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基于YOLOv7的火灾烟雾检测分析

电子技术（上海） 2024年第3期53卷 216-217页

作者：孟庆文吴润鑫张志飞济宁市消防救援支队山东272000 盐城工学院信息工程学院江苏224051

阐述基于YOLOv7系列的火灾烟雾检测模型。对采集的数据集分别利用YOLOv7,YOLOv7-tiny进行模型训练,同时结合PyQt技术创建检测系统。实验结果表明该模型的有效性。

关键词：智能控制火灾检测 YOLOv7 PyQt

NLRP3炎症小体在动脉粥样硬化中的作用机制和靶向炎症治疗的研究进展

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中国动脉硬化杂志 2024年第1期32卷 79-86页

作者：孟庆雯刘华江易泓汝刘启兵海南医学院第一附属医院心血管内科海南省海口市570100 海南医学院中医学院海南省海口市570100 海南医学院第一附属医院介入血管外科海南省海口市570100 海南医学院第一附属医院药学部海南省海口市570100

动脉粥样硬化(As)是由一系列复杂因素引起的病理过程,包括内皮功能障碍、动脉血管壁中脂质沉积、巨噬细胞浸润、平滑肌细胞功能失调、泡沫细胞形成等,炎症反应在这一过程中发挥了重要的作用。NOD样受体热蛋白结构域相关蛋白3(NLRP3)炎... 详细信息

动脉粥样硬化(As)是由一系列复杂因素引起的病理过程,包括内皮功能障碍、动脉血管壁中脂质沉积、巨噬细胞浸润、平滑肌细胞功能失调、泡沫细胞形成等,炎症反应在这一过程中发挥了重要的作用。NOD样受体热蛋白结构域相关蛋白3(NLRP3)炎症小体是炎症细胞的传导器,其激活后介导炎症反应,激活下游的白细胞介素18、白细胞介素1β,从而参与As的发生和发展。因此,针对NLRP3炎症小体和下游炎症因子的特异性抑制剂是目前临床药物研究的潜在靶点,有望成为治疗As的一种新的治疗措施。文章对NLRP3炎症小体的结构和激活机制及与As的关系进行了讨论,同时对靶向NLRP3炎症小体和下游炎症因子的药物进行了介绍。

关键词：动脉粥样硬化 NLRP3炎症小体靶向炎症治疗

敲低MKL1通过激活自噬流抑制心肌成纤维细胞活化与纤维化表型的作用研究

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转化医学杂志 2024年第1期13卷 1-6页

作者：魏俊萍符达佳孟庆雯林道飞林燕仔海南医学院第一附属医院心血管内一科海口570102 海南医学院第一附属医院心电图室海口570102

目的探究敲低巨核细胞白血病因子1(MKL1)对心肌成纤维细胞(CFs)活化与纤维化表型的影响及作用机制。方法选取人CFs,敲低CFs中MKL1表达,检测敲低效果;将CFs分为对照组、血管紧张素Ⅱ(AngⅡ)组、shNC+AngⅡ组、shMKL1+AngⅡ组,shNC+AngⅡ... 详细信息

