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Dosimetric comparison of different multileaf collimators in volumetric modulated arc therapy for malignant pleural mesothelioma

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Oncology and Translational Medicine 2015年第4期1卷 186-189页

作者： Fuli Zhang Huayong Jiang Weidong Xu Yadi Wang Junmao Gao qingzhi liu Na Lu Diandian Chen Bo Yao Jun Hou Jianping Chen Department of Radiation Oncology The Military General Hospital of Beijing PLA

Objective The aiom of the study was to compare the impacts of two types of multileaf collimators （MLC） [standard MLC with a width of 10 mm （sMLC） and micro-MLC with a width of 5 mm （mMLC）] on volumetric modulated arc therapy （VMAT） planning for malignant pleural mesothelioma. Methods VMAT for ten patients with inoperable malignant pleural mesotheliomas was retrospectively planned with the sMLC and mMLC. Histogram-based dose-volume parameters of the planning target vol- ume （PTV） [conformity index （CI） and homogeneous index （HI）] and organs-at-risk were compared for VMAT plans with sMLC （sMLC-VMAT） and mMLC （mMLC-VMAT）. Results The mMLC-VMAT plans were more efficient （average delivery time： 2.67±1.49 min） than the sMLC-VMAT plans （average delivery time： 4.21 ± 2.03 min; P 〈 0.05）. Moreover, compared to the sMLC plans, the mMLC plans demonstrated advantages in the dose coverage of the PTV （CI 0.75 ± 0.08 vs 0.73± 0.09; HI 1.09 ±0.02 vs 1.10± 0.02）, although the difference was not statistically significant （P 〉 0.05）. In addition, significant dose sparing in the fraction of the ipsilateral lung volume receiving 〉 20 Gy （V20; 54.72± 27.08 vs 58.52 ± 29.30） and 〉 30 Gy （V30; 42.74 ± 27.86 vs 46.86± 31.49） radiation, respectively, was observed for the mMLC plans （P 〈 0.05）. Conclusion Comparing sMLC-VMAT and mMLC-VMAT not only demonstrated the higher efficiency and better optimal target coverage of mMLC-VMAT, but also considerably improved the dose sparing of the ipsilateral lung in the VMAT plans for mali qnant pleural mesothelioma.

关键词： multileaf collimator (MLC) mesothelioma volumetric modulated arc therapy (VMAT)

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A dosimetric evaluation of flattening filter-free volumetric modulated arc therapy for postoperative treatment of cervical cancer

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Oncology and Translational Medicine 2016年第4期2卷 179-184页

作者： Fuli Zhang Huayong Jiang Weidong Xu Yadi Wang Junmao Gao qingzhi liu Ping Wang Na Lu Diandian Chen Bo Yao Jun Hou Heliang He Jianping Chen Radiation Oncology Department The PLA Army General Hospital of China

Objective The aim of the study was to compare flattening filter-free(FFF) beams and conventional flattening filter(FF) beams in volumetric modulated arc therapy(VMAT) for cervical cancer after surgery, through a retrospective planning *** VMAT plans of FFF beams and normal FF beams were designed for a cohort of 15 patients. The prescribed dose was 45 Gy to 1.8 Gy per fraction, and at least 95% of the planning target volume received this dose. Doses were computed with a commercially available treatment planning system using a Monte Carlo(MC) algorithm. Plans were compared according to dose-volume histogram analysis in terms of planning target volume homogeneity and conformity indices(HI and CI), as well as organs at risk(OAR) dose and volume parameters. Results FFF-VMAT was similar to FF-VMAT in terms of CI, but inferior to FF-VMAT considering HI. No statistically differences were observed between FFF-VMAT and FF-VMAT in following organ at risks including pelvic bone marrow, small bowel, bladder, rectum, and normal tissue(NT)..Conclusion For patients with cervical cancer after hysterectomy, the FFF beam achieved target and OAR dose distribution similar to that of the FF beam. Reduction of beam-on time in cervical cancer is beneficial.

