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Role of human papillomavirus and cell cycle-related variants in squamous cell carcinoma of the oropharynx

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The Journal of Biomedical Research 2010年第5期24卷 339-346页

作者： Guojun Li Zhigang Huang Xingming Chen qingyi wei Department of Head and Neck Surgery The University of Texas M.D.Anderson Cancer CenterHoustonTexas 77030-4095USA Department of Epidemiology The University of Texas M.D.Anderson Cancer CenterHoustonTexas 77030-4095USA Department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityKey Laboratory of O tolaryngology Head and Neck SurgeryMinistry of EducationBeijing Institute of OtolaryngologyBeijing 100730China Department of Otolaryngology Head and Neck Surgery Peking Union Medical College HospitalPeking Union Medical Collegea nd Chinese Academy of Medical SciencesBeijing 100005China.

SCCOP is a subset of squamous cell carcinoma of the head and neck and is characterized by aggressive local tumor growth that requires morbid local-regional therapies. It has a moderately high recurrence rate, common medical comorbidities, and a high frequency of second primary tumorst^a. It is estimated that in the USA approximately 9,000 new cases of SCCOP were diagnosed and 2,110 deaths would result from these cancers in 2006. The median age at diagnosis is approximately 60 y, and this disease occurs more frequently in men （-75%） than in womenta.

关键词：癌鳞状细胞颈口咽男人头部细胞周期胰岛素人类

Molecular epidemiology of DNA repair gene polymorphisms and head and neck cancer

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The Journal of Biomedical Research 2013年第3期27卷 179-192页

作者： Meilin Wang Haiyan Chu Zhengdong Zhang qingyi wei Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationSchool of Public HealthNanjing Medical University Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCancer CenterNanjing Medical University Department of Epidemiology the University of Texas M. D. Anderson Cancer Center

Although tobacco and alcohol consumption are two common risk factors of head and neck cancer （HNC）, other specific etiologic causes, such as viral infection and genetic susceptibility factors, remain to be understood. Hu- man DNA is often damaged by numerous endogenous and exogenous mutagens or carcinogens, and genetic vari- ants in interaction with environmental exposure to these agents may explain interindividual differences in HNC risk. Single nucleotide polymorphisms （SNPs） in genes involved in the DNA damage-repair response are reported to be risk factors for various cancer types, including HNC. Here, we reviewed epidemiological studies that have assessed the associations between HNC risk and SNPs in DNA repair genes involved in base-excision repair, nucleotide-excision repair, mismatch repair, double-strand break repair and direct reversion repair pathways. We found, however, that only a few SNPs in DNA repair genes were found to be associated with significantly in- creased or decreased risk of HNC, and, in most cases, the effects were moderate, depending upon locus-locus in- teractions among the risk SNPs in the pathways. We believe that, in the presence of exposure, additional pathway- based analyses of DNA repair genes derived from genome-wide association studies （GWASs） in HNC are needed.

关键词： DNA repair molecular epidemiology head and neck cancer genetic variation genome-wide asso-ciation study

非学术部门就业对博士生的质量需求——胜任力分类理论视角下基于招聘信息内容的分析

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高校教育管理 2023年第4期17卷 87-101页

作者：徐岚魏庆义厦门大学高等教育发展研究中心福建厦门361005

博士生培养规模的扩大以及学术劳动力市场的萎缩使博士生在非学术部门就业渐成主流。本研究通过搜集1317条非学术部门博士生招聘信息并进行内容分析发现,相较于学术职业,非学术部门就业在知识维度上偏重博士生所掌握知识的情境应用与转... 详细信息

博士生培养规模的扩大以及学术劳动力市场的萎缩使博士生在非学术部门就业渐成主流。本研究通过搜集1317条非学术部门博士生招聘信息并进行内容分析发现,相较于学术职业,非学术部门就业在知识维度上偏重博士生所掌握知识的情境应用与转化,在能力维度上要求博士生具备专业实践能力、可迁移能力、科研创新能力,在潜力维度上重视博士生“为人”“为事”“为学”的综合品质,期待博士生成为面向应用的高端创新人才与领导型人才。基于胜任力分类理论,本研究建构了领域具体性与任务具体性分类框架。面对非学术就业市场对博士生质量提出的新需求,专业学位博士生教育应当扩大规模,建立需求导向的培养反馈机制,优化面向实践情境的博士生培养模式及评价标准;学术学位博士生教育要强化博士生可迁移能力的“融入式”培养,为其多元化发展创设路径,并通过导师指导提升其非认知能力。

关键词：研究生教育专业学位博士生非学术部门就业博士生质量胜任力分类理论内容分析

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博士生教育质量评价变迁的历程、特征与趋势--基于治理理论分析视角

