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Deep Learning Models Based on Weakly Supervised Learning and Clustering Visualization for Disease Diagnosis

Computers, Materials & Continua 2023年第9期76卷 2649-2665页

作者： Jingyao Liu qinghe feng Jiashi Zhao Yu Miao Wei He Weili Shi Zhengang Jiang School of Computer and Information Engineering Chuzhou UniversityChuzhou239000China School of Computer Science and Technology Changchun University of Science and TechnologyChangchun130022China Zhongshan Institute of Changchun University of Science and Technology ZhongshanChina School of Intelligent Engineering Henan Institute of TechnologyXinxiang453003China

The coronavirus disease 2019(COVID-19)has severely disrupted both human life and the health care *** diagnosis and treatment have become increasingly important;however,the distribution and size of lesions vary widely among individuals,making it challenging to accurately diagnose the *** study proposed a deep-learning disease diagnosismodel based onweakly supervised learning and clustering visualization(W_CVNet)that fused classification with ***,the data were *** optimizable weakly supervised segmentation preprocessing method(O-WSSPM)was used to remove redundant data and solve the category imbalance ***,a deep-learning fusion method was used for feature extraction and classification recognition.A dual asymmetric complementary bilinear feature extraction method(D-CBM)was used to fully extract complementary features,which solved the problem of insufficient feature extraction by a single deep learning ***,an unsupervised learning method based on Fuzzy C-Means(FCM)clustering was used to segment and visualize COVID-19 lesions enabling physicians to accurately assess lesion distribution and disease *** this study,5-fold cross-validation methods were used,and the results showed that the network had an average classification accuracy of 85.8%,outperforming six recent advanced classification models.W_CVNet can effectively help physicians with automated aid in diagnosis to determine if the disease is present and,in the case of COVID-19 patients,to further predict the area of the lesion.

关键词： Classification COVID-19 deep learning segmentation unsupervised learning weakly supervised

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一种BiFPN-YOLOv8铁轨表面缺陷检测网络模型

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河南工学院学报 2024年第03期32卷 25-28+43页

作者：冯庆贺江铭凯郝巧红赵晓蕾赵强杨富超河南工学院智能工程学院中国电波传播研究所

针对铁轨表面存在的剥落、孔洞、瘢痕、划痕、裂缝、磨损缺陷，构建了一种BiFPN-YOLOv8铁轨表面缺陷检测网络模型。在数据准备中，通过Gauss噪声变换和水平变换进行铁轨表面图像数据增强；在网络构建中，通过在原YOLOv8网络模型中引入... 详细信息

针对铁轨表面存在的剥落、孔洞、瘢痕、划痕、裂缝、磨损缺陷，构建了一种BiFPN-YOLOv8铁轨表面缺陷检测网络模型。在数据准备中，通过Gauss噪声变换和水平变换进行铁轨表面图像数据增强；在网络构建中，通过在原YOLOv8网络模型中引入加权双向金字塔结构Bi FPN构建Bi FPN-YOLOv8网络模型用于提升铁轨表面缺陷检测性能；在实验仿真中，通过在RSDDs数据集上定量的对比和定性的检测结果评价，验证了BiFPN-YOLOv8网络模型在铁轨表面缺陷检测任务上的精准性和适用性。

关键词：铁轨表面缺陷检测 BiFPN-YOLOv8

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Towards growth of pure AB-stacked bilayer graphene single crystals

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Nano Research 2024年第5期17卷 4616-4621页

作者： Xiaowen Zhang Tao Zhou Yunlong Ren Zuo feng Ruixi Qiao qinghe Wang Bin Wang Jinxia Bai Muhong Wu Zhilie Tang Xu Zhou Kaihui Liu Xiaozhi Xu Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum MaterialsSchool of PhysicsSouth China Normal UniversityGuangzhou 510006China Guangdong-Hong Kong Joint Laboratory of Quantum Matter School of PhysicsSouth China Normal UniversityGuangzhou 510006China Physical Science and Engineering Division King Abdullah University of Science and TechnologyThuwal 23955–6900Saudi Arabia State Key Laboratory for Mesoscopic Physics Frontiers Science Center for Nano-optoelectronicsSchool of PhysicsPeking UniversityBeijing 100871China Institute for Frontier Science Nanjing University of Aeronautics and AstronauticsNanjing 210094China International Centre for Quantum Materials Collaborative Innovation Centre of Quantum MatterPeking UniversityBeijing 100871China Songshan Lake Materials Laboratory Institute of PhysicsChinese Academy of SciencesDongguan 523808China

Given its intriguing band structure and unique tunable bandgap,AB-stacked bilayer graphene has great potentials in the applications of high-end electronics,optoelectronics and *** epitaxial growth of AB-stacked single-crystal bilayer graphene films requires a strict AB-stacked lattice,identical orientations and seamless stitching of bilayer graphene ***,the particles inevitably present on the metal surface that produced during high temperature growth would induce random orientations,twisted stacking islands,and uncontrollable multilayers,which is a great challenge to ***,we propose a heat-resisting-box assisted strategy to produce nearly pure AB-stacked bilayer graphene single-crystal films on Cu/Ni(111)*** our technique,the particles on the Cu/Ni(111)surface are effectively eliminated,which greatly minimizes the occurrence of randomly twisted islands and uncontrollable *** as-grown AB-stacked bilayer graphene films show>99%alignment and>99%AB stacking *** work provides a promising method towards the growth of pure AB-stacked bilayer graphene single crystals and would accelerate its device applications.

