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试析生活中的化学运用与绿色化学

当代化工研究 2019年第1期 27-28页

作者：吕清源山东省昌乐二中山东262400

本文从"绿色化学"的概念着手,分析生活中化学运用现状问题,并提出生活中运用绿色化学的设想,以期增强人们对绿色化学知识概念的理解,有助于推动环保事业的发展,进而提升全民绿色环保意识,为环保事业尽一份绵薄之力。

关键词：化学运用绿色化学环境污染

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表面形貌对燃料电池密封件接触特性的影响

润滑与密封 2022年第8期47卷 134-140页

作者：张文超卜庆元李艳昆吕宝中车青岛四方机车车辆股份有限公司山东青岛266111 广东国鸿氢能科技有限公司广东云浮527300 北京理工大学重庆创新中心重庆401120

为探究燃料电池密封件表面形貌对密封接触特性的影响,采用Weierstrass-Mandelbrot分形函数表征密封件的表面形貌,基于Majumdar-Bhushan接触模型构建考虑密封件表面形貌的二维有限元模型。研究接触—一次线性加载—卸载—二次线性加载4... 详细信息

为探究燃料电池密封件表面形貌对密封接触特性的影响,采用Weierstrass-Mandelbrot分形函数表征密封件的表面形貌,基于Majumdar-Bhushan接触模型构建考虑密封件表面形貌的二维有限元模型。研究接触—一次线性加载—卸载—二次线性加载4个步骤下光滑表面与粗糙表面的接触特性,基于上述模型,研究材料硬度对燃料电池密封性能的影响。研究结果表明:粗糙表面二次加载后其应力分布均匀度低于第一次,且其2次加载后应力分布均匀度均低于光滑表面;粗糙表面二次加载后其最高应力与最大接触压力较第一次分别增加14.29%与89.29%,而光滑表面几乎维持不变;对于粗糙表面,其硬度越高,泄漏率越低,且其降低幅度随硬度增大而减小。

关键词：质子交换膜燃料电池 W-M分形函数泄漏率表面形貌粗糙度

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拖拉机齿轮泵轮齿接触的有限元分析

农机化研究 2012年第5期34卷 34-37页

作者：张青元吕新民西北农林科技大学机械与电子工程学院陕西省农业装备工程技术研究中心陕西杨凌712100

齿轮泵作为拖拉机上液压系统的加压元件,其工作状态直接影响着拖拉机的工作性能。为此,通过Pro/E参数化建模的方法,构建了齿轮泵轮齿的三维精确模型;利用Pro/E和ANSYS之间的无缝连接接口导入到AN-SYS中,采用solid95单元建立其质量较高... 详细信息

齿轮泵作为拖拉机上液压系统的加压元件,其工作状态直接影响着拖拉机的工作性能。为此,通过Pro/E参数化建模的方法,构建了齿轮泵轮齿的三维精确模型;利用Pro/E和ANSYS之间的无缝连接接口导入到AN-SYS中,采用solid95单元建立其质量较高的有限元模型,并对其复杂的边界条件进行简化处理,然后对其进行接触非线性有限元分析,得到了齿轮接触应力、应变的分布云图以及最大接触应力,为拖拉机齿轮泵的改进及优化提供依据。

关键词：拖拉机齿轮泵有限元分析接触应力

Phospholipid-bile salts-mixed micelles incorporated in oral fast dissolving films for improving the oral bioavailability of poorly water soluble drugs

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Phospholipid-bile salts-mixed micelles incorporated in oral ...

Toward tunable shape memory effect of NiTi alloy by grain size engineering:A phase field study

“好医生杯”中药制剂创新与发展论坛

作者： Qingyuan Lv Minggui Lin Chao Yu Baode Shen He Xu Chengying Shen Ling Dai Hailong Yuan Jin Han Department of Pharmacy 302 Military Hospital Institute of Tuberculosis 309 Military Hospital

The phospholipid-bile salts-mixed micelles(PL-BS-MMs)are potent carriers used for oral absorption of drugs that are poorly soluble in water;however,there are many limitations associated with liquid formulations.In the current study,the feasibility of preparing a solid PL-BS-MMs by incorporating liquid PL/SDC-MMs with solid fast dissolving oral films(FDOFs)carriers was examined.FDOFs incorporated with Cucurbitacin B(Cu B)loaded PL-BS-MMs have been developed and characterised.FDOFs were produced by solvent casting method.The formulation presenting the best characteristics before solidifying and after reconstitution.FDOFs containing Cu B loaded PL/SDC-MMs was easily reconstituted in a transparent and clear solution giving back a colloidal system with spherical micelles in the submicron range.The pharmacokinetics study showed that the FDOFs containing PL/SDC-MMs not only kept the absorption properties as same as liquid PL/SDC-MMs,but also significantly increased the oral bioavailability of Cu B compared to the Cu B solution(p<0.05).This study showed that the solid PL/SDC-MMs based on FDOFs could represent a novel platform for the delivery of poorly water soluble drugs via oral administration.Furthermore,the integration with the FDOFs could also provide a simple and cost-effective manner for the solidification of PL/SDC-MMs.