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学位与研究生教育 2023年第9期 85-93页

作者：徐岚魏庆义厦门大学高等教育发展研究中心厦门大学教育研究院研究生教育研究中心厦门361005 厦门大学教育研究院厦门361005

基于治理理论的视角,通过历史梳理发现:西方发达国家的博士生教育质量评价经历了学术逻辑主导的、政府介入的、新公共管理的以及基于整体治理的博士生教育质量评价四个阶段。具体来看,博士生教育质量评价在导向上由追求学术卓越转向回... 详细信息

基于治理理论的视角,通过历史梳理发现:西方发达国家的博士生教育质量评价经历了学术逻辑主导的、政府介入的、新公共管理的以及基于整体治理的博士生教育质量评价四个阶段。具体来看,博士生教育质量评价在导向上由追求学术卓越转向回应公共利益诉求;在组织形态上从封闭式转向各层级的整体协作;在治理方式上由设置学术标准转向提供网络式服务;在评判标准上由原创性知识贡献转向博士生发展质量。当今,西方发达国家的博士生教育质量评价发展趋势一方面是重心“下移”,为博士生个体提供支持;另一方面是整合质量文化和建立信任机制,推进网络式质量评价体系的完善。

关键词：博士生教育质量评价历史进程治理理论评价模式

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危险度评价中的非传统病例-对照研究

中国卫生统计 2004年第5期21卷 269-273页

作者：陈峰易洪刚赵杨于浩沈洪兵 qingyi wei 南京医科大学流行病与卫生统计学系 Dept.

近年来，复杂性疾病(complex disorder)的致病基因及其与环境的交互作用(interaction)已成为病因学研究的热点问题。病例-对照研究(case-control study)通过比较大量病人与种族相似、无关联的对照中变异等位基因的频率来评估基因、环境... 详细信息

近年来，复杂性疾病(complex disorder)的致病基因及其与环境的交互作用(interaction)已成为病因学研究的热点问题。病例-对照研究(case-control study)通过比较大量病人与种族相似、无关联的对照中变异等位基因的频率来评估基因、环境，及其交互作用与疾病的关联。由于这种方法易于实施而且对于基因定位非常有用，因而在分析遗传性疾病时发挥了重要的作用。

关键词：病例-对照研究危险度评价病因学研究复杂性疾病致病基因遗传性疾病病人热点问题传统交互作用

DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non-small-cell lung cancer

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Chronic Diseases and Translational Medicine 2018年第2期4卷 109-116页

作者： Xin (Eric) Jiang Ting Xu qingyi wei Peng Li Daniel R. Gomez Laurence E. Court Zhongxing Liao Department of Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Duke University DurhamNC 27708USA Duke Cancer Institute Duke University Medical CenterDurhamNC 27710USA Department of Medical Oncology Henan Cancer HospitalZhengzhouHenan 450008China Department of Radiation Physics The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Objective: The DNA repair capacity (DRC) of tumor cells is an important contributor to resistance to radiation and platinum-based drugs. Because DRC may be affected by tumor cell metabolism, we measured DRC in lymphocytes from patients with non-small-cell lung cancer (NSCLC) and compared the findings with the maximum standardized uptake value (SUVmax) on 18 F-fluorodeoxyglucose positron emission tomography (FDG PET) after (chemo)radiation therapy. Methods: This study included 151 patients with stage IA-IV NSCLC who had FDG PET at a single institution and donated blood samples before chemotherapy. We assessed the correlation of DRC, measured in peripheral T lymphocytes by a host-cell reac-tivation assay with SUVmax and their associations with overall survival (OS) time by hazards ratios calculated with a Cox pro-portional hazards regression model. Results: SUVmax of the primary tumor at diagnosis was inversely associated with lymphocyte DRC (r＝－0.175, P＝0.032), particularly among patients with advanced disease (r ＝－0.218, P ＝ 0.015). However, △SUVmax of primary tumor was not significantly associated with DRC (r＝0.005, P＝0.968). SUVmax of regional lymph nodes at diagnosis (r＝－0.307, P＝0.0008) and after (chemo)radiation treatment (r＝－0.329, P＝0.034) and SUVmax of the primary tumor after (chemo)radiation treatment (r＝－0.253, P＝0.045) were also inversely associated with OS time. Conclusion: DRC was inversely associated with primary tumor SUVmax before treatment but not with △SUVmax after (chemo)radiation.