关键词： bilayer graphene AB stacking uniform growth heat-resisting box

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Biallelic variants in RBM42 cause a multisystem disorder with neurological,facial,cardiac,and musculoskeletal involvement

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Protein & Cell 2024年第1期15卷 52-68页

作者： Yiyao Chen Bingxin Yang Xiaoyu Merlin Zhang Songchang Chen Minhui Wang Liya Hu Nina Pan Shuyuan Li Weihui Shi Zhenhua Yang Li Wang Yajing Tan Jian Wang Yanlin Wang qinghe Xing Zhonghua Ma Jinsong Li He-feng Huang Jinglan Zhang Chenming Xu Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China bstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentFudan UniversityShanghai 200011China Intermational Peace Matermity and Child Health Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Shanghai Key Laboratory of Embryo Original Diseases Shanghai 200030China State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Rice Biology the Key Laboratory of Molecular Biology of Crop Pathogens and InsectsInstitute of BiotechnologyZhejiang UniversityHangzhou 310058China Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of MedicineHoustonTX 77030USA Children's hospital of Fudan University Shanghai 201102China School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024ZhejiangChina Research Units of Embryo Original Diseases Chinese Academy of Medical Sciences(No.2019RU056)Shanghai 200011China

Here,we report a previously unrecognized syndromic neurodevelopmental disorder associated with biallelic loss-of-function variants in the RBM42 *** patient is a 2-year-old female with severe central nervous system(CNs)abnormalities,hypotonia,hearing loss,congenital heart defects,and dysmorphic facial *** whole-exome sequencing(WEs)reveals that the patient has two compound heterozygous variants,c.304C>T(p.R102*)and c.1312G>A(p.A438T),in the RBM42 gene which encodes an integral component of splicing complex in the RNA-binding motif protein *** p.A438T variant is in the RRM domain which impairs RBM42 pro-tein stability in ***,p.A438T disrupts the interaction of RBM42 with hnRNP K,which is the causa-tive gene for Au-Kline syndrome with overlapping disease characteristics seen in the index *** human R102*or A438T mutant protein failed to fully rescue the growth defects of RBM42 ortholog knockout△FgRbp1 in Fusarium while it was rescued by the wild-type(WT)human RBM42.A mouse model carying Rbm42 compound heterozygous variants,c.280C>T(p.Q94*)and c.1306_1308delinsACA(p.A436T),demonstrated gross fetal develop-mental defects and most of the double mutant animals died by ***-seq data confirmed that Rbm42 was involved in neurological and myocardial functions with an essential role in alternative splicing(As).Overall,we present clinical,genetic,and functional data to demonstrate that defects in RBM42 constitute the underlying etiology of a new neurodevelopmental disease which links the dysregulation of global AS to abnormal embryonic development.

关键词： RBM42 gene RNA-binding protein neurodevelopmental disorder Au-Kline syndrome alternative splicing

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基于LMMHD波浪能发电机特性的高效实时输出功率控制系统

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电力自动化设备 2024年第6期44卷 43-49页

作者：张庆贺赵峰刘保林李建李然彭爱武中国科学院电工研究所北京100190 中国科学院大学电子电气与通信工程学院北京100049

针对目前液态金属磁流体(LMMHD)波浪能发电机输出功率控制系统响应慢、精度差、变换效率低、低压下不能可靠换向的问题,在LMMHD波浪能发电机输出特性分析的基础上,提出一种通过实时调节LMMHD发电机等效负载来控制发电机输出功率的控制策... 详细信息

针对目前液态金属磁流体(LMMHD)波浪能发电机输出功率控制系统响应慢、精度差、变换效率低、低压下不能可靠换向的问题,在LMMHD波浪能发电机输出特性分析的基础上,提出一种通过实时调节LMMHD发电机等效负载来控制发电机输出功率的控制策略,该控制策略快速准确且多模块并联时不存在并联均流问题。通过对考虑寄生参数影响的主电路效率的理论分析,得到了所提输出功率控制策略下主电路效率的变化规律,进而提出了多模块并联的方案,提高了系统效率,降低了单模块的设计难度。并提出了一种滚动时域判断和双模块独立驱动的换向驱动方法,在实现低压下可靠换向的同时避免了电流从体二极管流通,降低了导通损耗。仿真和样机实验结果验证了所提策略的有效性。

