Recent progress in engineering near-infrared persistent luminescence nanoprobes for time-resolved biosensing/bioimaging

作     者：Ling Liang Na Chen Yiyi Jia Qinqin Ma Jie Wang Quan Yuan Weihong Tan 

作者机构：Molecular Science and Biomedicine LaboratoryInstitute of Chemical Biology and NanomedicineCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education)College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2019年第12卷第6期

页      面：1279-1292页

核心收录：

学科分类：0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：the National Natural Science Foundation of China (NSFC,No.21675120) the National Key R&D Program of China (Nos.2017YFA0208000 and 2016YFF0100800) Foundation for Innovative Research Groups of NSFC (No.21521063) the National Basic Research Program of China (No.2015CB932600) 

主　　题：near-infrared persistent luminescence nanoprobes biosensing bioimaging 

摘      要：Persistent luminescence nanoprobes (PLNPs) can remain luminescent after ceasing *** to the ultra-long decay time of persistent luminescence (PersL),autofluorescence interference can be efficiently eliminated by collecting PersL signal after autofluorescence decays completely,thus the imaging contrast and sensing sensitivity can be significantly *** near-infrared (NIR) light shows reduced scattering and absorption coefficient in penetrating biological organs or tissues,near-infrared persistent luminescence nanoprobes (NIR PLNPs) possess deep tissue penetration and offer a bright prospect in the areas of in vivo biosensing/*** this review,we firstly summarize the design of different types of NIR PLNPs for biosensing/bioimaging,such as transition metal ions-doped NIR PLNPs,lanthanide ions-doped NIR PLNPs,organic molecules-based NIR PLNPs,and semiconducting polymer self-assembled NIR ***,organic molecules-based NIR PLNPs and semiconductor self-assembled NIR PLNPs,for the first time,were introduced to the review of ***,the effects of different types of charge carriers on NIR PersL and luminescence decay of NIR PLNPs are significantly emphasized so as to build up an in-depth understanding of their luminescence *** includes the regulation of valence band and conduction band of different host materials,alteration of defect types,depth and concentration changes caused by ion doping,effective radiation transitions and energy transfer generated by different luminescence *** the design and potential of NIR PLNPs as long-lived luminescent materials,the current challenges and future perspective in this rapidly growing field are also discussed.