关键词： flattening filter-free(FFF) cervical cancer dosimetry volumetric modulated arc therapy(VMAT)

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低碳视角下我国能源结构优化研究

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生态经济 2011年第9期27卷 85-87,129页

作者：徐东刘清志王臻中国石油大港油田公司资本运营部天津大港300280 中国石油大学(华东)经济管理学院山东青岛266555

如今低碳经济已成为世界的主题,我国能源结构在这种形势下受到严峻的挑战,迫切需要调整能源结构应对能源危机和减少碳排放。在分析我国能源结构调整可行性的基础上,提出了调整我国能源结构的对策,为国民经济的良好运行提供能源保障,推... 详细信息

如今低碳经济已成为世界的主题,我国能源结构在这种形势下受到严峻的挑战,迫切需要调整能源结构应对能源危机和减少碳排放。在分析我国能源结构调整可行性的基础上,提出了调整我国能源结构的对策,为国民经济的良好运行提供能源保障,推动我国向低碳社会迈进。

关键词：低碳经济能源结构碳排放

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Gut Microbiota Contributes to Sexual Dimorphism in Murine Autoimmune Cholangitis

Gut Microbiota Contributes to Sexual Dimorphism in Murine Au...

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第十四届全国免疫学学术大会

作者： Mengxing Huang Siyu Yang Panyue Luo Jie Long qingzhi liu Jinjun Wang Yi He Liang Li Zhibin Zhao Zhexiong Lian Chronic Disease Laboratory School of MedicineSouth China University of Technology South China University of Technology Department of Thoracic Surgery Guangdong Provincial People's HospitalGuangdong Academy of Medical Sciences College of Environmental Science and Engineering Yangzhou University Department of Rheumatology and Immunology The Third Affiliated Hospital of Southern Medical University

Our data demonstrated that a transgenic murine model of primary biliary cholangitis(PBC),expressing dominant negative transforming growth factor β receptor Ⅱ(dnTGFβRⅡ) under the CD4 promoter,showed similarity to PBC patients which is *** dnTGFβRII mice developed more severe lymphocytic infiltration in the liver and had higher levels of inflammatory cytokines,including IFN-γ and TNF-α,than the male ***,elimination of testosterone through gonadectomy in male dnTGFβ RII mice did not influence disease severity,supporting that testosterone is an unessential factor in sustaining liver immune ***,we observed that treating dnTGFβRII mice with oral antibiotics markedly reduced the differences in the levels of lymphocytic infiltration and cytokines between males and females,suggesting that the commensal gut microbiome plays a role in determining the observed sexual differences in dnTGFβRII ***,we identified the diversity of gut microbiota composition and their metabolic functions in the male and female groups through metagenomic sequencing *** results revealed a testosterone-independent and commensal gut microbiota-mediated female bias in PBC.

关键词： Primary biliary cholangitis Sex-based differences Microbiome Testosterone

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面向数据库的化工软件集成环境的设计

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计算机与应用化学 2005年第11期22卷 980-984页

作者：胡仰栋伍联营刘清芝中国海洋大学化学化工学院山东青岛266003

对于化工领域,用户若能够在一个软件集成环境上对现有的化工软件进行集成,则可以很大程度上节省用户软件二次开发或掌握集成技术所耗费的人力物力。本文试图研究开发一种化工软件集成的环境。利用Windows自身的特点,以及其管理应用程序... 详细信息

对于化工领域,用户若能够在一个软件集成环境上对现有的化工软件进行集成,则可以很大程度上节省用户软件二次开发或掌握集成技术所耗费的人力物力。本文试图研究开发一种化工软件集成的环境。利用Windows自身的特点,以及其管理应用程序的一般方法,设计了化工软件的集成环境。该集成环境由界面集成模块、代码集成模块、数据集成模块和数据库管理子系统4个模块组成,对于4个模块分别给出了界面集成策略、代码集成策略、数据集成策略、数据库和数据库管理子系统的建立策略。