关键词：波浪能发电液态金属磁流体发电机输出功率控制全桥Boost电路模块化

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Derivatization based on tetrazine scaffolds:synthesis of tetrazine derivatives and their biomedical applications

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Organic Chemistry Frontiers 2022年第2期9卷 481-498页

作者： Hongbao Sun qinghe Xue Chang Zhang Haoxing Wu Ping feng Huaxi MR Research Center(HMRRC) Department of RadiologyFrontiers Science Center for Disease-related Molecular NetworkNational Clinical Research Center for GeriatricsFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengdu 610041China Clinical Trial Center West China Hospital of Sichuan UniversityChengdu 610041China

Bioorthogonal chemistry is widely used in biological systems and has been trialed in patients,attracting a lot of attention in this ***-based bioorthogonal reactions are essential in chemical biology applications,including cellular labeling,live-cell imaging,diagnosis,drug release,and oncotherapy,due to their tunable rapid reaction kinetics and unique fluorogenic ***,the scope of de novo tetrazine synthesis is restricted due to the limited supply of commercial starting ***,derivatization based on tetrazine scaffolds has been used to synthesize various tetrazine derivatives to enhance the applications of tetrazine bioorthogonal ***,the recent advances in tetrazine scaffold-based derivatizations,including tetrazine skeletons,aromatic substituents and alkyl substituents of tetrazines,have been *** advantages and limitations of the derivatization methods and applications of the developed tetrazine derivatives in bioorthogonal chemistry have also been highlighted.

关键词： materials. synthesis substituent

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A novel bimetallic RuFe nanocluster to enable highly efficient oxygen reduction in zinc-air batteries

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Progress in Natural Science:Materials International 2022年第6期32卷 769-775页

作者： Yang Li Duowen Ma Yuetao Wang Haibin Yang Zirui Lou Runzhi Qin qinghe Zhao feng Pan Huakun Liu School of Advanced Materials Peking University Shenzhen Graduate School Hydrogen Energy Institute Zhejiang University Institute for Superconducting and Electronic Materials University of Wollongong

Zinc-air batteries(ZABs) have the advantages of high energy density and safety but their large-scale application is hindered by sluggish kinetics of four-electron aqueous O2redox *** used Ruthenium(Ru)-based catalysts possess intrinsic oxygen evolution catalytic activity but suffer from insufficient oxygen reduction reaction(ORR) ***,to optimize the ORR activity of Ru-based catalyst,an iron(Fe)-coordinated,bimetallic RuFe cluster is constructed and homogeneously dispersed within nitrogen(N)-doped carbon layers(denoted as RuFe@NC).Benefitting from the optimized ORR activity and more active site exposure,the RuFe@NC exhibits superior ORR activity with a half wave potential(E1/2) of 0.88 V higher than that of Pt/C(0.82 V).Accordingly,the RuFe@NC-based ZAB outperforms the Pt/C+IrO2-based device,presenting a reduced polarization of 0.7 V and an enhanced cycling lifetime of 50 h at 10 mA ***,the optimized structural design ultralow Ru loading(0.013 mgRucm-2) overcomes the cost barriers and demonstrates its high *** bimetallic RuFe nanocluster opens a new way for future design of more efficient and stable catalytic systems.

关键词： Oxygen reduction reaction Bimetallic nanocluster Ru-based electrocatalyst Zinc-air battery

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Mo doped Ru-based cluster to promote alkaline hydrogen evolution with ultra-low Ru loading

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Chinese Journal of Structural Chemistry 2023年第11期42卷 6-12页

作者： Haibin Yang Duowen Ma Yang Li qinghe Zhao feng Pan Shisheng Zheng Zirui Lou School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhenGuangdong518055PR China Hydrogen Energy Institute Zhejiang UniversityHangzhou310000PR China

Green hydrogen energy developed through electrochemistry is one of the solutions to current energy *** less noble metal ruthenium(Ru)plays an important role in alkaline electrocatalytic hydrogen evolution reaction(HER)as an effective ***,the high cost(>110 RMB per gram)hinders the large-scale application of Ru in industrial hydrogen ***,the strong adsorption of OH*in-termediates over Ru limits the electrocatalytic performance in alkaline ***,we report the Mo-doped Ru nanocluster embedded on N-doped carbon framework(RuMo/NC)as alkaline HER catalyst,which shows excellent catalytic performance with an overpotential of 24.2 mV to reach 10 mA cm-2 with only 0.4 wt%o of Ru,much lower than that of most reported Ru-based *** calculations reveal the introduction of Mo has improved the activity by alleviating the poisoning effect of OH*over Ru in *** fully utilizing Ru in the catalyst,this work marks a step forward in the development of Ru-based catalysts in alkaline HER.