关键词： Cucurbitacin B phospholipid-bile salts-mixed micelles fast dissolving oral films oral bioavailability poorly water soluble drugs

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Journal of Materials Science & Technology 2024年第1期168卷 276-289页

作者： Bo Xu Chong Wang qingyuan Wang Failure Mechanics and Engineering Disaster Prevention Key Laboratory of Sichuan ProvinceSichuan UniversityChengdu 610065China Department of Mechanical Science and Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Key Laboratory of Deep Underground Science and Engineering (Sichuan University)Ministry of EducationChengdu 610065China

The inelastic deformations of shape memory alloys(SMAs)always show poor controllability due to the avalanche-like martensite transformation,and the effective control for the deformation of precision de-vices has been not yet mature.In this work,the phase field method was used to investigate the shape memory effects(SMEs)of NiTi SMAs undergoing grain size(GS)engineering,to obtain tunable one-way and stress-assisted two-way SMEs(OWSME and SATWSME).The OWSME and SATWSME of the systems with various gradient-nanograin structures and bimodal grain structure,as well as that with geometric gradients were simulated.The simulated results indicate that due to the GS dependences of martensite transformation and reorientation,the occurrence and expansion of martensite reorientation,martensite transformation and its reverse can be efficaciously controlled via the GS engineering.When combining the GS engineering and geometric gradient design,since the effects of GS and stress gradient can be su-perimposed or competing,and the responses of martensite reorientation,martensite transformation and its reverse to this are different,the OWSME and SATWSME of the geometrically graded systems with various nanograin structures can exhibit different improvements in controllability.In short,the reorienta-tion hardening modulus during OWSME is increased and the transformation temperature window during SATWSME is widened by GS engineering,indicating the improved controllability of SMEs.The optimal GS engineering schemes revealed in this work provide the basic reference and guidance for designing tun-able SMEs and producing NiTi-based driving devices catering to desired functional performance in various engineering fields.

关键词： Phase field NiTi Shape memory effect Grain size engineering Geometric gradient

Development and characterization of mucoadhesive buccal films containing phospholipid-bile salts-mixed micelles for Cucurbitacin B delivery

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Development and characterization of mucoadhesive buccal film...

2013年中国药学大会暨第十三届中国药师周

作者： Qingyuan Lv Chengying Shen Xianyi Li Baode Shen Chao Yu Pinghua Xu He Xu Jin Han Hailong Yuan Department of Pharmacy 302 Military Hospital Institute for Drug and Instrument Control Health Department GLD of PLA

Cucurbitacin B （Cu B）, a potent anti-cancer agents, suffers with the problems of gastrointestinal side effects and non-specific toxicity via oral administration and drawbacks in patients compliance and acceptance through injections. An integration of nanoscopic carriers with mucoadhesive buccal films drug delivery system would resolve these issues effectively with greater therapeutic benefits and clinical significance. Thus, the drug loaded mucoadhesive buccal film was developed and characterized in this study and the carboxymethyl chitosan （CCS） was choosed as a bioadhesive polymer, glycerol was choosed as a plasticizer and phospholipid-bile salts-mixed micelles （PL-BS-MMs） was selected as the nanoscopic carriers. The CCS-films containing Cu B loaded PL/SDC-MMs was evaluted for the mechanical properties, mucoadhesion properties, in vitro water-uptake, in vitro release and morphological properties, respectively. The optimal CCS-films containing Cu B loaded PL/SDC-MMs was easily reconstituted in a transparent and clear solution giving back a colloidal system with spherical micelles in the submicron range and presenting the good characteristics after reconstituting into micelles solution compared with corresponding results of initial Cu B-PL/SDC-MMs solution. The in vivo study revealed a greater and more extended release of Cu B from nanoscopic CCS-films compared to that from a conventional CCS films （C-CCS-films） and oral marketed tablet （Hulusupian）. The AUC 0-36h for CCS-films containing Cu B loaded PL/SDC-MMs was found to be 46.43±5.11 μg/mL/h in comparison to 4.44±1.21 μg/mL/h and 17.23±3.46 μg/mL/h for C-CCS-films and oral tablet, respectively. The absorption of Cu B from CCS-films containing Cu B loaded PL/SDC-MMs resulted in 2.69-fold increased in bioavailability as compared to conventional tablet formulation and 10.46 times with reference to the C-CCS-films formulation. Thus, this kind of mucoadhesive buccal film might be an alternative safe route for delivery of Cu B avoiding gastrointestinal side effects