关键词：集成环境化工软件数据库数据库管理子系统

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Comparison of the effects of two typesof multileaf collimators on tumor control probabilityin radiotherapy for breast cancer after conservativesurgery based on the EUD model

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Oncology and Translational Medicine 2017年第2期3卷 77-81页

作者： Fuli Zhang Yadi Wang Weidong Xu Huayong Jiang Junmao Gao qingzhi liu Na Lu Diandian Chen Bo Yao Jun Hou Heliang He Jianping Chen Department of Radiation Oncology General Hospital of Beijing Military Command

Objective To compute and compare the tumor control probability(TCP) of volumetric modulated arc therapy(VMAT) for breast cancer after conservative surgery based on two types of multileaf collimator(MLC) through a retrospective planning *** For a group of 9 patients diagnosed with left breast cancer,VMAT plan based on Agility MLC and beam modulator(BM) MLC were *** prescription dose was 50 Gy covering at least 95% of the planning target volume,2 Gy per *** were calculated according to dose-volume histogram(DVH) *** The TCP of the BM VMAT plan was slightly higher than that of the Agility VMAT plan(94.61% vs 94.23%) but was inferior with respect to delivery efficiency;the delivery time was reduced for Agility VMAT plan by 35% compared to BM VMAT *** For breast cancer radiation therapy after conservative surgery,BM VMAT plans provide slightly higher TCP while the delivery of Agility VMAT plans is significantly faster than the BM VMAT plans.

关键词： tumor control probability (TCP) breast cancer radiobiology volumetric modulated arctherapy (VMAT)

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高校社会学课程融入思政元素的教学实践

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科教导刊 2022年第5期 64-66页

作者：刘清芝青岛农业大学人文社会科学学院山东青岛266109

把思政工作贯穿于大学课程教学的全过程是实现立德树人目标的题中应有之义。社会学是具有综合性、应用性和思想性等特征的社会科学,教师在该课程开展思政教育过程中既要从其学科特点出发,还要明确其培养大学生的目标取向,更要结合实际... 详细信息

把思政工作贯穿于大学课程教学的全过程是实现立德树人目标的题中应有之义。社会学是具有综合性、应用性和思想性等特征的社会科学,教师在该课程开展思政教育过程中既要从其学科特点出发,还要明确其培养大学生的目标取向,更要结合实际探索社会学课程内容和思政元素的融合途径和创新教学方法,为解决社会主义中国“培养什么人、怎样培养人、为谁培养人”这一教育根本问题贡献力量。

关键词：社会学课程课程思政课程教学目标融合教学方法创新

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黄河三角洲生物资源可持续利用的对策

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中国石油大学学报（社会科学版） 2014年第6期30卷 36-40页

作者：刘清志中国石油大学经济管理学院山东青岛266580

生物资源是自然资源的重要组成部分,不仅为农、林、牧、渔业的发展提供了基础,而且为新能源的开发提供了保障。黄河三角洲生物资源丰富,利用效果显著。但还存在湿地退化、基础设施不配套、湿地研究与监测条件较差、保护和开发存在矛盾... 详细信息

生物资源是自然资源的重要组成部分,不仅为农、林、牧、渔业的发展提供了基础,而且为新能源的开发提供了保障。黄河三角洲生物资源丰富,利用效果显著。但还存在湿地退化、基础设施不配套、湿地研究与监测条件较差、保护和开发存在矛盾等问题。因此,应建立实时地理信息系统,大力发展生态旅游业,加大污染治理和环境保护力度,加快生物资源修复工作,进行资源监测和评估,提高全民保护意识等等,以科学合理地管理、利用、保护黄河三角洲地区的生物资源。

关键词：黄河三角洲生物资源可持续利用

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