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Quaternary Activity Characteristics and Regional Tectonic Significance of the Jiulong Fault in Jiujiang,Jiangxi Province,China

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Journal of Earth Science 2024年第4期35卷 1107-1117页

作者： Xin Qi Yuyong Jiao qinghua li Bin li Faculty of Engineering China University of GeosciencesWuhan430074China Wuhan Center China Geological SurveyWuhan430205China Institute of Geological Survey China University of GeosciencesWuhan430074China

Obtaining geological and landform dislocation features,as well as the measured stratigraphic activity age,provides direct evidence to evaluate fault activity,which is more difficult to do in areas with low tectonic activity,such as eastern and central China.A detailed investigation of the fault activity,trenching,drilling joint geological profile,geological survey,and chronological analysis were used to obtain the spatial geometry,fault kinematics,and activity chronology of the Jiulong *** conclusions are as follows:(1)The Jiulong fault was a fracture zone composed of four branch faults,with a width of around 30–40 m and good extendibility,while the maximum surface rupture length was 373 m.(2)The Jiulong fault has many strata dislocations,and the dislocation distance decreased from bottom to top,demonstrating synsedimentary structure characteristics,with a maximum stratigraphic dislocation distance of 18.2 m.(3)Preliminary analysis suggested the Jiulong fault as a secondary fracture of the Xiangfan-Guangji fault zone and provided evidence of the southeastward extension of the Xiangfan-Guangji fault.A preliminary hypothesis purported the Xiangfan-Guangji fault as the seismogenic fault of the Ms 5.0 magnitude earthquake in 1911.(4)According to OSL and ESR dating analyses,the upper breakpoint of the Jiulong fault cuts into the Late Pleistocene Xingang Formation(Qp3x)strata,and the latest active age of the Jiulong fault was 57.6 *** chronology analysis confirmed an active fault from the Late Pleistocene and identified a weak tectonic in Jiujiang Province,which represents the largest active fault outcrop uncovered in the area so *** study provides evidence and research materials for the evaluation of fault activity and seismic stability in this region.

关键词： active fault regional tectonic earthquakes seismic intensity tectonics

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Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

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Nano-Micro Letters 2024年第12期16卷 233-284页

作者： Qingdong Bao Xiaoting Zhang Zhankun Hao qinghua li Fan Wu Kaiyuan Wang Yang li Wenlong li Hua Gao State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyEye Institute of Shandong First Medical UniversityQingdao 266071People’s Republic of China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002People’s Republic of China Eye Hospital of Shandong First Medical University Jinan 250021People’s Republic of China College of Ophthalmology Shandong First Medical UniversityJinan 250000People’s Republic of China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore

The eye,a complex organ isolated from the systemic circulation,presents significant drug delivery challenges owing to its protective mechanisms,such as the blood-retinal barrier and corneal *** drug administration methods often fail to sustain therapeutic levels and may compromise patient safety and *** microneedles(PSMNs)have emerged as a transformative solution for ophthalmic drug ***,a comprehensive review of PSMNs in ophthalmology has not been published to *** this review,we critically examine the synergy between polysaccharide chemistry and microneedle technology for enhancing ocular drug *** provide a thorough analysis of PSMNs,summarizing the design principles,fabrication processes,and challenges addressed during fabrication,including improving patient comfort and *** also describe recent advances and the performance of various PSMNs in both research and clinical ***,we review the current regulatory frameworks and market barriers that are relevant to the clinical and commercial advancement of PSMNs and provide a final perspective on this research area.

关键词： Ocular delivery Polysaccharide Microneedles Drug administration

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Supramolecular assembly nanoparticle for trans-epithelial treatment of keratoconus

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Chinese Chemical Letters 2024年第10期35卷 27-29页

作者： Wenlong li Feishi Shan Qingdong Bao qinghua li Hua Gao Leyong Wang State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University Eye Hospital of Shandong First Medical University College of Ophthalmology Shandong First Medical University Key Laboratory of Mesoscopic Chemistry of MOE Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical Engineering Nanjing University

Keratoconus is a clinically prevalent corneal ectasia, characterized by progressive thinning and conical protrusion of the central cornea [1]. With an incidence rate of one in every 400 to2000 individuals, it stands as a leading cause of blindness among the youth. To date, there are no pharmacological interventions available for the treatment of keratoconus. In advanced cases culminating in blindness, corneal transplantation remains the only restorative option. However, this surgical procedure carries risks of immune rejection and chronic graft failure.