关键词： Cucurbitacin B phospholipid-bile salts-mixed micelles film carboxymethyl chitosan bioavailability

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小型断路器双金属片热弯曲特性的实验仿真

电器与能效管理技术 2022年第2期 46-52页

作者：潘庆元北京ABB低压电器有限公司北京100176

以小型断路器热脱扣用双金属片为研究对象,分别从理论计算、试验分析和数值仿真等角度对热弯曲特性进行了分析,提出了双金属片优化设计新思路,并以此为基础建立了双金属片热弯曲特性的仿真平台。开发和设计了热双金属片弯曲性能试验专... 详细信息

以小型断路器热脱扣用双金属片为研究对象,分别从理论计算、试验分析和数值仿真等角度对热弯曲特性进行了分析,提出了双金属片优化设计新思路,并以此为基础建立了双金属片热弯曲特性的仿真平台。开发和设计了热双金属片弯曲性能试验专用成套夹具,完善了试验平台和方法。利用数值仿真替代部分前期试验,结合实验设计方法,可快速求得设计参数最优解,降本增效。仿真平台还可应用于以热脱扣力脱扣行程为校验目标的机构参数协同设计。

关键词：小型断路器双金属片热比弯曲有限元实验仿真

Novel porous ceramic with high strength and thermal performance using MA hollow spheres

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Progress in Natural Science:Materials International 2022年第6期32卷 732-738页

作者： Anbang Chen Lang Li Chong Wang qingyuan Wang Failure Mechanics and Engineering Disaster Prevention Key Laboratory of Sichuan Province College of Architecture and Environment Sichuan University MOE Key Laboratory of Deep Earth Science and Engineering College of Architecture and Environment Sichuan University

The objective of this work is to obtain a multifunctional porous ceramic material at low cost with improved properties and that can be used in many applications like:thermal and acoustic insulation,refractory support and hot gas filtration elements.To that end,a novel facile strategy to fabricate porous ceramics by foaming and poreforming agent methods using magnesia-aluminum spinel hollow spheres(MASHSs) was reported for the first time,in which calcium aluminate cement(CAC) served as high-temperature binder.The influence of temperature ranging from 1500℃ to 1700℃ on the thermal conductivity,porosity and mechanical strength were investigated.The results show that,the obtained MASHSs ceramic exhibits high porosity(67.2-71.9%) and thermal conductivity(0.18-0.38 W/mK),and compressive strength(6.1-17.1 MPa),which is mainly due to the change in crack directions and microstructure optimization with the prolong of firing temperature.The crack directions changed from the surface of MASHSs to the interior MASHSs,which consumes more crack energy,and thus leading to the excellent mechanical performance.What is more,the introduction of MASHSs makes it difficult to lose heat at elevated temperature,and thereby improving the thermal conductivity of materials.

关键词： MA hollow Spheres Porous ceramics Thermal conductivity Mechanical property

Screening and design of COF-based mixed-matrix membrane for CH_(4)/N_(2) separation

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Chinese Journal of Chemical Engineering 2022年第2期35卷 170-177页

作者： Tongan Yan Dahuan Liu qingyuan Yang Chongli Zhong State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Separation Membranes and Membrane Processes Tiangong UniversityTianjin 300387China

Membrane separation is a high-efficiency,energy-saving,and environment-friendly separation technology.Covalent organic framework(COF)-based mixed-matrix membranes(MMMs)have broad application prospects in gas separation and are expected to provide new solutions for coal-bed methane purification.Herein,a high-throughput screening method is used to calculate and evaluate COF-based MMMs for CH_(4)/N_(2) separation.General design rules are proposed from thermodynamic and kinetic points of view using the computation-ready,experimental COFs.From our database containing 471,671 generated COFs,5 COF membrane materials were screened with excellent membrane selectivities,which were then used as the filler of MMMs for separation performance evaluation.Among them,BAR-NAP-Benzene_CF_(3) combined with polydimethylsiloxane and styrene-b-butadiene-b-styrene show high CH_(4) permeability of 4.43×10^(-13) mol·m·s^(-1)·Pa^(-1)·m^(-2) and high CH_(4)/N_(2) selectivity of 9.54,respectively.The obtained results may provide reasonable information for the design of COF-based membranes for the efficient separation of CH_(4)/N_(2).

关键词： Covalent organic frameworks Methane Molecular simulations Mixed-matrix membrane Nitrogen Separation