关键词： Hydrogen evolution reaction Ru-based electrocatalyst OH*poison DFT calculation

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SAR1B基因变异致乳糜微粒滞留病2例并文献复习

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中华儿科杂志 2024年第6期62卷 565-570页

作者：张宜琼伍俐亭成业陆怡李玉川冯佳燕邢清和李维君王建设复旦大学附属儿科医院肝病中心上海201102 江西省儿童医院临床营养科南昌330038 复旦大学附属儿科医院病理科上海201102 复旦大学生物医学研究院上海200032

目的总结SAR1B基因变异致乳糜微粒滞留病(CMRD)的基因型与临床特点。方法病例系列研究,总结2022年5月至2023年7月复旦大学附属儿科医院与江西省儿童医院诊治的2例CMRD患儿的临床资料与基因检测结果。分别以“乳糜微粒滞留病”“乳糜微... 详细信息

目的总结SAR1B基因变异致乳糜微粒滞留病(CMRD)的基因型与临床特点。方法病例系列研究,总结2022年5月至2023年7月复旦大学附属儿科医院与江西省儿童医院诊治的2例CMRD患儿的临床资料与基因检测结果。分别以“乳糜微粒滞留病”“乳糜微粒潴留病”“乳糜微粒保留病”“安德森病”“安德森综合征”“chylomicron retention disease”“Anderson syndrome”“Anderson disease”为检索词在中国知网、万方、维普、中国生物医学文献、PubMed数据库自建库至2024年1月进行检索。总结SAR1B基因变异致CMRD的主要临床表现及遗传学特点。结果2例患儿分别为1例11岁男童与1例4月龄女童。2例患儿均有脂质吸收不良、生长不良、胆固醇下降、转氨酶与肌酸激酶升高、维生素E缺乏,基因检查发现分别为SAR1B基因纯合变异(c.224A>G)和复合杂合变异(c.224A>G和c.554G>T)。例1随访1个月余,仍偶有下肢肌痛;例2随访1年余,生长已追赶至正常水平,2例患儿均无其他明显不适。文献复习符合检索条件中文文献0篇,英文文献22篇,包括本研究2例共有51例患者。51例CMRD患者中存在21种SAR1B基因变异,包含10种错义变异,4种无义变异,3种移码变异,框内缺失、剪接位点变异、大片段缺失与大片段缺失插入各1种。51例CMRD患者中,脂质吸收不良49例(腹泻或脂肪泻43例、呕吐17例、腹胀12例)、脂溶性维生素缺乏45例(维生素E缺乏43例、维生素A缺乏10例、维生素D缺乏9例、维生素K缺乏5例),生长不良35例,肝脏受累32例(转氨酶升高32例、脂肪肝5例、肝肿大3例),内镜下可见白色小肠黏膜29例,肌酸激酶升高17例,神经病变14例,眼部病变5例,棘形红细胞增多2例,心脏射血分数降低1例,无症状1例。结论CMRD常表现为婴儿早期脂质吸收不良和生长不良。实验室检测特点为低胆固醇血症,伴或不伴脂溶性维生素缺乏、肝酶和(或)肌酸激酶升高。SAR1B基因型以纯合型为主,错义变异多见。

关键词：低β脂蛋白血症吸收不良综合征儿童维生素E缺乏

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One-pot synthesis of FeNxC as efficient catalyst for high-performance zinc-air battery

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Journal of Energy Chemistry 2022年第3期31卷 100-106,I0004页

作者： Yang Li Kuanda Xu Qi Zhang Zhi Zheng Shunning Li qinghe Zhao Can Li Cheng Dong Zongwei Mei feng Pan Shixue Dou School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhen 518055GuangdongChina Institute for Superconducting and Electronic Materials University of WollongongWollongongNSW 2522Australia College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018ZhejiangChina

Rechargeable zinc-air batteries(ZAB)with a high theoretical energy density of 1086 Wh kg^(-1),have received tremendous research ***,the practical application of ZABs is still limited by high polarization and poor energy efficiency(low power density)due to the sluggish 4 electrons(e^(-))/oxygen(O_(2))kinetics over the air ***,a noble-metal-free Fe Nx C electrocatalyst is developed via a onepot approach,which provides a high density of the oxygen reduction reaction(ORR)active site and facilitates the ORR ***,the as-assembled Zn-air battery displayed a low charge–discharge voltage gap of 0.71 V at 10 m A cm^(-2),a remarkable peak power density as high as 181.2 m W cm^(-2),as well as the long-term durability for hundreds of hours,among the top level of those reported *** work provides a major boost for the practical application of Zn-air battery in the future.

关键词： FeNxC Oxygen reduction reaction Zinc-air battery

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