑块周围脂肪密度。独立样本t检验、单因素方差分析、mann-Whitney U检验、Kruskal-Wallis秩和检验和χ2检验用于比较组间差异。绘制受试者操作特征曲线分析模型评估颅内斑块易损性。结果钙化斑块组、混合斑块组和非钙化斑块组颈动脉周围脂肪密度值分别为-53.03[-46.02,-56.12]、-43.18[-39.30,-46.07]、-42.88[-39.86,-47.29]。与钙化斑块组相比,非钙化斑块组和混合斑块组颈动脉周围脂肪密度更高(P<0.001)。颈动脉周围脂肪密度是颅内易损斑块的独立危险因素(P=0.003,OR=1.165,95%CI:[1.054,1.287])。颈动脉周围脂肪密度对颅内动脉斑块易损性具有较好的预测价值,受试者操作特征曲线下面积为0.786,灵敏度和特异度分别为91.67%、61.54%。结论颈动脉周围脂肪密度是预测颈动脉不同类型斑块及颅内动脉斑块易损性的有效标记物,可以为影像诊断提供支持。

关键词：颈动脉周围脂肪密度高分辨率血管壁磁共振成像计算机断层成像血管造影颈动脉斑块颅内动脉易损斑块