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Effects of host identity on the gut microbiota:A comparative study on three microtinae species

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Animal Models and Experimental Medicine 2024年第2期7卷 98-105页

作者： Zhen Yao Wenli Zhao Baohong Tang qinghua li Zhenlong Wang School of life Sciences Zhengzhou UniversityZhengzhouHenan ProvinceP.R.China

Background:Gut microbiota exert an immense effect on host health and host environmental ***,the composition and structure of gut microbiota are determined by the environment and host genetic ***,the relative contribution of the environment and host genetic factors toward shaping the structure of gut microbiota has been poorly ***:In this study,we characterized the fecal microbial communities of the closely related voles Neodon fuscus,Lasiopodomys brandtii,and *** after caged feeding in the laboratory for 6 months,through high-throughput sequencing and bioinformatics ***:The results of pairwise comparisons of *** *** and *** *** revealed significant differences in bacterial diversity and composition after *** 991 same operational taxonomic units(OTUs)were shared in three voles,there were 362,291,and 303 species-specific OTUs in ***,***,and ***,*** relative abundances of Proteobacteria and Prevotella,which are reported to be enriched in high-altitude populations,were significantly higher in high-altitude *** than in low-altitude *** after ***,which produce various digestive enzymes for energy metabolism,and Spirochaetes,which can degrade cellulose,were found in higher abundance in subterranean *** than that in *** which dwells on the earth ***:Our findings showed that some components of gut microbiota still maintained dominance even when different host species are reared under the same environmental conditions,suggesting that these bacteria are substantially influenced by host factors.

关键词： gut microbiota high-altitude Lasiopodomys brandtii Neodon fuscus

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Co-incorporation of Chinese milk vetch(Astragalus sinicus L.)and chemical fertilizers alters microbial functional genes supporting short-time scale positive nitrogen priming effects in paddy soils

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Pedosphere 2024年第3期34卷 567-576页

作者： limin WANG Chunmei HE Dongfeng HUANG Juhua YU Cailing liU qinghua li Yibin HUANG Juan li Fei WANG Institute of Resources Environment and Soil FertilizerSoil and Fertilizer InstituteFujian Academy of Agricultural SciencesFuzhou 350012(China) School of Resources and Environment Engineering Anhui UniversityHefei 230601(China)

Nitrogen(N)priming is a microbially mediated biochemical process as affected by different incorporation ***,little information is known about the microbial mechanisms driving the response of N priming to co-operation of Chinese milk vetch(CMV,Astragalus sinicus L.)and different rates of chemical fertilizers in paddy soils in South ***,an anaerobic incubation experiment was conducted to study N priming effects(PE)and their relationships with soil microbial functional genes after CMV incorporation alone(M),co-incorporation of CMV with 100%(normal dosage)chemical fertilizers(MC100),and co-incorporation of CMV with 80% chemical fertilizers(MC80).Co-incorporation of CMV and chemical fertilizers enhanced the short-time scale(the first 20 d of incubation)positive PE of N,while no significant differences existed among the three treatments on day 60 or 90 of incubation(P>0.05).Compared with the M treatment,gross priming effect(GPE)in the MC100 and MC80 treatments significantly increased by 34.0% and 31.3%,respectively,and net priming effect(NPE)increased by 47.7% and 47.8%,respectively,during the first 20 d of incubation(Plikely attributed to soil nutrient availability and added substrate *** MC100 and MC80 treatments increased the gdhA gene abundance by 5.0% and 9.8%,increased the gdh2 gene abundance by 12.7% and 45.7%,and increased the nasB gene abundance by 9.5% and 41.4%,respectively,in comparison with the M treatment on day 20 of *** analyses indicated that soil microbial functional genes involved in N mineralization(gdhA and gdh2),assimilatory nitrate reduction(nasB),and nitrification(amoB)were significantly correlated with N priming under different incorporation practices during the incubation period(Plizers can regulate soil microbial community functional gene structure,which may accelerate mineralization and assimilatory nitrate reduction and inhibit

关键词： green manure gross priming effect incorporation practice microbial mechanism net priming effect rice field soil

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Evolution of the Mangrove Wetland since the Holocene: Current Progress and Future Perspectives

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Journal of Earth Science 2024年第5期35卷 1669-1678页

作者： Xueyan Yan Xianzhong Ke qinghua li Yiqun Gan Xianjun Xie Yamin Deng Geological Survey China University of Geosciences Wuhan Center China Geological Survey (Central South China Innovation Center for Geosciences) School of Environmental Studies China University of Geosciences