目的探究敲低巨核细胞白血病因子1(MKL1)对心肌成纤维细胞(CFs)活化与纤维化表型的影响及作用机制。方法选取人CFs,敲低CFs中MKL1表达,检测敲低效果;将CFs分为对照组、血管紧张素Ⅱ(AngⅡ)组、shNC+AngⅡ组、shMKL1+AngⅡ组,shNC+AngⅡ组与shMKL1+AngⅡ组分别转染shRNA NC、shRNA MKL1,AngⅡ组、shNC+AngⅡ组及shMKL1+AngⅡ组CFs再使用AngⅡ刺激建立心肌纤维化模型;处理结束后,检测各组CFs增殖活性,测定各组CFs细胞培养上清液中Ⅰ型胶原(COL-Ⅰ)、Ⅲ型胶原(COL-Ⅲ)水平,观察各组CFs中α-平滑肌肌动蛋白(α-SMA)表达,检测各组CFs中α-SMA、COL-Ⅰ、COL-Ⅲ蛋白表达水平。观察各组CFs自噬流,检测各组CFs中LC3Ⅱ/LC3Ⅰ蛋白比值、Beclin1蛋白表达水平。结果转染shMKL1的CFs中MKL1 mRNA相对表达量与蛋白相对表达量均低于未转染的CFs和转染shNC的CFs(P<0.05);与对照组比较,AngⅡ组同一时间下CFs增殖活性升高(P<0.05),上清液中COL-Ⅰ、COL-Ⅲ水平升高(P<0.05),CFs中α-SMA荧光染色强度增加,α-SMA、COL-Ⅰ、COL-Ⅲ蛋白相对表达量上调(P<0.05),自噬溶酶体与自噬体减少,LC3Ⅱ/LC3Ⅰ蛋白比值下降(P<0.05),Beclin1蛋白相对表达量下调(P<0.05);与AngⅡ组、shNC+AngⅡ组比较,shMKL1+AngⅡ组同一时间下CFs增殖活性降低(P<0.05),上清液中COL-Ⅰ、COL-Ⅲ降低(P<0.05),CFs中α-SMA荧光染色强度减弱,α-SMA、COL-Ⅰ、COL-Ⅲ蛋白相对表达量下调(P<0.05),CFs中自噬溶酶体与自噬体增加,LC3Ⅱ/LC3Ⅰ蛋白比值升高(P<0.05),Beclin1蛋白相对表达量上调(P<0.05)。结论敲低MKL1能够抑制CFs活化与心肌纤维化表型,该作用可能与激活细胞内阻滞的自噬流有关。

关键词：心肌纤维化心肌成纤维细胞细胞增殖巨核细胞性白血因子1 自噬流纤维化表型血管紧张素Ⅱ

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ETFE树脂粉末涂料的应用

化工生产与技术 2024年第3期30卷 14-18,33,I0003页

作者：王狄狮孟庆文余国军余晓霞黄才湘浙江巨化股份有限公司氟聚合物事业部浙江衢州324004

综述了乙烯-四氟乙烯共聚物(ETFE)树脂粉末理化性质、加工属性和国内外市场概况,详细介绍了其在化工防腐领域应用时的工艺要点。最后,指出了国内ETFE树脂粉末加工制造的发展方向及趋势。

关键词：乙烯-四氟乙烯共聚物树脂粉末涂料滚涂成膜静电喷涂

全反式维甲酸减轻内质网应激反应改善异丙肾上腺素诱导的大鼠心肌纤维化与心肌重构

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医学分子生物学杂志 2024年第3期21卷 203-210页

作者：魏俊萍孟庆雯林道飞林燕仔符达佳海南医学院第一附属医院心血管内一科海口市570102 海南医学院第一附属医院心电图室海口市570102

目的全反式维甲酸(all-trans retinoic acid,ATRA)对异丙肾上腺素(isoprenaline,ISO)诱导下大鼠心肌纤维化和心肌重构的影响及作用机制。方法将大鼠按随机数表法分为4组:对照组、ISO组、ATRA+ISO组、4-PBA(4-苯基丁酸,4-phenylbutyric a... 详细信息

