Phospholipid-bile salts-mixed micelles incorporated in oral fast dissolving films for improving the oral bioavailability of poorly water soluble drugs
作者单位：Department of Pharmacy302 Military Hospital Institute of Tuberculosis309 Military Hospital
会议名称：《“好医生杯”中药制剂创新与发展论坛》
会议日期：2013年
学科分类：1006[医学-中西医结合] 10[医学] 100602[医学-中西医结合临床]
基 金：supported by the National Key New Drugs Innovation Foundation(No.2013ZX09J13109-06C) the Natural Science Found of Beijing city of China(No.7122176) the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry(No.20101561)
关 键 词：Cucurbitacin B phospholipid-bile salts-mixed micelles fast dissolving oral films oral bioavailability poorly water soluble drugs
摘 要：The phospholipid-bile salts-mixed micelles(PL-BS-MMs)are potent carriers used for oral absorption of drugs that are poorly soluble in water;however,there are many limitations associated with liquid formulations.In the current study,the feasibility of preparing a solid PL-BS-MMs by incorporating liquid PL/SDC-MMs with solid fast dissolving oral films(FDOFs)carriers was examined.FDOFs incorporated with Cucurbitacin B(Cu B)loaded PL-BS-MMs have been developed and characterised.FDOFs were produced by solvent casting method.The formulation presenting the best characteristics before solidifying and after reconstitution.FDOFs containing Cu B loaded PL/SDC-MMs was easily reconstituted in a transparent and clear solution giving back a colloidal system with spherical micelles in the submicron range.The pharmacokinetics study showed that the FDOFs containing PL/SDC-MMs not only kept the absorption properties as same as liquid PL/SDC-MMs,but also significantly increased the oral bioavailability of Cu B compared to the Cu B solution(p0.05).This study showed that the solid PL/SDC-MMs based on FDOFs could represent a novel platform for the delivery of poorly water soluble drugs via oral administration.Furthermore,the integration with the FDOFs could also provide a simple and cost-effective manner for the solidification of PL/SDC-MMs.