Mangrove wetlands are among the four most productive tropical and subtropical ecosystems. They are also a core component of the coastal blue carbon ecosystem, which is of great ecological significance to human beings, plants, animals, and the global carbon balance. There has been a global decrease in the distribution of mangrove forests, and their ecological function has gradually degenerated since the Holocene. Sediment from coastal mangrove wetlands can provide records of climate change and human activities, and multiple proxies including palynology, leaf fossil, biomarkers, DNA, phytolith and stable isotopes, can be used to reconstruct the evolutionary stages of paleo-mangroves and to identify the effect of natural processes and human activities on the distribution and evolution of mangroves. This information can provide theoretical support for mangrove protection and for improving carbon sequestration capacity. This paper summarizes and compares the multiple proxies for mangrove reconstruction, reviews progress in the study of natural succession of global mangroves since the Holocene, expands on the influence mechanisms of human activities on mangrove growth and development and uses past information to lay a foundation for a model to predict future mangrove development.

关键词： mangrove Holocene multiproxy sedimentary environment climate change environ-mental geology

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Universal architecture and defect engineering dual strategy for hierarchical antimony phosphate composite toward fast and durable sodium storage

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Journal of Energy Chemistry 2024年第3期90卷 110-119,I0004页

作者： Jiawei Wu Gaoyu Wang Wei Zhang lixiang Wang Jian Peng qinghua li Zhixin liang Wenbo Fan Jiazhao Wang Shaoming Huang School of Materials and Energy Guangzhou Key Laboratory of Low-Dimensional Materials and Energy Storage DevicesGuangdong University of TechnologyGuangzhou 510006GuangdongChina School of Mechanical and Electrical Engineering Jiaxing Nanhu UniversityJiaxing 314001ZhejiangChina Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongInnovation CampusSquires WayNorth WollongongNSW2522Australia

Antimony(Sb)-ba sed anode materials are feasible candidates for sodium-ion batteries(SIBs) due to their high theoretical specific capacity and excellent electrical ***,they still suffer from volume distortion,structural collapse,and ionic conduction interruption upon ***,a hierarchical array-like nanofiber structure was designed to address these limitations by combining architecture engineering and anion tuning strategy,in which SbPO_(4-x) with oxygen vacancy nanosheet arrays are anchored on the surface of interwoven carbon nanofibers(SbPO_(4-x)@CNFs).In particular,bulky PO_(4)^(3-) anions mitigate the large volume distortion and generate Na_(3)PO_(4) with high ionic conductivity,collectively improving cyclic stability and ionic transport *** abundant oxygen vacancies substantially boost the intrinsic electronic conductivity of SbPO_4,further accelerating the reaction *** addition,hierarchical fibrous structures provide abundant active sites,construct efficient conducting networks,and enhance the electron/ion transport *** from the advanced structural design,the SbPO_(4-x)@CNFs electrodes exhibit outstanding cycling stability(1000 cycles at 1.0 A g^(-1) with capacity decay of 0.05% per cycle) and rapid sodium storage performance(293.8 mA h g^(-1) at 5.0 A g^(-1)).Importantly,systematic in-/ex-situ techniques have revealed the "multi-step conversion-alloying" reaction process and the "battery-capacitor dual-mode" sodium-storage *** work provides valuable insights into the design of anode materials for advanced SIBs with elevated stability and superior rate performance.

关键词： SbPO_(4) anodes Hierarchical nanostructures Oxygen vacancy Stress dispersion Sodium-ion batteries

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Efficient Polytelluride Anchoring for Ultralong-life Potassium Storage: Combined Physical Barrier and Chemisorption in Nanogrid-in-Nanofiber

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Nano-Micro Letters 2024年第4期16卷 364-378页

作者： qinghua li Dandan Yu Jian Peng Wei Zhang Jianlian Huang Zhixin liang Junling Wang Zeyu lin Shiyun Xiong Jiazhao Wang Shaoming Huang Guangzhou Key Laboratory of Low‑Dimensional Materials and Energy Storage Devices School of Materials and EnergyGuangdong University of TechnologyGuangzhou 510006People’s Republic of China College of Materials and Chemistry China Jiliang UniversityHangzhou 310018People’s Republic of China Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongInnovation CampusSquires WayNorth WollongongNSW 2522Australia