目的全反式维甲酸(all-trans retinoic acid,ATRA)对异丙肾上腺素(isoprenaline,ISO)诱导下大鼠心肌纤维化和心肌重构的影响及作用机制。方法将大鼠按随机数表法分为4组:对照组、ISO组、ATRA+ISO组、4-PBA(4-苯基丁酸,4-phenylbutyric acid)+ISO组,每组10只;ATRA+ISO组和4-PBA+ISO组预先分别通过腹腔注射ATRA与4-PBA,然后再通过背部皮下注射ISO进行诱导。心脏超声检测各组大鼠左心室舒张末期内径(left ventricular internal diameter in diastole,LVIDd)、左心室收缩末期内径(left ventricular internal diameter in systole,LVIDs)、左心室的射血分数(ejection fraction,EF)及短轴缩短率(fractional shortening,FS),称量各组大鼠体重、全心质量及左心室质量,计算全心质量指数(heart mass index,HMI)与左心室质量指数(left ventricle mass index,LVMI)。ELISA测定各组大鼠血清N端B型利钠肽原(N terminal pro B type natriuretic peptide,NT-proBNP)含量。HE染色和Masson染色观察各组大鼠心肌组织病理学变化与胶原纤维化程度。蛋白质印迹检测心肌组织中G蛋白偶联受体78(glucose-regulated protein 78,GRP78)、C/EBP同源蛋白(C/EBP homology protein,CHOP)、蛋白激酶R样内质网激酶(protein kinase R-like ER kinase,PERK)、磷酸化真核翻译起始因子2α(phosphorylated eukaryotic translation initiation factor 2α,p-eIF2α)、转化生长因子-β1(transforming growth factor-β1,TGF-β1)、α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)、胶原蛋白Collagen-Ⅰ及Collagen-Ⅲ的蛋白表达。结果与对照组比较,ISO组大鼠EF和FS显著降低(P<0.05),LVIDd、LVIDs、HMI及LVMI显著升高(P<0.05),血清NTproBNP含量显著增加(P<0.05),心肌组织病理损伤明显,胶原纤维面积显著增加(P<0.05),心肌组织中GRP78、CHOP、PERK、p-eIF2α、TGF-β1、α-SMA、Collagen-Ⅰ及Collagen-Ⅲ蛋白表达均显著上调(P<0.05);与ISO组比较,ATRA+ISO组和4-PBA+ISO组的大鼠EF和FS显著升高(P<0.05),LVIDd、LVIDs、HMI及LVMI显著降低(P<0.05),血清NT-proBNP含量显著减少(P<0.05),心肌组织损伤程度明显减轻,胶原纤维面积显著减小(P<0.05),心肌组织中GRP78、CHOP、PERK、p-eIF2α、TGF-β1、α-SMA、Collagen-Ⅰ及Collagen-Ⅲ蛋白表达均显著下调(P<0.05)。结论ATRA能够减轻ISO诱导的大鼠心肌损伤及其纤维化,抑制心肌重构,改善心功能,该作用与其抑制内质网应激反应有关。

关键词：心肌重构心肌纤维化异丙肾上腺素全反式维甲酸内质网应激

Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice

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Protein & Cell 2015年第2期6卷 152-156页

作者： Dekun Wang qingwen meng Lihong Huo meng Yang Lingling Wang Xinyu Chen JianchaoWang Zhiguo Li Xiaoying Ye Na Liu Qiuyan Li Zhen Dai Hongsheng Ouyang Ning Li Jun Zhou Lingyi Chen Lin Liu State Key Laboratory of Medicinal Chemical Biology Collaborative Innovation Center for Bietherapy Department of Genetics and Cell Biology College of Life Sciences Nankai University Tianjin 300071. China State Key Laboratory of Veterinary Biotechnology Harbin Veter- inary Research Institute Chinese Academy of Agricultural Sci- ences Harbin 150001 China State Key Laboratory for Agrobiotechnology College of Biological Sciences China Agricultural University Beijing 100193 China College of Animal Science and Veterinary Medicine Jilin Univer- sity Changchun 130062 China

Dear Editor Histone deacetylase 6 （Hdac6） is a mostly cytoplasmic class II HDAC. Many proteins have been identified as substrates of Hdac6. Among them, the most well characterized sub- strate of Hdac6 is a-tubulin. Through deacetylating acety- lated lysine 40 in a-tubulin, Hdac6 modulates the acetylation of microtubules （Hubbert et al., 2002）.

关键词： Embryonic Stem Embryonic Stem Cell H5N1 Virus Oral Squamous Cell Carcinoma Avian H5N1 Influenza

Silicon photonic integrated interrogator for fiber-optic distributed acoustic sensing

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Photonics Research 2024年第3期12卷 465-473页