关键词： DNA repair capacity Standardized uptake value 18F-fluorodeoxyglucose positron emission tomography Outcome Non-small-cell lung cancer

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食品中丙烯酰胺抑制策略的研究进展

食品科学 2021年第17期42卷 333-342页

作者：汪腾飞孙大文蒲洪彬韦庆益华南理工大学食品科学与工程学院现代食品工程研究中心广东省冷链食品智能感知与过程控制工程技术研究中心广东广州510006

丙烯酰胺(acrylamide,AM)是富含碳水化合物的食品发生美拉德反应而产生的一种有毒副产物,对人体的神经系统、免疫系统和遗传物质都有一定的毒性,此外还有潜在的致癌性。因此,检测以及控制食品中的AM含量至关重要。本文结合当前对AM的研... 详细信息

丙烯酰胺(acrylamide,AM)是富含碳水化合物的食品发生美拉德反应而产生的一种有毒副产物,对人体的神经系统、免疫系统和遗传物质都有一定的毒性,此外还有潜在的致癌性。因此,检测以及控制食品中的AM含量至关重要。本文结合当前对AM的研究进展从加工食品生产的3个主要阶段——农业生产阶段、预处理阶段和加工阶段阐述了多种AM抑制策略,并基于具体的抑制机理系统归纳了AM的控制措施,为抑制食品中AM的合成提供新思路。

关键词：丙烯酰胺抑制策略形成途径毒性热加工食品

DNA repair genotypes and phenotypes and cancer susceptibility

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Journal of Nanjing Medical University 2008年第1期22卷 46-46页

作者： qingyi wei Department of Epidemiology The University of Texas M.D. Anderson Cancer Center

The role of DNA repair in the etiology of cancers has been well illustrated in several hereditary syndromes, in which an inherited defect in DNA repair and related biological processes is associated with extraordinarily high incidence of cancer. For example, patients with xeroderma pigmentosum（XP） have germline mutations in genes involved nucleotide excision repair（NER） coupled with more than 1000-fold increased risk of UV-induced skin cancers. However, such associations between inherited DNA repair defect and risk of cancer have not been apparent in the general population.

关键词： DNA 修复型基因癌症基因表达

Construction and evaluation of a polygenic hazard score for prognostic assessment in localized gastric cancer

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Fundamental Research 2024年第5期4卷 1331-1338页

作者： Jing Ni Mengyun Wang Tianpei Wang Caiwang Yan Chuanli Ren Gang Li Yanbing Ding Huizhang Li Lingbin Du Yue Jiang Jiaping Chen Yanong Wang Dazhi Xu Meng Zhu Juncheng Dai Hongxia Ma Zhibin Hu Hongbing Shen qingyi wei Guangfu Jin Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineChina International Cooperation Center for Environment and Human HealthNanjing Medical UniversityNanjing 211166China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230032China Cancer Institute Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Public Health Institute of Gusu School The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215006China Department of Immunology School of Basic Medical SciencesNanjing Medical UniversityNanjing 211166China Department of Laboratory Medicine Clinical Medical College of Yangzhou UniversityYangzhou 225001China Department of General Surgery Jiangsu Cancer HospitalJiangsu Institute of Cancer ResearchThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Gastroenterology the Affiliated Hospital of Yangzhou UniversityYangzhou 225001China Zhejiang Provincial Office for Cancer Prevention and Control The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhouZhejiang 310022China Department of Gastric Cancer and Soft Tissue Sarcomas Fudan University Shanghai Cancer CenterShanghai 200032China Jiangsu Key Laboratory of Molecular and Translational Cancer Research Jiangsu Cancer HospitalJiangsu Institute of Cancer ResearchThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Institute for Precision Cancer Prevention and Medicine Great Bay Area Institutes of Precision MedicineGuangzhou 511466China Department of Population Health Sciences Duke University School of MedicineDurh

To investigate whether genetic variants may provide additional prognostic value to improve the existing clinical staging system for gastric cancer(GC),we performed two genome-wide association studies(GWASs)of GC survival in the Jiangsu(N=1049)and Shanghai(N=1405)*** using a TCGA dataset,we validated genetic markers identified from a meta-analysis of these two Chinese cohorts to determine GC survival-associated ***,we constructed a weighted polygenic hazard score(PHS)and developed a nomogram in combination with clinical *** also evaluated prognostic accuracy with the time-dependent receiver operating characteristic(ROC)curve,net reclassification improvement(NRI)and integrated discrimination improvement(IDI).We identified a single nucleotide polymorphism(SNP)of rs1618332 at 15q15.1 that was associated with the survival of GC patients with a P value of 4.12×10^(-8),and we also found additional 25 SNPs having consistent associations among these two Chinese cohort and TCGA *** PHS derived from these 26 SNPs(PHS-26)was an independent prognostic factor for GC survival(all P<0.001).The 5-year AUC of PHS-26 was 0.68,0.66 and 0.67 for Jiangsu,Shanghai and their pooled cohorts,respectively,which increased to 0.80,0.82 and 0.81,correspondingly,after being integrated into a nomogram together with variables of the clinical *** PHS-26 could improve the NRIs by 16.20%,4.90%and 8.70%,respectively,and the IDIs by 11.90%,8.00%and 9.70%,*** 26-SNP based PHS could substantially improve the accuracy of prognostic assessment and might facilitate precision medicine for GC patients.

关键词： Stomach neoplasm Survival Genome-wide association study Polygenic hazard score Nomogram