Metal tellurides(MTes) are highly attractive as promising anodes for high-performance potassium-ion batteries. The capacity attenuation of most reported MTe anodes is attributed to their poor electrical conductivity and large volume variation. The evolution mechanisms, dissolution properties, and corresponding manipulation strategies of intermediates(K-polytellurides, K-pTe_(x)) are rarely mentioned. Herein,we propose a novel structural engineering strategy to confine ultrafine CoTe_(2) nanodots in hierarchical nanogrid-in-nanofiber carbon substrates(CoTe_(2)@NC@NSPCNFs) for smooth immobilization of K-pTe_(x) and highly reversible conversion of CoTe_(2) by manipulating the intense electrochemical reaction process. Various in situ/ex situ techniques and density functional theory calculations have been performed to clarify the formation, transformation, and dissolution of K-pTe_(x)(K_(5)Te_(3) and K_(2)Te), as well as verifying the robust physical barrier and the strong chemisorption of K_(5)Te_(3) and K_(2)Te on S, N co-doped dual-type carbon substrates. Additionally, the hierarchical nanogrid-in-nanofiber nanostructure increases the chemical anchoring sites for K-pTe_(x), provides sufficient volume buffer space, and constructs highly interconnected conductive microcircuits, further propelling the battery reaction to new heights(3500 cycles at 2.0 A g^(-1)). Furthermore, the full cells further demonstrate the potential for practical applications. This work provides new insights into manipulating K-pTe_(x) in the design of ultralong-cycling MTe anodes for advanced PIBs.

关键词： Polytelluride dissolution Nanogrid-in-nanofiber structure Physicochemical adsorption Reaction mechanism Ultralonglife potassium storage

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Mechanisms of glutamate metabolic function and dysfunction in vasculardementia

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Neuroprotection 2024年第1期2卷 33-48页

作者： Jiawen Wang Yingmei Zhang Ning Tian Dongshan Ya Jiaxin Yang Yanlin Jiang Xiaoxia li Xiaohui lin Bin Yang qinghua li Rujia liao Laboratory of Neuroscience Afliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Department of Neurology Affliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Department of Pharmacology Affliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Department of Geriatrics Affliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Guangxi Clinical Research Center for NeurologicalDiseases Afiliated Hospitalof Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina

As the global population ages,research on the pathogenesis and treatment options for older patients with dementia has become increasingly *** dementia(VaD),the second most frequent type of dementia,is characterized by vascular impairment caused by inadequate blood supply to the *** is a complex neurological disorder involving multiple cells and signaling pathways,and its prevention and treatment pose clinical challenges with significant behavioral ***,the most abundant amino acid in the brain,plays a critical role as an excitatory neurotransmitter,impacting cognitive function,learning,and *** glutamate metabolism has been closely linked to dementia,and reduced blood flow to the brain can lead to excessive glutamate accumulation,resulting in neuronal *** article highlights the connection between VaD and glutamate metabolism,aiming to identify better methods for preventing and treating VaD via regulating glutamate metabolism.

关键词： glutamate ionotropic glutamate receptors metabolism metabotropic glutamate receptors vasculardementia

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脱冰工况下特高压输电铁塔地线横担受力特征及破坏模式

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中国电机工程学报 2024年第10期44卷 4157-4166,I0035页

作者：杨风利李清华邵帅李茂华朱彬荣中国电力科学研究院有限公司北京市西城区100055

受超设计覆冰及脱冰跳跃动力冲击影响,特高压耐张塔地线横担发生弯折破坏。该文采用ANSYS建立了地线-耐张塔-金具串有限元模型,通过脱冰跳跃工况下的几何非线性动力时程分析,确定了不同覆冰厚度时地线挂点处的纵向不平衡张力、垂直荷载... 详细信息

受超设计覆冰及脱冰跳跃动力冲击影响,特高压耐张塔地线横担发生弯折破坏。该文采用ANSYS建立了地线-耐张塔-金具串有限元模型,通过脱冰跳跃工况下的几何非线性动力时程分析,确定了不同覆冰厚度时地线挂点处的纵向不平衡张力、垂直荷载及动力冲击系数。采用梁杆混合单元建立了地线横担精细化有限元模型,将脱冰跳跃荷载峰值施加在挂点位置,分析得到了地线横担杆件应力分布云图,确定了首先发生失稳破坏的杆件位置,端部下平面第二节间主材弯曲应力与轴压应力之比为37.9%,杆端弯矩影响不可忽略。完成了地线30mm覆冰、大号侧整档100%脱冰工况下的地线横担真型试验,揭示了典型杆件在加载过程中的应变发展规律,反演了地线横担的起始破坏位置及失效模式,与有限元仿真结果及现场破坏形态基本吻合。

关键词：脱冰有限元仿真真型试验应变不平衡张力杆端弯矩

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