作者： ZHICHENG JIN JIAGENG CHEN YANMING CHANG qingwen LIU ZUYUAN HE State Key Laboratory of Advanced Optical Communication System and Networks Department of Electronic EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Distributed acoustic sensing(DAS)technology has been a promising tool in various ***,the large size and relatively high cost of DAS equipment composed of discrete devices restrict its further popularization to some degree,and the photonic integration technology offers a potential *** this paper,we demonstrate an integrated interrogator for DAS on the silicon-on-insulator(SOI)*** design of the chip revolves around a Mach–Zehnder modulator(MZM)transmitter and a dual-quadrature and dualpolarization coherent *** integrated interrogator supports multiple DAS schemes,including the time-gated digital optical frequency domain reflectometry(TGD-OFDR),which is adopted for system performance evaluation.59■strain resolution in 12.1km sensing fiber with 1.14 m spatial resolution(SR)is ***,along 49.0 km sensing fiber,81■strain resolution with 3.78 m SR is *** results show that the integrated interrogator has comparable performance to the discrete DAS *** the best of our knowledge,this is the first dedicated on-chip DAS interrogator,which validates the effectiveness of the blend of photonics integration and DAS technology.

关键词： fiber polarization modulator

Isotopic insights on quantitative assessments of interaction of eco-hydrological processes in multi-scale karst watersheds

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International Soil and Water Conservation Research 2024年第1期12卷 156-170页

作者： Zhuo Hao Yang Gao qingwen Zhang Wen Wen Agricultural Clean Watershed Research Group Institute of Environment and Sustainable Development in AgricultureCAASBeijing100081China Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchCASBeijing100101China School of Humanities and Social Sciences Beijing Institute of TechnologyBeijing100081China

The dynamics of hydrological processes and the storage mechanisms of karst water resources are the most important issues in karst *** impact of environmental changes on water quantity,and the evaluation and quantification of eco-hydrological processes remain poorly *** this study,high-frequency continuous monitoring in multi-scale karst watersheds in Southwest China combined the approaches of water isotopes and the hybrid single-particle lagrangian integrated trajectory(HYSPLIT)model to identify the recharge mechanisms between atmospheric vapor,rainfall,surface water,and groundwater,and to reveal the interaction of eco-hydrological *** dominant moisture sources in Puding(PD)County were the Indian Ocean(43-69%)and local moisture(24-33%).Theδ^(18)O and deuterium excess(d-excess)values showed a positive correlation indicating that secondary or sub-cloud evaporation was prominent in the wet *** water line-conditioned excess(lc-excess)indicated that karst water interacted with recent precipitation,groundwater,and evaporation across *** to its specific hydrogeological structure,surface water and rainwater have a higher contribution rate to groundwater *** Chenqi stream replenished the Houzhai River mainly in the form of groundwater,with percentages ranging from 38.1 to 93.5%in the wet season,and 47.8-80.1%in the dry *** the Houzhai outlet,surface water and groundwater interconverted frequently with a percentage of 45.6-49.1%.We believe this is the first systematic study to quantify the supply relationship between water vapor transport,rainfall,surface water and groundwater in the Chinese karst zone,making a significant move forward in the field of karst hydrological processes and improving the efficiency of water resource evaluation and management.

关键词： Stable isotope Moisture sources Water cycle Karst watersheds

Resonant Beam Communications:A New Design Paradigm and Challenges

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Journal of Communications and Information Networks 2024年第1期9卷 80-87页

作者： Yuanming Tian Dongxu Li Chuan Huang qingwen Liu Shengli Zhou Future Network of Intelligence Institute and School of Science and Engineering the Chinese University of Hong KongShenzhen 518172China School of Science and Engineering and the Future Network of Intelligence Institute the Chinese University of Hong KongShenzhen 518172China College of Electronics and Information Engineering Tongji UniversityShanghai 201804China Department of Electrical and Computer Engineering University of ConnecticutStorrsCT 06250USA

Resonant beam communications (RBCom), which adopts oscillating photons between two separate retroreflectors for information transmission, exhibits potential advantages over other types of wireless optical communications (WOC). However, echo interference generated by the modulated beam reflected from the receiver affects the transmission of the desired information. To tackle this challenge, a synchronization-based point-to-point RBCom system is proposed to eliminate the echo interference, and the design for the transmitter and receiver is discussed. Subsequently,the performance of the proposed RBCom is evaluated and compared with that of visible light communications(VLC)and free space optical communications (FOC). Finally, future research directions are outlined and several implementation challenges of RBCom systems are highlighted.

关键词： resonant beam communications(RBCom) wireless optical communications(WOC) echo interference elimination mobility multiple access